CN102239153A - 作为抗病毒剂促进剂的新的酰胺化合物 - Google Patents
作为抗病毒剂促进剂的新的酰胺化合物 Download PDFInfo
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- CN102239153A CN102239153A CN2009801490804A CN200980149080A CN102239153A CN 102239153 A CN102239153 A CN 102239153A CN 2009801490804 A CN2009801490804 A CN 2009801490804A CN 200980149080 A CN200980149080 A CN 200980149080A CN 102239153 A CN102239153 A CN 102239153A
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- ZFEAMMNVDPDEGE-LGRGJMMZSA-N tifuvirtide Chemical compound C([C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(C)=O)[C@@H](C)CC)[C@@H](C)O)[C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)C1=CC=C(O)C=C1 ZFEAMMNVDPDEGE-LGRGJMMZSA-N 0.000 description 1
- 239000012049 topical pharmaceutical composition Substances 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 229910052722 tritium Inorganic materials 0.000 description 1
- 210000001215 vagina Anatomy 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 229960000523 zalcitabine Drugs 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D277/24—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
Claims (15)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08166004 | 2008-10-07 | ||
EP08166004.5 | 2008-10-07 | ||
PCT/EP2009/062996 WO2010040762A1 (en) | 2008-10-07 | 2009-10-07 | New amide compounds as boosters of antivirals |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102239153A true CN102239153A (zh) | 2011-11-09 |
CN102239153B CN102239153B (zh) | 2016-05-11 |
Family
ID=40291161
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN200980149080.4A Expired - Fee Related CN102239153B (zh) | 2008-10-07 | 2009-10-07 | 作为抗病毒剂促进剂的酰胺化合物 |
Country Status (12)
Country | Link |
---|---|
US (1) | US8664391B2 (zh) |
EP (1) | EP2346842A1 (zh) |
JP (1) | JP5564050B2 (zh) |
KR (1) | KR101660812B1 (zh) |
CN (1) | CN102239153B (zh) |
AU (1) | AU2009301131B2 (zh) |
BR (1) | BRPI0920809A2 (zh) |
CA (1) | CA2739673C (zh) |
EA (1) | EA026673B1 (zh) |
NZ (1) | NZ591951A (zh) |
WO (1) | WO2010040762A1 (zh) |
ZA (1) | ZA201102553B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111455020A (zh) * | 2020-02-25 | 2020-07-28 | 深圳市安帝宝科技有限公司 | 一种1,5-脱水山梨醇检测试剂盒及检测方法 |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005030194A1 (en) * | 2003-09-30 | 2005-04-07 | Tibotec Pharmaceuticals Ltd. | Hcv inhibitiing sulfonamides |
WO2006108879A2 (en) * | 2005-04-15 | 2006-10-19 | Tibotec Pharmaceuticals Ltd. | Use of a sulfonamide compound for improving the pharmacokinetics of a drug |
CN1913889A (zh) * | 2004-01-30 | 2007-02-14 | 辉瑞大药厂 | 包含hiv蛋白酶抑制剂和细胞色素p450酶活性抑制剂的组合物 |
WO2008027932A2 (en) * | 2006-08-31 | 2008-03-06 | Abbott Laboratories | Cytochrome p450 oxidase inhibitors and uses thereof |
WO2009071650A2 (en) * | 2007-12-06 | 2009-06-11 | Tibotec Pharmaceuticals Ltd. | Amide compounds as boosters of antivirals |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6037157A (en) * | 1995-06-29 | 2000-03-14 | Abbott Laboratories | Method for improving pharmacokinetics |
AR037797A1 (es) | 2001-12-12 | 2004-12-01 | Tibotec Pharm Ltd | Combinacion de inhibidores de proteasa dependientes del citocromo p450 |
-
2009
- 2009-10-07 NZ NZ591951A patent/NZ591951A/xx not_active IP Right Cessation
- 2009-10-07 EA EA201170530A patent/EA026673B1/ru not_active IP Right Cessation
- 2009-10-07 KR KR1020117010183A patent/KR101660812B1/ko active IP Right Grant
- 2009-10-07 BR BRPI0920809A patent/BRPI0920809A2/pt not_active IP Right Cessation
- 2009-10-07 US US13/122,817 patent/US8664391B2/en not_active Expired - Fee Related
- 2009-10-07 AU AU2009301131A patent/AU2009301131B2/en not_active Ceased
- 2009-10-07 EP EP09783798A patent/EP2346842A1/en not_active Withdrawn
- 2009-10-07 WO PCT/EP2009/062996 patent/WO2010040762A1/en active Application Filing
- 2009-10-07 CA CA2739673A patent/CA2739673C/en active Active
- 2009-10-07 JP JP2011529584A patent/JP5564050B2/ja not_active Expired - Fee Related
- 2009-10-07 CN CN200980149080.4A patent/CN102239153B/zh not_active Expired - Fee Related
-
2011
- 2011-04-06 ZA ZA2011/02553A patent/ZA201102553B/en unknown
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005030194A1 (en) * | 2003-09-30 | 2005-04-07 | Tibotec Pharmaceuticals Ltd. | Hcv inhibitiing sulfonamides |
CN1913889A (zh) * | 2004-01-30 | 2007-02-14 | 辉瑞大药厂 | 包含hiv蛋白酶抑制剂和细胞色素p450酶活性抑制剂的组合物 |
WO2006108879A2 (en) * | 2005-04-15 | 2006-10-19 | Tibotec Pharmaceuticals Ltd. | Use of a sulfonamide compound for improving the pharmacokinetics of a drug |
WO2008027932A2 (en) * | 2006-08-31 | 2008-03-06 | Abbott Laboratories | Cytochrome p450 oxidase inhibitors and uses thereof |
WO2009071650A2 (en) * | 2007-12-06 | 2009-06-11 | Tibotec Pharmaceuticals Ltd. | Amide compounds as boosters of antivirals |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111455020A (zh) * | 2020-02-25 | 2020-07-28 | 深圳市安帝宝科技有限公司 | 一种1,5-脱水山梨醇检测试剂盒及检测方法 |
Also Published As
Publication number | Publication date |
---|---|
JP2012505157A (ja) | 2012-03-01 |
JP5564050B2 (ja) | 2014-07-30 |
AU2009301131A1 (en) | 2010-04-15 |
EA201170530A1 (ru) | 2011-12-30 |
AU2009301131B2 (en) | 2014-03-27 |
NZ591951A (en) | 2013-02-22 |
KR20110067056A (ko) | 2011-06-20 |
KR101660812B1 (ko) | 2016-09-28 |
US20110195969A1 (en) | 2011-08-11 |
CA2739673C (en) | 2016-11-22 |
BRPI0920809A2 (pt) | 2016-07-12 |
CN102239153B (zh) | 2016-05-11 |
EA026673B1 (ru) | 2017-05-31 |
EP2346842A1 (en) | 2011-07-27 |
ZA201102553B (en) | 2012-09-26 |
CA2739673A1 (en) | 2010-04-15 |
US8664391B2 (en) | 2014-03-04 |
WO2010040762A1 (en) | 2010-04-15 |
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