CN102247525B - Method for preparing pulse activating decoction - Google Patents
Method for preparing pulse activating decoction Download PDFInfo
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- CN102247525B CN102247525B CN201110247782.5A CN201110247782A CN102247525B CN 102247525 B CN102247525 B CN 102247525B CN 201110247782 A CN201110247782 A CN 201110247782A CN 102247525 B CN102247525 B CN 102247525B
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Abstract
The invention discloses a method for preparing pulse activating decoction. In the method, instead of a percolation process, membrane pressure filtration circulating extraction and separation combined technique is used to extract the active ingredients of medicinal materials in a formula, so the production period is shortened greatly, environment protection and slag utilization are promoted and the recovery rate of the active ingredients is increased greatly.
Description
Technical field
The invention belongs to pharmaceutical field, relate to a kind of preparation method of Chinese medicine preparation.
Background technology
Record of Chinese Pharmacopoeia version in 2010: SHENGMAI YIN has the effect of Yiqi and vein recovery, YIN nourishing and the production of body fluid promoting, clinical in QIYINLIANGXU, shortness of breath and palpitation, faint pulse spontaneous perspiration.Its prescription is for Radix Ginseng Rubra 100g, Radix Ophiopogonis 200g, Fructus Schisandrae Chinensis 100g.Its preparation method is that Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis powder are broken into coarse powder, with 65% ethanol, makes solvent, floods after 24 hours and carries out percolation, collect the about 4500ml of percolate, be evaporated to about 250ml, let cool, add water 400ml dilution, filter, separately add 60% syrup 300ml and appropriate antiseptic, and regulate pH value to prescribed limit, and add water to 1000ml, stir evenly, standing, filter embedding, sterilizing, obtains.In said method, adopt percolation to extract the effective ingredient of prescription medical material, exist ethanol in production cycle length, percolation process easily to wave the problems such as loose loss causes concentration to change, the effective ingredient response rate is low.
Summary of the invention
In view of this; the object of the present invention is to provide a kind of method of utilizing membrane filter pressing circulation extraction isolation integral technology to prepare SHENGMAI YIN; not only can significantly shorten the production cycle, be beneficial to environmental conservation and waste residue utilization, and can greatly improve the response rate of effective ingredient.
For achieving the above object, the invention provides following technical scheme:
The preparation method of SHENGMAI YIN, by the crude drug of following weight proportioning, made: 100 parts of 100 parts of Radix Ginseng Rubra, 200 parts of Radix Ophiopogonis and Fructus Schisandrae Chinensis, preparation method comprises the following steps:
A. Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis are mixed, be ground into coarse powder, standby;
B. to adding concentration of volume percent in material-compound tank, be 65% ethanol; Three-way valve is switched to material-compound tank position, the ethanol that is 65% by the concentration of volume percent in material-compound tank pumps into diaphragm filter press, while passing back into material-compound tank to pressing filtering liquid, under stirring condition, in material-compound tank, add step a gained medicated powder, finish, carry out membrane filter pressing circulation for the first time and extract, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, three-way valve being switched to material-compound tank position, is 65% ethanol to adding concentration of volume percent in material-compound tank again, carries out membrane filter pressing circulation for the second time and extracts, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, three-way valve being switched to material-compound tank position, is 65% ethanol to adding concentration of volume percent in material-compound tank again, carries out membrane filter pressing circulation for the third time and extracts, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge three pressing filtering liquids and pressed liquor, as extracting solution;
C. by the extracting solution decompression recycling ethanol of step b gained concentrated, let cool, thin up, filters, and filtrate adds syrup and antiseptic, regulates pH value to prescribed limit, adds water to ormal weight, stirs evenly, standing, filters, and obtains SHENGMAI YIN.
Preferably, described step b first adds to be equivalent to Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis 3 taste medical material gross weight 6-8 65% ethanol doubly, carries out membrane filter pressing circulation for the first time and extracts, and extraction time is 30-40 minute; Add and be equivalent to above-mentioned 3 taste medical material gross weight 2.5-4.5 65% ethanol doubly, carry out membrane filter pressing circulation for the second time and extract, extraction time is 15-25 minute; Add and be equivalent to above-mentioned 3 taste medical material gross weight 2-4 65% ethanol doubly, carry out membrane filter pressing circulation for the third time and extract, extraction time is 10-20 minute.
Preferred, described step b first adds 65% ethanol that is equivalent to 7 times of Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis gross weights, carries out membrane filter pressing circulation for the first time and extracts, and extraction time is 35 minutes; Add 65% ethanol that is equivalent to 3.5 times of above-mentioned 3 taste medical material gross weights again, carry out membrane filter pressing circulation for the second time and extract, extraction time is 20 minutes; Add 65% ethanol that is equivalent to 3 times of above-mentioned 3 taste medical material gross weights again, carry out membrane filter pressing circulation for the third time and extract, extraction time is 10 minutes.
Preferably, between described step b and step c, also comprise step b ＇: three-way valve is switched to material-compound tank position, in material-compound tank, add water, carry out membrane filter pressing circulation and thoroughly wash, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge pressing filtering liquid and pressed liquor, measure ethanol content, as next group Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis, extract the preparation liquid of solvent.
Preferred, described step b ＇ adds to be equivalent to Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis gross weight 2-4 water doubly, and 3-7 minute is washed in membrane filter pressing circulation thoroughly.
Isolation integral technology is extracted in membrane filter pressing circulation of the present invention, be that the discharging opening of material-compound tank is communicated with the charging aperture of diaphragm filter press by pump (as membrane pump etc.), the liquid outlet of diaphragm filter press is communicated with respectively the import of charging aperture and the filtrate tank of material-compound tank with three-way valve.When three-way valve switches to material-compound tank position, the liquid outlet of diaphragm filter press is communicated with the charging aperture of material-compound tank, form membrane filter pressing circulation extraction system, slip in material-compound tank is pumped to diaphragm filter press to carry out membrane filter pressing and passes back into (medicated powder is deposited in the filter cloth surface of each filter pressing chamber of diaphragm filter press equably) material-compound tank from diaphragm filter press pressing filtering liquid out, be re-used as and extract solvent and be pumped to diaphragm filter press and carry out membrane filter pressing and constantly circulate, thereby the membrane filter pressing circulation that realizes medical material is extracted; When three-way valve switches to filtrate tank position, the liquid outlet of diaphragm filter press is communicated with the import of filtrate tank, form membrane filter pressing solid-liquid separation system, after the membrane filter pressing circulation of medical material is extracted, to send into filtrate tank storage from diaphragm filter press pressing filtering liquid and pressed liquor out, thereby make herbal extract well separated with medicinal residues.
About extracting the problem of material, conventionally pulverizing medicinal materials is become coarse powder as extracting material, the soft medical material (as Radix Rehmanniae Preparata, Fructus Jujubae etc.) that difficulty is ground into coarse powder can add the water that 2-4 doubly measures to be ground into slip as extracting material with feed grinder or tissue mashing machine.
About the problem of charging sequence, when medical material fibre-bearing is less, can in material-compound tank, directly adds medicated powder and extract solvent, under stirring condition, carry out membrane filter pressing circulation and extract; When medical material fibre rich, should adopt the outer circulation method of feeding in raw material, to stop that medicated powder stops up in material-compound tank discharging opening and feeding pipe and phenomenon that stock circulation is obstructed.The reinforced method of so-called outer circulation is first by extracting first required whole solvents, to add in material-compound tank, three-way valve is switched to material-compound tank position, solvent is pumped into diaphragm filter press, when observing pressing filtering liquid (now actual for solvent) and pass back into material-compound tank (can observe from the manhole of material-compound tank), under stirring condition, progressively drop into again medicated powder, gained feed liquid is pumped to diaphragm filter press thereupon carries out membrane filter pressing pressing filtering liquid and passes back in material-compound tank and circulate, and medicated powder is deposited in the filter cloth surface of each filter pressing chamber of diaphragm filter press equably.
About extracting the problem of temperature, take water during as solvent, extract temperature and can be controlled at 50-90 ℃, according to polarized light microscopy method measurement result and in conjunction with bibliographical information, starch gelatinization temperature in plant tissue mostly is 70-71 ℃, for fear of occurring because starch gelatinization blocks cell inclusion (mostly being effective ingredient) stripping or stops up the phenomenons such as filter cloth, when the medical material of rich in starch is carried out to water extraction, extract temperature and should be controlled at below 70 ℃, preferably 55-65 ℃.And while adopting organic solvent extraction, depending on the boiling point height of organic solvent, can not heat (at room temperature extracting) or suitably heating.
About the problem of extraction time and extraction time, can require and economy requirement suitable adjustment extraction time and extraction time according to the response rate of index components.For the extraction of general medicinal material coarse powder, can selective extraction 2 times, extract 30-40 minute the 1st time, extract 10-20 minute the 2nd time; Higher for price of medicinal material, require the kind that the index components response rate is higher, extraction time can suitably increase, as extracts 4 times, extracts 40-60 minute for the 1st time, the 2-4 time extraction 10-20 minute; Also can carry out recycled by the solvent of extraction first using the extracting solution of last 1 time as next group material.When take alcohol-water mixed solution when extracting solvent, after extracting, available water is carried out membrane filter pressing and is thoroughly washed and squeeze medicinal residues, and gained pressing filtering liquid and pressed liquor are measured after alcohol content, can be used as the preparation liquid that next group material extracts solvent and carries out recycled.At water, carry out membrane filter pressing while thoroughly washing, also can close two liquid valves in low level in four jiaos of liquid valves of diaphragm filter press, make water fully soak unrestrained top filtering layer, to strengthen washing effect.
About part medical material in compound preparation prescription, need first extract volatile oil, medicinal residues merge the problem of carrying out decocting with other medical material again, owing to reaching a few hours with the process of water azeotropic extraction volatile oil, during the water soluble ingredient of medical material is fully soluble in the aqueous phase in the process of extracting volatile oil, therefore generally do not need medicinal residues and the merging of other medical material to carry out decocting, and in order to guarantee that the response rate of effective ingredient saves follow-up concentrated energy consumption simultaneously, can be after extracting volatile oil, the water of doubly measuring with 2-4 is heated to the 60-90 ℃ of saturating wash slag of membrane filter pressing, thoroughly wash 1-2 time, aqueous solution after the saturating washing liquid of gained and distillation merges, the solvent of water extraction first as other medical material.
About the problem of diaphragm filter press, filter cloth should be selected polypropylene multifilament filter cloth, and its Air permenbility selection principle is: less (as 3-10L/m with the appropriate to the occasion Air permenbility of selecting of organic solvent extraction
2.s) filter cloth is large (as 50-1200L/m with the appropriate to the occasion Air permenbility of selecting of water extraction
2.s) filter cloth.Membrane filter plate should select polypropylene etc. to meet the plastic material of medicinal requirements.Feed liquid pipeline should be selected the plastic conduit of 304 above rustless steels or non-PVC.
In the present invention, percentage ratio represents with " % " symbol, means the ratio of weight; But the percentage ratio of solution, except as otherwise herein provided, means and in solution 100ml, contains some grams of solutes; The percentage ratio of ethanol, means percent by volume, contains the some milliliters of ethanol in ie in solution 100ml.
Beneficial effect of the present invention is: (1) has improved the response rate of effective ingredient: the present invention adopts membrane filter pressing circulating extraction method to substitute percolation, system adopts the pressure-driven of 0.5-0.6Mpa, circulation is extracted and is piled up in hundreds of the powder beds on eluting face, the effect with pressurization percolation, extraction efficiency significantly improves, the response rate of index components significantly improves, for example, Radix Ginseng Rubra index components ginsenoside's content improves approximately 10% than existing method, and the content of Fructus Schisandrae Chinensis index components deoxyschizandrin improves approximately 13% than existing method; And the filter cloth aperture adopting because of diaphragm filter press is far below at present for the medicinal residues aperture of filter screen separated with decocting liquid, the clarity of gained extracting solution is good.(2) shortened the production cycle: extract the prescription medical material of same weight, adopt percolation at least to need 24 hours, and adopt membrane filter pressing circulating extraction method to be no more than 1.5 hours, extraction time shortens more than 90%; And the inventive method can realize the integrated of circulation extraction and solid-liquid separation equally, and because the filter cloth of diaphragm filter press is ultimate attainment close, the clarity of gained extracting solution is good.(3) be beneficial to environmental conservation and waste residue utilization: the medicinal residues that extract after isolation integral technical finesse through membrane filter pressing circulation are nearly dry powdered form block; water content is few; not only be convenient to transhipment; can not give environment; and be convenient to the later use of waste residue; as insert in coal dust burning reducing coal consumption, biofermentation is made feedstuff, dry distilling is made as that charcoal piece is warmed oneself or domestic fuel etc.
Accompanying drawing explanation
Fig. 1 is the preferred corollary apparatus figure that isolation integral technology is extracted in membrane filter pressing circulation.
The specific embodiment
In order to make the object, technical solutions and advantages of the present invention clearer, below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail.
The preferred corollary apparatus figure of membrane filter pressing circulation extraction isolation integral technology as shown in Figure 1, the discharging opening of material-compound tank is communicated with the charging aperture of diaphragm filter press by membrane pump, the liquid outlet of diaphragm filter press is communicated with respectively the import of charging aperture and the filtrate tank of material-compound tank with three-way valve, when three-way valve switches to material-compound tank position, the liquid outlet of diaphragm filter press is communicated with the charging aperture of material-compound tank, from diaphragm filter press pressing filtering liquid out, pass back into material-compound tank, form membrane filter pressing circulation extraction system; When three-way valve switches to filtrate tank position, the liquid outlet of diaphragm filter press is communicated with the import of filtrate tank, enters filtrate tank store from diaphragm filter press pressing filtering liquid out, forms membrane filter pressing solid-liquid separation system.
embodiment 1
Prescription: Radix Ginseng Rubra 5kg, Radix Ophiopogonis 10kg, Fructus Schisandrae Chinensis 5kg
Preparation method comprises the following steps:
A. the Radix Ginseng Rubra of recipe quantity, Radix Ophiopogonis and Fructus Schisandrae Chinensis are mixed, be ground into coarse powder, standby;
B. to adding 65% ethanol that is equivalent to 7 times of Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis gross weights in material-compound tank; Three-way valve is switched to material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, 65% ethanol in material-compound tank is pumped into diaphragm filter press and (adopt 5-8 L/m
2.s polypropylene multifilament filter cloth), while passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a gained medicated powder, finish, membrane filter pressing circulation is extracted 35 minutes, afterwards three-way valve is switched to filtrate tank position and carries out membrane filter pressing, collects pressing filtering liquid; After filter pressing, three-way valve is switched to material-compound tank position again, in material-compound tank, add 65% ethanol that is equivalent to 3.5 times of above-mentioned 3 taste medical material gross weights, membrane filter pressing circulation is extracted 20 minutes, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, three-way valve is switched to material-compound tank position again, in material-compound tank, add 65% ethanol that is equivalent to 3 times of above-mentioned 3 taste medical material gross weights, membrane filter pressing circulation is extracted 10 minutes, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge three pressing filtering liquids and pressed liquor, as extracting solution;
B. three-way valve is switched to material-compound tank position, in material-compound tank, add the water that is equivalent to 4 times of above-mentioned 3 taste medical material gross weights, close two liquid valves in low level in four jiaos of liquid valves of diaphragm filter press, membrane filter pressing circulation is washed 5 minutes thoroughly, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, start the squeezing program of diaphragm filter press, collect pressed liquor, last release, opens plate, slag dumping; Merge pressing filtering liquid and pressed liquor, measure ethanol content, as next group Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis, extract the preparation liquid of solvent;
C. by the extracting solution decompression recycling ethanol of step b gained and be concentrated into about 12.5L(11.5-13.5L), let cool, add water 20L dilution, filter, filtrate adds 60% syrup 15L and antiseptic, regulate pH value to 4.5-7.0, add water to 50L, stir evenly, standing, filter, embedding, sterilizing, obtains SHENGMAI YIN.
embodiment 2
Prescription: Radix Ginseng Rubra 5kg, Radix Ophiopogonis 10kg, Fructus Schisandrae Chinensis 5kg
Preparation method comprises the following steps:
A. the Radix Ginseng Rubra of recipe quantity, Radix Ophiopogonis and Fructus Schisandrae Chinensis are mixed, be ground into coarse powder, standby;
B. to adding 65% ethanol that is equivalent to 6 times of Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis gross weights in material-compound tank; Three-way valve is switched to material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, 65% ethanol in material-compound tank is pumped into diaphragm filter press and (adopt 5-8 L/m
2.s polypropylene multifilament filter cloth), while passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a gained medicated powder, finish, membrane filter pressing circulation is extracted 40 minutes, afterwards three-way valve is switched to filtrate tank position and carries out membrane filter pressing, collects pressing filtering liquid; After filter pressing, three-way valve is switched to material-compound tank position again, in material-compound tank, add 65% ethanol that is equivalent to 2.5 times of above-mentioned 3 taste medical material gross weights, membrane filter pressing circulation is extracted 25 minutes, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, three-way valve is switched to material-compound tank position again, in material-compound tank, add 65% ethanol that is equivalent to 2 times of above-mentioned 3 taste medical material gross weights, membrane filter pressing circulation is extracted 20 minutes, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge three pressing filtering liquids and pressed liquor, as extracting solution;
B. three-way valve is switched to material-compound tank position, in material-compound tank, add the water that is equivalent to 3 times of above-mentioned 3 taste medical material gross weights, close two liquid valves in low level in four jiaos of liquid valves of diaphragm filter press, membrane filter pressing circulation is washed 5 minutes thoroughly, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, start the squeezing program of diaphragm filter press, collect pressed liquor, last release, opens plate, slag dumping; Merge pressing filtering liquid and pressed liquor, measure ethanol content, as next group Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis, extract the preparation liquid of solvent;
C. by the extracting solution decompression recycling ethanol of step b gained and be concentrated into about 12.5L(11.5-13.5L), let cool, add water 20L dilution, filter, filtrate adds 60% syrup 15L and antiseptic, regulate pH value to 4.5-7.0, add water to 50L, stir evenly, standing, filter, embedding, sterilizing, obtains SHENGMAI YIN.
embodiment 3
Prescription: Radix Ginseng Rubra 5kg, Radix Ophiopogonis 10kg, Fructus Schisandrae Chinensis 5kg
Preparation method comprises the following steps:
A. the Radix Ginseng Rubra of recipe quantity, Radix Ophiopogonis and Fructus Schisandrae Chinensis are mixed, be ground into coarse powder, standby;
B. to adding 65% ethanol that is equivalent to 8 times of Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis gross weights in material-compound tank; Three-way valve is switched to material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, 65% ethanol in material-compound tank is pumped into diaphragm filter press and (adopt 5-8 L/m
2.s polypropylene multifilament filter cloth), while passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a gained medicated powder, finish, membrane filter pressing circulation is extracted 30 minutes, afterwards three-way valve is switched to filtrate tank position and carries out membrane filter pressing, collects pressing filtering liquid; After filter pressing, three-way valve is switched to material-compound tank position again, in material-compound tank, add 65% ethanol that is equivalent to 4.5 times of above-mentioned 3 taste medical material gross weights, membrane filter pressing circulation is extracted 15 minutes, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, three-way valve is switched to material-compound tank position again, in material-compound tank, add 65% ethanol that is equivalent to 4 times of above-mentioned 3 taste medical material gross weights, membrane filter pressing circulation is extracted 15 minutes, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge three pressing filtering liquids and pressed liquor, as extracting solution;
B. three-way valve is switched to material-compound tank position, in material-compound tank, add the water that is equivalent to 4 times of above-mentioned 3 taste medical material gross weights, close two liquid valves in low level in four jiaos of liquid valves of diaphragm filter press, membrane filter pressing circulation is washed 5 minutes thoroughly, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, start the squeezing program of diaphragm filter press, collect pressed liquor, last release, opens plate, slag dumping; Merge pressing filtering liquid and pressed liquor, measure ethanol content, as next group Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis, extract the preparation liquid of solvent;
C. by the extracting solution decompression recycling ethanol of step b gained and be concentrated into about 12.5L(11.5-13.5L), let cool, add water 20L dilution, filter, filtrate adds 60% syrup 15L and antiseptic, regulate pH value to 4.5-7.0, add water to 50L, stir evenly, standing, filter, embedding, sterilizing, obtains SHENGMAI YIN.
Employing is with a collection of medicinal raw material, adopt respectively method and existing method (Chinese Pharmacopoeia one of version in 2010 is recorded method) described in embodiment 1-3 to carry out contrast experiment, and products obtained therefrom is carried out to quality inspection, result shows: the product that described in employing embodiment 1-3, method makes all meets the requirement of quality standard, and the response rate of index components is higher.Wherein, the cost-effectiveness of method is than best described in embodiment 1, and in products obtained therefrom, index components ginsenoside's content improves approximately 10% than existing method, and the content of deoxyschizandrin improves approximately 13% than existing method.
Finally explanation is, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although by with reference to the preferred embodiments of the present invention, invention has been described, but those of ordinary skill in the art is to be understood that, can to it, make various changes in the form and details, and not depart from the spirit and scope of the present invention that appended claims limits.
Claims (5)
1. the preparation method of SHENGMAI YIN, by the crude drug of following weight proportioning, made: 100 parts of 100 parts of Radix Ginseng Rubra, 200 parts of Radix Ophiopogonis and Fructus Schisandrae Chinensis, it is characterized in that, preparation method comprises the following steps:
A. Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis are mixed, be ground into coarse powder, standby;
B. to adding concentration of volume percent in material-compound tank, be 65% ethanol; Three-way valve is switched to material-compound tank position, the ethanol that is 65% by the concentration of volume percent in material-compound tank pumps into diaphragm filter press, while passing back into material-compound tank to pressing filtering liquid, under stirring condition, in material-compound tank, add step a gained medicated powder, finish, carry out membrane filter pressing circulation for the first time and extract, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, three-way valve being switched to material-compound tank position, is 65% ethanol to adding concentration of volume percent in material-compound tank again, carries out membrane filter pressing circulation for the second time and extracts, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, three-way valve being switched to material-compound tank position, is 65% ethanol to adding concentration of volume percent in material-compound tank again, carries out membrane filter pressing circulation for the third time and extracts, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge three pressing filtering liquids and pressed liquor, as extracting solution;
C. by the extracting solution decompression recycling ethanol of step b gained concentrated, let cool, thin up, filters, and filtrate adds syrup and antiseptic, regulates pH value to prescribed limit, adds water to ormal weight, stirs evenly, standing, filters, and obtains SHENGMAI YIN.
2. the preparation method of SHENGMAI YIN according to claim 1, it is characterized in that, described step b first adds to be equivalent to the ethanol that Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis 3 taste medical material gross weight 6-8 concentration of volume percent is doubly 65%, carry out membrane filter pressing circulation for the first time and extract, extraction time is 30-40 minute; Add and be equivalent to the ethanol that above-mentioned 3 taste medical material gross weight 2.5-4.5 concentration of volume percent is doubly 65%, carry out membrane filter pressing circulation for the second time and extract, extraction time is 15-25 minute; Add and be equivalent to the ethanol that above-mentioned 3 taste medical material gross weight 2-4 concentration of volume percent is doubly 65%, carry out membrane filter pressing circulation for the third time and extract, extraction time is 10-20 minute.
3. the preparation method of SHENGMAI YIN according to claim 2, it is characterized in that, described step b first adds to be equivalent to the ethanol that the concentration of volume percent of 7 times of Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis gross weights is 65%, carries out membrane filter pressing circulation for the first time and extracts, and extraction time is 35 minutes; Add and be equivalent to the ethanol that the concentration of volume percent of 3.5 times of above-mentioned 3 taste medical material gross weights is 65%, carry out membrane filter pressing circulation for the second time and extract, extraction time is 20 minutes; Add and be equivalent to the ethanol that the concentration of volume percent of 3 times of above-mentioned 3 taste medical material gross weights is 65%, carry out membrane filter pressing circulation for the third time and extract, extraction time is 10 minutes.
4. according to the preparation method of the SHENGMAI YIN described in the arbitrary claim of claims 1 to 3, it is characterized in that, between described step b and step c, also comprise step b ＇: three-way valve is switched to material-compound tank position, in material-compound tank, add water, carrying out membrane filter pressing circulation washes thoroughly, afterwards three-way valve is switched to filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge pressing filtering liquid and pressed liquor, measure ethanol content, as next group Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis, extract the preparation liquid of solvent.
5. the preparation method of SHENGMAI YIN according to claim 4, is characterized in that, described step b ＇ adds to be equivalent to Radix Ginseng Rubra, Radix Ophiopogonis and Fructus Schisandrae Chinensis gross weight 2-4 water doubly, and 3-7 minute is washed in membrane filter pressing circulation thoroughly.
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