CN102257387A - 严重脓毒病和败血性休克期间用于快速确定死亡高风险病人的方法和试剂盒 - Google Patents

严重脓毒病和败血性休克期间用于快速确定死亡高风险病人的方法和试剂盒 Download PDF

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CN102257387A
CN102257387A CN2009801518443A CN200980151844A CN102257387A CN 102257387 A CN102257387 A CN 102257387A CN 2009801518443 A CN2009801518443 A CN 2009801518443A CN 200980151844 A CN200980151844 A CN 200980151844A CN 102257387 A CN102257387 A CN 102257387A
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patient
level
septic shock
day
compound
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D·帕扬·德拉加朗代里
A·C·卢卡谢维奇
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Assistance Publique Hopitaux de Paris APHP
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/26—Infectious diseases, e.g. generalised sepsis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
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  • Biomedical Technology (AREA)
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  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN2009801518443A 2008-10-28 2009-10-27 严重脓毒病和败血性休克期间用于快速确定死亡高风险病人的方法和试剂盒 Pending CN102257387A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US12/259,596 2008-10-28
US12/259,596 US8283131B2 (en) 2008-10-28 2008-10-28 Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock
US15852009P 2009-03-09 2009-03-09
US61/158,520 2009-03-09
PCT/IB2009/007493 WO2010049818A1 (en) 2008-10-28 2009-10-27 Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock

Publications (1)

Publication Number Publication Date
CN102257387A true CN102257387A (zh) 2011-11-23

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CN2009801518443A Pending CN102257387A (zh) 2008-10-28 2009-10-27 严重脓毒病和败血性休克期间用于快速确定死亡高风险病人的方法和试剂盒

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US (1) US20110287433A1 (https=)
EP (1) EP2350646B1 (https=)
JP (1) JP5619016B2 (https=)
CN (1) CN102257387A (https=)
WO (1) WO2010049818A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102636645A (zh) * 2012-04-24 2012-08-15 广州吉赛生物科技有限公司 一种sTERM-1酶联免疫检测试剂盒及其方法
WO2020035063A1 (zh) * 2018-08-17 2020-02-20 北京市心肺血管疾病研究所 血清S100a8/a9复合体水平在急性心肌梗死预后判断中的应用
CN116298318A (zh) * 2023-03-20 2023-06-23 复旦大学附属中山医院 一种脓毒症患者围术期器官功能障碍的诊断试剂盒
CN118717994A (zh) * 2024-07-26 2024-10-01 浙江大学医学院附属第一医院(浙江省第一医院) 肝硬化中S100A8/A9诱导NK细胞产生IFNγ的应用
CN119492874A (zh) * 2024-10-30 2025-02-21 首都医科大学附属北京儿童医院保定医院 S100a8/a9在评估感染性疾病病情严重程度中的应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2556771T3 (es) * 2009-01-19 2016-01-20 bioMérieux S.A. Procedimientos para determinar la susceptibilidad de contraer una infección nosocomial en un paciente y para establecer un pronóstico de evolución de un síndrome séptico
KR20140018249A (ko) * 2011-01-21 2014-02-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 혈중 엔도칸 수준을 측정하는 것에 의해, 패혈증 환자의 호흡부전, 신부전 또는 혈소판감소의 위험을 예측하기 위한 방법 및 키트
FR2970975B1 (fr) * 2011-01-27 2016-11-04 Biomerieux Sa Procede et kit pour determiner in vitro le statut immunitaire d'un individu
EP3074536B1 (en) * 2013-11-25 2019-06-19 Children's Hospital Medical Center Temporal pediatric sepsis biomarker risk model
EP3117030B1 (en) * 2014-03-14 2022-04-27 Hancock, Robert, E.W. Diagnostic for sepsis
KR101929772B1 (ko) * 2016-11-02 2018-12-17 연세대학교 산학협력단 패혈증 진단을 위한 정보를 제공하는 방법 및 이를 이용한 키트
US20230151434A1 (en) * 2020-04-07 2023-05-18 The Wistar Institute Of Anatomy And Biology Reawakening of dormant tumor cells by modified lipids derived from stress activated neutrophils
WO2022229421A2 (en) * 2021-04-30 2022-11-03 F. Hoffmann-La Roche Ag Strem1 marker panels for early detection of sepsis
CN114606308A (zh) * 2022-01-26 2022-06-10 江门市中心医院 脓毒症ards的预后与治疗标志物

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1297922A (zh) * 1999-11-26 2001-06-06 上海博道基因技术有限公司 一种多肽－人钙结合s100蛋白21和编码该多肽的多核苷酸
US20060035221A1 (en) * 2001-12-04 2006-02-16 B.R.A.H.M.S Aktiengesellschaft Use of the glycine n-acyl transferase (gnat) for the diagnosis and therapy of inflammatory diseases and sepsis
US20060234295A1 (en) * 2002-11-20 2006-10-19 Andreas Bergmann Sandwich immunoassay for identifying partial proanp peptides
CN1897959A (zh) * 2003-09-29 2007-01-17 沃伦药品公司 用于治疗和预防脓毒病和粘连形成的组织保护细胞因子
CN101124336A (zh) * 2004-07-23 2008-02-13 阿斯彭生物制药有限公司 用于诊断阑尾炎的方法和设备
CN101193622A (zh) * 2005-06-09 2008-06-04 比奥里波克斯公司 治疗炎性疾病的方法和组合物
EP1950310A1 (en) * 2007-01-23 2008-07-30 Charite-Universitätsmedizin Berlin Method for risk prediction of a postoperative sepsis in a human
WO2008104321A1 (en) * 2007-02-28 2008-09-04 B.R.A.H.M.S. Aktiengesellschaft Method for the selective determination of procalcitonin 1-116 for diagnostic purposes and antibodies and kits for carrying out such a method

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7659087B2 (en) * 2004-07-23 2010-02-09 Aspenbio Pharma, Inc. Methods and devices for diagnosis of appendicitis
WO2007041623A2 (en) * 2005-10-03 2007-04-12 Biosite Incorporated Methods and compositions for diagnosis and/or prognosis in systemic inflammatory response syndromes
EP2085486A1 (en) * 2008-02-01 2009-08-05 Assistance Publique - Hopitaux de Paris Methods and kits for the rapid determination of patients at high risk of death during septic shock
US8283131B2 (en) * 2008-10-28 2012-10-09 Assistance Publique-Hopitaux De Paris Methods and kits for the rapid determination of patients at high risk of death during severe sepsis and septic shock

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1297922A (zh) * 1999-11-26 2001-06-06 上海博道基因技术有限公司 一种多肽－人钙结合s100蛋白21和编码该多肽的多核苷酸
US20060035221A1 (en) * 2001-12-04 2006-02-16 B.R.A.H.M.S Aktiengesellschaft Use of the glycine n-acyl transferase (gnat) for the diagnosis and therapy of inflammatory diseases and sepsis
US20060234295A1 (en) * 2002-11-20 2006-10-19 Andreas Bergmann Sandwich immunoassay for identifying partial proanp peptides
CN1897959A (zh) * 2003-09-29 2007-01-17 沃伦药品公司 用于治疗和预防脓毒病和粘连形成的组织保护细胞因子
CN101124336A (zh) * 2004-07-23 2008-02-13 阿斯彭生物制药有限公司 用于诊断阑尾炎的方法和设备
CN101193622A (zh) * 2005-06-09 2008-06-04 比奥里波克斯公司 治疗炎性疾病的方法和组合物
EP1950310A1 (en) * 2007-01-23 2008-07-30 Charite-Universitätsmedizin Berlin Method for risk prediction of a postoperative sepsis in a human
WO2008104321A1 (en) * 2007-02-28 2008-09-04 B.R.A.H.M.S. Aktiengesellschaft Method for the selective determination of procalcitonin 1-116 for diagnostic purposes and antibodies and kits for carrying out such a method

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
DIDIER PAYEN ET AL.: "Gene profiling in human blood leucocytes during recovery from septic shock", 《INTENSIVE CARE MEDICINE》 *
MASAKI IKEMOTO ET AL.: "New ELISA System for Myeloid-related Protein Complex (MRP8/14) and Its Clinical Significance as a Sensitive Marker for Inflammatory Responses Associated with Transplant Rejection", 《CLINICAL CHEMISTRY》 *
任延波等: "脓毒症早期大鼠肾脏细胞凋亡及炎症细胞因子的变化", 《中国危重病急救医学》 *
张淑伟等: "猪链球菌2型的致病机制", 《生命的化学》 *
王戎机等: "龈沟液12000蛋白质的N-末端氨基酸序列分析及其临床意义", 《中华口腔医学杂志》 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102636645A (zh) * 2012-04-24 2012-08-15 广州吉赛生物科技有限公司 一种sTERM-1酶联免疫检测试剂盒及其方法
WO2020035063A1 (zh) * 2018-08-17 2020-02-20 北京市心肺血管疾病研究所 血清S100a8/a9复合体水平在急性心肌梗死预后判断中的应用
CN116298318A (zh) * 2023-03-20 2023-06-23 复旦大学附属中山医院 一种脓毒症患者围术期器官功能障碍的诊断试剂盒
CN118717994A (zh) * 2024-07-26 2024-10-01 浙江大学医学院附属第一医院(浙江省第一医院) 肝硬化中S100A8/A9诱导NK细胞产生IFNγ的应用
CN119492874A (zh) * 2024-10-30 2025-02-21 首都医科大学附属北京儿童医院保定医院 S100a8/a9在评估感染性疾病病情严重程度中的应用

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US20110287433A1 (en) 2011-11-24
JP5619016B2 (ja) 2014-11-05
WO2010049818A1 (en) 2010-05-06
EP2350646A1 (en) 2011-08-03
EP2350646B1 (en) 2016-01-13
JP2012507030A (ja) 2012-03-22

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Application publication date: 20111123