CN102293686A - Multi-degree-of-freedom electric micro-injection instrument - Google Patents
Multi-degree-of-freedom electric micro-injection instrument Download PDFInfo
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- CN102293686A CN102293686A CN2010102067879A CN201010206787A CN102293686A CN 102293686 A CN102293686 A CN 102293686A CN 2010102067879 A CN2010102067879 A CN 2010102067879A CN 201010206787 A CN201010206787 A CN 201010206787A CN 102293686 A CN102293686 A CN 102293686A
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Abstract
The invention provides a multi-degree-of-freedom electric micro-injection instrument. In the multi-degree-of-freedom electric micro-injection instrument, an X-axis direction sliding rail is arranged on a pedestal; an X-axis direction translation platform is arranged on the X-axis direction sliding rail; a micrometer head knob is arranged on one side of the X-axis direction translation platform; a Y-axis direction sliding rail is arranged on the X-axis direction translation platform; a Y-axis direction translation platform is arranged on the Y-axis direction sliding rail; a micrometer head knob is arranged on one side of the Y-axis direction translation platform; a Z-axis direction sliding block sleeve is arranged on the Y-axis direction translation platform; a micrometer head knob is arranged on the top of the sleeve and is connected with a Z-axis direction sliding block in the sleeve; the middle part of the sleeve is provided with an opening through which a substrate is connected with the Z-axis direction sliding block; a connecting plate is arranged on the bottom side of the substrate and is connected with the Z-axis direction sliding block through a pitch adjusting nut; a microinjector and a motor are arranged on the substrate; one end of a screw rod is connected with a needle core of the microinjector; and the other end of the screw rod is connected with the output end of the motor. The multi-degree-of-freedom electric micro-injection instrument has a simple structure and the effects of stable and high-precision needle tip positioning and slow controlled injection.
Description
Technical field
The present invention relates to medical micro-injection instrument, relate in particular to a kind of microscopically that is used for to the electronic micro-injection instrument of the multiple degrees of freedom of retina cavity of resorption administration.
Background technology
As everyone knows, retinopathy such as detachment of retina, diabetic renal papillary necrosis, the retinal vein occlusion can have a strong impact on vision, even cause losing one's sight.At present,, just extensively be carried out in (as rat, mice etc.) in the zoopery, to inquire into the curative effect of disease mechanisms, the new treatment method of observation at a large amount of research work of these diseases.Think that at present the retina cavity of resorption is relative immunity absolution district, using the retina cavity of resorption, to inject the needs of this technology increasing, especially carries out gene transfection to retina cell.Yet, want on top of retina cavity of resorption injection art, difficulty is very big, microscopically, during injection operation because unexpected, the uncontrollable shake of staff all may cause choroid to stab the back massive hemorrhage and/or puncture retina, stabs crystalline lens, operation failure.In addition, too fast liquid stream also can cause tangible iatrogenic injury.
Flow rate of liquid when researcher is arranged micro-injection compares research, use manual Hamilton syringe, behind the injection pump syringe of air operated Eppendorf syringe and slowly slowspeed machine pump driving, the result thinks the slow controlled injection liquid stream that the injection pump syringe provides, can obviously alleviate iatrogenic injury, but this injection pump is expensive, be difficult to popularize, and, even if used injection pump, how guaranteeing for a long time that syringe needle is positioned under the poor retina, also is the test to operator's experience, muscle power and microsurgery skill.
How to set up accurately, the retina cavity of resorption injection of safety, favorable repeatability, be that all are engaged in the challenge that retina basic research personnel face.
In view of the injection of Mus retina cavity of resorption, difficulty is high and success rate is low, and using the auxiliary microsurgery system of apparatus is natural idea.Pinpoint microinjection is used very extensive in medical research.The auxiliary facilities of using in the experiment has two kinds at present, and a kind of stereotactic apparatus that is to use is installed at syringe on the support, and it has 3DOF, and syringe needle is goed deep into target organ or tissue, is usually used in the position, deep, as administration in Mus, rabbit intracranial nerve nucleus; Another kind is to the endocellular injection instrument, can obtain 1 degree of freedom or 2DOF, utilizes desk-top microscope direct-view down, uses glass needle that genetic fragment transfered cell/sperm is injected ovum.Because the requirement of intraocular injection is under operating microscope, does the scleral tunnel puncture orifice, need change degree of freedom at any time, not that simple directly the bundle worn sclera, choroid, therefore apply mechanically stereotactic apparatus/endocellular injection instrument and be difficult to coupling.In specific operation process, after the operator saw syringe needle clearly, what need to eliminate was the interference of unexpected shake, except stability is arranged, accuracy, also need with operating microscope can put in order with, do not hinder the eyepiece activity.
Have the needle point location of stable, pinpoint accuracy and slowly controlled injection be accurately, the key of the retina cavity of resorption injection technique success of safety, favorable repeatability.
Summary of the invention
Main purpose of the present invention is to overcome the above-mentioned shortcoming that existing product exists, and provide a kind of multiple degrees of freedom electronic micro-injection instrument, effect with simple and reasonable, easy and simple to handle, stable and pinpoint accuracy needle point location and slow controlled injection can effectively realize accurately, the retina cavity of resorption injection of safety, favorable repeatability.
The objective of the invention is to realize by following technical scheme.
The electronic micro-injection instrument of multiple degrees of freedom of the present invention is characterized in that, comprises base 1, X-direction translation stage 6, Y direction translation stage 7, Z-direction slipping block 8, pitching adjustment nut 5, substrate 11, motor 15, lead screw 16, microsyringe 13; This is provided with X-direction above base 1 slide rail is provided with X-direction translation stage 6 on the slide rail of this X-direction, a side of this X-direction translation stage 6 is provided with differential head knob 2; This is provided with Y direction above X-direction translation stage 6 slide rail is provided with Y direction translation stage 7 on the slide rail of this Y direction, a side of this Y direction translation stage 7 is provided with differential head knob 3; This is provided with the sleeve 9 of Z-direction slipping block 8 above Y direction translation stage 7, these sleeve 9 tops are provided with differential head knob 4, and this differential head knob 4 is connected with the Z-direction slipping block 8 that is positioned at sleeve 9, and these sleeve 9 middle parts are provided with opening, and substrate 11 is connected with Z-direction slipping block 8; These substrate 11 bottom sides are provided with connecting plate, and this connecting plate is adjusted nut 5 by pitching and is connected with Z-direction slipping block 8, and this is provided with microsyringe 13 and motor 15 above substrate 11; These lead screw 16 1 ends are connected with the nook closing member 12 of microsyringe 13, and lead screw 16 other ends are connected with motor 15 outfans.
The electronic micro-injection instrument of aforesaid multiple degrees of freedom, wherein the connecting plate that is provided with of substrate 11 bottom sides is vertical mutually with substrate 11.
The electronic micro-injection instrument of aforesaid multiple degrees of freedom, wherein X-direction translation stage 6 along X-direction translation 0.01 to 30mm.
The electronic micro-injection instrument of aforesaid multiple degrees of freedom, wherein Y direction translation stage 7 along Y direction translation 0.01 to 30mm.
The electronic micro-injection instrument of aforesaid multiple degrees of freedom, wherein the Z-direction slipping block moves 0.01 to 40mm along Z-direction.
The electronic micro-injection instrument of aforesaid multiple degrees of freedom, wherein the length of lead screw 16 is 0.01 to 50mm.
The beneficial effect of the electronic micro-injection instrument of multiple degrees of freedom of the present invention, it is simple and reasonable, injection position degree of accuracy height, adopt the translation stage of level orientation, the slipping block and the pitching adjustment nut of vertical orientations can realize that multivariant inserting needle and needle point move, take motor-driven to realize the injection of medicine constant speed, can satisfy the needs of special medicine experiment, reduce iatrogenic injury, improve the success rate of micro-injection as the injection of retina cavity of resorption.
Description of drawings:
Fig. 1 is the electronic micro-injection instrument of a multiple degrees of freedom of the present invention perspective view.
Main label declaration: 1 base, 2 be X-direction differential knob, 3 for Y direction differential knob, 4 for Z-direction differential knob, 5 pitching adjust nut, 6 for the X-direction translation stage, 7 for the Y direction translation stage, 8 for Z-direction slide block, 9 be Z-direction slide block sleeve, 11 substrates, 12 microsyringe nook closing members, 13 microsyringes, 14 microsyringe syringe needles, 15 motors, 16 lead screw.
The specific embodiment
As shown in Figure 1, the electronic micro-injection instrument of multiple degrees of freedom of the present invention, it comprises base 1, X-direction translation stage 6, Y direction translation stage 7, Z-direction slipping block 8, pitching adjustment nut 5, substrate 11, motor 15, lead screw 16, microsyringe 13; This is provided with X-direction above base 1 slide rail is provided with X-direction translation stage 6 on the slide rail of this X-direction, a side of this X-direction translation stage 6 is provided with differential head knob 2; This is provided with Y direction above X-direction translation stage 6 slide rail is provided with Y direction translation stage 7 on the slide rail of this Y direction, a side of this Y direction translation stage 7 is provided with differential head knob 3; This is provided with the sleeve 9 of Z-direction slipping block 8 above Y direction translation stage 7, these sleeve 9 tops are provided with differential head knob 4, and this differential head knob 4 is connected with the Z-direction slipping block 8 that is positioned at sleeve 9, and these sleeve 9 middle parts are provided with opening, and substrate 11 is connected with Z-direction slipping block 8; These substrate 11 bottom sides are provided with connecting plate, and this connecting plate is adjusted nut 5 by pitching and is connected with Z-direction slipping block 8, and this is provided with microsyringe 13 and motor 15 above substrate 11; These lead screw 16 1 ends are connected with the nook closing member 12 of microsyringe 13, and lead screw 16 other ends are connected with motor 15 outfans.
As shown in Figure 1, the electronic micro-injection instrument of multiple degrees of freedom of the present invention, wherein, the connecting plate that these substrate 11 bottom sides are provided with is vertical mutually with substrate 11; This X-direction translation stage 6 along X-direction translation 0.01 to 30mm; This Y direction translation stage 7 along Y direction translation 0.01 to 30mm; This Z-direction slipping block moves 0.01 to 40mm along Z-direction; The length of this lead screw 16 is 0.01 to 50mm.
As shown in Figure 1, the use of the electronic micro-injection instrument of multiple degrees of freedom of the present invention at first is fixed in microsyringe 13 on the substrate 11, and the nook closing member 12 of microsyringe 13 is connected with lead screw 16; Then adjust nut 5 by the differential head knob 2,3,4 and the pitching of the rotation of operator's both hands X-direction, Y direction and Z-direction, make syringe needle point 14 accurately arrive assigned address, open motor switch starter motor 15 by the operator then, motor 15 work backs drive lead screw 16 rotations, thereby advance nook closing member 12, make the interior liquid of needle tubing arrive appointed part by needle point 14 injections.
The advantage of the electronic micro-injection instrument of multiple degrees of freedom of the present invention: it has multiple degrees of freedom clamp-type machinery mount, the microsyringe needle tubing is installed on the substrate, the operator uses differential head knob regulation and control syringe needle moving in X-direction, Y direction and Z-direction under operating microscope; Adjust nut by pitching simultaneously and adjust moving of syringe needle pitch orientation, realize that microsyringe is multivariant mobile, the purposiveness that effective elimination operator exists is in various degree trembled and strength type trembles, the native system degree of accuracy is high, every operation differential head knob once, the only mobile 0.01mm of needle point makes operation meticulousr and steady, and this is for being even more important under the long-time operation state.In addition, be connected by lead screw between motor and the nook closing member, motor at the uniform velocity drives the propelling nook closing member, thereby realizes that drug slow injects target organ, makes iatrogenic injury microminiaturization once more; Moreover the electronic micro-injection instrument of this multiple degrees of freedom is simple and reasonable, is convenient to operation, and cost is lower, the result of use ideal.
The above, it only is preferred embodiment of the present invention, be not that the present invention is done any pro forma restriction, every foundation technical spirit of the present invention all still belongs in the scope of technical solution of the present invention any simple modification, equivalent variations and modification that above embodiment did.
Claims (6)
1. the electronic micro-injection instrument of multiple degrees of freedom is characterized in that, comprises base, X-direction translation stage, Y direction translation stage, Z-direction slipping block, pitching adjustment nut, substrate, motor, lead screw, microsyringe; This is provided with the slide rail of X-direction above base, the X-direction translation stage is set on the slide rail of this X-direction, and a side of this X-direction translation stage is provided with differential head knob; This is provided with Y direction above X-direction translation stage slide rail is provided with the Y direction translation stage on the slide rail of this Y direction, a side of this Y direction translation stage is provided with differential head knob; This is provided with Z-direction slipping block sleeve above Y direction translation stage, this sleeve top is provided with differential head knob, and this differential head knob is connected with the Z-direction slipping block that is positioned at sleeve, and this sleeve middle part is provided with opening, and substrate is connected with the Z-direction slipping block; This substrate base side is provided with connecting plate, and this connecting plate is adjusted nut by pitching and is connected with the Z-direction slipping block, and this is provided with microsyringe and motor above substrate; This lead screw one end is connected with the nook closing member of microsyringe, and the lead screw other end is connected with motor output end.
2. the electronic micro-injection instrument of multiple degrees of freedom according to claim 1 is characterized in that the connecting plate that described substrate base side is provided with is vertical mutually with substrate.
3. the electronic micro-injection instrument of multiple degrees of freedom according to claim 1 is characterized in that, described X-direction translation stage along X-direction translation 0.01 to 30mm.
4. the electronic micro-injection instrument of multiple degrees of freedom according to claim 1 is characterized in that, described Y direction translation stage along Y direction translation 0.01 to 30mm.
5. the electronic micro-injection instrument of multiple degrees of freedom according to claim 1 is characterized in that described Z-direction slipping block moves 0.01 to 40mm along Z-direction.
6. the electronic micro-injection instrument of multiple degrees of freedom according to claim 1 is characterized in that, the length of described lead screw is 0.01 to 50mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010206787 CN102293686B (en) | 2010-06-23 | 2010-06-23 | Multi-degree-of-freedom electric micro-injection instrument |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010206787 CN102293686B (en) | 2010-06-23 | 2010-06-23 | Multi-degree-of-freedom electric micro-injection instrument |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102293686A true CN102293686A (en) | 2011-12-28 |
| CN102293686B CN102293686B (en) | 2013-09-18 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010206787 Expired - Fee Related CN102293686B (en) | 2010-06-23 | 2010-06-23 | Multi-degree-of-freedom electric micro-injection instrument |
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| CN (1) | CN102293686B (en) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110252592A (en) * | 2019-06-04 | 2019-09-20 | 陕西科技大学 | A kind of nanoliter level liquid droplet distribution device and method based on wetability partitioned organization |
| CN110368184A (en) * | 2019-08-08 | 2019-10-25 | 哈尔滨工业大学 | Retinal vessel medicine injecting device and its injecting method for ophthalmologic operation robot |
| CN110368185A (en) * | 2019-08-08 | 2019-10-25 | 哈尔滨工业大学 | A kind of retinal vessel medicine injecting device for ophthalmologic operation robot |
| CN112891013A (en) * | 2021-01-27 | 2021-06-04 | 中国人民解放军空军军医大学 | Device for injecting medicine into colorectal cavity of small rodent experimental animal |
| CN118021516A (en) * | 2024-02-29 | 2024-05-14 | 中国科学院自动化研究所 | Medicine injection device for automatic puncture of blood vessel |
| CN118021516B (en) * | 2024-02-29 | 2024-10-29 | 中国科学院自动化研究所 | Medicine injection device for automatic puncture of blood vessel |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2105295U (en) * | 1991-10-28 | 1992-05-27 | 机械电子工业部天津工程机械研究所 | Electric micro injector |
| JP2007306991A (en) * | 2006-05-16 | 2007-11-29 | Terumo Corp | Syringe pump and method of use thereof |
| CN201735051U (en) * | 2010-06-23 | 2011-02-09 | 吴建国 | Multi-freedom degree electronic microscale injection instrument |
-
2010
- 2010-06-23 CN CN 201010206787 patent/CN102293686B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2105295U (en) * | 1991-10-28 | 1992-05-27 | 机械电子工业部天津工程机械研究所 | Electric micro injector |
| JP2007306991A (en) * | 2006-05-16 | 2007-11-29 | Terumo Corp | Syringe pump and method of use thereof |
| CN201735051U (en) * | 2010-06-23 | 2011-02-09 | 吴建国 | Multi-freedom degree electronic microscale injection instrument |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110252592A (en) * | 2019-06-04 | 2019-09-20 | 陕西科技大学 | A kind of nanoliter level liquid droplet distribution device and method based on wetability partitioned organization |
| CN110252592B (en) * | 2019-06-04 | 2021-03-16 | 陕西科技大学 | Nano-liter-level liquid drop distribution device and method based on wettability partition structure |
| CN110368184A (en) * | 2019-08-08 | 2019-10-25 | 哈尔滨工业大学 | Retinal vessel medicine injecting device and its injecting method for ophthalmologic operation robot |
| CN110368185A (en) * | 2019-08-08 | 2019-10-25 | 哈尔滨工业大学 | A kind of retinal vessel medicine injecting device for ophthalmologic operation robot |
| CN110368184B (en) * | 2019-08-08 | 2021-05-04 | 哈尔滨工业大学 | Retinal vessel medicine injector for ophthalmic surgery robot and injection method thereof |
| CN112891013A (en) * | 2021-01-27 | 2021-06-04 | 中国人民解放军空军军医大学 | Device for injecting medicine into colorectal cavity of small rodent experimental animal |
| CN112891013B (en) * | 2021-01-27 | 2023-08-25 | 中国人民解放军空军军医大学 | Device for injecting medicine into colorectal of small rodent experimental animal |
| CN118021516A (en) * | 2024-02-29 | 2024-05-14 | 中国科学院自动化研究所 | Medicine injection device for automatic puncture of blood vessel |
| CN118021516B (en) * | 2024-02-29 | 2024-10-29 | 中国科学院自动化研究所 | Medicine injection device for automatic puncture of blood vessel |
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| Publication number | Publication date |
|---|---|
| CN102293686B (en) | 2013-09-18 |
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