CN102309006A - Food with health care effect - Google Patents
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- CN102309006A CN102309006A CN201110256065A CN201110256065A CN102309006A CN 102309006 A CN102309006 A CN 102309006A CN 201110256065 A CN201110256065 A CN 201110256065A CN 201110256065 A CN201110256065 A CN 201110256065A CN 102309006 A CN102309006 A CN 102309006A
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Abstract
The invention belongs to the technical field of health food, and discloses a health care food, which comprises raw materials of 10-100 weight parts of cordyceps sinensis extractive, 10-200 weight parts of amino acid and / or 1-50 weight parts of vitamin. Having been studying for many years, the applicant discovers that combination of cordyceps sinensis extractive, amino acid and / or vitamin has good health care effect based on modern medicine theory. According to immunity enhancing pharmacological test, it is proved that cordyceps sinensis extractive, amino acid and / or vitamin have good synergistic effect, and the combination of the three has better pharmacological effect compared with single usage of cordyceps sinensis.
Description
Technical field
The invention belongs to the medicines and health protection food technology field, be specifically related to the health food that a kind of raw material is Cordyceps, amino acid and vitamin.
Background technology
Health food is a kind of food, has the general character of normal food, can regulate the function of human body, and it is edible to be suitable for specific crowd, but can not treat disease.The growth rate of countries in the world health food development in recent years is all very fast, and health care (function) food is called as " healthy food " in European and American countries, be called as in Japan " functional food ".The rise of China's health care (function) food is at beginning of the nineties late 1980s; Development through one, two generations; Also will march toward the third generation; Be that health food not only needs human body and this product of zoopery proof to have a certain physiological regulation function, more need find out structure, content, the mechanism of action and due stable form in food with this health factor.
Chinese caterpillar fungus is claimed Cordyceps sinensis, CORDYCEPS etc. again.The bacterium worm combination that fungi of Clavicipitaceae (Cordyceps Militaris) and bat moth larvae form under specific condition, stroma goes out head, the Dan Sheng, elongated like baseball rod of larva, long 4～11cm.Cordyceps sinensis is the famous precious Chinese medicine of China, the traditional Chinese medicine document think Cordyceps sinensis distinguish the flavor of sweet warm in nature, the effect that secret lean gas is arranged, protect lung kidney tonifying, hemostasis and phlegm.The modern medicine clinical research shows that Cordyceps sinensis can be treated phthisical cough phlegm blood, night sweat, impotence, seminal emission, jaundice disease, pulmonary tuberculosis and diseases such as old age is weak, chronic cough and asthma, has strong taking in concurrently to hold back calm effect.
Cordyceps sinensis is the famous precious Chinese medicine of China; Therefore; Its research and development are the emphasis of healthcare field always, existing bibliographical information a large amount of exploitations about Cordyceps sinensis, on the market be that the health food of raw material is also very many with Cordyceps sinensis; Therefore, it is significant how Cordyceps sinensis to be carried out deep development.
Summary of the invention
For these reasons; The scientific research personnel of our company is through research for many years; Is the basis with the modern medical theory, find Cordyceps (one or more in Cordyceps sinensis polysaccharide, cordycepin, the cordycepic acid) and amino acid with or the vitamin combination after have good function of health care, the present invention confirms through pharmacological testing; Cordyceps and amino acid and/or vitamin have good synergy, have better pharmacological action than independent use Cordyceps sinensis.
The present invention realizes through following technical proposals.
A kind of food with health role, Cordyceps is the 10-100 weight portion in the raw-food material, amino acid/11 0-200 weight portion and/or vitamin are the 1-50 weight portion.
Above-mentioned said Cordyceps refers to one or more of Cordyceps sinensis polysaccharide, cordycepin, cordycepic acid.Cordyceps is natural cs extract or ferment cordyceps sinensis bacterium powder extracts.
Above-mentioned said vitamin is vitamin C, vitamin A, vitamin E, Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, vitamin D, vitamin K, folic acid, niacinamide, Cobastab
5, in the biotin one or more, or contain one or more of compound of above-mentioned composition, or contain one or more of extract or concentrate of the food of above-mentioned composition.
Above-mentioned said amino acid be in aspartic acid, glutamic acid, cysteine, serine, glycine, threonine, alanine, valine, leucine, isoleucine, proline, phenylalanine, tyrosine, histidine and the lysine one or more.
Above-mentioned said health food also comprises one or more of white granulated sugar, glucose, FOS, maltose, oligoisomaltose, rose candy, Sweet-scented Osmanthus, citric acid, blueberry juice, prune juice, acid Chinese quince juice, dark plum juice, orange juice, matrimony vine juice, brewer's wort, cherry, lemon mint extract, Sucralose.
Above-mentioned said food has the effect that improves immunity, also has effects such as antiviral, anti-inflammation.
Above-mentioned said health food is an oral formulations.
Above-mentioned said oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned said health food is a beverage.
One, pharmacological test example
Test 1
Improve immunity function property experiment 1
Experimental animal: the female small white mouse of Kunming kind, body weight 18-22g.
Trial drug:
Test 1 group: Cordyceps sinensis.
Test 2 groups: cordycepin 10mg, winter propylhomoserin 2mg, glutamic acid 8mg, vitamin C 0.3mg, vitamin E 0.3mg, Cobastab
10.4mg.
Test 3 groups: Cordyceps sinensis polysaccharide 50mg; Cordycepic acid 50mg; Amino acid 200mg (aspartic acid 10mg, glutamic acid 10mg, cysteine 10mg, serine 15mg, glycine 10mg, threonine 10mg, alanine 15mg, valine 15mg, leucine 25mg, isoleucine 15mg, proline 15mg, phenylalanine 10mg, tyrosine 15mg, histidine 15mg, lysine 10mg), vitamin 50mg (vitamin A, vitamin E, Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, vitamin D, vitamin K, folic acid, each 5mg of niacinamide).
Test 4 groups: cordycepin 20mg; Cordycepic acid 20mg; Cordyceps sinensis polysaccharide 35mg; Amino acid/11 00mg (glutamic acid 15mg, cysteine 5mg, threonine 5mg, valine 15mg, isoleucine 15mg, proline 15mg, phenylalanine 15mg, histidine 15mg), vitamin 40mg (vitamin B2 10mg, calciferol 0mg, vitamin K5 mg, niacinamide 5mg).
Test method: get the mouse random packet: blank group, trial drug group, mouse gastric infusion every day 1 time, each dosage is 1g/kg, the blank group waits the distilled water of capacity.Respectively animal being carried out each item immune indexes behind the 30d continuously measures.
Mouse delayed allergy (DTH) is measured: in irritating stomach the 26th day, inject 2% sheep red blood cell (SRBC) (SRBC) 0.2ml/ to mouse peritoneal and only carry out sensitization, after immunity the 4th day the left back toe ring of the every mouse hypodermic injection 20%SRBC of portion (20 μ l/ only) attack.And before attacking, measure the same position of the left back sufficient intestines of every mouse thickness with attack back 24h, and calculate and attack forward and backward difference, carry out variance analysis.
Result of the test is seen table 1.
Table 1 pair mouse DTH is measured result (24h)
Annotate: compare * * P＜0.01 with control group; Compare △ P＜0.05 for 1 group with test.
2, improve immunity function property experiment 2
Trial drug:
Test 1 group: Cordyceps sinensis.
Test 2 groups: Cordyceps sinensis polysaccharide 15mg, aspartic acid 20mg, Catergen mg.
Test 3 groups: cordycepic acid 60mg; Amino acid/11 00mg (aspartic acid 5mg, glutamic acid 5mg, cysteine 3mg, serine 15mg, glycine 5mg, threonine 12mg, alanine 5mg, valine 5mg, leucine 15mg, isoleucine 5mg, proline 5mg, phenylalanine 1mg, tyrosine 13mg, histidine 1mg, lysine 5mg), vitamin 5mg (retinol1 mg, Cobastab
11mg, Cobastab
21mg, Cobastab
61mg, Cobastab
50.5mg, biotin 0.5mg).
Test 4 groups: cordycepin 15mg; Cordyceps sinensis polysaccharide 55mg; Amino acid 55mg (cysteine 3mg, threonine 5mg, valine 15mg, proline 15mg, phenylalanine 12mg, histidine 5mg), vitamin 4.8mg (vitamin D 0.53mg, folic acid 0.45mg, Cobastab
50.02mg, vitamin E 3mg, vitamin A 0.8mg).
Test method: get the mouse random packet: blank group, trial drug group, mouse gastric infusion every day 1 time, testing 1 group is 1g/kg to testing 4 groups of each dosages, the blank group waits the distilled water of capacity.Respectively animal being carried out each item immune indexes behind the 30d continuously measures.
ConA inducing mouse SPL transformation experiment (mtt assay): to the aseptic spleen of getting of each group mouse, the system splenocyte suspension, using RPMI 1640 complete culture solutions adjustment splenocyte concentration is 3 * 10
9Individual/L, carry out lymphproliferation response according to MTr method in the program, survey its absorbance (A) in 752-C ultraviolet-uisible spectrophotometer 570nm wavelength at last, calculate ConA
+With ConA
-The absorbance value difference in each hole.Carry out variance analysis.Result of the test is seen table 2.
Table 2 couple mouse spleen lymphocyte conversion test result measures result (24h)
Annotate: compare * * P＜0.01, * P＜0.05 with control group; Compare △ P＜0.05 for 1 group with test.
Test 3
Improve immunity function property experiment 3
Trial drug:
Test 1 group: Cordyceps sinensis.
Test 2 groups: Cordyceps sinensis polysaccharide 25mg, phenylalanine-3,4-quinone mg, tyrosine 2mg, histidine 5mg, folic acid 3mg, vitamin E 4mg, fruit of Chinese wolfberry 1g.
Test 3 groups: cordycepin 100mg; Amino acid 200mg (aspartic acid 20mg, cysteine 10mg, serine 15mg, glycine 10mg, threonine 10mg, alanine 15mg, leucine 25mg, isoleucine 15mg, proline 15mg, phenylalanine 15mg, tyrosine 20mg, histidine 15mg, lysine 15mg), vitamin 30mg (vitamin C, vitamin A, vitamin E, Cobastab
2,, Cobastab
12, vitamin D, vitamin K, folic acid, niacinamide, each 3mg of biotin).
Test 4 groups: cordycepic acid 60mg, amino acid 80mg (glutamic acid 10mg, cysteine 15mg, threonine 5mg, isoleucine 25mg, proline 15mg, phenylalanine 10mg), vitamin 5.5mg (prokeyvit .5mg, niacinamide 1mg).
Experimental animal: the female small white mouse of Kunming kind, body weight 18-22g.
Test method: get the mouse random packet: blank group, trial drug group, mouse gastric infusion every day 1 time, each dosage is 1.5g/kg, the blank group waits the distilled water of capacity.Respectively animal being carried out each item immune indexes behind the 30d continuously measures.
Serum hemolysin is measured: in irritating stomach the 25th day to mouse peritoneal injection 2%SRBC (0.2ml/ only); After immunity, plucked the eyeball blood sampling on the 5th day; Separation of serum is also measured at the clear hemolysin of the enterprising promoting circulation of blood of Microhemagglutination plate: hatch 3h for 37 ℃, statistics hemagglutination degree calculates the corresponding antibodies product.Carry out variance analysis.Result of the test is seen table 3.
Table 3 pair mice serum hemolysin is measured the result
Annotate: compare * * P＜0.01, * P＜0.05 with control group; Compare △ P＜0.05 for 1 group with test.
Two, preparation embodiment
Embodiment 1
A kind of health food, healthy food material are cordycepin 10mg, winter propylhomoserin 2mg, glutamic acid 8mg, vitamin C 1mg.
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Embodiment 2
A kind of health food; Healthy food material is Cordyceps sinensis polysaccharide 30mg; Cordycepin 30mg; Cordycepic acid 40mg; Amino acid 200mg (aspartic acid 10mg, glutamic acid 10mg, cysteine 10mg, serine 15mg, glycine 10mg, threonine 10mg, alanine 15mg, valine 15mg, leucine 25mg, isoleucine 15mg, proline 15mg, phenylalanine 10mg, tyrosine 15mg, histidine 15mg, lysine 10mg), vitamin 50mg (vitamin A 5mg, vitamin E 5mg, Cobastab
115.25mg, Cobastab
22.5mg, vitamin K5 mg, niacinamide 4.75mg, Cobastab
52.5mg, biotin 5mg, vitamin K5 mg).
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Embodiment 3
A kind of health food; Healthy food material is cordycepic acid 50mg; Amino acid/11 00mg (glutamic acid 15mg, cysteine 5mg, threonine 5mg, valine 15mg, isoleucine 15mg, proline 15mg, phenylalanine 15mg, histidine 15mg), vitamin A, vitamin E, Cobastab
1Be total to 30mg (each 10mg).
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Embodiment 4
A kind of health food, healthy food material are Cordyceps sinensis polysaccharide 25mg, aspartic acid 20mg, and vitamin E2 5mg.
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Embodiment 5
A kind of health food; Healthy food material is cordycepin 40mg; Cordyceps sinensis polysaccharide 25mg; Amino acid/11 00mg (aspartic acid 5mg, glutamic acid 8mg, cysteine 3mg, serine 15mg, glycine 9mg, threonine 2mg, alanine 8mg, valine 5mg, leucine 5mg, isoleucine 5mg, proline 5mg, phenylalanine 2mg, tyrosine 13mg, histidine 3mg, lysine 12mg), vitamin D, vitamin K, folic acid, niacinamide be 20mg (each 5mg) altogether.
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Embodiment 6
A kind of health food, healthy food material are cordycepic acid 30mg, amino acid 55mg (cysteine 5mg, threonine 5mg, valine 15mg, proline 15mg, phenylalanine 10mg, histidine 5mg), vitamin D 1mg.
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Embodiment 7
A kind of health food, healthy food material are Cordyceps sinensis polysaccharide 10mg, proline 20mg, vitamin E, niacinamide, Cobastab
1, Cobastab
2, Cobastab
6Be total to 8mg (each 1.6mg).
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Embodiment 8
A kind of health food; Healthy food material is cordycepin 55mg; Amino acid/11 00mg (aspartic acid 5mg, cysteine 10mg, serine 8mg, glycine 5mg, threonine 12mg, alanine 15mg, leucine 25mg, isoleucine 20mg), vitamin 5mg (vitamin C 2mg, calciferol mg, vitamin K1 mg).
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Embodiment 9
A kind of health food, healthy food material are cordycepin 75mg, amino acid 25mg (cysteine 5mg, threonine 5mg, valine 5mg, proline 5mg, histidine 5mg), vitamin 4.5mg (vitamin E 3mg, biotin 1.5mg).
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Embodiment 10
A kind of health food, healthy food material are cordycepic acid 35mg, cordycepin 35mg, phenylalanine-3,4-quinone mg, tyrosine 2mg, histidine 5mg, vitamin C 4mg.
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Embodiment 11
A kind of health food; Healthy food material is cordycepin 100mg; Amino acid 200mg (aspartic acid 20mg, cysteine 10mg, serine 15mg, glycine 10mg, threonine 10mg, alanine 15mg, leucine 25mg, isoleucine 15mg, proline 15mg, phenylalanine 15mg, tyrosine 20mg, histidine 15mg, lysine 15mg), vitamin C 15mg.
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Embodiment 12
A kind of health food, healthy food material are cordycepin 60mg, amino acid 80mg (glutamic acid 10mg, cysteine 15mg, threonine 5mg, isoleucine 25mg, proline 15mg, phenylalanine 10mg), vitamin C 5.5mg.
Above-mentioned health food is prepared into oral formulations; Oral formulations is tablet, pill, capsule or oral liquid.
Above-mentioned health food is prepared into beverage.
Claims (9)
1. a food with health role is characterized in that Cordyceps is the 10-100 weight portion in the raw-food material, and amino acid/11 0-200 weight portion and/or vitamin are the 1-50 weight portion.
2. a kind of food with health role according to claim 1, wherein Cordyceps refers to one or more of Cordyceps sinensis polysaccharide, cordycepin, cordycepic acid; Cordyceps is natural cs extract or ferment cordyceps sinensis bacterium powder extracts.
3. a kind of food with health role according to claim 1, said vitamin is vitamin C, vitamin A, vitamin E, Cobastab
1, Cobastab
2, Cobastab
6, Cobastab
12, vitamin D, vitamin K, folic acid, niacinamide, Cobastab
5, in the biotin one or more, or contain one or more of compound of above-mentioned composition, or contain one or more of extract or concentrate of the food of above-mentioned composition.
4. a kind of food with health role according to claim 1, wherein amino acid be in aspartic acid, glutamic acid, cysteine, serine, glycine, threonine, alanine, valine, leucine, isoleucine, proline, phenylalanine, tyrosine, histidine and the lysine one or more.
5. a kind of food with health role according to claim 1, wherein health food also comprises one or more of white granulated sugar, glucose, FOS, maltose, oligoisomaltose, rose candy, Sweet-scented Osmanthus, citric acid, blueberry juice, prune juice, acid Chinese quince juice, dark plum juice, orange juice, matrimony vine juice, brewer's wort, cherry, lemon mint extract, Sucralose.
6. improve the immunity Application in Food according to each described a kind of food with health role of claim 1-5 in preparation.
7. according to each described a kind of food with health role of claim 1-5, wherein health food is an oral formulations.
8. a kind of food with health role according to claim 7, wherein oral formulations is tablet, pill, capsule or oral liquid.
9. a kind of food with health role according to claim 7, wherein health food is a beverage.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110256065A CN102309006A (en) | 2011-09-01 | 2011-09-01 | Food with health care effect |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110256065A CN102309006A (en) | 2011-09-01 | 2011-09-01 | Food with health care effect |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102309006A true CN102309006A (en) | 2012-01-11 |
Family
ID=45422874
Family Applications (1)
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|---|---|---|---|
| CN201110256065A Pending CN102309006A (en) | 2011-09-01 | 2011-09-01 | Food with health care effect |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445151A (en) * | 2012-10-08 | 2013-12-18 | 李津龙 | Cordyceps militaris oral liquid and preparation method thereof |
| CN103621871A (en) * | 2013-11-27 | 2014-03-12 | 山东隆科特酶制剂有限公司 | Compound amino acid health-care product and preparation method thereof |
| CN103766917A (en) * | 2014-01-12 | 2014-05-07 | 金勇� | Formula of selenium-containing cordyceps sinensis healthcare food |
| CN103907919A (en) * | 2013-01-04 | 2014-07-09 | 杨立英 | Composition capable of reducing athletic fatigue and rapidly replenishing physical fitness |
| CN104187686A (en) * | 2014-09-26 | 2014-12-10 | 洛阳华以生物工程有限公司 | Health product for improving immunity |
| CN104643085A (en) * | 2015-03-11 | 2015-05-27 | 桓仁满族自治县益仁堂中药材有限公司 | Multivitamin granules containing cordyceps sinensis |
| CN105249104A (en) * | 2015-10-29 | 2016-01-20 | 常州亚当生物技术有限公司 | Cordyceps sinensis mycelia beverage and application of cordyceps sinensis mycelia beverage |
| CN105614845A (en) * | 2015-12-19 | 2016-06-01 | 江苏神华药业有限公司 | Amino acid tablets and preparation method thereof |
| CN106418026A (en) * | 2016-08-10 | 2017-02-22 | 彭志文 | Compound papaya juice and preparing method thereof |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103445151A (en) * | 2012-10-08 | 2013-12-18 | 李津龙 | Cordyceps militaris oral liquid and preparation method thereof |
| CN103445151B (en) * | 2012-10-08 | 2014-12-24 | 李津龙 | Cordyceps militaris oral liquid and preparation method thereof |
| CN103907919A (en) * | 2013-01-04 | 2014-07-09 | 杨立英 | Composition capable of reducing athletic fatigue and rapidly replenishing physical fitness |
| CN103621871A (en) * | 2013-11-27 | 2014-03-12 | 山东隆科特酶制剂有限公司 | Compound amino acid health-care product and preparation method thereof |
| CN103621871B (en) * | 2013-11-27 | 2015-04-29 | 山东隆科特酶制剂有限公司 | Compound amino acid health-care product and preparation method thereof |
| CN103766917A (en) * | 2014-01-12 | 2014-05-07 | 金勇� | Formula of selenium-containing cordyceps sinensis healthcare food |
| CN104187686A (en) * | 2014-09-26 | 2014-12-10 | 洛阳华以生物工程有限公司 | Health product for improving immunity |
| CN104187686B (en) * | 2014-09-26 | 2016-10-05 | 洛阳华以生物工程有限公司 | A kind of health product improving immunity |
| CN104643085A (en) * | 2015-03-11 | 2015-05-27 | 桓仁满族自治县益仁堂中药材有限公司 | Multivitamin granules containing cordyceps sinensis |
| CN105249104A (en) * | 2015-10-29 | 2016-01-20 | 常州亚当生物技术有限公司 | Cordyceps sinensis mycelia beverage and application of cordyceps sinensis mycelia beverage |
| CN105614845A (en) * | 2015-12-19 | 2016-06-01 | 江苏神华药业有限公司 | Amino acid tablets and preparation method thereof |
| CN106418026A (en) * | 2016-08-10 | 2017-02-22 | 彭志文 | Compound papaya juice and preparing method thereof |
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Application publication date: 20120111 |