CN102302709B - Preparation method for medicament for treating pediatric disease - Google Patents
Preparation method for medicament for treating pediatric disease Download PDFInfo
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Abstract
The invention discloses a preparation method for medicament for treating pediatric disease. In the preparation method, active ingredients of prescription medicinal medicines are extracted by using a diaphragm filtering circulation extraction separation integration technology instead of a decoction method, so technological process can be simplified, production cycle is greatly shortened and energy consumption is reduced; therefore, the method is favorable for environmental protection and utilization of waste residues, and remarkably improves the recovery rate of active ingredients.
Description
Technical field
The invention belongs to pharmaceutical field, relate to a kind of preparation method of Chinese medicine preparation.
Background technology
Chinese patent ZL95117486.X discloses and a kind ofly can treat multiple pediatric diseases such as infantile anemia, infantile anorexia, infantile diarrhea, has nourishing the brain and improving intelligence, replenishing QI to invigorate the spleen, nourishing blood to tranquillize the mind, improves digestive function, promotes the medicine of effect such as children's upgrowth and development.Made by the following weight proportion raw material: Radix Codonopsis 50-70, Radix Astragali 10-30, Rhizoma Atractylodis Macrocephalae 50-70, Poria 30-50, Rhizoma Dioscoreae 50-70, Semen Coicis 50-70, Radix Ophiopogonis 50-70, Radix Polygoni Multiflori 50-70, Fructus Jujubae 10-30, Fructus Crataegi 10-30, Fructus Hordei Germinatus 10-30, Ramulus Mori 30-50, Pericarpium Citri Reticulatae 40-70, wherein Pericarpium Citri Reticulatae can replace with Oleum Citri Reticulatae, and the ratio of Oleum Citri Reticulatae consumption and other component gross weight is 0.30-0.8ml:440-710g.Optimization formula is: Radix Codonopsis 60g, Radix Astragali 20g, Rhizoma Atractylodis Macrocephalae 60g, Poria 40g, Rhizoma Dioscoreae 60g, Semen Coicis 60g, Radix Ophiopogonis 60g, Radix Polygoni Multiflori Preparata 60g, Fructus Jujubae 20g, Fructus Crataegi (parched to brown) 20g, Fructus Hordei Germinatus (parched) 20g, Ramulus Mori 40g, Oleum Citri Reticulatae 0.6ml.Its preparation method is that Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Semen Coicis, Radix Ophiopogonis, Radix Polygoni Multiflori, Fructus Jujubae, Fructus Crataegi, Fructus Hordei Germinatus and Ramulus Mori 12 flavor medicines are decocted with water twice, collecting decoction, filter, filtrate is concentrated in right amount, add acceptable accessories and Oleum Citri Reticulatae, adopt practice of pharmacy to make pharmaceutical preparation, namely.Adopt decocting method to extract the effective ingredient of prescription medical material in the above-mentioned preparation method, exist extraction time long, extract that temperature height, energy consumption height, thermal sensitivity composition easily lose, shortcomings such as the effective ingredient response rate is low, post processing trouble.
Summary of the invention
In view of this; the object of the present invention is to provide a kind of method of utilizing membrane filter pressing circulation extraction separation integrated technique to prepare above-mentioned treatment pediatric disease medicine; not only can simplify technological process; significantly shorten the production cycle; energy efficient; be beneficial to environmental conservation and waste residue utilization, and can greatly improve the response rate of effective ingredient.
For achieving the above object, the invention provides following technical scheme:
The preparation method for the treatment of pediatric disease medicine, make by Oleum Citri Reticulatae with by following raw materials by weight proportions: Radix Codonopsis 50-70 part, Radix Astragali 10-30 part, Rhizoma Atractylodis Macrocephalae 50-70 part, Poria 30-50 part, Rhizoma Dioscoreae 50-70 part, Semen Coicis 50-70 part, Radix Ophiopogonis 50-70 part, Radix Polygoni Multiflori 50-70 part, Fructus Jujubae 10-30 part, Fructus Crataegi 10-30 part, Fructus Hordei Germinatus 10-30 part, Ramulus Mori 30-50 part, the ratio of described Oleum Citri Reticulatae and above-mentioned raw materials gross weight is 0.3-0.8ml:440-710g, and preparation method may further comprise the steps:
A. Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Semen Coicis, Radix Ophiopogonis, Radix Polygoni Multiflori, Fructus Jujubae, Fructus Crataegi, Fructus Hordei Germinatus and Ramulus Mori are mixed, be ground into coarse powder, standby;
B. in material-compound tank, add water, be heated to 50-90 ℃ and insulation; Three-way valve is switched to the material-compound tank position, water in the material-compound tank is pumped into diaphragm filter press, when passing back into material-compound tank to pressing filtering liquid, the medicated powder that under stirring condition, adds step a gained in the material-compound tank, finish, under 50-90 ℃ condition, carry out the membrane filter pressing circulation first time and extract, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, again three-way valve is switched to the material-compound tank position, in material-compound tank, add water, under 50-90 ℃ condition, carry out the membrane filter pressing circulation second time and extract, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge twice pressing filtering liquid and pressed liquor, as extracting solution;
C. the extracting solution with step b gained concentrates, and adds acceptable accessories and Oleum Citri Reticulatae, adopts practice of pharmacy to make pharmaceutical preparation, namely gets the medicine for the treatment of pediatric disease.
Preferably, described step b adds earlier to be equivalent to step a gained medicated powder weight 6-9 water doubly, carries out the membrane filter pressing circulation first time and extract under 55-65 ℃ condition, and extraction time is 20-40 minute; Add and be equivalent to step b1 gained medicated powder weight 3-5 water doubly, carry out the membrane filter pressing circulation second time and extract under 55-65 ℃ condition, extraction time is 10-20 minute.
Preferred, described step b adds the water that is equivalent to 7.5 times of step a gained medicated powder weight earlier, carries out the membrane filter pressing circulation first time and extract under 65 ℃ condition, and extraction time is 30 minutes; Add the water that is equivalent to 3 times of step b1 gained medicated powder weight again, carry out the membrane filter pressing circulation second time and extract under 65 ℃ condition, extraction time is 10 minutes.
Membrane filter pressing circulation extraction separation integrated technique of the present invention, be that the discharging opening of material-compound tank is communicated with the charging aperture of diaphragm filter press by pump (as membrane pump etc.), the liquid outlet of diaphragm filter press is communicated with the import of charging aperture and the filtrate tank of material-compound tank respectively with three-way valve.When three-way valve switches to the material-compound tank position, the liquid outlet of diaphragm filter press is communicated with the charging aperture of material-compound tank, constitute membrane filter pressing circulation extraction system, slip in the material-compound tank is pumped to diaphragm filter press to carry out the pressing filtering liquid that membrane filter pressing comes out from diaphragm filter press and passes back into (medicated powder then is deposited on the filter cloth surface of each filter pressing chamber of diaphragm filter press equably) the material-compound tank, be re-used as and extract solvent and be pumped to diaphragm filter press and carry out membrane filter pressing and constantly circulate, thereby the membrane filter pressing circulation that realizes medical material is extracted; When three-way valve switches to the filtrate tank position, the liquid outlet of diaphragm filter press is communicated with the import of filtrate tank, constitute the membrane filter pressing solid-liquid separation system, after the membrane filter pressing circulation extraction of medical material finishes, to send into the filtrate tank storage from pressing filtering liquid and pressed liquor that diaphragm filter press comes out, thereby herbal extract is well separated with medicinal residues.
About extracting the problem of material, usually pulverizing medicinal materials is become coarse powder as extracting material, the soft medical material (as Radix Rehmanniae Preparata, Fructus Jujubae etc.) that difficulty is ground into coarse powder can add the water that 2-4 doubly measures and be ground into slip as extracting material with feed grinder or tissue mashing machine.
About the problem of charging sequence, when the medical material fibre-bearing more after a little while, can be in material-compound tank directly add medicated powder and extract solvent, under stirring condition, carry out the membrane filter pressing circulation and extract; When the medical material fibre rich, then should adopt the outer circulation method of feeding in raw material, to stop that medicated powder stops up in material-compound tank discharging opening and feeding pipe and phenomenon that the stock circulation is obstructed.The reinforced method of so-called outer circulation is will extract required whole solvents earlier first to add in the material-compound tank, three-way valve is switched to the material-compound tank position, solvent is pumped into diaphragm filter press, (can observe from the manhole of material-compound tank) when passing back into material-compound tank when observing pressing filtering liquid (this moment is actual to be solvent), under stirring condition, progressively drop into medicated powder again, the gained feed liquid is pumped to diaphragm filter press thereupon carries out the membrane filter pressing pressing filtering liquid and passes back in the material-compound tank and circulate, and medicated powder then is deposited on the filter cloth surface of each filter pressing chamber of diaphragm filter press equably.
About extracting the problem of temperature, when being solvent with water, extracting temperature can control at 50-90 ℃, according to polarized light microscopy method measurement result and in conjunction with bibliographical information, starch gelatinization temperature in the plant tissue mostly is 70-71 ℃, for fear of occurring because starch gelatinization blocks cell inclusion (mostly being effective ingredient) stripping or stops up phenomenons such as filter cloth, the medical material of rich in starch is carried out water when carrying, extract temperature and should control below 70 ℃, preferred 55-65 ℃.And when adopting organic solvent extraction, the boiling point height of looking organic solvent can not heat (namely at room temperature extracting) or suitably heating.
About the problem of extraction time and extraction time, can require according to the response rate of index components and economy requirement suitable adjustment extraction time and extraction time.For the extraction of general medicinal material coarse powder, but selective extraction 2 times extracted 30-40 minute for the 1st time, extracted 10-20 minute for the 2nd time; Higher for price of medicinal material, require the higher kind of the index components response rate, extraction time can suitably increase, as extracts 4 times, extracts the 2-4 time extraction 10-20 minute 40-60 minute the 1st time; Also last 1 time extracting solution can be carried out recycled as the solvent of extraction first of next group material.When serving as when extracting solvent with alcohol-water mixed solution, carry out membrane filter pressing and wash and squeeze medicinal residues thoroughly in the extraction back available water that finishes, after gained pressing filtering liquid and pressed liquor are measured pure content, can be used as the next group material and extract preparing solvent liquid and carry out recycled.Carry out membrane filter pressing when washing thoroughly at water, also can close two liquid valves that are in low level in four jiaos of liquid valves of diaphragm filter press, water is fully soaked overflow the top filtering layer, to strengthen washing effect.
Need to extract earlier volatile oil about part medical material in the compound preparation prescription, medicinal residues merge the problem of carrying out decocting with other medical material again, reach a few hours owing to extract the process of volatile oil with the water azeotropic, during the water soluble ingredient of medical material fully is soluble in the aqueous phase in the process of extracting volatile oil, so generally do not need medicinal residues and the merging of other medical material are carried out decocting, and save follow-up concentrated energy consumption simultaneously for the response rate that guarantees effective ingredient, can be after extracting volatile oil, the water of doubly measuring with 2-4 is heated to the 60-90 ℃ of saturating wash slag of membrane filter pressing, wash 1-2 time thoroughly, aqueous solution after the saturating washing liquid of gained and the distillation merges, as the extraction solvent of water first of other medical material.
About the problem of diaphragm filter press, filter cloth should be selected polypropylene multifilament filter cloth for use, and its Air permenbility selection principle is: less (as 3-10L/m with the appropriate to the occasion Air permenbility of selecting for use of organic solvent extraction
2.s) filter cloth is big (as 50-1200L/m with the appropriate to the occasion Air permenbility of selecting for use of water extraction
2.s) filter cloth.Membrane filter plate should select polypropylene etc. to meet the plastic material of medicinal requirements.The feed liquid pipeline should be selected the plastic conduit of 304 above rustless steels or non-PVC for use.
Beneficial effect of the present invention is: (1) has improved the response rate of effective ingredient: the present invention adopts the membrane filter pressing circulating extraction method to substitute the effective ingredient that decocting method extracts the prescription medical material, this method system adopts the pressure-driven of 0.5-0.6Mpa, circulation is extracted and is piled up in hundreds of the powder beds on the eluting face, effect with pressurized column chromatography or pressurization percolation, extraction efficiency significantly improves, the extraction temperature reduces, and the loss of thermal sensitivity composition reduces, and the response rate of index components significantly improves; And the filter cloth aperture of adopting because of diaphragm filter press is far below being used for the filter screen aperture that medicinal residues separate with decocting liquid at present, and gained extracting solution clarity is good, and naked eyes visible particle thing can not enter in the finished product, has also correspondingly improved the content of active ingredient in the finished product.(2) simplified technological process, shortened the production cycle: the inventive method can realize the integrated of extraction and solid-liquid separation that circulate, and does not have the worry of the existing follow-up solid-liquid separation of decocting method.(3) energy savings: with 1m
3Water is heated to 55-65 ℃ from 20 ℃ and needs raw coal 18.4-21.7kg, needs raw coal 37.6kg and be heated to 98 ℃, and 42-51% on year-on-year basis lowers consumption.(4) be beneficial to environmental conservation and waste residue utilization: the medicinal residues after membrane filter pressing circulation extraction separation integrated technique is handled are the nearly powdered form block of doing; water content is few; not only be convenient to transhipment; can not pollute to environment; and be convenient to the later use of waste residue; as insert in the coal dust burning with reduce the coal consumption, biofermentation is made feedstuff, dry distilling is made as the charcoal piece and makes heating or domestic fuel etc.
Description of drawings
Fig. 1 is the preferred corollary apparatus figure of membrane filter pressing circulation extraction separation integrated technique.
The specific embodiment
In order to make the purpose, technical solutions and advantages of the present invention clearer, below in conjunction with accompanying drawing the preferred embodiments of the present invention are described in detail.
The preferred corollary apparatus figure of membrane filter pressing circulation extraction separation integrated technique as shown in Figure 1, the discharging opening of material-compound tank is communicated with the charging aperture of diaphragm filter press by membrane pump, the liquid outlet of diaphragm filter press is communicated with the import of charging aperture and the filtrate tank of material-compound tank respectively with three-way valve, when three-way valve switches to the material-compound tank position, the liquid outlet of diaphragm filter press is communicated with the charging aperture of material-compound tank, the pressing filtering liquid that comes out from diaphragm filter press passes back into material-compound tank, constitutes membrane filter pressing circulation extraction system; When three-way valve switched to the filtrate tank position, the liquid outlet of diaphragm filter press was communicated with the import of filtrate tank, and the pressing filtering liquid that comes out from diaphragm filter press enters the filtrate tank storage, constitutes the membrane filter pressing solid-liquid separation system.
Embodiment 1
Prescription: Radix Codonopsis 6kg, Radix Astragali 2kg, Rhizoma Atractylodis Macrocephalae 6kg, Poria 4kg, Rhizoma Dioscoreae 6kg, Semen Coicis 6kg, Radix Ophiopogonis 6kg, Radix Polygoni Multiflori Preparata 6kg, Fructus Jujubae 2kg, Fructus Crataegi (parched to brown) 2kg, Fructus Hordei Germinatus (parched) 2kg, Ramulus Mori 4kg, Oleum Citri Reticulatae 60ml
Preparation method may further comprise the steps:
A. Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Semen Coicis, Radix Ophiopogonis, Radix Polygoni Multiflori, Fructus Jujubae, Fructus Crataegi, Fructus Hordei Germinatus and Ramulus Mori are mixed, be ground into coarse powder, standby;
B. in material-compound tank, add the water that is equivalent to 7.5 times of step a gained medicated powder weight, be heated to 65 ℃ and insulation; Three-way valve is switched to the material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, the water in the material-compound tank is pumped into diaphragm filter press (adopt 80 ± 10 L/m
2.s polypropylene multifilament filter cloth), when passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a gained medicated powder, finish, 65 ℃ of membrane filter pressing circulations were extracted 30 minutes, afterwards three-way valve were switched to the filtrate tank position and carried out membrane filter pressing, collected pressing filtering liquid; After filter pressing finishes, three-way valve is switched to the material-compound tank position again, add 65 ℃ the water of being preheated to that is equivalent to 3 times of step a gained medicated powder weight in the material-compound tank, the circulation of insulation membrane filter pressing was extracted 10 minutes, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, start the squeezing program of diaphragm filter press, collect pressed liquor, last release is opened plate, slag dumping; Merge twice pressing filtering liquid and pressed liquor, as extracting solution;
C. the extracting solution with step b gained concentrates, and adds sucrose, refined honey mixing, filters, and adds citric acid and antiseptic, and mixing adds Oleum Citri Reticulatae again, adds water to 100L, mixing, and packing, namely.
Embodiment 2
Prescription: Radix Codonopsis 6kg, Radix Astragali 2kg, Rhizoma Atractylodis Macrocephalae 6kg, Poria 4kg, Rhizoma Dioscoreae 6kg, Semen Coicis 6kg, Radix Ophiopogonis 6kg, Radix Polygoni Multiflori Preparata 6kg, Fructus Jujubae 2kg, Fructus Crataegi (parched to brown) 2kg, Fructus Hordei Germinatus (parched) 2kg, Ramulus Mori 4kg, Oleum Citri Reticulatae 60ml
Preparation method may further comprise the steps:
A. Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Semen Coicis, Radix Ophiopogonis, Radix Polygoni Multiflori, Fructus Jujubae, Fructus Crataegi, Fructus Hordei Germinatus and Ramulus Mori are mixed, be ground into coarse powder, standby;
B. in material-compound tank, add the water that is equivalent to 6 times of step a gained medicated powder weight, be heated to 55 ℃ and insulation; Three-way valve is switched to the material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, the water in the material-compound tank is pumped into diaphragm filter press (adopt 80 ± 10 L/m
2.s polypropylene multifilament filter cloth), when passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a gained medicated powder, finish, 55 ℃ of membrane filter pressing circulations were extracted 40 minutes, afterwards three-way valve were switched to the filtrate tank position and carried out membrane filter pressing, collected pressing filtering liquid; After filter pressing finishes, three-way valve is switched to the material-compound tank position again, add 55 ℃ the water of being preheated to that is equivalent to 4 times of step a gained medicated powder weight in the material-compound tank, the circulation of insulation membrane filter pressing was extracted 15 minutes, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, start the squeezing program of diaphragm filter press, collect pressed liquor, last release is opened plate, slag dumping; Merge twice pressing filtering liquid and pressed liquor, as extracting solution;
C. the extracting solution with step b gained concentrates, and adds sucrose, refined honey mixing, filters, and adds citric acid and antiseptic, and mixing adds Oleum Citri Reticulatae again, adds water to 100L, mixing, and packing, namely.
Embodiment 3
Prescription: Radix Codonopsis 6kg, Radix Astragali 2kg, Rhizoma Atractylodis Macrocephalae 6kg, Poria 4kg, Rhizoma Dioscoreae 6kg, Semen Coicis 6kg, Radix Ophiopogonis 6kg, Radix Polygoni Multiflori Preparata 6kg, Fructus Jujubae 2kg, Fructus Crataegi (parched to brown) 2kg, Fructus Hordei Germinatus (parched) 2kg, Ramulus Mori 4kg, Oleum Citri Reticulatae 60ml
Preparation method may further comprise the steps:
A. Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Semen Coicis, Radix Ophiopogonis, Radix Polygoni Multiflori, Fructus Jujubae, Fructus Crataegi, Fructus Hordei Germinatus and Ramulus Mori are mixed, be ground into coarse powder, standby;
B. in material-compound tank, add the water that is equivalent to 9 times of step a gained medicated powder weight, be heated to 60 ℃ and insulation; Three-way valve is switched to the material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, the water in the material-compound tank is pumped into diaphragm filter press (adopt 80 ± 10 L/m
2.s polypropylene multifilament filter cloth), when passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a gained medicated powder, finish, 60 ℃ of membrane filter pressing circulations were extracted 20 minutes, afterwards three-way valve were switched to the filtrate tank position and carried out membrane filter pressing, collected pressing filtering liquid; After filter pressing finishes, three-way valve is switched to the material-compound tank position again, add 60 ℃ the water of being preheated to that is equivalent to 3 times of step a gained medicated powder weight in the material-compound tank, the circulation of insulation membrane filter pressing was extracted 20 minutes, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, start the squeezing program of diaphragm filter press, collect pressed liquor, last release is opened plate, slag dumping; Merge twice pressing filtering liquid and pressed liquor, as extracting solution;
C. the extracting solution with step b gained concentrates, and adds sucrose, refined honey mixing, filters, and adds citric acid and antiseptic, and mixing adds Oleum Citri Reticulatae again, adds water to 100L, mixing, and packing, namely.
Employing is with a collection of raw material, adopt the described method of embodiment 1-3 and existing method (the open method of Chinese patent ZL 95117486.X) to compare test respectively, and products obtained therefrom carried out quality inspection, the result shows: the product that adopts the described method of embodiment 1-3 to make, the response rate of each index components all are higher than the product that existing method makes.Wherein, the cost-effectiveness of embodiment 1 described method is than best, and products obtained therefrom contains n-butanol extract and is no less than 7%, is higher than 5% of existing method; Contain Radix Polygoni Multiflori Preparata with 2,3,5,9 '-tetrahydroxystilbene-2-O-β-D glucoside meter is not less than 350 μ g/ml, is higher than 200 μ g/ml of existing method.
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although by invention has been described with reference to the preferred embodiments of the present invention, but those of ordinary skill in the art is to be understood that, can make various changes to it in the form and details, and not depart from the spirit and scope of the present invention that appended claims limits.
Claims (3)
1. treat the preparation method of pediatric disease medicine, make by Oleum Citri Reticulatae with by following raw materials by weight proportions: Radix Codonopsis 50-70 part, Radix Astragali 10-30 part, Rhizoma Atractylodis Macrocephalae 50-70 part, Poria 30-50 part, Rhizoma Dioscoreae 50-70 part, Semen Coicis 50-70 part, Radix Ophiopogonis 50-70 part, Radix Polygoni Multiflori 50-70 part, Fructus Jujubae 10-30 part, Fructus Crataegi 10-30 part, Fructus Hordei Germinatus 10-30 part, Ramulus Mori 30-50 part, the ratio of described Oleum Citri Reticulatae and above-mentioned raw materials medicine gross weight is 0.3-0.8ml:440-710g, it is characterized in that preparation method may further comprise the steps:
A. Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Poria, Rhizoma Dioscoreae, Semen Coicis, Radix Ophiopogonis, Radix Polygoni Multiflori, Fructus Jujubae, Fructus Crataegi, Fructus Hordei Germinatus and Ramulus Mori are mixed, be ground into coarse powder, standby;
B. in material-compound tank, add water, be heated to 50-90 ℃ and insulation; Three-way valve is switched to the material-compound tank position, water in the material-compound tank is pumped into diaphragm filter press, when passing back into material-compound tank to pressing filtering liquid, the medicated powder that under stirring condition, adds step a gained in the material-compound tank, finish, under 50-90 ℃ condition, carry out the membrane filter pressing circulation first time and extract, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, again three-way valve is switched to the material-compound tank position, in material-compound tank, add water, under 50-90 ℃ condition, carry out the membrane filter pressing circulation second time and extract, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing finishes, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge twice pressing filtering liquid and pressed liquor, as extracting solution;
C. the extracting solution with step b gained concentrates, and adds acceptable accessories and Oleum Citri Reticulatae, adopts practice of pharmacy to make pharmaceutical preparation, namely gets the medicine for the treatment of pediatric disease.
2. the preparation method for the treatment of pediatric disease medicine according to claim 1, it is characterized in that, described step b adds earlier to be equivalent to step a gained medicated powder weight 6-9 water doubly, carries out the membrane filter pressing circulation first time and extract under 55-65 ℃ condition, and extraction time is 20-40 minute; Add and be equivalent to step a gained medicated powder weight 3-5 water doubly, carry out the membrane filter pressing circulation second time and extract under 55-65 ℃ condition, extraction time is 10-20 minute.
3. the preparation method for the treatment of pediatric disease medicine according to claim 2, it is characterized in that, described step b adds the water that is equivalent to 7.5 times of step a gained medicated powder weight earlier, carries out the membrane filter pressing circulation first time and extract under 65 ℃ condition, and extraction time is 30 minutes; Add the water that is equivalent to 3 times of step a gained medicated powder weight again, carry out the membrane filter pressing circulation second time and extract under 65 ℃ condition, extraction time is 10 minutes.
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| CN1310638C (en) * | 2004-11-25 | 2007-04-18 | 张平 | Spleen invigorating appetizing effervescence tablet for children and preparation method thereof |
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