CN102293896B - Preparation method of tablet for tonifying kidney and controlling asthma - Google Patents
Preparation method of tablet for tonifying kidney and controlling asthma Download PDFInfo
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- CN102293896B CN102293896B CN 201110247758 CN201110247758A CN102293896B CN 102293896 B CN102293896 B CN 102293896B CN 201110247758 CN201110247758 CN 201110247758 CN 201110247758 A CN201110247758 A CN 201110247758A CN 102293896 B CN102293896 B CN 102293896B
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Abstract
The invention discloses a preparation method of a tablet for tonifying kidney and asthma. According to the preparation method disclosed by the invention, effective components in medicinal materials in a prescription are extracted by adopting a diaphragm filter press circulation, extraction and separation integrated technology, thus a process flow can be simplified, the production period is greatly shortened, the energy consumption is reduced, environmental protection and utilization of waste residue are facilitated, and the recovery rate of the effective components can be greatly improved.
Description
Technical field
The invention belongs to pharmaceutical field, relate to a kind of preparation method of Chinese medicine preparation.
Background technology
The Sanitation Ministry medicine standard WS3-B-2333-97 record: the kidney and relieve asthma sheet has the effect of temperature male wind-supplying kidney, clinical seasonality outbreak for prevention and treatment bronchial asthma, chronic bronchitis cough with asthma etc.Its prescription is by Radix Rehmanniae 10g, and Radix Rehmanniae Preparata 10g, Herba Epimedii (Adeps Caprae seu ovis is processed) 10g, Fructus Psoraleae (salt is processed) 10g, Semen Cuscutae (salt is processed) 10g, Rhizoma Dioscoreae 10g, Pericarpium Citri Reticulatae 3g and Radix Aconiti Lateralis Preparata 6g totally eight flavor medicines form.Its preparation method is that Rhizoma Dioscoreae powder is broken into fine powder; Radix Aconiti Lateralis Preparata decocts with water 2 hours, filters filtrate for later use; The Six-elements such as medicinal residues and all the other Radix Rehmanniae decoct with water three times, first and second time each 3 hours, 2 hours for the third time, filter, merging filtrate adds Radix Aconiti Lateralis Preparata filtrate, being evaporated to relative density is 1.38(80 ℃) more than, add the Rhizoma Dioscoreae fine powder, mixing, vacuum drying becomes dry extract, add appropriate amount of auxiliary materials, granulation, tabletting, sugar coating or film-coat, and get final product.Adopt decocting method to extract the effective ingredient of medical material in the said method, have long, high, the shortcomings such as energy consumption is high, the thermal sensitivity composition easily loses, the effective ingredient response rate is low, post processing trouble of extraction temperature of extraction time.
Summary of the invention
In view of this; the object of the present invention is to provide a kind of method of utilizing membrane filter pressing circulation extraction isolation integral technology to prepare the kidney and relieve asthma sheet; not only can simplification of flowsheet; significantly shorten the production cycle; energy efficient; be beneficial to environmental conservation and waste residue utilization, and can greatly improve the response rate of effective ingredient.
For achieving the above object, the invention provides following technical scheme:
The preparation method of kidney and relieve asthma sheet, made by the crude drug of following weight proportioning: 6 parts of 10 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 10 parts of Herba Epimedii, 10 parts of Fructus Psoraleaes, 10 parts of Semen Cuscutae, 10 parts of Rhizoma Dioscoreaes, 3 parts of Pericarpium Citri Reticulataes and Radix Aconiti Lateralis Preparatas, preparation method may further comprise the steps:
A. the extraction of Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Aconiti Lateralis Preparata
A1. Radix Aconiti Lateralis Preparata is ground into coarse powder, for subsequent use;
A2. Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae and Pericarpium Citri Reticulatae are mixed, be ground into coarse powder, for subsequent use; Radix Rehmanniae Preparata is broken into slip with pigment, for subsequent use;
A3. in material-compound tank, add entry, be heated to 50-90 ℃ and insulation; Three-way valve is switched to the material-compound tank position, water in the material-compound tank is pumped into diaphragm filter press, when passing back into material-compound tank to pressing filtering liquid, under stirring condition, in material-compound tank, add step a1 gained medicated powder, finish, under 50-90 ℃ condition, carry out the membrane filter pressing circulation first time and extract, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, again three-way valve is switched to the material-compound tank position, in material-compound tank, add entry, water in the material-compound tank is pumped into diaphragm filter press, when passing back into material-compound tank to pressing filtering liquid, under stirring condition, in material-compound tank, add step a2 gained medicated powder and Radix Rehmanniae Preparata slip, finish, under 50-90 ℃ condition, carry out the membrane filter pressing circulation second time and extract, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, again three-way valve is switched to the material-compound tank position, in material-compound tank, add entry, under 50-90 ℃ condition, carry out for the third time membrane filter pressing circulation and extract, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge three pressing filtering liquids and pressed liquor, as extracting solution;
B. preparation
B1. Rhizoma Dioscoreae powder is broken into fine powder, for subsequent use;
B2. the extracting solution of step a3 gained being evaporated to 80 ℃ of relative densities is more than 1.38, adds the Rhizoma Dioscoreae fine powder of step b1 gained, mixing, and vacuum drying becomes dry extract, adds adjuvant, granulation, tabletting, sugar coating or film-coat namely get the kidney and relieve asthma sheet.
Preferably, described step a3 adds first to be equivalent to Radix Aconiti Lateralis Preparata weight 6-8 water doubly, carries out the membrane filter pressing circulation first time and extract under 55-65 ℃ condition, and extraction time is 30-50 minute; Add and be equivalent to Radix Aconiti Lateralis Preparata, Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Rehmanniae Preparata 7 flavor medical material gross weight 4-6 water doubly, carry out the membrane filter pressing circulation second time and extract under 55-65 ℃ condition, extraction time is 30-40 minute; Add and be equivalent to Radix Aconiti Lateralis Preparata, Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Rehmanniae Preparata 7 flavor medical material gross weight 3-5 water doubly, carry out for the third time membrane filter pressing circulation and extract under 55-65 ℃ condition, extraction time is 10-20 minute.
Preferred, described step a3 adds first the water that is equivalent to 7 times of Radix Aconiti Lateralis Preparata weight, carries out the membrane filter pressing circulation first time and extract under 65 ℃ condition, and extraction time is 40 minutes; Add the water be equivalent to 4.5 times of Radix Aconiti Lateralis Preparata, Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Rehmanniae Preparata 7 flavor medical material gross weights again, carry out membrane filter pressing circulation extraction second time under 65 ℃ condition, extraction time is 35 minutes; Add the water be equivalent to 3.5 times of Radix Aconiti Lateralis Preparata, Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Rehmanniae Preparata 7 flavor medical material gross weights again, carry out for the third time membrane filter pressing circulation and extract under 65 ℃ condition, extraction time is 15 minutes.
The isolation integral technology is extracted in membrane filter pressing circulation of the present invention, be that the discharging opening of material-compound tank is communicated with the charging aperture of diaphragm filter press by pump (such as membrane pump etc.), the liquid outlet of diaphragm filter press is communicated with respectively the import of charging aperture and the filtrate tank of material-compound tank with three-way valve.When three-way valve switches to the material-compound tank position, the liquid outlet of diaphragm filter press is communicated with the charging aperture of material-compound tank, consist of membrane filter pressing circulation extraction system, slip in the material-compound tank is pumped to diaphragm filter press to carry out membrane filter pressing and passes back into (medicated powder then is deposited on the filter cloth surface of each filter pressing chamber of diaphragm filter press equably) the material-compound tank from diaphragm filter press pressing filtering liquid out, be re-used as and extract solvent and be pumped to diaphragm filter press and carry out membrane filter pressing and constantly circulate, thereby the membrane filter pressing circulation that realizes medical material is extracted; When three-way valve switches to the filtrate tank position, the liquid outlet of diaphragm filter press is communicated with the import of filtrate tank, consist of the membrane filter pressing solid-liquid separation system, after the membrane filter pressing circulation extraction of medical material is complete, to send into the filtrate tank storage from diaphragm filter press pressing filtering liquid and pressed liquor out, thereby herbal extract is well separated with medicinal residues.
About extracting the problem of material, usually pulverizing medicinal materials is become coarse powder as extracting material, the soft medical material (such as Radix Rehmanniae Preparata, Fructus Jujubae etc.) that difficulty is ground into coarse powder can add the water that 2-4 doubly measures and be ground into slip as extracting material with feed grinder or tissue mashing machine.
About the problem of charging sequence, when the medical material fibre-bearing is less, can in material-compound tank, directly adds medicated powder and extract solvent, under stirring condition, carry out the membrane filter pressing circulation and extract; When the medical material fibre rich, then should adopt the outer circulation method of feeding in raw material, to stop that medicated powder stops up in material-compound tank discharging opening and feeding pipe and phenomenon that the stock circulation is obstructed.The reinforced method of so-called outer circulation is will extract first first required whole solvents to add in the material-compound tank, three-way valve is switched to the material-compound tank position, solvent is pumped into diaphragm filter press, (can observe from the manhole of material-compound tank) when passing back into material-compound tank when observing pressing filtering liquid (this moment is actual to be solvent), under stirring condition, progressively drop into again medicated powder, the gained feed liquid is pumped to diaphragm filter press thereupon carries out the membrane filter pressing pressing filtering liquid and passes back in the material-compound tank and circulate, and medicated powder then is deposited on the filter cloth surface of each filter pressing chamber of diaphragm filter press equably.
About extracting the problem of temperature, during take water as solvent, extract temperature and can be controlled at 50-90 ℃, according to polarized light microscopy method measurement result and in conjunction with bibliographical information, starch gelatinization temperature in the plant tissue mostly is 70-71 ℃, for fear of occurring because starch gelatinization blocks cell inclusion (mostly being effective ingredient) stripping or stops up the phenomenons such as filter cloth, when the medical material of rich in starch is carried out water extraction, extract temperature and should be controlled at below 70 ℃, preferred 55-65 ℃.And when adopting organic solvent extraction, can not heat (namely at room temperature extracting) or suitably heating depending on the boiling point height of organic solvent.
About the problem of extraction time and extraction time, can require according to the response rate of index components and economy requirement suitable adjustment extraction time and extraction time.For the extraction of general medicinal material coarse powder, but selective extraction 2 times extracted 30-40 minute for the 1st time, extracted 10-20 minute for the 2nd time; Higher for price of medicinal material, require the higher kind of the index components response rate, extraction time can suitably increase, as extracts 4 times, extracts the 2-4 time extraction 10-20 minute 40-60 minute the 1st time; Also last 1 time extracting solution can be carried out recycled as the first extraction solvent of next group material.When take alcohol-water mixed solution as the extraction solvent, carry out membrane filter pressing in the complete rear available water of extraction and thoroughly wash and squeeze medicinal residues, after gained pressing filtering liquid and pressed liquor were measured pure content, the preparation liquid that can be used as next group material extraction solvent carried out recycled.Carry out membrane filter pressing when thoroughly washing at water, also can close two liquid valves that are in low level in four jiaos of liquid valves of diaphragm filter press, water is fully soaked overflow the top filtering layer, to strengthen washing effect.
Need extract first volatile oil about part medical material in the compound preparation prescription, medicinal residues merge the problem of carrying out decocting with other medical material again, reach a few hours owing to extract the process of volatile oil with the water azeotropic, during the water soluble ingredient of medical material fully is soluble in the aqueous phase in the process of extracting volatile oil, so generally do not need medicinal residues and the merging of other medical material are carried out decocting, and save simultaneously follow-up concentrated energy consumption for the response rate that guarantees effective ingredient, can be after extracting volatile oil, the water of doubly measuring with 2-4 is heated to the 60-90 ℃ of saturating wash slag of membrane filter pressing, thoroughly wash 1-2 time, aqueous solution after the saturating washing liquid of gained and the distillation merges, as the first water extraction solvent of other medical material.
About the problem of diaphragm filter press, filter cloth should be selected polypropylene multifilament filter cloth, and its Air permenbility selection principle is: less (such as 3-10L/m with the appropriate to the occasion Air permenbility of selecting of organic solvent extraction
2.s) filter cloth is large (such as 50-1200L/m with the appropriate to the occasion Air permenbility of selecting of water extraction
2.s) filter cloth.Membrane filter plate should select polypropylene etc. to meet the plastic material of medicinal requirements.The feed liquid pipeline should be selected the plastic conduit of 304 above rustless steels or non-PVC.
Beneficial effect of the present invention is: (1) has improved the response rate of effective ingredient: the present invention adopts the membrane filter pressing circulating extraction method to extract the effective ingredient of prescription medical material, the party's genealogy of law adopts the pressure-driven of 0.5-0.6Mpa, circulation is extracted and is piled up in hundreds of the powder beds on the eluting face, effect with pressurized column chromatography or pressurization percolation, extraction efficiency significantly improves, the extraction temperature reduces, and the loss of thermal sensitivity composition reduces, and the content of index components significantly increases; And the filter cloth aperture of adopting because of diaphragm filter press is far below being used at present the aperture of filter screen that medicinal residues separate with decocting liquid, and gained extracting solution clarity is good, and naked eyes visible particle thing can not enter in the finished product, has also correspondingly improved the content of active ingredient in the finished product.(2) simplified technological process, shortened the production cycle: the Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and the Radix Aconiti Lateralis Preparata that extract same weight, adopt decocting method to need 10 hours, and adopt the membrane filter pressing circulating extraction method to be no more than 2 hours, extraction time shortens more than 80%; And the inventive method has realized the integrated of circulation extraction and solid-liquid separation, does not have the worry of the existing follow-up solid-liquid separation of decocting method.(3) energy savings: with 1m
3Water is heated to 55-65 ℃ from 20 ℃ and needs raw coal 18.4-21.7kg, needs raw coal 37.6kg and be heated to 98 ℃, and 42-51% on year-on-year basis lowers consumption; The extraction time of prescription medical material foreshortened to 2 hours by 10 hours, and the extraction energy consumption is reduced greatly.(4) be beneficial to environmental conservation and waste residue utilization: the medicinal residues after the isolation integral technical finesse is extracted in the membrane filter pressing circulation are the nearly powdered form block of doing; water content is few; not only be convenient to transhipment; can not give environment; and be convenient to later use; as insert in the coal dust burning with reduce the coal consumption, biofermentation is made feedstuff, dry distilling is made as the charcoal piece and makes heating or domestic fuel etc.
Description of drawings
Fig. 1 is the preferred corollary apparatus figure that the isolation integral technology is extracted in the membrane filter pressing circulation.
The specific embodiment
In order to make the purpose, technical solutions and advantages of the present invention clearer, below in conjunction with accompanying drawing the preferred embodiments of the present invention are described in detail.
The preferred corollary apparatus figure of membrane filter pressing circulation extraction isolation integral technology as shown in Figure 1, the discharging opening of material-compound tank is communicated with the charging aperture of diaphragm filter press by membrane pump, the liquid outlet of diaphragm filter press is communicated with respectively the import of charging aperture and the filtrate tank of material-compound tank with three-way valve, when three-way valve switches to the material-compound tank position, the liquid outlet of diaphragm filter press is communicated with the charging aperture of material-compound tank, pass back into material-compound tank from diaphragm filter press pressing filtering liquid out, consist of membrane filter pressing circulation extraction system; When three-way valve switched to the filtrate tank position, the liquid outlet of diaphragm filter press was communicated with the import of filtrate tank, entered filtrate tank from diaphragm filter press pressing filtering liquid out and stored, and consisted of the membrane filter pressing solid-liquid separation system.
Embodiment 1
Prescription: Radix Rehmanniae 5kg, Radix Rehmanniae Preparata 5kg, Herba Epimedii (Adeps Caprae seu ovis is processed) 5kg, Fructus Psoraleae (salt is processed) 5kg, Semen Cuscutae (salt is processed) 5kg, Rhizoma Dioscoreae 5kg, Pericarpium Citri Reticulatae 1.5kg, Radix Aconiti Lateralis Preparata 3kg
Preparation method may further comprise the steps:
A. the extraction of Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Aconiti Lateralis Preparata
A1. the Radix Aconiti Lateralis Preparata with recipe quantity is ground into coarse powder, and is for subsequent use;
A2. Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae and the Pericarpium Citri Reticulatae with recipe quantity mixes, and is ground into coarse powder, and be for subsequent use; The Radix Rehmanniae Preparata of recipe quantity is added the water of 4 times of weight, be ground into slip, for subsequent use;
A3. in material-compound tank, add the water that is equivalent to 7 times of Radix Aconiti Lateralis Preparata weight, be heated to 65 ℃ and insulation; Three-way valve is switched to the material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, the water in the material-compound tank is pumped into diaphragm filter press (adopt 80 ± 10 L/m
2.s polypropylene multifilament filter cloth), when passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a1 gained medicated powder, finish, 65 ℃ of membrane filter pressing circulations were extracted 40 minutes, afterwards three-way valve were switched to the filtrate tank position and carried out membrane filter pressing, collected pressing filtering liquid; After filter pressing is complete, again three-way valve is switched to the material-compound tank position, add 65 ℃ the water of being preheated to that is equivalent to 4.5 times of Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Aconiti Lateralis Preparata 7 flavor medical material gross weights in the material-compound tank, water in the material-compound tank is pumped into diaphragm filter press, when passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a2 gained medicated powder and Radix Rehmanniae Preparata slip, finish, 65 ℃ of membrane filter pressing circulations were extracted 35 minutes, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, again three-way valve is switched to the material-compound tank position, add 65 ℃ the water of being preheated to that is equivalent to 3.5 times of Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Aconiti Lateralis Preparata 7 flavor medical material gross weights in the material-compound tank, the circulation of insulation membrane filter pressing was extracted 15 minutes, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, start the squeezing program of diaphragm filter press, collect pressed liquor, last release is opened plate, slag dumping; Merge three pressing filtering liquids and pressed liquor, as extracting solution;
B. preparation
B1. the Rhizoma Dioscoreae powder with recipe quantity is broken into fine powder, and is for subsequent use;
B2. the extracting solution of step a3 gained being evaporated to 80 ℃ of relative densities is more than 1.38, adds the Rhizoma Dioscoreae fine powder of step b1 gained, mixing, and vacuum drying becomes dry extract, adds adjuvant, granulation, tabletting, sugar coating or film-coat namely get the kidney and relieve asthma sheet.
Embodiment 2
Prescription: Radix Rehmanniae 5kg, Radix Rehmanniae Preparata 5kg, Herba Epimedii (Adeps Caprae seu ovis is processed) 5kg, Fructus Psoraleae (salt is processed) 5kg, Semen Cuscutae (salt is processed) 5kg, Rhizoma Dioscoreae 5kg, Pericarpium Citri Reticulatae 1.5kg, Radix Aconiti Lateralis Preparata 3kg
Preparation method may further comprise the steps:
A. the extraction of Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Aconiti Lateralis Preparata
A1. the Radix Aconiti Lateralis Preparata with recipe quantity is ground into coarse powder, and is for subsequent use;
A2. Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae and the Pericarpium Citri Reticulatae with recipe quantity mixes, and is ground into coarse powder, and be for subsequent use; The Radix Rehmanniae Preparata of recipe quantity is added the water of 2 times of weight, be ground into slip, for subsequent use;
A3. in material-compound tank, add the water that is equivalent to 6 times of Radix Aconiti Lateralis Preparata weight, be heated to 55 ℃ and insulation; Three-way valve is switched to the material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, the water in the material-compound tank is pumped into diaphragm filter press (adopt 80 ± 10 L/m
2.s polypropylene multifilament filter cloth), when passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a1 gained medicated powder, finish, 55 ℃ of membrane filter pressing circulations were extracted 50 minutes, afterwards three-way valve were switched to the filtrate tank position and carried out membrane filter pressing, collected pressing filtering liquid; After filter pressing is complete, again three-way valve is switched to the material-compound tank position, add 55 ℃ the water of being preheated to that is equivalent to 4 times of Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Aconiti Lateralis Preparata 7 flavor medical material gross weights in the material-compound tank, water in the material-compound tank is pumped into diaphragm filter press, when passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a2 gained medicated powder and Radix Rehmanniae Preparata slip, finish, 55 ℃ of membrane filter pressing circulations were extracted 40 minutes, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, again three-way valve is switched to the material-compound tank position, add 55 ℃ the water of being preheated to that is equivalent to 3 times of Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Aconiti Lateralis Preparata 7 flavor medical material gross weights in the material-compound tank, the circulation of insulation membrane filter pressing was extracted 20 minutes, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, start the squeezing program of diaphragm filter press, collect pressed liquor, last release is opened plate, slag dumping; Merge three pressing filtering liquids and pressed liquor, as extracting solution;
B. preparation
B1. the Rhizoma Dioscoreae powder with recipe quantity is broken into fine powder, and is for subsequent use;
B2. the extracting solution of step a3 gained being evaporated to 80 ℃ of relative densities is more than 1.38, adds the Rhizoma Dioscoreae fine powder of step b1 gained, mixing, and vacuum drying becomes dry extract, adds adjuvant, granulation, tabletting, sugar coating or film-coat namely get the kidney and relieve asthma sheet.
Embodiment 3
Prescription: Radix Rehmanniae 5kg, Radix Rehmanniae Preparata 5kg, Herba Epimedii (Adeps Caprae seu ovis is processed) 5kg, Fructus Psoraleae (salt is processed) 5kg, Semen Cuscutae (salt is processed) 5kg, Rhizoma Dioscoreae 5kg, Pericarpium Citri Reticulatae 1.5kg, Radix Aconiti Lateralis Preparata 3kg
Preparation method may further comprise the steps:
A. the extraction of Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Aconiti Lateralis Preparata
A1. the Radix Aconiti Lateralis Preparata with recipe quantity is ground into coarse powder, and is for subsequent use;
A2. Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae and the Pericarpium Citri Reticulatae with recipe quantity mixes, and is ground into coarse powder, and be for subsequent use; The Radix Rehmanniae Preparata of recipe quantity is added the water of 3 times of weight, be ground into slip, for subsequent use;
A3. in material-compound tank, add the water that is equivalent to 8 times of Radix Aconiti Lateralis Preparata weight, be heated to 60 ℃ and insulation; Three-way valve is switched to the material-compound tank position, open agitator, membrane pump and the diaphragm filter press of material-compound tank, the water in the material-compound tank is pumped into diaphragm filter press (adopt 80 ± 10 L/m
2.s polypropylene multifilament filter cloth), when passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a1 gained medicated powder, finish, 60 ℃ of membrane filter pressing circulations were extracted 30 minutes, afterwards three-way valve were switched to the filtrate tank position and carried out membrane filter pressing, collected pressing filtering liquid; After filter pressing is complete, again three-way valve is switched to the material-compound tank position, add 60 ℃ the water of being preheated to that is equivalent to 6 times of Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Aconiti Lateralis Preparata 7 flavor medical material gross weights in the material-compound tank, water in the material-compound tank is pumped into diaphragm filter press, when passing back into material-compound tank to pressing filtering liquid, in material-compound tank, at the uniform velocity add step a2 gained medicated powder and Radix Rehmanniae Preparata slip, finish, 60 ℃ of membrane filter pressing circulations were extracted 30 minutes, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, again three-way valve is switched to the material-compound tank position, add 60 ℃ the water of being preheated to that is equivalent to 5 times of Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Aconiti Lateralis Preparata 7 flavor medical material gross weights in the material-compound tank, the circulation of insulation membrane filter pressing was extracted 10 minutes, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, start the squeezing program of diaphragm filter press, collect pressed liquor, last release is opened plate, slag dumping; Merge three pressing filtering liquids and pressed liquor, as extracting solution;
B. preparation
B1. the Rhizoma Dioscoreae powder with recipe quantity is broken into fine powder, and is for subsequent use;
B2. the extracting solution of step a3 gained being evaporated to 80 ℃ of relative densities is more than 1.38, adds the Rhizoma Dioscoreae fine powder of step b1 gained, mixing, and vacuum drying becomes dry extract, adds adjuvant, granulation, tabletting, sugar coating or film-coat namely get the kidney and relieve asthma sheet.
Employing is with a collection of medicinal raw material, adopt respectively the described method of embodiment 1-3 and existing method (the Sanitation Ministry medicine standard WS3-B-2333-97 records method) to compare experiment, and products obtained therefrom carried out quality inspection, the result shows: the product that adopts the described method of embodiment 1-3 to make all meets the requirement of quality standard, and the response rate of index components is higher than existing method.Wherein, the cost-effectiveness of embodiment 1 described method is than best, and the index components content of products obtained therefrom sees the following form.
Explanation is at last, above embodiment is only unrestricted in order to technical scheme of the present invention to be described, although by invention has been described with reference to the preferred embodiments of the present invention, but those of ordinary skill in the art is to be understood that, can make various changes to it in the form and details, and not depart from the spirit and scope of the present invention that appended claims limits.
Claims (3)
1. the preparation method of kidney and relieve asthma sheet is made by the crude drug of following weight proportioning: 10 parts of Radix Rehmanniae, 10 parts of Radix Rehmanniae Preparata, 10 parts of Herba Epimedii, 10 parts of Fructus Psoraleaes, 10 parts of Semen Cuscutae, 10 parts of Rhizoma Dioscoreaes, 6 parts of 3 parts of Pericarpium Citri Reticulataes and Radix Aconiti Lateralis Preparatas is characterized in that preparation method may further comprise the steps:
A. the extraction of Radix Rehmanniae, Radix Rehmanniae Preparata, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Aconiti Lateralis Preparata
A1. Radix Aconiti Lateralis Preparata is ground into coarse powder, for subsequent use;
A2. Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae and Pericarpium Citri Reticulatae are mixed, be ground into coarse powder, for subsequent use; Radix Rehmanniae Preparata is broken into slip with pigment, for subsequent use;
A3. in material-compound tank, add entry, be heated to 50-90 ℃ and insulation; Three-way valve is switched to the material-compound tank position, water in the material-compound tank is pumped into diaphragm filter press, when passing back into material-compound tank to pressing filtering liquid, under stirring condition, in material-compound tank, add step a1 gained medicated powder, finish, under 50-90 ℃ condition, carry out the membrane filter pressing circulation first time and extract, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, again three-way valve is switched to the material-compound tank position, in material-compound tank, add entry, water in the material-compound tank is pumped into diaphragm filter press, when passing back into material-compound tank to pressing filtering liquid, under stirring condition, in material-compound tank, add step a2 gained medicated powder and Radix Rehmanniae Preparata slip, finish, under 50-90 ℃ condition, carry out the membrane filter pressing circulation second time and extract, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, again three-way valve is switched to the material-compound tank position, in material-compound tank, add entry, under 50-90 ℃ condition, carry out for the third time membrane filter pressing circulation and extract, afterwards three-way valve is switched to the filtrate tank position and carry out membrane filter pressing, collect pressing filtering liquid; After filter pressing is complete, start the squeezing program of diaphragm filter press, collect pressed liquor; Merge three pressing filtering liquids and pressed liquor, as extracting solution;
B. preparation
B1. Rhizoma Dioscoreae powder is broken into fine powder, for subsequent use;
B2. the extracting solution of step a3 gained being evaporated to 80 ℃ of relative densities is more than 1.38, adds the Rhizoma Dioscoreae fine powder of step b1 gained, mixing, and vacuum drying becomes dry extract, adds adjuvant, granulation, tabletting, sugar coating or film-coat namely get the kidney and relieve asthma sheet.
2. the preparation method of kidney and relieve asthma sheet according to claim 1, it is characterized in that, described step a3 adds first to be equivalent to Radix Aconiti Lateralis Preparata weight 6-8 water doubly, carries out the membrane filter pressing circulation first time and extract under 55-65 ℃ condition, and extraction time is 30-50 minute; Add and be equivalent to Radix Aconiti Lateralis Preparata, Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Rehmanniae Preparata 7 flavor medical material gross weight 4-6 water doubly, carry out the membrane filter pressing circulation second time and extract under 55-65 ℃ condition, extraction time is 30-40 minute; Add and be equivalent to Radix Aconiti Lateralis Preparata, Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Rehmanniae Preparata 7 flavor medical material gross weight 3-5 water doubly, carry out for the third time membrane filter pressing circulation and extract under 55-65 ℃ condition, extraction time is 10-20 minute.
3. the preparation method of kidney and relieve asthma sheet according to claim 2 is characterized in that, described step a3 adds first the water that is equivalent to 7 times of Radix Aconiti Lateralis Preparata weight, carries out the membrane filter pressing circulation first time and extract under 65 ℃ condition, and extraction time is 40 minutes; Add the water be equivalent to 4.5 times of Radix Aconiti Lateralis Preparata, Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Rehmanniae Preparata 7 flavor medical material gross weights again, carry out membrane filter pressing circulation extraction second time under 65 ℃ condition, extraction time is 35 minutes; Add the water be equivalent to 3.5 times of Radix Aconiti Lateralis Preparata, Radix Rehmanniae, Herba Epimedii, Fructus Psoraleae, Semen Cuscutae, Pericarpium Citri Reticulatae and Radix Rehmanniae Preparata 7 flavor medical material gross weights again, carry out for the third time membrane filter pressing circulation and extract under 65 ℃ condition, extraction time is 15 minutes.
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| CN104056006A (en) * | 2014-06-23 | 2014-09-24 | 宋克垣 | Drug for treatment of chronic bronchitis and preparation method thereof |
| CN106235127A (en) * | 2016-07-29 | 2016-12-21 | 王兴民 | A kind of common yam rhizome powder nursing one's health chronic asthma and preparation method thereof |
| CN113230340A (en) * | 2021-06-09 | 2021-08-10 | 复旦大学附属华山医院 | Application of kidney-tonifying asthma-preventing prescription in preparation of medicine for treating pulmonary fibrosis |
| CN116077605A (en) * | 2022-12-01 | 2023-05-09 | 太极集团重庆桐君阁药厂有限公司 | Preparation method of agilawood qi-transforming tablet |
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| CN1060214A (en) * | 1991-07-27 | 1992-04-15 | 四川涪陵制药厂 | The preparation method of kidney and relieve asthma Chinese medicine patent medicine |
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| CN1060214A (en) * | 1991-07-27 | 1992-04-15 | 四川涪陵制药厂 | The preparation method of kidney and relieve asthma Chinese medicine patent medicine |
Non-Patent Citations (2)
| Title |
|---|
| 中华人民共和国卫生部药典委员会编.补肾防喘片.《中华人民共和国卫生部药品标准中药成方制剂第十二册》.1997,第72页. * |
| 陈彪等.隔膜压滤工艺在甘草流浸膏生产上的应用研究.《2008年成渝药学学术年会论文集》.2008,第117-118页. * |
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