CN102247821A - 高pH耐受性色谱填料及制备方法 - Google Patents
高pH耐受性色谱填料及制备方法 Download PDFInfo
- Publication number
- CN102247821A CN102247821A CN 201010178559 CN201010178559A CN102247821A CN 102247821 A CN102247821 A CN 102247821A CN 201010178559 CN201010178559 CN 201010178559 CN 201010178559 A CN201010178559 A CN 201010178559A CN 102247821 A CN102247821 A CN 102247821A
- Authority
- CN
- China
- Prior art keywords
- silica gel
- reaction
- packing material
- hybrid layer
- inorganic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000000945 filler Substances 0.000 title abstract description 29
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims abstract description 86
- 239000011159 matrix material Substances 0.000 claims abstract description 38
- 239000000741 silica gel Substances 0.000 claims abstract description 38
- 229910002027 silica gel Inorganic materials 0.000 claims abstract description 38
- 238000006243 chemical reaction Methods 0.000 claims abstract description 27
- 239000000377 silicon dioxide Substances 0.000 claims abstract description 24
- 239000011248 coating agent Substances 0.000 claims abstract description 10
- 238000000576 coating method Methods 0.000 claims abstract description 10
- 230000004048 modification Effects 0.000 claims abstract description 8
- 238000012986 modification Methods 0.000 claims abstract description 8
- 229920000642 polymer Polymers 0.000 claims abstract description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 17
- 239000000463 material Substances 0.000 claims description 16
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 15
- 238000012856 packing Methods 0.000 claims description 15
- 238000007385 chemical modification Methods 0.000 claims description 13
- 239000003153 chemical reaction reagent Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 9
- 230000007062 hydrolysis Effects 0.000 claims description 8
- 238000006460 hydrolysis reaction Methods 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- 230000008569 process Effects 0.000 claims description 7
- 230000005526 G1 to G0 transition Effects 0.000 claims description 4
- IJKVHSBPTUYDLN-UHFFFAOYSA-N dihydroxy(oxo)silane Chemical compound O[Si](O)=O IJKVHSBPTUYDLN-UHFFFAOYSA-N 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 125000000962 organic group Chemical group 0.000 claims description 2
- 229910000077 silane Inorganic materials 0.000 claims description 2
- -1 silane compound Chemical class 0.000 claims description 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 230000008901 benefit Effects 0.000 abstract description 4
- 230000007547 defect Effects 0.000 abstract 1
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 30
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
- 238000003756 stirring Methods 0.000 description 15
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
- BOTDANWDWHJENH-UHFFFAOYSA-N Tetraethyl orthosilicate Chemical compound CCO[Si](OCC)(OCC)OCC BOTDANWDWHJENH-UHFFFAOYSA-N 0.000 description 10
- 238000002156 mixing Methods 0.000 description 10
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 10
- 238000001291 vacuum drying Methods 0.000 description 10
- 238000005406 washing Methods 0.000 description 10
- 238000007789 sealing Methods 0.000 description 8
- 230000035800 maturation Effects 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 239000003054 catalyst Substances 0.000 description 5
- 238000001816 cooling Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 230000009257 reactivity Effects 0.000 description 5
- 238000010992 reflux Methods 0.000 description 5
- 238000009423 ventilation Methods 0.000 description 5
- 238000005303 weighing Methods 0.000 description 5
- 238000009826 distribution Methods 0.000 description 4
- FHBURLBCXNMPJX-UHFFFAOYSA-N n-[bis(dimethylamino)-ethylsilyl]-n-methylmethanamine Chemical compound CC[Si](N(C)C)(N(C)C)N(C)C FHBURLBCXNMPJX-UHFFFAOYSA-N 0.000 description 4
- 229920000307 polymer substrate Polymers 0.000 description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- SCPYDCQAZCOKTP-UHFFFAOYSA-N silanol Chemical compound [SiH3]O SCPYDCQAZCOKTP-UHFFFAOYSA-N 0.000 description 3
- 229910052710 silicon Inorganic materials 0.000 description 3
- 239000010703 silicon Substances 0.000 description 3
- 229910018557 Si O Inorganic materials 0.000 description 2
- 230000002411 adverse Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000007935 neutral effect Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- LIVNPJMFVYWSIS-UHFFFAOYSA-N silicon monoxide Inorganic materials [Si-]#[O+] LIVNPJMFVYWSIS-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000007445 Chromatographic isolation Methods 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 206010019133 Hangover Diseases 0.000 description 1
- HMDDXIMCDZRSNE-UHFFFAOYSA-N [C].[Si] Chemical compound [C].[Si] HMDDXIMCDZRSNE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- KCWYOFZQRFCIIE-UHFFFAOYSA-N ethylsilane Chemical compound CC[SiH3] KCWYOFZQRFCIIE-UHFFFAOYSA-N 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000005416 organic matter Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003222 pyridines Chemical class 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 229940126586 small molecule drug Drugs 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Landscapes
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201010178559 CN102247821B (zh) | 2010-05-21 | 2010-05-21 | 高pH耐受性色谱填料及制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 201010178559 CN102247821B (zh) | 2010-05-21 | 2010-05-21 | 高pH耐受性色谱填料及制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102247821A true CN102247821A (zh) | 2011-11-23 |
CN102247821B CN102247821B (zh) | 2013-06-26 |
Family
ID=44975600
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 201010178559 Active CN102247821B (zh) | 2010-05-21 | 2010-05-21 | 高pH耐受性色谱填料及制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN102247821B (zh) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102489271A (zh) * | 2011-11-24 | 2012-06-13 | 济南大学 | 耐碱性硅胶色谱填料的制备方法 |
JP2015096489A (ja) * | 2013-09-20 | 2015-05-21 | エア プロダクツ アンド ケミカルズ インコーポレイテッドAir Products And Chemicals Incorporated | 有機アミノシラン前駆体およびこれを含む膜の堆積方法 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060070937A1 (en) * | 2004-10-01 | 2006-04-06 | Rustamov Ismail M | PH stable chromatographic media using templated multilayer organic/inorganic grafting |
CN101717513A (zh) * | 2009-11-10 | 2010-06-02 | 中国药科大学 | 一种杂化有序介孔硅胶色谱固定相填料及制备方法 |
-
2010
- 2010-05-21 CN CN 201010178559 patent/CN102247821B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20060070937A1 (en) * | 2004-10-01 | 2006-04-06 | Rustamov Ismail M | PH stable chromatographic media using templated multilayer organic/inorganic grafting |
CN101717513A (zh) * | 2009-11-10 | 2010-06-02 | 中国药科大学 | 一种杂化有序介孔硅胶色谱固定相填料及制备方法 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102489271A (zh) * | 2011-11-24 | 2012-06-13 | 济南大学 | 耐碱性硅胶色谱填料的制备方法 |
JP2015096489A (ja) * | 2013-09-20 | 2015-05-21 | エア プロダクツ アンド ケミカルズ インコーポレイテッドAir Products And Chemicals Incorporated | 有機アミノシラン前駆体およびこれを含む膜の堆積方法 |
EP2860182A3 (en) * | 2013-09-20 | 2015-08-05 | Air Products And Chemicals, Inc. | Organoaminosilane precursors and methods for depositing films comprising same |
EP3339312A1 (en) * | 2013-09-20 | 2018-06-27 | Versum Materials US, LLC | Organoaminosilane precursors and methods for depositing films comprising same |
US10453675B2 (en) | 2013-09-20 | 2019-10-22 | Versum Materials Us, Llc | Organoaminosilane precursors and methods for depositing films comprising same |
US10460929B2 (en) | 2013-09-20 | 2019-10-29 | Versum Materials Us, Llc | Organoaminosilane precursors and methods for depositing films comprising same |
US11139162B2 (en) | 2013-09-20 | 2021-10-05 | Versum Materials Us, Llc | Organoaminosilane precursors and methods for depositing films comprising same |
Also Published As
Publication number | Publication date |
---|---|
CN102247821B (zh) | 2013-06-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Yu et al. | Chiral metal–organic framework d-His-ZIF-8@ SiO2 core–shell microspheres used for HPLC enantioseparations | |
Sharma et al. | Toward efficient nanoporous catalysts: Controlling site-isolation and concentration of grafted catalytic sites on nanoporous materials with solvents and colorimetric elucidation of their site-isolation | |
CA2581627C (en) | Ph stable chromatographic media using templated multilayer organic/inorganic grafting | |
Okamoto et al. | Novel packing material for optical resolution:(+)-poly (triphenylmethyl methacrylate) coated on macroporous silica gel | |
Xu et al. | Chiral core-shell microspheres β-CD-COF@ SiO2 used for HPLC enantioseparation | |
JP4943396B2 (ja) | クロマトグラフィー分離のための多孔質有機・無機ハイブリッド粒子、及びそれらの製造法 | |
CN105688993B (zh) | 一种负载型聚合酸性离子液体催化剂及其制备方法和应用 | |
CN101120007A (zh) | 新型有机硅烷和与其共价键合的基质以及合成方法和用途 | |
Zhang et al. | Chiral porous organic frameworks and their application in enantioseparation | |
CN103551118B (zh) | 一种柱[5]芳烃键合硅胶固定相及其制备方法与应用 | |
Mou et al. | Synthesis of fuel bioadditive by esterification of glycerol with acetic acid over hydrophobic polymer-based solid acid | |
CN102247821B (zh) | 高pH耐受性色谱填料及制备方法 | |
CN105777988A (zh) | 一种含p有机聚合物及其制备方法和应用 | |
CN114471496A (zh) | 一种多模式和多功能分子笼高效液相色谱固定相的制备方法及应用 | |
CN102101042A (zh) | 四氮杂杯[2]芳烃[2]三嗪键合硅胶固定相及其制备方法与应用 | |
Teng et al. | Hollow Mesoporous Organic Polymeric Nanospheres (HMOPNs)‐Supported Carbene Rovis Catalyst: Mesopore and Morphology‐Dependent Catalytic Performances in Asymmetric Organocascade | |
CN117720106B (zh) | 一种二氯甲烷的纯化方法 | |
CN102101043B (zh) | 聚乙烯基咪唑型硅胶填料的制备方法 | |
Grieb et al. | Chiral high-performance liquid chromatography with cellulose carbamate-coated phases influence of support surface chemistry on enantioselectivity | |
CN103551133A (zh) | 一种多作用力混合模式键合硅胶固定相及其制备方法与应用 | |
Chen et al. | Chiral ionic liquid-multi walled carbon nanotubes composite membrane applied to the separation of amino acid enantiomers | |
CN102489276B (zh) | 一种苄基氮桥连杯[2]芳烃[2]三嗪键合硅胶固定相及其制备方法和用途 | |
Hsiao et al. | Enantioselective addition of diethylzinc to benzaldehyde over mesoporous SBA-15 functionalized with chiral proline derivatives | |
CN110743622B (zh) | 一种蒙脱土固载手性化合物及其制备方法 | |
CN1204963C (zh) | 杯芳烃键合硅胶固定相及其制备方法和用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: ZHEJIANG WELCH MATERIALS, INC. Effective date: 20130521 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20130521 Address after: 201203 Shanghai Zhangjiang hi tech Park Cailun Road No. 1 Building No. 511 720 Applicant after: WELCH MATERIALS TECHNOLOGY (SHANGHAI) Co.,Ltd. Applicant after: ZHEJIANG YUEXU MATERIAL TECHNOLOGY CO.,LTD. Address before: 201203 Shanghai Zhangjiang hi tech Park Cailun Road No. 1 Building No. 511 720 Applicant before: Welch Materials Technology (Shanghai) Co.,Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
EE01 | Entry into force of recordation of patent licensing contract | ||
EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20111123 Assignee: ZHEJIANG YUEXU MATERIAL TECHNOLOGY CO.,LTD. Assignor: ZHEJIANG YUEXU MATERIAL TECHNOLOGY CO.,LTD.|WELCH MATERIALS TECHNOLOGY (SHANGHAI) Co.,Ltd. Contract record no.: 2014330000012 Denomination of invention: High pH tolerance chromatographic filler and preparation method thereof Granted publication date: 20130626 License type: Exclusive License Record date: 20140127 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: High pH tolerance chromatographic filler and preparation method thereof Effective date of registration: 20140922 Granted publication date: 20130626 Pledgee: Agricultural Bank of China Limited by Share Ltd. Jinhua Economic Development Zone Branch Pledgor: ZHEJIANG YUEXU MATERIAL TECHNOLOGY CO.,LTD.|WELCH MATERIALS TECHNOLOGY (SHANGHAI) Co.,Ltd. Registration number: 2014990000782 |
|
PLDC | Enforcement, change and cancellation of contracts on pledge of patent right or utility model | ||
C56 | Change in the name or address of the patentee |
Owner name: YUEXU TECHNOLOGY (SHANGHAI) CO., LTD. Free format text: FORMER NAME: WELCH MATERIALS HANGHAI INC. |
|
CP01 | Change in the name or title of a patent holder |
Address after: 201203 Shanghai Zhangjiang hi tech Park Cailun Road No. 1 Building No. 511 720 Patentee after: WELCH MATERIALS (SHANGHAI) Inc. Patentee after: ZHEJIANG YUEXU MATERIAL TECHNOLOGY CO.,LTD. Address before: 201203 Shanghai Zhangjiang hi tech Park Cailun Road No. 1 Building No. 511 720 Patentee before: Welch Materials Technology (Shanghai) Co.,Ltd. Patentee before: ZHEJIANG YUEXU MATERIAL TECHNOLOGY CO.,LTD. |
|
CP02 | Change in the address of a patent holder | ||
CP02 | Change in the address of a patent holder |
Address after: 201600 Room 102, 1st Floor, 2nd Floor, 3rd Floor, Building 10, No. 85, Mingnan Road, Songjiang District, Shanghai Patentee after: WELCH MATERIALS (SHANGHAI) Inc. Patentee after: ZHEJIANG YUEXU MATERIAL TECHNOLOGY CO.,LTD. Address before: Building 511, No. 1, Lane 720, Cailun Road, Zhangjiang High tech Park, Shanghai, March 2012 Patentee before: WELCH MATERIALS (SHANGHAI) Inc. Patentee before: ZHEJIANG YUEXU MATERIAL TECHNOLOGY CO.,LTD. |