CN214434672U - Elastic bone repair support - Google Patents
Elastic bone repair support Download PDFInfo
- Publication number
- CN214434672U CN214434672U CN202021122377.1U CN202021122377U CN214434672U CN 214434672 U CN214434672 U CN 214434672U CN 202021122377 U CN202021122377 U CN 202021122377U CN 214434672 U CN214434672 U CN 214434672U
- Authority
- CN
- China
- Prior art keywords
- support
- derivatives
- elastic
- bone repair
- elastic bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Abstract
The utility model provides an elastic bone repair bracket, which relates to the technical field of medical materials and comprises a bracket structure and a filling structure; the support structure comprises at least one layer of support layer, the support layer comprises a plurality of fold line structures with the same extension direction, and the support layer forms an elastic structure along the extension direction of the fold line structures; the filling structures are filled between the adjacent fold line structures; the filling structure has a fibrous, spongy, porous and gel structure. The elastic bone repair bracket provided by the utility model has elasticity by designing the structure; when the elastic bone repairing support is used, the elastic bone repairing support is extruded, so that the size of the elastic bone repairing support is reduced, the elastic bone repairing support with the reduced size is placed at a bone defect position, and the problem that an operation incision is large in the bone repairing support transplanting process is solved.
Description
Technical Field
The utility model relates to a medical material technical field particularly, relates to an elasticity bone repair support.
Background
The bone repair scaffold plays an important role in the bone reconstruction process; most of the existing bone repair scaffolds are made of hard materials, and a large operation incision is often needed in the bone repair scaffold transplanting process made of the hard materials, so that secondary injury to soft tissues of an injured part is caused.
SUMMERY OF THE UTILITY MODEL
The utility model solves the problem that the operation incision of the bone repair bracket is larger in the transplanting process.
In order to solve the problems, the utility model provides an elastic bone repair bracket, which comprises a bracket structure and a filling structure;
the support structure comprises at least one layer of support layer, the support layer comprises a plurality of fold line structures with the same extension direction, and the support layer forms an elastic structure along the extension direction of the fold line structures;
the filling structures are filled between the adjacent fold line structures;
the filling structure has a fibrous, spongy, porous and gel structure.
The bone repair bracket has elasticity by designing the structure.
Optionally, the scaffold structure has a volume greater than a volume at the bone defect.
The elastic bone repairing support is fixed through the bone defect position, and the stability of the elastic bone repairing support is improved.
Optionally, two adjacent plate-shaped structures in the fold line structure are connected to form a V-shaped structure. The V-shaped structures which are adjacently arranged are sequentially extruded to generate deformation, so that the broken line structure has larger deformability.
Optionally, when the stent structure comprises two or more support layers, the opening directions of the V-shaped structures in adjacent support layers are opposite. The elastic bone repair bracket has elasticity in two directions, and is convenient to implant into bone defects.
Optionally, the distance between adjacent fold line structures ranges from 1.1mm to 1.4 mm.
Optionally, the material of the scaffold structure is selected from one or more of polycaprolactone, polylactic acid, collagen, gelatin, chitosan, polyurethane, a derivative of polycaprolactone, a derivative of polylactic acid, a derivative of collagen, a derivative of gelatin, a derivative of chitosan, and a derivative of polyurethane.
Optionally, the material of the scaffold structure further comprises inorganic particles.
Optionally, the inorganic particles are selected from one or more of hydroxyapatite, tricalcium phosphate, derivatives of hydroxyapatite, and derivatives of tricalcium phosphate.
Optionally, the content of the inorganic particles in the scaffold structure ranges from 0% to 90%.
Optionally, the material of the filling structure is one or more selected from collagen, gelatin, chitosan, sodium alginate, hyaluronic acid, elastin, fibrin, polypeptide, collagen derivatives, gelatin derivatives, chitosan derivatives, sodium alginate derivatives, hyaluronic acid derivatives, elastin derivatives, fibrin derivatives and polypeptide derivatives.
Compared with the prior art, the utility model provides an elasticity bone repair support has following advantage:
the elastic bone repair bracket provided by the utility model has elasticity by designing the structure; when the elastic bone repairing support is used, the elastic bone repairing support is extruded, so that the size of the elastic bone repairing support is reduced, the elastic bone repairing support with the reduced size is placed at a bone defect position, the elastic bone repairing support can be transplanted through a small incision, and the problem that the operation incision is large in the bone repairing support transplanting process is solved.
Drawings
Fig. 1 is a schematic structural view of the elastic bone repair scaffold of the present invention;
fig. 2 is a schematic view of the structure of the support layer according to the present invention.
Description of reference numerals:
1-a scaffold structure; 11-a support layer; 111-fold line configuration; 1111-plate-like structure; 2-filling structure.
Detailed Description
Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary and intended to be used for explaining the present invention, and should not be construed as limiting the present invention, and all other embodiments obtained by those skilled in the art without creative efforts based on the embodiments of the present invention belong to the protection scope of the present invention.
In order to make the aforementioned objects, features and advantages of the present invention more comprehensible, embodiments accompanied with figures are described in detail below.
In order to solve the problem that the surgical incision is large in the conventional bone repair scaffold in the transplanting process, the utility model provides an elastic bone repair scaffold, which is shown in figure 1 and comprises a scaffold structure 1 and a filling structure 2; wherein the support structure 1 is a three-dimensional structure, and the shape of the support structure 1 is determined according to the shape of the bone defect; the support structure 1 comprises at least one layer of support layer 11, each support layer 11 comprises a plurality of fold line structures 111 with the same extension direction, and the support layer 11 forms an elastic structure along the extension direction of the fold line structures 111; the filling structures 2 are filled between the adjacent fold line structures 111, and the structures of the filling structures 2 include fibers, sponges, pores and gels.
The broken line structure 111 in the present application specifically means that the broken line structure 111 is formed by connecting a plurality of plate-shaped structures 1111 end to end in sequence to form a zigzag connection structure, that is, the extension directions of two adjacent plate-shaped structures 1111 are different, and an included angle is formed between two adjacent plate-shaped structures 1111.
Because an included angle is formed between two adjacent plate-shaped structures 1111 forming the folding line structure 111, when the folding line structure 111 is extruded from the extending direction of each folding line structure 111, the included angle between two adjacent plate-shaped structures 1111 is reduced under the extrusion action, so that the length of the folding line structure 111 is shortened; when the folding line structure 111 is not squeezed any more, the included angle between two adjacent plate-shaped structures 1111 is restored to the original angle, so that the length of the folding line structure 111 is restored to the original length, and the folding line structure 111 has a certain elasticity along the extending direction of the folding line structure 111.
In this application, each supporting layer 11 includes a plurality of fold line structures 111, and in this application, it is further preferable that the extending directions of the plurality of fold line structures 111 in the same supporting layer 11 are the same, and when the supporting layer 11 is pressed along the extending directions of the plurality of fold line structures 111, the plurality of fold line structures 111 in the supporting layer 11 are deformed at the same time, and the length is shortened; when the supporting layer 11 is not pressed any more, the lengths of the plurality of fold line structures 111 are all restored to the original lengths, so that the supporting layer 11 has a certain elasticity along the extending direction of the plurality of fold line structures 111 forming the supporting layer 11, forming an elastic structure.
The stent structure 1 of the present application may comprise one supporting layer 11, or may comprise two or more supporting layers 11, and the number of the supporting layers 11 is determined according to the size of the bone defect.
Through carrying out stack from top to bottom to a plurality of supporting layers 11 for carry out fixed connection between the adjacent folded layer 11, guarantee that supporting structure 1 possesses the side space, make and fill back to supporting structure 1's space with filling structure 2, on guaranteeing elastic bone repair support elastic basis, still can guarantee that supporting structure 1 and the filling structure 2 that elastic bone repair support side interval set up support the vertical growth of osteocyte, improve bone repair effect.
Gaps are arranged between the adjacent fold line structures 111 in each supporting layer 11, and the gaps are filled with filling structures 2, and the filling structures 2 are preferably fibrous, spongy, porous and gel-like structures in the present application.
By arranging the filling structure 2 into a fibrous, spongy, porous or gel structure, on one hand, the filling structure 2 can perform certain shrinkage deformation when the fold line structure 111 is extruded and deformed by utilizing the characteristic that the structures have certain shrinkage elasticity, and after the fold line structure 111 is not extruded any more, the filling structure 2 can restore to the original state, so that after the filling structure 2 is filled between the adjacent fold line structures 111, the supporting layer 11 can still keep elasticity, and the elastic bone repair support provided by the application has elasticity; on the other hand, the filling structure 2 is arranged into a fibrous, spongy, porous or gel structure, so that a plurality of gaps are distributed in the filling structure 2, and according to the characteristic that cells can grow in the gaps such as the pores more easily, the gaps distributed in the filling structure 2 are more favorable for guiding the growth of bone cells, so that the capability of the elastic bone repair scaffold for guiding the regeneration of bone tissues is improved.
The elastic bone repair bracket provided by the utility model has elasticity by designing the structure; when the elastic bone repairing support is used, the elastic bone repairing support is extruded, so that the size of the elastic bone repairing support is reduced, the elastic bone repairing support with the reduced size is placed at a bone defect position, the elastic bone repairing support can be transplanted through a small incision, and the problem that the operation incision is large in the bone repairing support transplanting process is solved.
The support structure 1 is a support structure of the elastic bone repair support, and the shape and the volume of the elastic bone repair support are determined by the shape and the volume of the support structure 1; specifically, the shape and volume of the scaffold structure 1 may be determined according to the shape and volume of the bone defect, and the volume of the scaffold structure 1 may be the same as the volume of the bone defect; the volume of the support structure 1 is preferably slightly larger than that of the bone defect, namely the volume of the elastic bone repair support is slightly larger than that of the bone defect; when the elastic bone repair bracket is transplanted, the elastic bone repair bracket is extruded at first, so that the volume of the elastic bone repair bracket is reduced; after the elastic bone repair scaffold with the reduced volume is transplanted to the bone defect, the extrusion force applied to the elastic bone repair scaffold is cancelled, and the size of the elastic bone repair scaffold is recovered; because the initial volume of elasticity bone repair support is greater than the volume of bone defect department, consequently, this elasticity repair support's size resumes to and is the same with bone defect department size, and under the restriction of bone defect department, the volume no longer changes to make elasticity bone repair support blocked in this bone defect department, fix this elasticity bone repair support through bone defect department, improve elasticity bone repair support's stability.
The plurality of plate-shaped structures 1111 connected in sequence can form a fold line structure with any shape, and in order to make the supporting layer 11 have better elasticity, the fold line structure 111 is preferably a wave-shaped structure in the present application, that is, every two adjacent connected plate-shaped structures 1111 in the fold line structure 111 form a V-shaped structure, and the opening directions of every two adjacent V-shaped structures are opposite.
Through setting up broken line structure 111 into the wave structure, when extruding along the extending direction of broken line structure 111, the V style of calligraphy structure of adjacent setting extrudees in proper order, produces and warp for this broken line structure 111 has great deformability, thereby makes supporting layer 11 have great elasticity, and then makes this elasticity bone repair support have great elasticity.
Because the elasticity of the elastic bone repair support is formed by structural design, the elasticity has certain directionality, for example, the elastic direction of the support layer 11 is consistent with the extending direction of the broken line structure 111 in the support layer 11, so that the elastic direction of the elastic bone repair support can be designed by designing the extending directions of the broken line structures 111 in different support layers 11 of the same elastic bone repair support; the extending directions of the fold line structures 111 in the adjacent supporting layers 11 are set to be different directions, so that the elastic directions of the adjacent supporting layers 11 are different, the elastic bone repairing support has elasticity in different directions, the anisotropy of the mechanical property of the elastic bone repairing support is realized, and the elastic bone repairing support is more suitable for the field of bone tissue engineering.
The anisotropy in the mechanical property of the bone repair support is realized through structural design, the mechanical property of the support is easy to control, the preparation process is easy to realize, and specifically, the bone repair support in the application can be prepared through the technologies of 3D printing, stereolithography and the like.
When the support structure 1 comprises two or more support layers 11, the fold line structures 111 in adjacent support layers 11 may be the same or different; the present application prefers that the openings of the V-shaped structures in adjacent support layers 11 are in opposite directions.
Referring to fig. 1 and 2, the opening directions of the V-shaped structures in the adjacent supporting layers 11 are opposite, specifically, the opening directions of the V-shaped structures at the same position in the two adjacent supporting layers 11 are opposite.
The opening direction of the V-shaped structure in the adjacent supporting layer 11 is set to be an opposite structure, so that the elastic bone repairing support has elasticity in two directions, and is convenient to implant into a bone defect.
In order to ensure the elasticity of the elastic bone repair scaffold, the interval between the adjacent fold line structures 111 is preferably 1.1mm to 1.4 mm.
The material of the scaffold structure 1 is preferably selected from one or more of polycaprolactone, polylactic acid, collagen, gelatin, chitosan, polyurethane, derivatives of polycaprolactone, derivatives of polylactic acid, derivatives of collagen, derivatives of gelatin, derivatives of chitosan and derivatives of polyurethane.
Materials such as polycaprolactone have good biocompatibility and biodegradability, and the materials are selected as cell growth supporting materials for the support structure 1, so that the elastic bone repair support provided by the application has good bone induction and bone conduction performances, promotes the growth of new bone tissues, and induces the formation of osteoblasts.
Further, the material of the scaffold structure 1 preferably further includes inorganic particles, and the inorganic particles are selected from one or more of hydroxyapatite, tricalcium phosphate, derivatives of hydroxyapatite, and derivatives of tricalcium phosphate; further preferably, the content of the inorganic particles in the scaffold 1 is in the range of 0 to 90%.
The composition and structure of the inorganic particles such as hydroxyapatite, tricalcium phosphate and the like are similar to those of natural bones, and the inorganic particles are nontoxic, harmless and carcinogenic to human bodies, have good biocompatibility and are beneficial to inducing and promoting the growth of bone tissues.
The material of the filling structure 2 is preferably selected from one or more of collagen, gelatin, chitosan, sodium alginate, hyaluronic acid, elastin, fibrin, polypeptide, collagen derivative, gelatin derivative, chitosan derivative, sodium alginate derivative, hyaluronic acid derivative, elastin derivative, fibrin derivative and polypeptide derivative.
The material is used as the material of the filling structure 2, so that the prepared elastic bone repair scaffold has better compatibility and degradability, and no toxic substance is generated after degradation, thereby improving the bone repair capability of the elastic bone repair scaffold.
The elastic bone repair support provided by the application adopts common biological materials as raw materials, and the structure is designed, so that the bone repair support has elasticity, and is convenient for a doctor to perform implantation operation; in the operation process of a doctor, pressure is only required to be applied to the support from the side surface, so that the size of the elastic bone repair support is reduced, the pressure applied to the support is cancelled after the elastic bone repair support with the reduced size is placed in the defect, and the elastic bone repair support can be fixed at the defect after the size of the support is recovered.
The support structure 1 in the elastic bone repair support can be manufactured by one or more manufacturing methods of 3D printing, stereolithography, injection molding, tape casting, die casting and material reduction manufacturing in a matched manner; the filling structure 2 can be manufactured by one or more of electrostatic spinning, centrifugal spinning, 3d printing, pore-forming method, freeze-drying molding and template method.
The preparation method of the elastic bone repair scaffold provided by the application comprises the following steps: mixing 9 parts of polycaprolactone with 1 part of hydroxyapatite powder, and preparing a supporting layer 11 from the mixture by using a 3D printing technology; the diameter of the broken line structure fiber in the supporting layer 11 is 0.6mm, and the distance between the adjacent broken line structures 111 is 1.4 mm; gelatin is used as a raw material of the filling structure 2, gelatin fiber is prepared by adopting an electrostatic spinning technology, the fiber is filled into gaps of adjacent broken line structures 111 in the supporting layer 11, and the multiple supporting layers 11 are connected to obtain the elastic bone repair support.
The application provides another preparation method of the elastic bone repair scaffold, which comprises the following steps: mixing 4 parts of polycaprolactone, 4 parts of polylactic acid and 2 parts of tricalcium phosphate powder, and preparing a support structure 1 from the mixture by using an injection molding technology, wherein the diameter of the inner line of the support structure 1 is 0.4mm, and the distance between adjacent fold line structures 111 is 1.1 mm; the elastic bone repair scaffold is prepared by using chitosan as a raw material of the filling structure 2 and adopting a freeze-drying method, internal micropores are obtained in the filling structure 2, and the filling structure 2 is filled into gaps between adjacent broken line structures 111 in the scaffold structure 1, so that the elastic bone repair scaffold is obtained.
The application provides a preparation method of the elastic bone repair scaffold, which comprises the following steps: using polycaprolactone as a raw material, and preparing a supporting layer 11 by using a 3D printing technology, wherein the diameter of a fiber in the supporting layer 11 is 0.4 mm; gelatin is used as a raw material of the filling structure 2, an electrostatic spinning technology is adopted to prepare gelatin fibers, the fibers are filled into gaps of adjacent broken line structures 111 in the supporting layers 11, and the multiple supporting layers 11 are connected to obtain the elastic bone repairing support.
Although the present disclosure has been described above, the scope of the present disclosure is not limited thereto. Those skilled in the art can make various changes and modifications without departing from the spirit and scope of the present disclosure, and such changes and modifications will fall within the scope of the present invention.
Claims (10)
1. An elastic bone repair scaffold, which is characterized by comprising a scaffold structure (1) and a filling structure (2);
the support structure (1) comprises at least one support layer (11), the support layer (11) comprises a plurality of fold line structures (111) with the same extension direction, and the support layer (11) forms an elastic structure along the extension direction of the fold line structures (111);
the filling structures (2) are filled between the adjacent fold line structures (111);
the filling structure (2) comprises a porous filling structure and a gel filling structure.
2. The elastic bone repair scaffold according to claim 1, characterized in that the volume of said scaffold structure (1) is larger than the volume at the bone defect.
3. The elastic bone repair scaffold according to claim 1, characterized in that two adjacent plate structures (1111) in said fold line structure (111) are connected to form a V-shaped structure.
4. The elastic bone repair scaffold according to claim 3, wherein said scaffold structure (1) comprises two or more said support layers (11) with opposite directions of openings of said V-shaped structures in adjacent said support layers (11).
5. The elastic bone repair scaffold according to claim 1, wherein the spacing between adjacent said fold line structures (111) ranges from 1.1mm to 1.4 mm.
6. The elastic bone repair scaffold according to claim 1, wherein the material of said scaffold structure (1) is selected from one of polycaprolactone, polylactic acid, collagen, gelatin, chitosan, polyurethane, derivatives of polycaprolactone, derivatives of polylactic acid, derivatives of collagen, derivatives of gelatin, derivatives of chitosan, derivatives of polyurethane.
7. The elastic bone repair scaffold according to claim 6, characterized in that the material of said scaffold structure (1) further comprises inorganic particles.
8. The elastic bone repair scaffold according to claim 7, wherein the inorganic particles are selected from one of hydroxyapatite, tricalcium phosphate, a derivative of hydroxyapatite, a derivative of tricalcium phosphate.
9. The elastic bone repair scaffold according to claim 7, wherein the content of said inorganic particles in said scaffold structure (1) is in the range of 0-90%.
10. The elastic bone repair scaffold according to any one of claims 1 to 9, wherein the material of the filling structure (2) is selected from one of collagen, gelatin, chitosan, sodium alginate, hyaluronic acid, elastin, fibrin, polypeptide, collagen derivatives, gelatin derivatives, chitosan derivatives, sodium alginate derivatives, hyaluronic acid derivatives, elastin derivatives, fibrin derivatives, and polypeptide derivatives.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021122377.1U CN214434672U (en) | 2020-06-17 | 2020-06-17 | Elastic bone repair support |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202021122377.1U CN214434672U (en) | 2020-06-17 | 2020-06-17 | Elastic bone repair support |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN214434672U true CN214434672U (en) | 2021-10-22 |
Family
ID=78107686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202021122377.1U Active CN214434672U (en) | 2020-06-17 | 2020-06-17 | Elastic bone repair support |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN214434672U (en) |
-
2020
- 2020-06-17 CN CN202021122377.1U patent/CN214434672U/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4790625B2 (en) | Cartilage repair prosthesis | |
| CN113939250A (en) | Implants made of skeletonized polyhedral unit cells, coiled unit cells or reticular unit cells | |
| CN102725006B (en) | Porosity tissue scaffold | |
| KR100975381B1 (en) | Kneadable, pliable bone replacement material | |
| DE19654884C2 (en) | Molded body | |
| US20110076316A1 (en) | Scalable matrix for the in vivo cultivation of bone and cartilage | |
| CN102596102A (en) | Bone graft material | |
| US20210369912A1 (en) | 2d and 3d bioscaffold extracellular structural unit and tissue structure design and methods of manufacture | |
| CN102596271A (en) | Dynamic bioactive bone graft material having an engineered porosity | |
| CN101141987A (en) | Medical material, artificial tooth root and method of producing material for clinical use | |
| EP1363551A1 (en) | Implant with access channels | |
| AU2001292570A1 (en) | Implant with access channels | |
| US20190022273A1 (en) | Devices and compositions and methods of use thereof | |
| EP2600912B1 (en) | Self-expandable biopolymer-mineral composite | |
| WO2013063602A1 (en) | Design and fabrication of biomimetic soft tissue scaffolds based on controlled assembly of highly crystalline beta-glucan nanofibrils and use in reconstructive surgery | |
| EP2863838B1 (en) | Compression and kink resistant implants | |
| CN214434672U (en) | Elastic bone repair support | |
| US11547568B2 (en) | Implant and kit for treating a bone defect | |
| WO2013173906A1 (en) | Collagenous foam materials | |
| CN108744065A (en) | A kind of tissue recovery support and its preparation method and application | |
| WO2012117739A1 (en) | Bone filling material | |
| CN112546299A (en) | 3D-printed artificial periosteum, artificial bone, artificial skeleton and preparation method thereof | |
| CN218793244U (en) | Degradable three-dimensional porous scaffold | |
| CN203138749U (en) | Artificial vertebral plate | |
| KR102611664B1 (en) | A medical device for cartilage regeneration-protection by mechanical stimulation and biodegradability |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| GR01 | Patent grant | ||
| GR01 | Patent grant |