CN102231951A - 用于核酸传递系统的可释放的偶联物 - Google Patents

用于核酸传递系统的可释放的偶联物 Download PDF

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Publication number
CN102231951A
CN102231951A CN200980145913XA CN200980145913A CN102231951A CN 102231951 A CN102231951 A CN 102231951A CN 200980145913X A CN200980145913X A CN 200980145913XA CN 200980145913 A CN200980145913 A CN 200980145913A CN 102231951 A CN102231951 A CN 102231951A
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China
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group
compound
cooh
ch2ch2o
alkyl
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CN200980145913XA
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English (en)
Chinese (zh)
Inventor
赵洪
夏靖
普拉莎娜·瑞迪
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Enzon Pharmaceuticals Inc
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Enzon Pharmaceuticals Inc
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Publication of CN102231951A publication Critical patent/CN102231951A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CN200980145913XA 2008-11-17 2009-11-17 用于核酸传递系统的可释放的偶联物 Pending CN102231951A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11532608P 2008-11-17 2008-11-17
US11535008P 2008-11-17 2008-11-17
US61/115,326 2008-11-17
US61/115,350 2008-11-17
PCT/US2009/064711 WO2010057154A1 (en) 2008-11-17 2009-11-17 Releasable conjugates for nucleic acids delivery systems

Publications (1)

Publication Number Publication Date
CN102231951A true CN102231951A (zh) 2011-11-02

Family

ID=42170405

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980145913XA Pending CN102231951A (zh) 2008-11-17 2009-11-17 用于核酸传递系统的可释放的偶联物

Country Status (7)

Country Link
US (1) US20110230420A1 (https=)
EP (1) EP2362729A1 (https=)
JP (1) JP2012509066A (https=)
CN (1) CN102231951A (https=)
CA (1) CA2742842A1 (https=)
TW (1) TW201029668A (https=)
WO (1) WO2010057154A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017025057A1 (en) * 2015-08-11 2017-02-16 Coherent Biopharma Multi-ligand drug conjugates and uses thereof
CN106466484A (zh) * 2015-08-11 2017-03-01 同宜医药开曼有限公司 一种具有细胞内吞介导功能的多靶向配体-药物偶联体
CN107629118A (zh) * 2017-10-31 2018-01-26 天津大学 基于组氨酸的靶向性穿膜肽载体及用途

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US10766928B2 (en) 2012-10-05 2020-09-08 The University Of Kansas Targeted conformationally-constrained kinked endosomal disrupting peptides
WO2014055754A1 (en) * 2012-10-05 2014-04-10 The University Of Kansas Conformationally-constrained kinked endosomal-disrupting peptides
US9365599B2 (en) 2012-10-26 2016-06-14 Korea Atomic Energy Research Institute N3S1 chelator-folate derivatives, preparation method thereof and composition for diagnosis or treatment of cancer containing the same as an active ingredient
EA037478B1 (ru) 2015-08-04 2021-04-01 Дьюк Юниверсити Генетически кодируемые внутренне неупорядоченные полимеры-"невидимки" для доставки и способы их применения
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
WO2018053201A1 (en) 2016-09-14 2018-03-22 Duke University Triblock polypeptide-based nanoparticles for the delivery of hydrophilic drugs
JP2020500150A (ja) 2016-09-23 2020-01-09 デューク ユニバーシティ 下限臨界溶液温度挙動を有する非反復かつ非構造的ポリペプチド
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
WO2019147954A1 (en) 2018-01-26 2019-08-01 Duke University Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same
EP3788343B1 (en) 2018-04-30 2024-03-27 Duke University Stimuli-responsive peg-like polymer-based drug delivery platform
US11649275B2 (en) 2018-08-02 2023-05-16 Duke University Dual agonist fusion proteins
US12594347B2 (en) 2018-09-07 2026-04-07 Duke University Nanoparticulate drug delivery systems
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
US20250297258A1 (en) * 2021-07-07 2025-09-25 Ractigen Therapeutics Oligonucleotide-based delivery vehicle for oligonucleotides agents and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008034124A2 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

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WO1999042091A2 (en) * 1998-02-19 1999-08-26 Massachusetts Institute Of Technology Use of polycations as endosomolytic agents
ATE427948T1 (de) * 2001-04-24 2009-04-15 Purdue Research Foundation Folat-mimetika und deren folatrezeptorbindende konjugate
AU2003225495B2 (en) * 2002-04-05 2009-01-15 Roche Innovation Center Copenhagen A/S Oligomeric compounds for the modulation HIF-1alpha expression
US7713738B2 (en) * 2003-02-10 2010-05-11 Enzon Pharmaceuticals, Inc. Oligomeric compounds for the modulation of survivin expression
WO2004106511A1 (ja) * 2003-05-30 2004-12-09 Nippon Shinyaku Co., Ltd. Ｂｃｌ−２の発現抑制をするオリゴ二本鎖ＲＮＡとそれを含有する医薬組成物
US20050261170A1 (en) * 2004-01-22 2005-11-24 Immunomedics, Inc. Folate conjugates and complexes
GB0415263D0 (en) * 2004-07-07 2004-08-11 Norwegian Radium Hospital Res Method
CN101060849A (zh) * 2004-11-17 2007-10-24 巴尔的摩马里兰大学 作为有效的siRNA载体的高分支HK肽
US20080206869A1 (en) * 2005-01-24 2008-08-28 Avaris Ab Nucleic Acid Complex
WO2008034123A2 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Polymeric conjugates containing positively-charged moieties

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008034124A2 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017025057A1 (en) * 2015-08-11 2017-02-16 Coherent Biopharma Multi-ligand drug conjugates and uses thereof
CN106466484A (zh) * 2015-08-11 2017-03-01 同宜医药开曼有限公司 一种具有细胞内吞介导功能的多靶向配体-药物偶联体
CN108135881A (zh) * 2015-08-11 2018-06-08 同宜医药开曼有限公司 多配体药物偶联体及其用途
CN108135881B (zh) * 2015-08-11 2020-11-13 同宜医药（苏州）有限公司 多配体药物偶联体及其用途
CN106466484B (zh) * 2015-08-11 2021-05-04 同宜医药（苏州）有限公司 一种具有细胞内吞介导功能的多靶向配体-药物偶联体
CN107629118A (zh) * 2017-10-31 2018-01-26 天津大学 基于组氨酸的靶向性穿膜肽载体及用途

Also Published As

Publication number Publication date
EP2362729A1 (en) 2011-09-07
WO2010057154A1 (en) 2010-05-20
US20110230420A1 (en) 2011-09-22
JP2012509066A (ja) 2012-04-19
TW201029668A (en) 2010-08-16
CA2742842A1 (en) 2010-05-20

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Application publication date: 20111102