CN102293686B - Multi-degree-of-freedom electric micro-injection instrument - Google Patents
Multi-degree-of-freedom electric micro-injection instrument Download PDFInfo
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- CN102293686B CN102293686B CN 201010206787 CN201010206787A CN102293686B CN 102293686 B CN102293686 B CN 102293686B CN 201010206787 CN201010206787 CN 201010206787 CN 201010206787 A CN201010206787 A CN 201010206787A CN 102293686 B CN102293686 B CN 102293686B
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Abstract
The invention provides a multi-degree-of-freedom electric micro-injection instrument. In the multi-degree-of-freedom electric micro-injection instrument, an X-axis direction sliding rail is arranged on a pedestal; an X-axis direction translation platform is arranged on the X-axis direction sliding rail; a micrometer head knob is arranged on one side of the X-axis direction translation platform; aY-axis direction sliding rail is arranged on the X-axis direction translation platform; a Y-axis direction translation platform is arranged on the Y-axis direction sliding rail; a micrometer head knob is arranged on one side of the Y-axis direction translation platform; a Z-axis direction sliding block sleeve is arranged on the Y-axis direction translation platform; a micrometer head knob is arranged on the top of the sleeve and is connected with a Z-axis direction sliding block in the sleeve; the middle part of the sleeve is provided with an opening through which a substrate is connected with the Z-axis direction sliding block; a connecting plate is arranged on the bottom side of the substrate and is connected with the Z-axis direction sliding block through a pitch adjusting nut; a microinjector and a motor are arranged on the substrate; one end of a screw rod is connected with a needle core of the microinjector; and the other end of the screw rod is connected with the output end of the motor. The multi-degree-of-freedom electric micro-injection instrument has a simple structure and the effects of stable and high-precision needle tip positioning and slow controlled injection.
Description
Technical field
The present invention relates to Medical Microinjection Instrument, relate in particular to a kind of for the multi-freedom degree electronic microscale injection instrument of microscopically to the subretinal space administration.
Background technology
As everyone knows, the retinopathy such as detachment of retina, diabetic renal papillary necrosis, the retinal vein occlusion can have a strong impact on vision, even cause losing one's sight.At present, for a large amount of research work of these diseases, just extensively be carried out in (such as rat, mice etc.) in the zoopery, with the curative effect of inquiring into disease mechanisms, observing new cure.Think that at present subretinal space is relative immunity absolution district, using subretinal space, to inject the needs of this technology increasing, especially carries out gene transfection to retina cell.Yet, want skillfully to grasp subretinal space injection art, difficulty is very large, microscopically, during injection operation because unexpected, the uncontrollable shake of staff all may cause choroid to stab rear massive hemorrhage and/or puncture retina, stabs crystalline lens, operation failure.In addition, too fast liquid stream also can cause obvious iatrogenic injury.
Flow rate of liquid when researcher is arranged micro-injection compares research, use manual Hamilton syringe, behind the injection pump syringe of air operated Eppendorf syringe and slowly slowspeed machine pump driving, the result thinks the slow controlled injection liquid stream that the injection pump syringe provides, can obviously alleviate iatrogenic injury, but this injection pump is expensive, be difficult to popularize, and, even if used injection pump, how guaranteeing for a long time that syringe needle is positioned under the poor retina, also is the test to operator's experience, muscle power and Microsurgical Techniques.
How to set up accurately, the subretinal space injection of safety, favorable repeatability, be that all are engaged in the challenge that the retina basic research personnel faces.
In view of the injection of Rat retina cavity of resorption, difficulty is high and success rate is low, and using apparatus assisted Microsurgery system is natural idea.Pinpoint microinjection is used very extensive in medical research.The auxiliary facilities of using in the experiment at present has two kinds, and a kind of is to use stereotactic apparatus, and syringe is installed on the support, and it has 3DOF, and syringe needle is goed deep into target organ or tissue, is usually used in the position, deep, such as administration in to Mus, rabbit intracranial nerve nucleus; Another kind is to the endocellular injection instrument, can obtain 1 degree of freedom or 2DOF, utilizes under the desk-top surgical microscope, uses glass needle that genetic fragment transfered cell/sperm is injected ovum.Because the requirement of intraocular injection is under operating microscope, does the scleral tunnel puncture orifice, need to change at any time degree of freedom, not that simple directly the bundle worn sclera, choroid, therefore apply mechanically stereotactic apparatus/endocellular injection instrument and be difficult to coupling.In specific operation process, after the operator saw syringe needle clearly, what need to eliminate was the interference of unexpected shake, except stability is arranged, accuracy, also need with operating microscope can be whole and, do not hinder eyepiece movable.
Have the needle point location of stable, pinpoint accuracy and slowly controlled injection be accurately, the key of the subretinal space injection technique success of safety, favorable repeatability.
Summary of the invention
Main purpose of the present invention is to overcome the above-mentioned shortcoming that existing product exists, and provide a kind of multi-freedom degree electronic microscale injection instrument, effect with simple and reasonable, easy and simple to handle, stable and pinpoint accuracy needle point location and slow controlled injection can effectively realize accurately, the subretinal space injection of safety, favorable repeatability.
The objective of the invention is to be realized by following technical scheme.
Multi-freedom degree electronic microscale injection instrument of the present invention is characterized in that, comprises base 1, X-direction translation stage 6, Y direction translation stage 7, Z-direction slipping block 8, pitching adjusting nut 5, substrate 11, motor 15, lead screw 16, microsyringe 13; This is provided with X-direction above base 1 slide rail arranges X-direction translation stage 6 on the slide rail of this X-direction, a side of this X-direction translation stage 6 is provided with differential head knob 2; This is provided with Y direction above X-direction translation stage 6 slide rail arranges Y direction translation stage 7 on the slide rail of this Y direction, a side of this Y direction translation stage 7 is provided with differential head knob 3; This is provided with the sleeve 9 of Z-direction slipping block 8 above Y direction translation stage 7, these sleeve 9 tops are provided with differential head knob 4, and this differential head knob 4 is connected with the Z-direction slipping block 8 that is positioned at sleeve 9, and these sleeve 9 middle parts are provided with opening, and substrate 11 is connected with Z-direction slipping block 8; These substrate 11 bottom sides are provided with connecting plate, and this connecting plate is connected with Z-direction slipping block 8 by pitching adjusting nut 5, and this is provided with microsyringe 13 and motor 15 above substrate 11; These lead screw 16 1 ends are connected with the nook closing member 12 of microsyringe 13, and lead screw 16 other ends are connected with motor 15 outfans.
Aforesaid multi-freedom degree electronic microscale injection instrument, wherein the connecting plate that is provided with of substrate 11 bottom sides is mutually vertical with substrate 11.
Aforesaid multi-freedom degree electronic microscale injection instrument, wherein X-direction translation stage 6 is along X-direction translation 0.01 to 30mm.
Aforesaid multi-freedom degree electronic microscale injection instrument, wherein Y direction translation stage 7 is along Y direction translation 0.01 to 30mm.
Aforesaid multi-freedom degree electronic microscale injection instrument, wherein the Z-direction slipping block moves 0.01 to 40mm along Z-direction.
Aforesaid multi-freedom degree electronic microscale injection instrument, wherein the length of lead screw 16 is 0.01 to 50mm.
The beneficial effect of multi-freedom degree electronic microscale injection instrument of the present invention, it is simple and reasonable, the injection position degree of accuracy is high, adopt the translation stage of level orientation, slipping block and the pitching adjusting nut of vertical orientations can realize that multivariant inserting needle and needle point move, take motor-driven to realize the injection of medicine constant speed, can satisfy the special medicine experiment such as the needs of subretinal space injection, reduce iatrogenic injury, improve the success rate of micro-injection.
Description of drawings:
Fig. 1 is multi-freedom degree electronic microscale injection instrument perspective view of the present invention.
Main label declaration: 1 base, 2 be X-direction differential knob, 3 for Y direction differential knob, 4 for Z-direction differential knob, 5 pitching adjusting nuts, 6 for the X-direction translation stage, 7 for the Y direction translation stage, 8 for Z-direction slide block, 9 be Z-direction slide block sleeve, 11 substrates, 12 microsyringe nook closing members, 13 microsyringes, 14 microsyringe syringe needles, 15 motors, 16 lead screw.
The specific embodiment
As shown in Figure 1, multi-freedom degree electronic microscale injection instrument of the present invention, it comprises base 1, X-direction translation stage 6, Y direction translation stage 7, Z-direction slipping block 8, pitching adjusting nut 5, substrate 11, motor 15, lead screw 16, microsyringe 13; This is provided with X-direction above base 1 slide rail arranges X-direction translation stage 6 on the slide rail of this X-direction, a side of this X-direction translation stage 6 is provided with differential head knob 2; This is provided with Y direction above X-direction translation stage 6 slide rail arranges Y direction translation stage 7 on the slide rail of this Y direction, a side of this Y direction translation stage 7 is provided with differential head knob 3; This is provided with the sleeve 9 of Z-direction slipping block 8 above Y direction translation stage 7, these sleeve 9 tops are provided with differential head knob 4, and this differential head knob 4 is connected with the Z-direction slipping block 8 that is positioned at sleeve 9, and these sleeve 9 middle parts are provided with opening, and substrate 11 is connected with Z-direction slipping block 8; These substrate 11 bottom sides are provided with connecting plate, and this connecting plate is connected with Z-direction slipping block 8 by pitching adjusting nut 5, and this is provided with microsyringe 13 and motor 15 above substrate 11; These lead screw 16 1 ends are connected with the nook closing member 12 of microsyringe 13, and lead screw 16 other ends are connected with motor 15 outfans.
As shown in Figure 1, multi-freedom degree electronic microscale injection instrument of the present invention, wherein, the connecting plate that these substrate 11 bottom sides are provided with is mutually vertical with substrate 11; This X-direction translation stage 6 is along X-direction translation 0.01 to 30mm; This Y direction translation stage 7 is along Y direction translation 0.01 to 30mm; This Z-direction slipping block moves 0.01 to 40mm along Z-direction; The length of this lead screw 16 is 0.01 to 50mm.
As shown in Figure 1, the use of multi-freedom degree electronic microscale injection instrument of the present invention at first is fixed in microsyringe 13 on the substrate 11, and the nook closing member 12 of microsyringe 13 is connected with lead screw 16; Then rotated differential head knob 2,3,4 and the pitching adjusting nut 5 of X-direction, Y direction and Z-direction by operator's both hands, make syringe needle point 14 accurately arrive assigned address, then open motor switch starter motor 15 by the operator, drive lead screw 16 rotations after motor 15 work, thereby advance nook closing member 12, make the interior liquid of needle tubing arrive appointed part by needle point 14 injections.
The advantage of multi-freedom degree electronic microscale injection instrument of the present invention: it has multiple degrees of freedom clamp-type machinery mount, the microsyringe needle tubing is installed on the substrate, the operator uses differential head knob regulation and control syringe needle in the movement of X-direction, Y direction and Z-direction under operating microscope; Adjust simultaneously the movement of syringe needle pitch orientation by the pitching adjusting nut, realize the multivariant movement of microsyringe, the purposiveness that effective elimination operator exists is in various degree trembled and strength type trembles, the native system degree of accuracy is high, every operation differential head knob once, needle point is mobile 0.01mm only, makes operation meticulousr and steady, and this is for being even more important under the long-time operation state.In addition, be connected by lead screw between motor and the nook closing member, motor at the uniform velocity drives the propelling nook closing member, thereby realizes that drug slow injects target organ, so that iatrogenic injury microminiaturization again; Moreover this multi-freedom degree electronic microscale injection instrument is simple and reasonable, convenient operation, and cost is lower, and result of use is desirable.
The above, it only is preferred embodiment of the present invention, be not that the present invention is done any pro forma restriction, every foundation technical spirit of the present invention all still belongs in the scope of technical solution of the present invention any simple modification, equivalent variations and modification that above embodiment does.
Claims (2)
1. a multi-freedom degree electronic microscale injection instrument is characterized in that, comprises base, X-direction translation stage, Y direction translation stage, Z-direction slipping block, pitching adjusting nut, substrate, motor, lead screw, microsyringe; This is provided with the slide rail of X-direction above base, the X-direction translation stage is set on the slide rail of this X-direction, and a side of this X-direction translation stage is provided with differential head knob; This is provided with Y direction above X-direction translation stage slide rail arranges the Y direction translation stage on the slide rail of this Y direction, a side of this Y direction translation stage is provided with differential head knob; This is provided with Z-direction slipping block sleeve above Y direction translation stage, this sleeve top is provided with differential head knob, and the differential head knob on this sleeve top is connected with the Z-direction slipping block that is positioned at sleeve, and this sleeve middle part is provided with opening, and substrate is connected with the Z-direction slipping block; This substrate base side is provided with connecting plate, and this connecting plate is connected with the Z-direction slipping block by the pitching adjusting nut, and this is provided with microsyringe and motor above substrate; This lead screw one end is connected with the nook closing member of microsyringe, and the lead screw other end is connected with motor output end;
The connecting plate that this substrate base side is provided with is mutually vertical with substrate; This X-direction translation stage is along X-direction translation 0.01 to 30mm; This Y direction translation stage is along Y direction translation 0.01 to 30mm; This Z-direction slipping block moves 0.01 to 40mm along Z-direction.
2. multi-freedom degree electronic microscale injection instrument according to claim 1 is characterized in that, the length of described lead screw is 0.01 to 50mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010206787 CN102293686B (en) | 2010-06-23 | 2010-06-23 | Multi-degree-of-freedom electric micro-injection instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010206787 CN102293686B (en) | 2010-06-23 | 2010-06-23 | Multi-degree-of-freedom electric micro-injection instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102293686A CN102293686A (en) | 2011-12-28 |
| CN102293686B true CN102293686B (en) | 2013-09-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN 201010206787 Expired - Fee Related CN102293686B (en) | 2010-06-23 | 2010-06-23 | Multi-degree-of-freedom electric micro-injection instrument |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110252592B (en) * | 2019-06-04 | 2021-03-16 | 陕西科技大学 | Nano-liter-level liquid drop distribution device and method based on wettability partition structure |
| CN110368184B (en) * | 2019-08-08 | 2021-05-04 | 哈尔滨工业大学 | Retinal vessel medicine injector for ophthalmic surgery robot and injection method thereof |
| CN110368185A (en) * | 2019-08-08 | 2019-10-25 | 哈尔滨工业大学 | A kind of retinal vessel medicine injecting device for ophthalmologic operation robot |
| CN112891013B (en) * | 2021-01-27 | 2023-08-25 | 中国人民解放军空军军医大学 | Device for injecting medicine into colorectal of small rodent experimental animal |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2105295U (en) * | 1991-10-28 | 1992-05-27 | 机械电子工业部天津工程机械研究所 | Electric micro injector |
| CN201735051U (en) * | 2010-06-23 | 2011-02-09 | 吴建国 | Multi-freedom degree electronic microscale injection instrument |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4833732B2 (en) * | 2006-05-16 | 2011-12-07 | テルモ株式会社 | Syringe pump |
-
2010
- 2010-06-23 CN CN 201010206787 patent/CN102293686B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2105295U (en) * | 1991-10-28 | 1992-05-27 | 机械电子工业部天津工程机械研究所 | Electric micro injector |
| CN201735051U (en) * | 2010-06-23 | 2011-02-09 | 吴建国 | Multi-freedom degree electronic microscale injection instrument |
Non-Patent Citations (1)
| Title |
|---|
| JP特开2007-306991A 2007.11.29 |
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| CN102293686A (en) | 2011-12-28 |
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