CN102316935A - 用于治疗肝炎的包含聚乙二醇化干扰素、利巴韦林和vx-950的治疗方案 - Google Patents

用于治疗肝炎的包含聚乙二醇化干扰素、利巴韦林和vx-950的治疗方案 Download PDF

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Publication number
CN102316935A
CN102316935A CN2009801480304A CN200980148030A CN102316935A CN 102316935 A CN102316935 A CN 102316935A CN 2009801480304 A CN2009801480304 A CN 2009801480304A CN 200980148030 A CN200980148030 A CN 200980148030A CN 102316935 A CN102316935 A CN 102316935A
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CN
China
Prior art keywords
weeks
patients
pegylated interferon
ribavirin
administered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801480304A
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English (en)
Chinese (zh)
Inventor
R·S·考夫曼
C·J·C·蒂托瓦
R·波罗
R·P·G·范赫斯维克
M·G·博蒙
G·R·皮焦
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of CN102316935A publication Critical patent/CN102316935A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/212—IFN-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biotechnology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2009801480304A 2008-09-24 2009-09-24 用于治疗肝炎的包含聚乙二醇化干扰素、利巴韦林和vx-950的治疗方案 Pending CN102316935A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US9984908P 2008-09-24 2008-09-24
US61/099849 2008-09-24
US10965508P 2008-10-30 2008-10-30
US61/109655 2008-10-30
US24304109P 2009-09-16 2009-09-16
US61/243041 2009-09-16
PCT/US2009/058218 WO2010036799A1 (en) 2008-09-24 2009-09-24 Therapeutic regimen comprising peg- interferon, ribavirin and vx-950 for the treatment of hepatitis "

Publications (1)

Publication Number Publication Date
CN102316935A true CN102316935A (zh) 2012-01-11

Family

ID=41396114

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801480304A Pending CN102316935A (zh) 2008-09-24 2009-09-24 用于治疗肝炎的包含聚乙二醇化干扰素、利巴韦林和vx-950的治疗方案

Country Status (11)

Country Link
US (2) US20110236351A1 (https=)
EP (1) EP2328656A1 (https=)
JP (1) JP2012503669A (https=)
KR (1) KR20110074870A (https=)
CN (1) CN102316935A (https=)
AU (1) AU2009296653A1 (https=)
CA (1) CA2738477A1 (https=)
EA (1) EA201170484A1 (https=)
IL (1) IL211810A0 (https=)
MX (1) MX2011003121A (https=)
WO (1) WO2010036799A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8399615B2 (en) 2005-08-19 2013-03-19 Vertex Pharmaceuticals Incorporated Processes and intermediates
EP2358736A1 (en) * 2008-10-15 2011-08-24 Intermune, Inc. Therapeutic antiviral peptides
WO2010093843A2 (en) * 2009-02-12 2010-08-19 Vertex Pharmaceuticals Incorporated Hcv combination therapies
TW201116540A (en) * 2009-10-01 2011-05-16 Intermune Inc Therapeutic antiviral peptides
DE202012012955U1 (de) 2011-10-21 2014-07-14 Abbvie Inc. Eine Kombination aus mindestens zwei direkt wirkenden antiviralen Wirkstoffen (DAAs) für die Verwendung zur Behandlung von HCV
US8492386B2 (en) 2011-10-21 2013-07-23 Abbvie Inc. Methods for treating HCV
EP2583677A3 (en) 2011-10-21 2013-07-03 Abbvie Inc. Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon.
US8466159B2 (en) 2011-10-21 2013-06-18 Abbvie Inc. Methods for treating HCV
EA201892448A1 (ru) 2016-04-28 2019-06-28 Эмори Юниверсити Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123076A2 (en) * 2004-06-08 2005-12-29 Vertex Pharmaceuticals, Inc. Pharmaceutical compositions
WO2007127801A2 (en) * 2006-04-26 2007-11-08 Vertex Pharmaceuticals Incorporated Hepatitis c virus infection biomarkers

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201424733A (zh) * 2004-10-29 2014-07-01 Vertex Pharma 劑量型式
JP2010528013A (ja) * 2007-05-21 2010-08-19 バーテックス ファーマシューティカルズ インコーポレイテッド Ｖｘ−９５０を含む用量形態およびそれらの投与レジメン

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005123076A2 (en) * 2004-06-08 2005-12-29 Vertex Pharmaceuticals, Inc. Pharmaceutical compositions
WO2007127801A2 (en) * 2006-04-26 2007-11-08 Vertex Pharmaceuticals Incorporated Hepatitis c virus infection biomarkers

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HENDRIK等人: "Rapid Decline of Viral RNA in Hepatitis C Patients Treated With VX-950: A Phase Ib, Placebo-Controlled, Randomized Study", 《GASTROENTEROLOGY》 *
MCHUTCHISON等人: "Results of an interim analysis of a phase 2 study of telaprevir(vx-950)with peginterferon a-2a and ribavirin in previously untreated subjects with hapatitis C", 《JOURNAL OF HEPATITIS C》 *

Also Published As

Publication number Publication date
EP2328656A1 (en) 2011-06-08
AU2009296653A1 (en) 2010-04-01
CA2738477A1 (en) 2010-04-01
US20110236351A1 (en) 2011-09-29
IL211810A0 (en) 2011-06-30
US8871812B2 (en) 2014-10-28
US20130101554A1 (en) 2013-04-25
EA201170484A1 (ru) 2012-03-30
JP2012503669A (ja) 2012-02-09
KR20110074870A (ko) 2011-07-04
WO2010036799A1 (en) 2010-04-01
MX2011003121A (es) 2011-04-21

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