CN102258632A - Anti-acne cream by using camellia oleifera seed oil - Google Patents

Abstract

The invention relates to an anti-acne cream by using camellia oleifera seed oil, which belongs to the technical field of biology. The invention is characterized in that the refining camellia oleifera seed oil which has strong affinity to sebum is taken as a substrate, a slug extract for clearing heat and detoxifying as well as quickening blood and dispelling stasis is added, and viaminate for reducing sebum secrete as well as dredging the obstructed pores is added; the cream provided in the invention is prepared by using minocycline special for killing acne propionic acid bacillus under the anaerobic environment. The method comprises the following steps: weighting 2-5g of slug extract, 1-3g of viaminate and 1-2g of minocycline to well mix, sieving with a sieve with 100 meshes to be spare; weighting 50g-75g of glycerin, 0.5g-1g of ethylparaben and a certain amount of purified water to mix, heating to the temperature of 80 DEG C to be spare, wherein the obtained mixture is an aqueous phase; weighting 80g-120g of refined camellia oleifera, 5g-8g of tween 80, 10g of triethanolamine, heating to the temperature of 80 DEG C to stir for dissolving, wherein the obtained mixture is oil phase; slowly adding the oil phase into the water phase, then supplementing purified water to 1000 ml, and stirring in the same direction to prepare a substrate, adding the above sieved medicament fine powders when the temperature of the substrate reaches to 40 DEG C, continuously and uniformly stirring to form the cream. According to the invention, by cooperation and addition of combined various drugs, the anti-acne cream has effect for treating acne in multi-links of sterilizing, diminishing inflammation, reducing sebum secrete, dredging obstructed pores, improving skin microcirculation and the like. The anti-acne cream of the invention is better than all products of the same kind in the current market.

Description

A kind of camellia seed oil pox cream that disappears

Technical field: biotechnology

Background technology:

Acne is commonly called as acne, comedo.Be a kind of common hair follicle, sebaceous gland chronic inflammatory diseases, good sending out in adolescence, the male is up to 90%, and the women about 80%.The acne pathogenic factor has multiple factor, and it is generally acknowledged that main cause is: the adolescence androgen secretion increases, and causes the sebaceous gland enlargement, and smegma increases, and makes hair follicle, sebaceous gland conduit keratinization thromboembolism simultaneously, and the sebum stasis of blood is amassed in hair follicle and formed fat bolt, i.e. acne.Under anaerobic environment, a large amount of hypertrophy breedings of anaerobe such as propionibacterium acnes produce fat dissolving enzyme, separate sebum and produce free acid, hair follicle stimulating causes inflammation, and causes the follicular wall damage to be broken, the long-pending sebum of the stasis of blood enters intradermal, thereby causes the hair follicle inflammatory reaction of varying degree on every side.In addition, heredity, dyshormonia, greasiness polysaccharide and zest diet, high temperature and some chemical factor also play a part certain to the generation of acne development.Though acne does not influence the body normal physiological function, influences appearance, cause one stress to the patient, so the exploitation of acne medicine obtains more and more paying attention to.Chinese medicine thinks that plain body sun heat contains partially, heat in blood is stopped up outward, and QI and blood stasis is accumulate the resistance skin, and send out primary disease: the lung stomach is damp and hot to be another main pathogenesis of acne morbidity, surfeit delicious food savoury, it is damp and hot then to increase the weight of the lung stomach, follow through on smoke, on stop up in face, acne then occurs, saying of " the pathologic change caused by rich and fatty diet, foot is given birth to nail-like boil " just arranged in " element is asked the vital QI of the body connecting with natural QI opinion "; The depressed emotion fire-transformation is intimately fought mutually with QI and blood, and acne takes place.

The acne treatment medicine of present clinical usefulness: in the oral anti-infective, the most frequently used antibiotic is tetracycline, Macrolide, clindamycin or chloromycetin etc., in being applicable to, severe acne, local antibiotic treatment failure maybe can not tolerate, have and form pigmentation tendency and trunk affected individual after cicatrix or the inflammation.But should be no less than 2 months the course of treatment of oral anti-infective, is no more than 4～6 months.Can occur maximum clinical improvements in treatment after 3～4 months, not improve if having, may be relevant with the drug resistance factor.Isotretinoin is the most effective sebaceous gland inhibitor, can play a role at a plurality of links of acne morbidity, has the effect of dwindling sebaceous gland tissue, inhibition sebaceous gland activity, reducing sebum secretion and epithelial cell keratinization and inhibition propionibacterium acnes, not only can remove ripe acne, and can suppress the micropowder thorn, prevention of recurrence is kept the acne relieved state.Oral isotretinoin is mainly used in severe acne, as acne conglobata, nodositas acne cystica and cicatrix acne etc.Other drug comprises: the antiandrogen medicine; Corticosteroid; Sulfasalazine; Oral zinc preparation or the like all exists the course of treatment long, and side effect is big, is difficult to adhere to, drug effect is average, be difficult to be completely cured.Local application comprises: the solution of clindamycin, benzoyl peroxide, Azelaic Acid, anti-androgens, gel, pledget, emulsifiable paste etc.Curative effect is pool meaning not all.Chinese medicine is used the product of lung-heat clearing and detoxification, eliminating heat pathogen by purging the bowels, removing heat from blood eliminating stagnation always, and onset is thorough slowly and not.Thereby study the new Fang Xinfa that treats this disease, become the focus of current the world of medicine.

Summary of the invention:

The present invention is to be substrate with the refined oil Oleum Camelliae, with Limax extract, Viaminate, the compatible compound cream agent of minocycline.To acne determined curative effect, energy treating both the principal and secondary aspects of a disease, the side separates as follows:

Camellia seed oil: it is close that its composition and human body skin include the fat composition, very easily absorbed by skin, be not only the good carrier that enters dermal drug, and itself has certain therapeutical effect to acne: one, insatiable hunger in the camellia seed oil is closed fatty acid, particularly single insatiable hunger and is closed fatty acid and linoleic acid the content that reduces skin histology oxygen is arranged, can reduce oxidation harmful substance the gathering in skin of excretory sebaceous gland, reduce the generation and the calmness of lipid peroxide again; The activity that fatty acid can increase SOD is closed in single insatiable hunger, stablizes tyrosinase activity, thereby reduces melanic formation; SOD increases and can also stablize the important immunocyte-macrophage membrane of body, thereby protection is to the harmful metabolite that exists in the skin histology and the immune clearance ability of microorganism.

They are two years old, unsaturated fatty acid energy cholesterol reducing, triglyceride and low density lipoprotein are seized with terror white in the camellia seed oil, the energy prevention of arterial is atherosis, monounsaturated fatty acid can also make the ratio of high density lipoprotein/low-density lipoprotein raise, can suppress the release of thromboxane B2 (TXB2), thereby the minimizing platelet aggregation is prevented and treated thrombosis.More than two be to keep the unimpeded most important factor of skin microcirculation, skin blood fortune has been improved, oxygen and nutrient substance enter skin easily, the metabolism harmful substance is easy to discharge, the skin nature is with regard to soft and moist, brilliance.

The Limax extract: the Compendium of Materia Medica record, Limax has clearing away heat and expelling wind, subduing swelling and detoxicating, the effect of stimulating the menstrual flow of broken expectorant.Commonly used with treatment innominate toxic swelling, worm venom.Modern study discloses Limax excellent antibiotic, antiviral and antitumaous effect.The hemorheology of improvement and human body immunity improving effect are arranged, among the peoplely transfer Limax mucus to control acne with vinegar or Mel to imitate work.

Viaminate: the action pathway of its treatment acne mainly contains four: the basal cell maturation process is prolonged, and the sebaceous gland cell number is reduced, sebum synthesizes also corresponding minimizing, thereby sebum secretion is reduced.2. can suppress the keratinization of epidermis by the division and the renewal of reconciliation statement chrotoplast, thereby play the effect that pore is stopped up in mediation.3. can change the lipid components in the sebaceous gland, suppress to depend on the propionibacterium acnes of lipid ambient growth, thereby reach antiphlogistic purpose.4. significantly alleviate the nonspecific inflammation reaction.In sum, viaminate can act on each link of acne treatment, farthest reaches the purpose of removing.

Minocycline: have highly lipophilic, minocycline all has bacteriostasis to multiple anaerobe and aerobe, gram positive bacteria and gram-negative bacteria, coccus, bacillus, some fungus and vermiform mite worm.The effect that has all biotype propionibacterium acness of remarkable inhibition especially, minocycline also have the effect that suppresses sebum secretion.Minocycline can also suppress the chemotaxis of neutrophilic granulocyte, suppresses to participate in the oxygen intermediate of inflammation, thereby has anti-inflammatory effect.Minocycline also can make nodulocystic acne patient's tuberosity cyst number reduce reduced.

Collaborative, the summation action of above-mentioned four medicine compatibilities can be from the metabolic turnovers of sterilization, antiinflammatory, reduction sebum secretion, reconciliation statement chrotoplast, and pore is stopped up in mediation, improve cutaneous circulation too many levels performance therapeutical effect.Excellent in all like products of current market.

The specific embodiment:

In [prescription] every 1000g ointment, contain camellia seed oil 80～120g, Limax extract 2～5g, Viaminate 1～3g, minocycline 1～2g; Adjuvant vitamin e1～2g, ethyl hydroxybenzoate 0.5g～1g, tween ₈₀5～8g, glycerol 50g, triethanolamine 10g is made into 1000g with purified water.

[preparation method] (quintessence oil Oleum Camelliae) preparation technology in earlier stage is: Camellia cold pressing gained hair edible vegetable oil, through physics come unstuck-deacidification-deodorize-decolouring-winterization defat-fine straining forms.Later stage (one-tenth cream) takes by weighing recipe quantity Limax extract, Viaminate, minocycline mixing respectively, and it is standby to cross 100 mesh sieves; Take by weighing recipe quantity glycerol, ethyl hydroxybenzoate mixes with a certain amount of purified water, be heated to 80 ℃ standby, this is a water; Take by weighing the smart Oleum Camelliae of recipe quantity, Tween 80, octadecanol mixing, be heated to 80 ℃ of stirring and dissolving, this is an oil phase.Oil phase is slowly added aqueous phase, restock purified water to 1000 milliliter, and stir in the same direction and make substrate, when treating that substrate temperature reaches 40 ℃, add the above-mentioned fine drug powder that sieves again, continue to stir until becoming cream, packing, storage.

Claims (1)

1. This invention be use with the strong refined oil Oleum Camelliae of sebum affinity be substrate, add heat-clearing and toxic substances removing blood-activating and stasis-dissolving prescription Limax extract, reduce sebum secretion, pore agent Viaminate is stopped up in mediation; Under anaerobic environment, specially kill the unguentum that the minocycline of propionibacterium acnes develops.Collaborative and the summation action that all medicines of this invention share can be stopped up pore from sterilization, antiinflammatory, reduction sebum secretion, mediation, the camellia seed oil that improves too many levels performance treatment acne effects such as the skin microcirculation pox cream that disappears.Excellent in all like products of current market.Following claim is proposed now:

   1, this is invented main medicament composing prescription and is: quintessence oil Oleum Camelliae 80～120g, Limax extract 2～5g, Viaminate 1～3g, minocycline 1～2g.

   2, the used camellia seed oil of this invention is a camellia seed kernel through the clear crude oil of cold pressing gained, through physics come unstuck-deacidification-deodorize-decolouring-winterization defat-fine straining forms.

   3, this invention earlier respectively with water and oil phase mixing, after oil phase slowly injects water, adds main medicine such as Limax extract, Viaminate, minocycline again and stirs into cream in system cream process when allowing its temperature transfer to 40 ℃.

   4, the pox cream that disappears of this invention is applicable to following various acne: slight acne I, and the acne sum is no more than 30, and a small amount of pimple and pustule can be arranged; Moderate acne II, skin lesion number are 31-59, and pimple, the pustule of moderate quatity can be arranged; Moderate acne III, a large amount of pimples and pustule, the skin lesion number is between 51-100, and seeing once in a while has big inflammatory damage, and tuberosity is in 3.Severe acne IV, skin lesion number are more than 100, and tuberosity or cyst are mainly tuberosity, cyst or polymerism more than 3.

   5, the pox cream that disappears of this invention is not suitable for pregnant woman and preparation thereof 3 months women and children with interior gestation.Serious hepatic and kidney function obstacle person avoids usefulness.