CN102233636B - Method for manufacturing filling structure - Google Patents
Method for manufacturing filling structure Download PDFInfo
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- CN102233636B CN102233636B CN 201010174653 CN201010174653A CN102233636B CN 102233636 B CN102233636 B CN 102233636B CN 201010174653 CN201010174653 CN 201010174653 CN 201010174653 A CN201010174653 A CN 201010174653A CN 102233636 B CN102233636 B CN 102233636B
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Abstract
The invention relates to a method for manufacturing a filling structure. The method comprises the following steps of: providing a mold which comprises a female die and a male die; injecting a biomaterial into the female die to ensure that the upper surface of the biomaterial is higher than that of the female die; pressing the female die and the male die and extruding the upper surface of the biomaterial at the same time to ensure that the density of the upper side part of the biomaterial is higher than that of the lower side part; drying the biomaterial; and taking the dried biomaterial out of the female die. By the method for manufacturing the filling structure, filling structures which are provided with holes of different sizes and have different compactness can be manufactured in a relatively simple mode, a process is relatively simple and convenient, and the filling structure can be relatively quickly and conveniently manufactured.
Description
Technical field
The present invention relates to a kind of manufacture method of interstitital texture, particularly have the manufacture method of the interstitital texture of different densityes.
Background technology
Generally speaking, in the therapeutic process after finishing tooth pulling surgery, reparation and regeneration particular importance with the root of the tooth surrounding tissue, because if properly do not carry out repair process, and let alone the wound normal healing in operation exodontia back, then the alveolar bone height and the width of agomphosis may atrophy reach 40%-60% in 1 year.Cause the reason of atrophy, mainly be because be positioned at the Regeneration and Repair speed of the alveolar bone of below, what the Regeneration and Repair speed of gum was come above being positioned at is slow, cause the gum of top except cross growth, also can expand downwards along the teeth groove of agomphosis, and then cause the atrophy of alveolar bone height and the width.
In addition, because the arrangement of original tooth row is very tight, so the teeth groove of agomphosis tends to be subjected to the strength of lateral compression, and change the balance of original teeth arrangement.Such as the following chin of agomphosis tooth, the rear side adjacent teeth is dumped forward, cause the difficulty of installing artificial tooth in the future or manually planting tooth.More the person because the significantly atrophy of alveolar bone height and the width of agomphosis may also need to perform the operation earlier, excises unnecessary gum before planting tooth, plants the required height and the width of tooth to provide.
The repairing of carrying out at the exodontia back is to use artificiality to insert in the teeth groove of agomphosis at present.Such as using osteoproliferation collagen (collagen sponge) as artificial filler, and the collocation operation inserts in the teeth groove of agomphosis, to reduce the atrophy of alveolar bone height and the width.But the shortcoming of this method is that the alveolar bone height and the width still have a little atrophy, its reason is that artificiality there is no the effect of obstruct, still can't completely cut off the gum that is positioned at the top and grow downwards, and keep a space that the cell growth is provided, so the alveolar bone height and the width still might atrophy.
Another kind of mode of the prior art is to place a periodontal regenerative film at the intersection of gum and alveolar bone, in order to completely cut off a space in teeth groove, provides paradenlal tissue regeneration.But this kind mode there is no the drug therapy by other owing to be self-regeneration and the regeneration that relies on alveolar bone fully, thus its to repair the needed time longer.
Existing another kind of artificiality 1 is for comprising the living doctor's material that is constituted with colloid cavernous body 10 in addition.Please refer to Fig. 1, is an existing artificiality schematic diagram, and artificiality 1 is to be made up of a colloid cavernous body 10 and a film 11, and wherein film 11 is ends that are adhered to colloid cavernous body 10 with chemical cross-linking agent (chemical cross-linker).
But the shortcoming of this kind mode is, because colloid cavernous body 10 and film 11, its material character of sticker are different; Both contacts area of colloid cavernous body 10 and film 11 with and the differences such as flatness on surface, so the bonding of interface can produce many problems, is difficult for such as bonding, to such an extent as in the problem that gets loose at the interface of adhesion; The chemical cross-linking agent that applies (chemical cross-linker) may be too much or very little, is difficult for controlling, and causes chemical cross-linking agent (chemical cross-linker) to waste or bonding not firm problem is arranged.
Therefore, how can improve the manufacturing issue of present artificiality, be the target that relevant dealer endeavours to solve.
Summary of the invention
The manufacture method that the purpose of this invention is to provide interstitital texture particularly has the manufacture method of the interstitital texture of different densityes.
Another object of the present invention provides and can replace the existing manufacture method that is used for the interstitital texture of tissue repair.
Another object of the present invention provides the manufacture method of the interstitital texture that solves agomphosis periodontal tissues deletion problem.
Another object of the present invention provides the manufacture method of the interstitital texture that is applied to orthopaedics.
Another object of the present invention provides faster and the manufacture method of more convenient interstitital texture.
For achieving the above object, the invention provides a kind of manufacture method of interstitital texture, comprise the following step:
One mould is provided, and this mould comprises a master mold and a male model;
Inject all one's life and cure material (biomedical material) in described master mold, make the described doctor's of giving birth to material upper surface be higher than the upper surface of described master mold;
The described master mold of pressing and described male model push described upper surface of giving birth to doctor's material whereby, make the density of the described doctor's of giving birth to material upper portion greater than the density of lower portion;
The dry described doctor's material of giving birth to; And
By taking out the described doctor's of giving birth to material in this master mold.
In manufacture method provided by the invention, preferably, injecting the described doctor's of giving birth to material after the step of described master mold, this manufacture method also comprises adds a chemistry crosslinking agent in the step of the described doctor's of giving birth to material upper surface.
In manufacture method provided by the invention, preferably, after the step that adds described chemistry crosslinking agent, this manufacture method comprises that also one leaves standstill the step of the described doctor's of giving birth to material, makes it produce chemical sexual intercourse connection, 30 minutes～6 hours chemical crosslink reaction time.
In manufacture method provided by the invention, preferably, described male model is a plate, has a plurality of spaces hole on the described plate, in the step process of carrying out the dry described doctor's of giving birth to material, accelerate dry run by described a plurality of spaces hole of described male model plate.
In manufacture method provided by the invention, preferably, the temperature range of described male model is 70～150 ℃, so that described doctor's material production heat cross-linking of giving birth to.
In manufacture method provided by the invention, preferably, when 70～150 ℃ of the temperature ranges of described male model, be 30 minutes～6 hours heat time heating time.
In manufacture method provided by the invention, preferably, described master mold is constituted with a master mold internal layer by a master mold is outer; Before the step of carrying out the dry described doctor's of giving birth to material, comprise and take out the outer field step of described master mold.
In manufacture method provided by the invention, preferably, described master mold internal layer has a plurality of spaces hole, in the step process of carrying out the dry described doctor's of giving birth to material, is that the described a plurality of holes by described master mold internal layer accelerate dry run.
In manufacture method provided by the invention, preferably, the described master mold of described pressing and described male model, the step that described upper surface of giving birth to doctor's material is pushed whereby, be to push the extremely described porosity (porosity) of giving birth to the lower portion of curing material of the described doctor's of giving birth to material between 50%～99%, and the described porosity of doctor's material upper portion of giving birth to is between 0.1%～30%.
In manufacture method provided by the invention, preferably, dry described step of giving birth to doctor's material is the dry described doctor's of giving birth to material to the porosity (porosity) of the lower portion of the described doctor's of giving birth to material between 50%～99%, and the described porosity of doctor's material upper portion of giving birth to is between 0.1%～30%.
In manufacture method provided by the invention, preferably, in the step of being taken out the described doctor's of giving birth to material by described master mold, be to have a plurality of holes up to the described doctor's of giving birth to material lower portion, each this hole diameter is between 50～300 μ m, and described doctor's material upper portion of giving birth to has a plurality of holes, and each described hole diameter just takes out the described doctor's of giving birth to material from described master mold less than 30 μ m.
Interstitital texture manufacture method provided by the invention, comprising provides a mould, mould to comprise a master mold and a male model; Inject all one's life and cure material in master mold, make and give birth to the upper surface that doctor's material upper surface is higher than master mold; Pressing master mold and male model push the upper surface of giving birth to doctor's material whereby, make the density of living doctor's material upper portion greater than the density of lower portion; The dry doctor's material of giving birth to; And give birth to doctor's material by taking out in the master mold.
Manufacture method according to interstitital texture provided by the invention, an advantage of the present invention is for providing the interstitital texture with different densityes, can solve the bonding problem of heterogeneity material interface, solve the variety of issue that uses chemical cross-linking agent (chemical cross-linker) and derive, and can make with more convenient mode.
The invention provides a kind of manufacture method with interstitital texture of different densityes, described interstitital texture can replace the existing tissue repair that is used for, and solves agomphosis problem or the problem of orthopaedics patchery thing.The purposes that is to say interstitital texture is not limited with tooth section with preparation, can be applicable to other departments, such as orthopaedics yet.Be example with orthopaedics, bone can be divided into outer cortical bone and inner spongy bone again, all can insert auxiliary curing with prepared interstitital texture according to needs.
About the manufacture method of interstitital texture of the present invention, can be further understood by following detailed Description Of The Invention and appended diagram.
Description of drawings
The following drawings only is intended to the present invention done and schematically illustrates and explain, not delimit the scope of the invention.Wherein:
Fig. 1 is existing interstitital texture schematic diagram;
Fig. 2 a-Fig. 2 d is the manufacture method flow chart of interstitital texture of the present invention;
Fig. 3 a and Fig. 3 b are the structural representation of the master mold of another embodiment of the present invention.
The main element label declaration:
Artificiality 1; Colloid cavernous body 10; Film 11; Interstitital texture 2; Mould 20; Master mold 201; Male model 202; Give birth to doctor's material 21; Upper portion 211; Lower portion 212; Master mold 30; Master mold internal layer 301; Master mold skin 302.
The specific embodiment
Understand for technical characterictic of the present invention, purpose and effect being had more clearly, now contrast description of drawings the specific embodiment of the present invention.
Please refer to Fig. 2 a-Fig. 2 d, these figure show in the first embodiment of the invention, the preparation method of interstitital texture 2.Its preparation method comprises step S1 provides a mould 20, and wherein mould 20 comprises a master mold 201 and a male model 202.Then, carry out step S2, inject all one's life and cure material 21 in master mold 201.Carry out step S3 again, pressing master mold 201 and male model 202 push the upper surface of giving birth to doctor's material 21 whereby, make the density of living doctor's material 21 upper portions 211 greater than the density of lower portion 212.Carry out step S4 afterwards, the dry doctor's material 21 of giving birth to.Carry out step S5 at last, give birth to doctor's material 21 by taking out in the master mold 201.
See also Fig. 2 a and Fig. 2 b, it has shown the process of step S1 to S2 of the present invention.Mould 20 at first is provided, Fig. 2 b shows that the living doctor of injection material 21 is in the step S2 of master mold 201 then, wherein living doctor's material 21 upper surfaces are higher than the upper surface of master mold 201, that is to say that the doctor's material 21 of giving birth to that adds is porous living doctor materials 21 more more than original made finished product that causes.And, in one embodiment, can earlier dry slightly master mold 201 interior giving birth to cure material 21, make giving birth in the master mold 201 cure material 21 and have spongiform blank, carry out step S3 again.
Wherein, give birth to the material of doctor's material 21 for having the porous doctor's of giving birth to material, the source comprises collagen (collagen), gelatin (gelatin), sodium hyaluronate (hyaluronic acid, HA), spherical chitosan (chitosan), chitin (chitin), poly-bran acid (poly glutamic acid, PGA), oxyhydrogen-base apatite (hydroxyapatite, HAP), tricalcium phosphate (tricalcium phosphate, TCP), give birth to doctor's glass (bioglass).Wherein, when being used in the alveolar bone interstitital texture when preparing, give birth to 21 its preferred embodiments of doctor's material for selecting collagen (collagen), gelatin (gelatin) etc. for use.In addition, when being used in the orthopaedics material when preparing, give birth to 21 preferred embodiments of doctor's material for select for use oxyhydrogen-base apatite (hydroxyapatite, HAP), tricalcium phosphate (tricalcium phosphate, TCP), give birth to doctor's glass (bioglass), sodium hyaluronate (hyaluronic acid, HA) etc.
After step S2, and carry out before the step S3, also can comprise and add a chemistry crosslinking agent (chemical cross-linker) in the step S21 that gives birth to doctor's material 21 upper surfaces, shown in Fig. 2 b.Wherein, chemistry crosslinking agent (chemical cross-linker) can be selected from glutaraldehyde (glutaraldehyde), carbodiimide (carbodiimide), amino silane (aminosilane), green gardenin (genipin), pregnancy thiazolinyl diisocyanate (hexamethylene diisocyanate, HMDI), formaldehyde (formaldehyde), acyl azide (acyl azide).Certainly, the chemistry crosslinking agent (chemicalcross-linker) that it also can use other equivalences reaches the purpose of chemical crosslinking.In a preferred embodiment, the chemistry crosslinking agent of use (chemical cross-linker) can be selected glutaraldehyde, and the best working concentration of glutaraldehyde is about percent by volume 0.001%～3.000%.And in another preferred embodiment, the chemistry crosslinking agent (chemical cross-linker) that uses can be selected 1-(3-dimethylamino-propyl)-3-ethyl-carbodiimide hydrochloride (1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride, EDC) (a kind of compound of carbodiimide), and the best working concentration of EDC is about molar concentration 1～300mM.
For instance, when chemistry crosslinking agent (chemical cross-linker) was used in crosslinked with collagen albumen or other biomolecule, preferred embodiment can be selected glutaraldehyde (glutaraldehyde), carbodiimide (carbodiimide), green gardenin (genipin) etc. for use according to the difference of the mechanical strength of its range of application.If the crosslinked living doctor's material of desire is oxyhydrogen-base apatite (hydroxyapatite, HAP), tricalcium phosphate (tricalcium phosphate, when TCP), material is cured in life doctor's glass (bioglass) or other lifes, the preferred embodiment of its chemical cross-linking agent (chemical cross-linker) be amino containing silane (aminosilane), pregnancy thiazolinyl diisocyanate (hexamethylene diisocyanate, HMDI), green gardenin (genipin) etc.
Wherein, after carrying out step S21, and carry out before the step S3, also comprise and leave standstill the step S22 that gives birth to doctor's material 21, make whereby and give birth to the chemical sexual intercourse connection of doctor's material 21 generations, wherein Fan Ying time is 30 minutes～24 hours; And the preferable enforcement reaction time is 30 minutes～6 hours.
Please refer to Fig. 2 b and Fig. 2 c, it has shown the process of preparation method's of the present invention step S2 to S3.In an embodiment of the present invention, when pressing master mold 201 and male model 202, during the step S3 that whereby upper surface of giving birth to doctor's material 21 pushed, can continue to be squeezed to the porosity of the upper portion 211 of giving birth to doctor's material 21 between 0.1%～30%, and the porosity of the lower portion 212 of living doctor's material 21 is between 50%～99%.
Certainly, pressing master mold 201 and male model 202, the step S3 that the upper surface of giving birth to doctor's material 21 is pushed whereby, male model 202 can be chosen as a plate, and master mold 201 is a groove at this moment, and pressing master mold 201 pushes the upper surface of giving birth to doctor's material 21 with male model 202, shown in Fig. 2 c.Certainly, master mold 201 and male model 202 can have other design according to the interstitital texture shape, are not limited with the above-mentioned embodiment that is mentioned.
Wherein, the Controllable Temperature of male model 202 can make doctor's material 21 upper surfaces of giving birth to that are squeezed produce heat cross-linking built in 70 ℃～150 ℃ whereby.When the temperature range of male model 202 is 70 ℃～150 ℃, be about 30 minutes required heat time heating time～24 hours; Wherein, the preferable enforcement reaction time is 30 minutes～6 hours.
In addition, please refer to Fig. 3 a and Fig. 3 b, shown another embodiment of this case, this embodiment is in order to accelerate after male model 202, master mold 30 pressings finish, and giving birth to doctor's material 21 can be faster dry, the particular design of doing at master mold 30.Wherein, master mold 30 is constituted in the double-decker mode, meaning is that master mold 30 is made of a master mold internal layer 301 and outer 302 an of master mold, and master mold internal layer 301 places master mold skin 302, that is to say that outer 302 sizes of master mold are slightly larger than master mold internal layer 301, master mold internal layer 301 can overlap with master mold skin 302 and be combined into one, and the master mold 30 that constitutes is for cylindric.Wherein master mold internal layer 301 has a plurality of spaces hole, the outer 302 no holes of master mold.Each hole size on the master mold internal layer 301 is about 100 μ m～2mm.In the present embodiment, master mold internal layer 301 surfaces have a plurality of holes, and purpose reduces in hope gives birth to the dry required time of doctor's material; Outer 302 of master mold is to prevent that the doctor's material solution of giving birth to that injects master mold 30 is not lost via master mold internal layer 301 before forming sponge-like body.
Living doctor's material 21 after the process step S3 extruding, the density of its upper portion 211 can be cured material 21 thereby obtain giving birth to of different densityes greater than the density of lower portion 212, and living doctor material 21 was given birth to for porous and was cured material 21 this moment, shown in Fig. 2 c.In one embodiment, giving birth to doctor's material 21 is porous material, and its upper portion 211 is compacted zone, and wherein each hole diameter is less than 30 μ m, and porosity is between 0.1%～30%; Give birth to doctor's material 21 lower portion 212 and have a plurality of holes, each hole diameter is greater than 50 μ m, and preferred embodiment is that porosity is between 50%～99% between 50～300 μ m.In one embodiment, pressing master mold 201 and male model 202, whereby among the step S3 that the upper surface of giving birth to doctor's material 21 is pushed, be extruding give birth to doctor's material 21 to the porosity of the lower portion 212 of giving birth to doctor's material 21 between 50%～99%, and life is cured the porosity of material 21 upper portions 211 between 0.1%～30%, just completing steps S3.
Afterwards, curing in the material 21 dry the giving birth to of step S4, is the dry doctor of giving birth to of the mode material 21 with freeze drying, vacuum drying and heated-air drying etc.And in a preferred embodiment, the drying mode that uses is freeze drying.Wherein, in one embodiment, give birth in doctor's material 21 in that step S4 is dry, be the dry doctor's of giving birth to material 21 to the porosity of giving birth to doctor's material 21 lower portion 212 between 50%～99%, and life is cured the porosity of material 21 upper portions 211 between 0.1%～30%, just completing steps S4.
Subsequently, take out the step of giving birth to doctor's material 21 at step S5 by master mold 201, be to have a plurality of holes up to giving birth to doctor's material 21 lower portion, each hole diameter is between 50～300 μ m, have a plurality of holes and give birth to doctor's material 21 upper portions, each hole diameter is just taken out from master mold 201 and is given birth to doctor's material 21 less than 30 μ m.Shown in Fig. 2 d, it has shown that the interstitital texture 2 of taking out at last has different densityes, and wherein the density of upper portion 211 can be greater than the density of lower portion 212.
In addition, constituted in the double-decker mode at this case master mold 30, the manufacture method that interstitital texture 2 is more detailed comprises that will give birth to doctor's material 21 solution earlier injects master mold 30, and is dried a few hours to a couple of days, makes the existing blank of the spongelike structure of giving birth to doctor's material 21.Then, utilize the previous male model of carrying 202, master mold 30 pressings to come to make a compacted zone in the upper surface of giving birth to doctor's material.After pressing finishes, before the step of giving birth to doctor's material drying, male model 202, master mold 30 are stood upside down and place, and master mold outer 302 is taken out, keep master mold internal layer 301, come the accelerated material dry run by a plurality of holes of master mold internal layer 301; The step of placing of wherein male model 202, master mold 30 being stood upside down is also inessential, that is to say that male model 202, master mold 30 are not that certain need handstand placed.This embodiment can effectively reduce living doctor's material 21 and carry out the required time of drying steps.Certainly, method described above is only made a living and is cured an embodiment of material 21 dryings, and the method for the most lifelong doctor's material 21 dryings is not as limit.
In sum, preparation method of the present invention can comprise step S1, S2, S3, S4, S5; In addition, also can following step carry out, comprise step S1, S2, S21, S22, S3, S4, S5.
In addition, in above-mentioned two kinds of preparation methods, at step S3, can 2 kinds of different process choice be arranged with control male model 202 temperature.The temperature control that is to say male model 202 can be between room temperature or 70 ℃～150 ℃, wherein when temperature control is between 70 ℃～150 ℃, gives birth to and cures material 21 and can produce heat cross-linking.And, also can arrange in pairs or groups and use master mold 201 or make interstitital texture 2 with the master mold 30 that the double-decker mode is constituted.
In sum, the manufacturing process that manufacture method provided by the invention is more concrete mainly can be divided into:
(1) simple extruding, its step is S1, S2, S3, S4, S5, wherein among the step S3, male model 202 temperature are room temperature.
(2) chemical crosslinking mode merges with extruding to be used, and its step is S1, S2, S21, S22, S3, S4, S5, and wherein among the step S3, male model 202 temperature are room temperature.
(3) the heat cross-linking mode merges use with extruding, and its step is S1, S2, S3, S4, S5, and wherein among the step S3, male model 202 temperature are controlled at 70 ℃～150 ℃.
(4) chemical crosslinking mode and heat cross-linking mode and extruding merge to be used, and its step is S1, S2, S21, S22, S3, S4, S5, and wherein among the step S3, male model 202 temperature are controlled at 70 ℃～150 ℃.
Certainly, above-mentioned four kinds of preparation methods all can be selected to use master mold 201 or make interstitital texture 2 with the master mold 30 that the double-decker mode is constituted.
The manufacture method advantage of interstitital texture provided by the present invention comprises and can produce interstitital texture with different hole sizes, the interstitital texture with different densityes can be provided with better simply mode; Solve the problem of differing material properties bonding interface: solve and use chemical cross-linking agent (chemicalcross-linker) and problem and the material source of deriving are single, technology is comparatively easy, is therefore making on the interstitital texture faster and more convenient.
The above only is the schematic specific embodiment of the present invention, is not in order to limit scope of the present invention.Any those skilled in the art, the equivalent variations of doing under the prerequisite that does not break away from design of the present invention and principle and modification all should belong to the scope of protection of the invention.
Claims (11)
1. the manufacture method of an interstitital texture comprises the following step:
One mould is provided, and this mould comprises a master mold and a male model;
Inject all one's life and cure material in described master mold, make the described doctor's of giving birth to material upper surface be higher than the upper surface of described master mold, the wherein said doctor's of giving birth to material is for having the porous doctor's of giving birth to material;
The described master mold of pressing and described male model push described upper surface of giving birth to doctor's material whereby, make the density of the described doctor's of giving birth to material upper portion greater than the density of lower portion;
The dry described doctor's material of giving birth to; And
By taking out the described doctor's of giving birth to material in this master mold.
2. manufacture method as claimed in claim 1 wherein, is being injected the described doctor's of giving birth to material after the step of described master mold, and this manufacture method also comprises adds a chemistry crosslinking agent in the step of the described doctor's of giving birth to material upper surface.
3. manufacture method as claimed in claim 2, wherein, after the step that adds described chemistry crosslinking agent, this manufacture method comprises that also one leaves standstill the step of the described doctor's of giving birth to material, makes it produce chemical sexual intercourse connection, 30 minutes～6 hours chemical crosslink reaction time.
4. manufacture method as claimed in claim 1, wherein, described male model is a plate, has a plurality of spaces hole on the described plate, in the step process of carrying out the dry described doctor's of giving birth to material, accelerate dry run by described a plurality of spaces hole of described male model plate.
5. manufacture method as claimed in claim 1, wherein, the temperature range of described male model is 70～150 ℃, so that described doctor's material production heat cross-linking of giving birth to.
6. manufacture method as claimed in claim 5, wherein, when 70～150 ℃ of the temperature ranges of described male model, be 30 minutes～6 hours heat time heating time.
7. manufacture method as claimed in claim 1, wherein, described master mold is constituted with a master mold internal layer by a master mold is outer; Before the step of carrying out the dry described doctor's of giving birth to material, comprise and take out the outer field step of described master mold.
8. manufacture method as claimed in claim 7, wherein, described master mold internal layer has a plurality of spaces hole, in the step process of carrying out the dry described doctor's of giving birth to material, is that the described a plurality of holes by described master mold internal layer accelerate dry run.
9. manufacture method as claimed in claim 1, wherein, the described master mold of described pressing and described male model, the step that described upper surface of giving birth to doctor's material is pushed whereby, be to push the extremely described porosity of giving birth to the lower portion of curing material of the described doctor's of giving birth to material between 50%～99%, and the described porosity of doctor's material upper portion of giving birth to is between 0.1%～30%.
10. manufacture method as claimed in claim 1, wherein, dry described step of giving birth to doctor's material is the dry described doctor's of giving birth to material to the porosity of the lower portion of the described doctor's of giving birth to material between 50%～99%, and the described porosity of doctor's material upper portion of giving birth to is between 0.1%～30%.
11. manufacture method as claimed in claim 1, wherein, in the step of being taken out the described doctor's of giving birth to material by described master mold, be to have a plurality of holes up to the described doctor's of giving birth to material lower portion, each this hole diameter is between 50～300 μ m, and described doctor's material upper portion of giving birth to has a plurality of holes, and each described hole diameter just takes out the described doctor's of giving birth to material from described master mold less than 30 μ m.
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201010174653 CN102233636B (en) | 2010-05-06 | 2010-05-06 | Method for manufacturing filling structure |
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| CN 201010174653 CN102233636B (en) | 2010-05-06 | 2010-05-06 | Method for manufacturing filling structure |
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| CN102233636A CN102233636A (en) | 2011-11-09 |
| CN102233636B true CN102233636B (en) | 2013-08-21 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001164124A (en) * | 1999-10-01 | 2001-06-19 | Kyocera Corp | Resin composite, and electric wave absorber using the same and production method thereof |
| US20040096475A1 (en) * | 2002-07-09 | 2004-05-20 | Pentax Corporation | Calcium phosphate-synthetic resin composite body containing calcium phosphate block and method for production thereof |
| CN201389088Y (en) * | 2009-04-27 | 2010-01-27 | 柏登生医股份有限公司 | Filling structure for preventing alveolar bone from atrophy and depression |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1187101C (en) * | 2002-09-28 | 2005-02-02 | 中国科学院上海硅酸盐研究所 | Prepn process of degradeable bioactive porous active calcium silicate ceramic material |
| GB0610333D0 (en) * | 2006-05-24 | 2006-07-05 | Orthogem Ltd | Bone repair or augmentation device |
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2010
- 2010-05-06 CN CN 201010174653 patent/CN102233636B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001164124A (en) * | 1999-10-01 | 2001-06-19 | Kyocera Corp | Resin composite, and electric wave absorber using the same and production method thereof |
| US20040096475A1 (en) * | 2002-07-09 | 2004-05-20 | Pentax Corporation | Calcium phosphate-synthetic resin composite body containing calcium phosphate block and method for production thereof |
| CN201389088Y (en) * | 2009-04-27 | 2010-01-27 | 柏登生医股份有限公司 | Filling structure for preventing alveolar bone from atrophy and depression |
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| CN102233636A (en) | 2011-11-09 |
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