CN102247328A - Salidroside freeze-dried powder injection and preparation method thereof - Google Patents
Salidroside freeze-dried powder injection and preparation method thereof Download PDFInfo
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- CN102247328A CN102247328A CN2010101733745A CN201010173374A CN102247328A CN 102247328 A CN102247328 A CN 102247328A CN 2010101733745 A CN2010101733745 A CN 2010101733745A CN 201010173374 A CN201010173374 A CN 201010173374A CN 102247328 A CN102247328 A CN 102247328A
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- dried powder
- hongjingtian
- powder injection
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- injection agent
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Abstract
A salidroside freeze-dried powder injection and a preparation method thereof relate to a freeze-dried powder injection prepared by salidroside and a preparation method thereof. Research finds that common stonecrop herb has a plurality of efficacy and functions which mainly comprise the following various pharmacological effects: anti-hypoxia, anti-fatigue, anti-shock, anti-aging, anti-tumor, cardiac cerebral function improvement, and the like. The invention relates to a salidroside freeze-dried powder injection which is prepared by 1-10 parts by weight of chemically-synthesized salidroside and 1-10 parts by weight of pharmaceutic adjuvants. The injection of the invention is applicable to the treatment of various shock and cardio-cerebrovascular diseases.
Description
Technical field
What the present invention relates to is a kind of Hongjingtian glycoside freeze dried powder injection agent and preparation method thereof, is specifically related to a kind of lyophilized injectable powder that utilizes the rhodioside preparation and preparation method thereof.
Background technology
Radix Rhodiolae is Crassulaceae rhodiola (Rhodiola.L) plant, is perennial herb or semishrub plant, mainly is distributed in Himalayas, the northwestward, Asia and the North America in the Northern Hemisphere, and height above sea level is at 1600～4000m.There are 96 kinds of rhodiola plants in the whole world, and China has 73 kinds, mainly is distributed in southwest, northwest, Central China, North China and northeast, especially with Yunnan, Sichuan and Tibet extremely frigid zones most species.Radix Rhodiolae mainly is used as medicine with root and stem, mainly contain rhodioside, 27 seed amino acids that contain the human body needs, wherein there are 7 kinds to be that human body can not synthesize and essential amino acid, the 21 kinds of trace element such as ferrum, zinc, molybdenum, titanium, manganese that also contain biologically active, wherein contain flavone compound, contain alkaloid in the base of leaf.
The former Soviet Union discovers, Radix Rhodiolae has " counter-pressure " and acts on and the system that excites nerve, the melancholy symptom that reduces, allaying tiredness and prevention altitude sickness etc., can improve the patient because of symptoms such as ability to work decline, sleep disorder, inappetence, restlessness, hypertension, headaches.Modern study finds that Radix Rhodiolae has multiple pharmacodynamic feature, mainly shows: anti-hypoxia, resisting fatigue, shock, defying age, antitumor and improve many-sided pharmacological action such as cardio cerebral function.
Summary of the invention
The purpose of this invention is to provide a kind of Hongjingtian glycoside freeze dried powder injection agent and preparation method thereof.
Above-mentioned purpose is achieved through the following technical solutions:
Hongjingtian glycoside freeze dried powder injection agent, the rhodioside 1-10 weight portion of Hongjingtian glycoside freeze dried powder injection agent chemosynthesis and pharmaceutic adjuvant 1-10 weight portion are prepared from.
Described Hongjingtian glycoside freeze dried powder injection agent, described pharmaceutic adjuvant are sodium sulfite or sodium sulfite or sodium pyrosulfite or thiourea.
A kind of Hongjingtian glycoside freeze dried powder injection agent preparation method: the rhodioside powder and the pharmaceutic adjuvant that take by weighing chemosynthesis, place sterile chamber, add an amount of water for injection dissolving, regulate pH value to 6.0-8.0, make material solution, adding activated carbon adsorption in material solution filters, in filtrate, add water for injection to ormal weight, and use the microporous filter membrane adsorption filtration, check the pH and the rhodioside content of filtrate, aseptic subpackaged in cillin bottle after the passed examination, the false add butyl rubber bung, place the freeze drying box lyophilization to obtain dried powder cillin bottle, pack and promptly make Hongjingtian glycoside freeze dried powder injection agent.
Described Hongjingtian glycoside freeze dried powder injection agent preparation method is dissolved in the water for injection for making rhodioside, and pH value is controlled at 6.0-8.0.
Described Hongjingtian glycoside freeze dried powder injection agent preparation method, solution was wanted microporous filter membrane before lyophilization.
The invention provides a kind of Hongjingtian glycoside freeze dried powder injection agent tool drug effect rapidly, reliable effect, can be used for the patient's of unsuitable oral administration advantage.The present invention also provides the preparation technology of this Hongjingtian glycoside freeze dried powder injection, and selected adjuvant mouldability is better.Solution is behind filtering with microporous membrane before the lyophilizing, and solution clarity, safety and stability are higher.
The specific embodiment of the present invention:
Embodiment 1:
Rhodioside powder 3 grams that take by weighing chemosynthesis add sodium sulfite 30 grams and mix, place sterile chamber, add an amount of water for injection dissolving, regulate pH value to 7.5, make material solution, adding activated carbon adsorption in material solution filters, in filtrate, add water for injection extremely to 100ml, and use filtering with microporous membrane, check the pH and the rhodioside content of filtrate, aseptic subpackaged in 50 cillin bottles after the passed examination, the false add butyl rubber bung, place the freeze drying box lyophilization to obtain dried powder cillin bottle, sealed packet changes promptly makes 50 of Hongjingtian glycoside freeze dried powder injection agents.
Embodiment 2:
Rhodioside powder 5 grams that take by weighing chemosynthesis add sodium sulfite 50 grams and mix, place sterile chamber, add an amount of water for injection dissolving, regulate pH value to 8.0, make material solution, adding activated carbon adsorption in material solution filters, in filtrate, add water for injection extremely to 100ml, and use filtering with microporous membrane, check the pH and the rhodioside content of filtrate, aseptic subpackaged in 50 cillin bottles after the passed examination, the false add butyl rubber bung, place the freeze drying box lyophilization to obtain dried powder cillin bottle, sealed packet changes promptly makes 50 of Hongjingtian glycoside freeze dried powder injection agents.
Embodiment 3:
Rhodioside powder 4 grams that take by weighing chemosynthesis add sodium pyrosulfite 40 grams and mix, place sterile chamber, add an amount of water for injection dissolving, regulate pH value to 7.5, make material solution, adding activated carbon adsorption in material solution filters, in filtrate, add water for injection extremely to 100ml, and use filtering with microporous membrane, check the pH and the rhodioside content of filtrate, aseptic subpackaged in 50 cillin bottles after the passed examination, the false add butyl rubber bung, place the freeze drying box lyophilization to obtain dried powder cillin bottle, sealed packet changes promptly makes 50 of Hongjingtian glycoside freeze dried powder injection agents.
Embodiment 4:
Rhodioside powder 5 grams that take by weighing chemosynthesis add thiourea 50 grams and mix, place sterile chamber, add an amount of water for injection dissolving, regulate pH value to 8.0, make material solution, adding activated carbon adsorption in material solution filters, in filtrate, add water for injection extremely to 100ml, and use filtering with microporous membrane, check the pH and the rhodioside content of filtrate, aseptic subpackaged in 50 cillin bottles after the passed examination, the false add butyl rubber bung, place the freeze drying box lyophilization to obtain dried powder cillin bottle, sealed packet changes promptly makes 50 of Hongjingtian glycoside freeze dried powder injection agents.
Claims (5)
1. Hongjingtian glycoside freeze dried powder injection agent, it is characterized in that: Hongjingtian glycoside freeze dried powder injection agent is prepared from by chemosynthesis rhodioside 1-10 weight portion and pharmaceutic adjuvant 1-10 weight portion.
2. Hongjingtian glycoside freeze dried powder injection agent according to claim 1 is characterized in that: described pharmaceutic adjuvant is sodium sulfite or sodium sulfite or sodium pyrosulfite or thiourea.
3. Hongjingtian glycoside freeze dried powder injection agent preparation method, it is characterized in that: the rhodioside powder and the pharmaceutic adjuvant that take by weighing chemosynthesis, place sterile chamber, add an amount of water for injection dissolving, regulate pH value to 6.0-8.0, make material solution, adding activated carbon adsorption in material solution filters, in filtrate, add water for injection to ormal weight, and use the microporous filter membrane adsorption filtration, check the pH and the rhodioside content of filtrate, aseptic subpackaged in cillin bottle after the passed examination, the false add butyl rubber bung places the freeze drying box lyophilization to obtain dried powder cillin bottle, packs and promptly makes Hongjingtian glycoside freeze dried powder injection agent.
4. Hongjingtian glycoside freeze dried powder injection agent preparation method according to claim 3 is characterized in that: be dissolved in the water for injection for making rhodioside, pH value is controlled at 6.0～8.0.
5. according to the Hongjingtian glycoside freeze dried powder injection agent preparation method of claim 3, it is characterized in that: solution was wanted microporous filter membrane before lyophilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101733745A CN102247328A (en) | 2010-05-17 | 2010-05-17 | Salidroside freeze-dried powder injection and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2010101733745A CN102247328A (en) | 2010-05-17 | 2010-05-17 | Salidroside freeze-dried powder injection and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102247328A true CN102247328A (en) | 2011-11-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2010101733745A Pending CN102247328A (en) | 2010-05-17 | 2010-05-17 | Salidroside freeze-dried powder injection and preparation method thereof |
Country Status (1)
| Country | Link |
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| CN (1) | CN102247328A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822158A (en) * | 2017-01-25 | 2017-06-13 | 首都医科大学附属北京安贞医院 | Rhodioside or its officinal salt are preparing the application in preventing and treating obstructive sleep apnea induction type hypertension drug and health products |
| CN110403949A (en) * | 2019-08-21 | 2019-11-05 | 天津龙尔达科技发展有限公司 | Rhodioside is in preparation for treating the application in pulmonary fibrosis disease drug |
-
2010
- 2010-05-17 CN CN2010101733745A patent/CN102247328A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106822158A (en) * | 2017-01-25 | 2017-06-13 | 首都医科大学附属北京安贞医院 | Rhodioside or its officinal salt are preparing the application in preventing and treating obstructive sleep apnea induction type hypertension drug and health products |
| CN106822158B (en) * | 2017-01-25 | 2020-11-10 | 首都医科大学附属北京安贞医院 | Salidroside for preventing and treating obstructive sleep apnea induced hypertension |
| CN110403949A (en) * | 2019-08-21 | 2019-11-05 | 天津龙尔达科技发展有限公司 | Rhodioside is in preparation for treating the application in pulmonary fibrosis disease drug |
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| DD01 | Delivery of document by public notice |
Addressee: Li Jianhong Document name: Notification of Passing Preliminary Examination of the Application for Invention |
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| C06 | Publication | ||
| PB01 | Publication | ||
| DD01 | Delivery of document by public notice |
Addressee: Nanjing Jizhong Medical Technology Co., Ltd. Li Jianhong Document name: Notification of Publication of the Application for Invention |
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| DD01 | Delivery of document by public notice |
Addressee: Nanjing Jizhong Medical Technology Co., Ltd. Document name: Notification of before Expiration of Request of Examination as to Substance |
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20111123 |