CN102238939B - 药物气溶胶组合物 - Google Patents

药物气溶胶组合物 Download PDF

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Publication number
CN102238939B
CN102238939B CN200980148430.5A CN200980148430A CN102238939B CN 102238939 B CN102238939 B CN 102238939B CN 200980148430 A CN200980148430 A CN 200980148430A CN 102238939 B CN102238939 B CN 102238939B
Authority
CN
China
Prior art keywords
pharmaceutical aerosol
adjuvant
aerosol composition
pharmaceutical
hfa
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN200980148430.5A
Other languages
English (en)
Chinese (zh)
Other versions
CN102238939A (zh
Inventor
阿尔马·卢拉
吉纳·马尔霍特拉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cipla Ltd
Original Assignee
Cipla Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2009/002575 external-priority patent/WO2010052450A1/fr
Application filed by Cipla Ltd filed Critical Cipla Ltd
Publication of CN102238939A publication Critical patent/CN102238939A/zh
Application granted granted Critical
Publication of CN102238939B publication Critical patent/CN102238939B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/12—Aerosols; Foams
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Otolaryngology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200980148430.5A 2008-11-04 2009-11-04 药物气溶胶组合物 Expired - Fee Related CN102238939B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
IN2351MU2008 2008-11-04
IN2351/MUM/2008 2008-11-04
IN2402MU2008 2008-11-14
IN2402/MUM/2008 2008-11-14
PCT/GB2009/002575 WO2010052450A1 (fr) 2008-11-04 2009-10-29 Bromure de tiotropium ayant un faible degré de cristallinité
GBPCT/GB2009/002575 2009-10-29
PCT/GB2009/002617 WO2010052466A2 (fr) 2008-11-04 2009-11-04 Composition pharmaceutique en aérosol

Publications (2)

Publication Number Publication Date
CN102238939A CN102238939A (zh) 2011-11-09
CN102238939B true CN102238939B (zh) 2015-05-20

Family

ID=41630445

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980148430.5A Expired - Fee Related CN102238939B (zh) 2008-11-04 2009-11-04 药物气溶胶组合物

Country Status (12)

Country Link
EP (1) EP2362766A2 (fr)
JP (1) JP2012507574A (fr)
KR (1) KR20110096538A (fr)
CN (1) CN102238939B (fr)
AU (1) AU2009312598A1 (fr)
BR (1) BRPI0916047A2 (fr)
CA (1) CA2742718A1 (fr)
MX (1) MX2011004730A (fr)
NZ (1) NZ592861A (fr)
RU (1) RU2565438C2 (fr)
WO (1) WO2010052466A2 (fr)
ZA (1) ZA201103347B (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2493827C1 (ru) * 2012-10-03 2013-09-27 Шолекс Девелопмент Гмбх Стабильный комбинированный раствор фенотерола гидробромида и ипратропия бромида
WO2014064410A2 (fr) 2012-10-23 2014-05-01 Cipla Limited Composition pharmaceutique
GB201306984D0 (en) * 2013-04-17 2013-05-29 Mexichem Amanco Holding Sa Composition
KR101484481B1 (ko) * 2014-08-07 2015-01-20 주식회사 다림바이오텍 Pde-5 저해제를 포함하는 설하분무제의 제조방법 및 이에 의하여 제조된 설하분무용 조성물
CN107320464A (zh) * 2017-04-28 2017-11-07 北京北朋科技有限公司 高ph值的布地奈德混悬液的制备方法
GB2573297A (en) * 2018-04-30 2019-11-06 Mexichem Fluor Sa De Cv Pharmaceutical composition
US20220040086A1 (en) * 2018-10-01 2022-02-10 Kindeva Drug Delivery L.P. Formulation and aerosol canisters, inhalers, and the like containing the formulation
CN114796166A (zh) * 2021-01-29 2022-07-29 北京远大九和药业有限公司 一种含有萜烯类挥发油的气雾剂及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6641800B1 (en) * 1991-09-25 2003-11-04 Fisons Ltd. Pressurized aerosol compositions comprising powdered medicament dispersed in hydrofluoroalkane

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684698A (en) * 1986-05-02 1987-08-04 Gaf Corporation Water soluble multicomplex of chlorothiazide, furosemide and poly(N-vinyl-2-pyrrolidone)
EP0655237A1 (fr) * 1993-11-27 1995-05-31 Hoechst Aktiengesellschaft Composition d'aerosol medicinal
CA2232378C (fr) * 1995-09-19 2009-04-14 Fujisawa Pharmaceutical Co., Ltd. Compositions en aerosol
EP1019020A1 (fr) * 1997-09-29 2000-07-19 Inhale Therapeutic Systems, Inc. Preparations bioactives stabilisees et leur procedes d'utilisation
DE10214031A1 (de) * 2002-03-27 2004-02-19 Pharmatech Gmbh Verfahren zur Herstellung und Anwendung von Mikro- und Nanoteilchen durch aufbauende Mikronisation
ATE453641T1 (de) * 2003-11-03 2010-01-15 Boehringer Ingelheim Int Neues kristallines anhydrat mit anticholinerger wirksamkeit
CN101166738B (zh) * 2005-05-02 2011-06-01 贝林格尔·英格海姆国际有限公司 噻托溴铵的新晶型
ES2396978T5 (es) * 2005-12-19 2015-12-04 Sicor, Inc. Forma cristalina novedosa de bromuro de tiotropio y procedimiento para la preparación de la misma
EP2327403A3 (fr) * 2007-02-19 2011-08-31 Cipla Limited Combinaisons pharmaceutiques contenant au moins deux bronchodilateurs
GB0801876D0 (en) * 2008-02-01 2008-03-12 Vectura Group Plc Suspension formulations

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6641800B1 (en) * 1991-09-25 2003-11-04 Fisons Ltd. Pressurized aerosol compositions comprising powdered medicament dispersed in hydrofluoroalkane

Also Published As

Publication number Publication date
EP2362766A2 (fr) 2011-09-07
WO2010052466A2 (fr) 2010-05-14
CN102238939A (zh) 2011-11-09
RU2565438C2 (ru) 2015-10-20
WO2010052466A3 (fr) 2010-11-04
CA2742718A1 (fr) 2010-05-14
MX2011004730A (es) 2011-05-30
RU2011122652A (ru) 2012-12-20
AU2009312598A1 (en) 2010-05-14
BRPI0916047A2 (pt) 2015-11-10
JP2012507574A (ja) 2012-03-29
KR20110096538A (ko) 2011-08-30
ZA201103347B (en) 2012-01-25
NZ592861A (en) 2013-01-25
WO2010052466A8 (fr) 2011-11-24

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Granted publication date: 20150520

Termination date: 20151104

EXPY Termination of patent right or utility model