CN102319308A - Preparation method of heat-clearing cough-relieving oral liquid for children - Google Patents
Preparation method of heat-clearing cough-relieving oral liquid for children Download PDFInfo
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- CN102319308A CN102319308A CN201110247790A CN201110247790A CN102319308A CN 102319308 A CN102319308 A CN 102319308A CN 201110247790 A CN201110247790 A CN 201110247790A CN 201110247790 A CN201110247790 A CN 201110247790A CN 102319308 A CN102319308 A CN 102319308A
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Abstract
The invention discloses a preparation method of heat-clearing cough-relieving oral liquid for children; effective components of prescription medicinal materials are extracted by integrated technology of diaphragm pressure filtration circulation extraction separation instead of existing decoction methods, which not only simplifies the process flow, greatly shortens the production period, saves the energy consumption, facilitates environment protection and waste residue utilization, but also greatly improves the recovery rate of the effective components; In the preparation steps, direct filtration by an ultrafiltration membrane is adopted instead of a method of filtration after standing for 24 hours, which thoroughly solves the quality problem that finished products are easy to generate precipitates which do not disperse by shaking and thus do not meet related regulations under a mixture term, and further shortens the production period.
Description
Technical field
The invention belongs to pharmaceutical field, relate to a kind of method for preparing of Chinese medicine preparation.
Background technology
Record of Chinese Pharmacopoeia version in 2010: the infantile heat-clearing and antitussive oral liquid has reducing heat and dispersing lung-QI, relievings asthma, and the effect of sore-throat relieving, the clinical flu that is used for due to the treating cold due to wind-heat, disease is seen fever with chills, cough expectorant is yellow, tachypnea is panted, xerostomia hoarseness, laryngopharynx swelling and pain.Its prescription is Herba Ephedrae 90g, Semen Armeniacae Amarum (parched) 120g, Gypsum Fibrosum 270g, Radix Glycyrrhizae 90g, Radix Scutellariae 180g, Radix Isatidis 180g, Rhizoma Menispermi 90g.Its preparation method is with Herba Ephedrae, Gypsum Fibrosum decocte with water 30 minutes, adds the five tastes such as all the other Semen Armeniacae Amarum (parched) again, decocts secondary, 2 hours for the first time, and 1 hour for the second time; Collecting decoction filters, and filtrate decompression is concentrated into about 600ml, leaves standstill 24 hours, filters; Filtrating adds Mel 200g, sucrose 100g and sodium benzoate 3g, boils to make dissolving, adds water and makes into 1000ml, stirs cold preservation 24-48 hour; Filter, embedding, sterilization promptly gets.Adopt decocting method to extract the effective ingredient of prescription medical material in the said method, have long, shortcomings such as the extraction temperature is high, energy consumption is high, the thermal sensitivity composition is prone to loss, the effective ingredient response rate is low, post processing trouble of extraction time.
Summary of the invention
In view of this; The object of the present invention is to provide a kind of method of utilizing membrane filter pressing circulation extraction isolation integral technology to prepare the infantile heat-clearing and antitussive oral liquid; Not only can simplify technological process, significantly shorten the production cycle, energy efficient; Be beneficial to environmental conservation and waste residue utilization, and can greatly improve the response rate of effective ingredient.
For achieving the above object, the present invention provides following technical scheme:
The method for preparing of infantile heat-clearing and antitussive oral liquid, processed by following raw materials by weight proportions: 90 parts of 90 parts in Herba Ephedrae, 120 parts of Semen Armeniacae Amarum (parched), 270 parts in Gypsum Fibrosum, 90 parts in Radix Glycyrrhizae, 180 parts of Radix Scutellariaes, 180 parts of Radix Isatidis and Rhizoma Menispermis may further comprise the steps:
A. Herba Ephedrae, Semen Armeniacae Amarum (parched), Gypsum Fibrosum, Radix Glycyrrhizae, Radix Scutellariae, Radix Isatidis and Rhizoma Menispermi are mixed, be ground into coarse powder, subsequent use;
B. in material-compound tank, add entry, be heated to 50-90 ℃ and insulation; Three-way valve is switched to the material-compound tank position; Water in the material-compound tank is pumped into diaphragm filter press, when pressing filtering liquid passes back into material-compound tank, under stirring condition, in material-compound tank, add step a gained medicated powder; Finish; Under 50-90 ℃ condition, carry out the membrane filter pressing circulation extraction first time, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, again three-way valve is switched to the material-compound tank position, in material-compound tank, add entry, under 50-90 ℃ condition, carry out the membrane filter pressing circulation extraction second time, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge twice pressing filtering liquid and pressed liquor, as extracting solution;
C. step b gained extracting solution is evaporated to, leaves standstill, filter, filtrating adds Mel, sucrose and sodium benzoate, boils to make dissolving, adds water to ormal weight, stirs, and cold preservation filters, and promptly gets the infantile heat-clearing and antitussive oral liquid;
Perhaps, with step b gained extracting solution concentrating under reduced pressure, ultrafilter membrane filters, and filtrating adds Mel, sucrose and sodium benzoate, boils to make dissolving, adds water to ormal weight, stirs, and promptly gets the infantile heat-clearing and antitussive oral liquid.
Preferably, said step b adds earlier to be equivalent to 7 flavor prescription medical material gross weight 6-8 water doubly, under 55-65 ℃ condition, carries out the membrane filter pressing circulation extraction first time, and extraction time is 30-40 minute; Add and be equivalent to 7 flavor prescription medical material gross weight 3-5 water doubly, under 55-65 ℃ condition, carry out the membrane filter pressing circulation extraction second time, extraction time is 10-20 minute.
Preferred, said step b adds the water that is equivalent to 7 times of 7 flavor prescription medical material gross weights earlier, under 65 ℃ condition, carries out the membrane filter pressing circulation extraction first time, and extraction time is 30 minutes; Add the water that is equivalent to 4 times of 7 flavor prescription medical material gross weights again, under 65 ℃ condition, carry out the membrane filter pressing circulation extraction second time, extraction time is 15 minutes.
Preferably, said step c is with step b gained extracting solution concentrating under reduced pressure, and ultrafilter membrane filters, and filtrating adds Mel, sucrose and sodium benzoate, boils to make dissolving, adds water to ormal weight, stirs, and promptly gets the infantile heat-clearing and antitussive oral liquid.The aperture of ultrafilter membrane can be decided according to the grading curve of feed liquid, is to the maximum suitable with membrane aperture less than the particle diameter and the flux of smallest particles.In the present invention, the preferred aperture of ultrafilter membrane is the ceramic membrane of 50-200nm, and more preferably the aperture is the hollow fiber ceramic membrane of 100-200nm.
Membrane filter pressing circulation extraction isolation integral technology of the present invention; Be that the discharging opening of material-compound tank is communicated with the charging aperture of diaphragm filter press through pump (like membrane pump etc.), the liquid outlet of diaphragm filter press is communicated with the import of the charging aperture and the filtrate tank of material-compound tank respectively with three-way valve.When three-way valve switches to the material-compound tank position; The liquid outlet of diaphragm filter press is communicated with the charging aperture of material-compound tank; Constitute membrane filter pressing circulation extraction system; Slip in the material-compound tank is pumped to diaphragm filter press and carries out membrane filter pressing, and the pressing filtering liquid that comes out from diaphragm filter press passes back into (medicated powder then is deposited on the filter cloth surface of each filter pressing chamber of diaphragm filter press equably) the material-compound tank, remakes to extracting solvent to be pumped to diaphragm filter press and to carry out membrane filter pressing and constantly circulate, thereby realizes the membrane filter pressing circulation extraction of medical material; When three-way valve switches to the filtrate tank position; The liquid outlet of diaphragm filter press is communicated with the import of filtrate tank; Constitute the membrane filter pressing solid-liquid separation system; After the membrane filter pressing circulation extraction of medical material finishes, will send into the filtrate tank storage from pressing filtering liquid and pressed liquor that diaphragm filter press comes out, thereby herbal extract is well separated with medicinal residues.
About extracting the problem of material, become coarse powder as extracting material pulverizing medicinal materials usually, the soft medical material (like Radix Rehmanniae Preparata, Fructus Jujubae etc.) that difficulty is ground into coarse powder can add the water that 2-4 doubly measures and be ground into slip as extracting material with feed grinder or tissue mashing machine.
About the problem of charging sequence, when the medical material fibre-bearing more after a little while, can be in material-compound tank directly add medicated powder and extract solvent, under stirring condition, carry out the membrane filter pressing circulation extraction; When the medical material fibre rich, then should adopt the outer circulation method of feeding in raw material, to stop that medicated powder stops up in material-compound tank discharging opening and feeding pipe and phenomenon that the stock circulation is obstructed.The reinforced method of so-called outer circulation is will extract required whole solvents earlier first to add in the material-compound tank; Three-way valve is switched to the material-compound tank position; Solvent is pumped into diaphragm filter press; (can observe from the manhole of material-compound tank) when passing back into material-compound tank when observing pressing filtering liquid (this moment actual for solvent), under stirring condition, progressively drop into medicated powder again, the gained feed liquid is pumped to diaphragm filter press thereupon carries out the membrane filter pressing pressing filtering liquid and passes back into and circulate in the material-compound tank, and medicated powder then is deposited on the filter cloth surface of each filter pressing chamber of diaphragm filter press equably.
About extracting the problem of temperature, when being solvent, extracting temperature and can be controlled at 50-90 ℃ with water; Measure the result and combine bibliographical information according to the polarized light microscopy method; Mostly starch gelatinization temperature in the plant tissue is 70-71 ℃, for fear of occurring because of starch gelatinization blocks cell inclusion (being mostly effective ingredient) stripping or stops up phenomenons such as filter cloth, the medical material of rich in starch is carried out water when carrying; Extract temperature and should be controlled at below 70 ℃, preferred 55-65 ℃.And when adopting organic solvent extraction, the boiling point height of looking organic solvent can not heat (promptly at room temperature extracting) or suitably heating.
About the problem of extraction time and extraction time, can require according to the response rate of index components and economy requirement suitable adjustment extraction time and extraction time.For the extraction of general medicinal material coarse powder, but selective extraction 2 times extracted 30-40 minute for the 1st time, extracted 10-20 minute for the 2nd time; Higher for price of medicinal material, require the higher kind of the index components response rate, extraction time can suitably increase, as extracts 4 times, extracts the 2-4 time extraction 10-20 minute 40-60 minute the 1st time; Also can last 1 time extracting solution be carried out recycled as the solvent of extraction first of next group material.When serving as when extracting solvent with alcohol-water mixed solution, carry out membrane filter pressing and wash and squeeze medicinal residues thoroughly in the extraction back available water that finishes, after gained pressing filtering liquid and pressed liquor are measured pure content, can be used as next group material extraction preparing solvent liquid and carry out recycled.Carry out membrane filter pressing when washing thoroughly at water, also can close two liquid valves that are in low level in four jiaos of liquid valves of diaphragm filter press, water is fully soaked overflow the top filtering layer, to strengthen washing thoroughly effect.
Need to extract earlier volatile oil about part medical material in the compound preparation prescription, medicinal residues merge the problem of carrying out decocting with other medical material again, because the process of extracting volatile oil with the water azeotropic reaches several hours; During the water soluble ingredient of medical material fully is soluble in the aqueous phase in the process of extracting volatile oil; Do not carry out decocting so generally need medicinal residues and other medical material not merged, and practice thrift follow-up concentrated energy consumption simultaneously for the response rate that guarantees effective ingredient, can be behind extraction volatile oil; The water of doubly measuring with 2-4 is heated to 60-90 ℃ of membrane filter pressing and passes through the wash slag; Wash 1-2 time thoroughly, the aqueous solution after gained passes through washing liquid and distills merges, as the extraction solvent of water first of other medical material.
About the problem of diaphragm filter press, filter cloth should be selected polypropylene multifilament filter cloth for use, and its Air permenbility selection principle is: less (like 3-10L/m with the appropriate to the occasion Air permenbility of selecting for use of organic solvent extraction
2.s) filter cloth is big (like 50-1200L/m with the appropriate to the occasion Air permenbility of selecting for use of water extraction
2.s) filter cloth.Membrane filter plate should select polypropylene etc. to meet the plastic material of medicinal requirements.The feed liquid pipeline should be selected the plastic conduit of 304 above rustless steels or non-PVC for use.
Beneficial effect of the present invention is: the response rate of effective ingredient has been improved in (1): the present invention adopts the membrane filter pressing circulating extraction method to substitute the effective ingredient that decocting method extracts the prescription medical material, and this method system adopts the pressure-driven of 0.5-0.6Mpa, and circulation extraction is piled up in hundreds of the powder beds on the eluting face; Effect with pressurized column chromatography or pressurization percolation; Extraction efficiency significantly improves, and extracts temperature and reduces, and the loss of thermal sensitivity composition reduces; The response rate of index components significantly improves; For example, contain Herba Ephedrae and reach 0.30mg/ml, improve about 35% than existing method (0.22mg/ml) in ephedrine hydrochloride and pseudoephedrine hydrochloride total amount; And the filter cloth aperture of adopting because of diaphragm filter press is far below be used for the isolating filter screen of medicinal residues and decocting liquid aperture at present, and the clarity of gained extracting solution is good.(2) simplified technological process, shortened the production cycle: extract the prescription medical material of same weight, adopt decocting method to need 3.5 hours, and adopt the membrane filter pressing circulating extraction method to be no more than 1 hour, extraction time shortens more than 70%; And the inventive method can realize the integrated of circulation extraction and solid-liquid separation, does not have the worry of the existing follow-up solid-liquid separation of decocting method.(3) energy savings: with 1m
3Water is heated to 55-65 ℃ from 20 ℃ and needs raw coal 18.4-21.7kg, needs raw coal 37.6kg and be heated to 98 ℃, and 42-51% on year-on-year basis lowers consumption; The extraction time of prescription medical material foreshortened to 1 hour by 3.5 hours, and the extraction energy consumption is reduced greatly.(4) be beneficial to environmental conservation and waste residue utilization: the medicinal residues after the technical finesse of membrane filter pressing circulation extraction isolation integral are the nearly powdered form block of doing; Water content is few; Not only be convenient to transhipment, can not pollute, and be convenient to the later use of waste residue to environment; As insert in the coal dust burning with reduce the coal consumption, biofermentation is made feedstuff, dry distilling is made as the charcoal piece and makes heating or domestic fuel etc.(5) though existing method has adopted multiple times of filtration in the preparation process; As being left standstill, concentrated extracting solution filtered in 24 hours and preparation seasoning liquid cold preservation operations such as filtration in 24-48 hour; But still the deposition of not loosing that exists finished product be prone to produce to shake and do not meet the quality problems of relevant regulations under the mixture item, the present invention is carrying out the improved while to extraction step, also the preparation step is improved; Substitute the method that leaves standstill 24 hours after-filtration with the ultrafilter membrane Direct Filtration; Thoroughly solved molecular weight more than 30,000 invalid component (like starch, protein, phlegmatic temperament etc.) can save follow-uply to the influence of finished product character with preparation proportion liquid cold preservation filtering operation in 24-48 hour, further shorten the production cycle; Products obtained therefrom can not produce the deposition of not loosing of shaking yet, and meets quality regulation.
Description of drawings
Fig. 1 is the preferred corollary apparatus figure of membrane filter pressing circulation extraction isolation integral technology.
The specific embodiment
In order to make the object of the invention, technical scheme and advantage clearer, will combine accompanying drawing that the preferred embodiments of the present invention are carried out detailed description below.
The preferred corollary apparatus figure of membrane filter pressing circulation extraction isolation integral technology is as shown in Figure 1; The discharging opening of material-compound tank is communicated with the charging aperture of diaphragm filter press through membrane pump; The liquid outlet of diaphragm filter press is communicated with the import of the charging aperture and the filtrate tank of material-compound tank respectively with three-way valve, and when three-way valve switched to the material-compound tank position, the liquid outlet of diaphragm filter press was communicated with the charging aperture of material-compound tank; The pressing filtering liquid that comes out from diaphragm filter press passes back into material-compound tank, constitutes membrane filter pressing circulation extraction system; When three-way valve switched to the filtrate tank position, the liquid outlet of diaphragm filter press was communicated with the import of filtrate tank, and the pressing filtering liquid that comes out from diaphragm filter press gets into the filtrate tank storage, constitutes the membrane filter pressing solid-liquid separation system.
Embodiment 1
Prescription: Herba Ephedrae 1.8kg, Semen Armeniacae Amarum (parched) 2.4kg, Gypsum Fibrosum 5.4kg, Radix Glycyrrhizae 1.8kg, Radix Scutellariae 3.6kg, Radix Isatidis 3.6kg, Rhizoma Menispermi 1.8kg
Method for preparing may further comprise the steps:
A. Herba Ephedrae, Semen Armeniacae Amarum (parched), Gypsum Fibrosum, Radix Glycyrrhizae, Radix Scutellariae, Radix Isatidis and the Rhizoma Menispermi with recipe quantity mixes, and is ground into coarse powder, and be subsequent use;
B. in material-compound tank, add the water that is equivalent to 7 times of above-mentioned 7 flavor medical material gross weights, be heated to 65 ℃ and insulation; Three-way valve is switched to the material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, the water in the material-compound tank is pumped into diaphragm filter press (adopt 80 ± 10 L/m
2.s polypropylene multifilament filter cloth), when pressing filtering liquid passes back into material-compound tank, in material-compound tank, at the uniform velocity add step a gained medicated powder; Finish; 65 ℃ of membrane filter pressing circulation extraction 30 minutes switch to the filtrate tank position with three-way valve afterwards and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes; Again three-way valve is switched to the material-compound tank position, in material-compound tank, add 65 ℃ the water of being preheated to be equivalent to 4 times of above-mentioned 7 flavor medical material gross weights, insulation membrane filter pressing circulation extraction 15 minutes; Afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, start the squeezing program of diaphragm filter press, collect pressed liquor, last release is opened plate, slag dumping; Merge twice pressing filtering liquid and pressed liquor, as extracting solution;
C. step b gained extracting solution is evaporated to about 12L, uses the aperture to carry out ultrafiltration as the hollow fiber ceramic membrane of 100nm, filtrating adds Mel 4kg, sucrose 2kg and sodium benzoate 60g; Boil and make dissolving, add water and make into 20L, stir; Embedding, sterilization promptly gets the infantile heat-clearing and antitussive oral liquid.
Embodiment 2
Prescription: Herba Ephedrae 1.8kg, Semen Armeniacae Amarum (parched) 2.4kg, Gypsum Fibrosum 5.4kg, Radix Glycyrrhizae 1.8kg, Radix Scutellariae 3.6kg, Radix Isatidis 3.6kg, Rhizoma Menispermi 1.8kg
Method for preparing may further comprise the steps:
A. Herba Ephedrae, Semen Armeniacae Amarum (parched), Gypsum Fibrosum, Radix Glycyrrhizae, Radix Scutellariae, Radix Isatidis and the Rhizoma Menispermi with recipe quantity mixes, and is ground into coarse powder, and be subsequent use;
B. in material-compound tank, add the water that is equivalent to 8 times of above-mentioned 7 flavor medical material gross weights, be heated to 60 ℃ and insulation; Three-way valve is switched to the material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, the water in the material-compound tank is pumped into diaphragm filter press (adopt 80 ± 10 L/m
2.s polypropylene multifilament filter cloth), when pressing filtering liquid passes back into material-compound tank, in material-compound tank, at the uniform velocity add step a gained medicated powder; Finish; 60 ℃ of membrane filter pressing circulation extraction 35 minutes switch to the filtrate tank position with three-way valve afterwards and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes; Again three-way valve is switched to the material-compound tank position, in material-compound tank, add 60 ℃ the water of being preheated to be equivalent to 3 times of above-mentioned 7 flavor medical material gross weights, insulation membrane filter pressing circulation extraction 10 minutes; Afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, start the squeezing program of diaphragm filter press, collect pressed liquor, last release is opened plate, slag dumping; Merge twice pressing filtering liquid and pressed liquor, as extracting solution;
C. step b gained extracting solution is evaporated to about 12L, uses the aperture to carry out ultrafiltration as the hollow fiber ceramic membrane of 200nm, filtrating adds Mel 4kg, sucrose 2kg and sodium benzoate 60g; Boil and make dissolving, add water and make into 20L, stir; Embedding, sterilization promptly gets the infantile heat-clearing and antitussive oral liquid.
Embodiment 3
Prescription: Herba Ephedrae 1.8kg, Semen Armeniacae Amarum (parched) 2.4kg, Gypsum Fibrosum 5.4kg, Radix Glycyrrhizae 1.8kg, Radix Scutellariae 3.6kg, Radix Isatidis 3.6kg, Rhizoma Menispermi 1.8kg
Method for preparing may further comprise the steps:
A. Herba Ephedrae, Semen Armeniacae Amarum (parched), Gypsum Fibrosum, Radix Glycyrrhizae, Radix Scutellariae, Radix Isatidis and the Rhizoma Menispermi with recipe quantity mixes, and is ground into coarse powder, and be subsequent use;
B. in material-compound tank, add the water that is equivalent to 6 times of above-mentioned 7 flavor medical material gross weights, be heated to 55 ℃ and insulation; Three-way valve is switched to the material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, the water in the material-compound tank is pumped into diaphragm filter press (adopt 80 ± 10 L/m
2.s polypropylene multifilament filter cloth), when pressing filtering liquid passes back into material-compound tank, in material-compound tank, at the uniform velocity add step a gained medicated powder; Finish; 55 ℃ of membrane filter pressing circulation extraction 40 minutes switch to the filtrate tank position with three-way valve afterwards and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes; Again three-way valve is switched to the material-compound tank position, in material-compound tank, add 55 ℃ the water of being preheated to be equivalent to 5 times of above-mentioned 7 flavor medical material gross weights, insulation membrane filter pressing circulation extraction 20 minutes; Afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, start the squeezing program of diaphragm filter press, collect pressed liquor, last release is opened plate, slag dumping; Merge twice pressing filtering liquid and pressed liquor, as extracting solution;
C. step b gained extracting solution is evaporated to about 12L, left standstill 24 hours, filter, filtrating adds Mel 4kg, sucrose 2kg and sodium benzoate 60g; Boil and make dissolving, add water and make into 20L, stir cold preservation 24-48 hour; Filter, embedding, sterilization promptly gets the infantile heat-clearing and antitussive oral liquid.
Employing is with a collection of medicinal raw material; Adopt said method of embodiment 1-3 and existing method (Chinese Pharmacopoeia one one of version in 2010 is recorded method) to compare experiment respectively; And products obtained therefrom carried out quality inspection; The result shows: the product that adopts the said method of embodiment 1-3 to make all meets the requirement of quality standard, and the content of index components is higher.Wherein, the cost-effectiveness of embodiment 1 said method is than best, contains Herba Ephedrae in the products obtained therefrom and reaches 0.30mg/ml in the total amount of ephedrine hydrochloride and pseudoephedrine hydrochloride, improves about 35% than existing method (0.22mg/ml); Further; Embodiment 1-2 substitutes the operation of leaving standstill 24 hours after-filtration with the ultrafilter membrane Direct Filtration in the preparation step; Save operation simultaneously with 24-48 hour after-filtration of preparation proportion liquid cold preservation; Products obtained therefrom can not produce the deposition of not loosing of shaking, and has solved thoroughly that existing method products obtained therefrom is prone to produce the deposition of not loosing of shaking and the quality problems that do not meet relevant regulations under the mixture item.
Explanation is at last; Above embodiment is only unrestricted in order to technical scheme of the present invention to be described; Although through invention has been described with reference to the preferred embodiments of the present invention; But those of ordinary skill in the art should be appreciated that and can make various changes to it in form with on the details, and the spirit and scope of the present invention that do not depart from appended claims and limited.
Claims (4)
1. the method for preparing of infantile heat-clearing and antitussive oral liquid; Process by following raw materials by weight proportions: 90 parts of 90 parts in Herba Ephedrae, 120 parts of Semen Armeniacae Amarum (parched), 270 parts in Gypsum Fibrosum, 90 parts in Radix Glycyrrhizae, 180 parts of Radix Scutellariaes, 180 parts of Radix Isatidis and Rhizoma Menispermis; It is characterized in that, may further comprise the steps:
A. Herba Ephedrae, Semen Armeniacae Amarum (parched), Gypsum Fibrosum, Radix Glycyrrhizae, Radix Scutellariae, Radix Isatidis and Rhizoma Menispermi are mixed, be ground into coarse powder, subsequent use;
B. in material-compound tank, add entry, be heated to 50-90 ℃ and insulation; Three-way valve is switched to the material-compound tank position; Water in the material-compound tank is pumped into diaphragm filter press, when pressing filtering liquid passes back into material-compound tank, under stirring condition, in material-compound tank, add step a gained medicated powder; Finish; Under 50-90 ℃ condition, carry out the membrane filter pressing circulation extraction first time, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, again three-way valve is switched to the material-compound tank position, in material-compound tank, add entry, under 50-90 ℃ condition, carry out the membrane filter pressing circulation extraction second time, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge twice pressing filtering liquid and pressed liquor, as extracting solution;
C. step b gained extracting solution is evaporated to, leaves standstill, filter, filtrating adds Mel, sucrose and sodium benzoate, boils to make dissolving, adds water to ormal weight, stirs, and cold preservation filters, and promptly gets the infantile heat-clearing and antitussive oral liquid;
Perhaps, with step b gained extracting solution concentrating under reduced pressure, ultrafilter membrane filters, and filtrating adds Mel, sucrose and sodium benzoate, boils to make dissolving, adds water to ormal weight, stirs, and promptly gets the infantile heat-clearing and antitussive oral liquid.
2. the method for preparing of infantile heat-clearing and antitussive oral liquid according to claim 1; It is characterized in that; Said step b adds earlier to be equivalent to 7 flavor prescription medical material gross weight 6-8 water doubly, under 55-65 ℃ condition, carries out the membrane filter pressing circulation extraction first time, and extraction time is 30-40 minute; Add and be equivalent to 7 flavor prescription medical material gross weight 3-5 water doubly, under 55-65 ℃ condition, carry out the membrane filter pressing circulation extraction second time, extraction time is 10-20 minute.
3. the method for preparing of infantile heat-clearing and antitussive oral liquid according to claim 2; It is characterized in that; Said step b adds the water that is equivalent to 7 times of 7 flavor prescription medical material gross weights earlier, under 65 ℃ condition, carries out the membrane filter pressing circulation extraction first time, and extraction time is 30 minutes; Add the water that is equivalent to 4 times of 7 flavor prescription medical material gross weights again, under 65 ℃ condition, carry out the membrane filter pressing circulation extraction second time, extraction time is 15 minutes.
4. according to the method for preparing of the described infantile heat-clearing and antitussive oral liquid of the arbitrary claim of claim 1 to 3, it is characterized in that ultrafilter membrane is that the aperture is the ceramic membrane of 50-200nm among the said step c.
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| CN117100605A (en) * | 2023-10-20 | 2023-11-24 | 四川天和药业有限公司 | Traditional chinese medicine liquid extraction filter equipment |
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