CN102231951A - 用于核酸传递系统的可释放的偶联物 - Google Patents

用于核酸传递系统的可释放的偶联物 Download PDF

Info

Publication number
CN102231951A
CN102231951A CN200980145913XA CN200980145913A CN102231951A CN 102231951 A CN102231951 A CN 102231951A CN 200980145913X A CN200980145913X A CN 200980145913XA CN 200980145913 A CN200980145913 A CN 200980145913A CN 102231951 A CN102231951 A CN 102231951A
Authority
CN
China
Prior art keywords
group
compound
cooh
ch2ch2o
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200980145913XA
Other languages
English (en)
Chinese (zh)
Inventor
赵洪
夏靖
普拉莎娜·瑞迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzon Pharmaceuticals Inc
Original Assignee
Enzon Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzon Pharmaceuticals Inc filed Critical Enzon Pharmaceuticals Inc
Publication of CN102231951A publication Critical patent/CN102231951A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
CN200980145913XA 2008-11-17 2009-11-17 用于核酸传递系统的可释放的偶联物 Pending CN102231951A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11532608P 2008-11-17 2008-11-17
US11535008P 2008-11-17 2008-11-17
US61/115,326 2008-11-17
US61/115,350 2008-11-17
PCT/US2009/064711 WO2010057154A1 (en) 2008-11-17 2009-11-17 Releasable conjugates for nucleic acids delivery systems

Publications (1)

Publication Number Publication Date
CN102231951A true CN102231951A (zh) 2011-11-02

Family

ID=42170405

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980145913XA Pending CN102231951A (zh) 2008-11-17 2009-11-17 用于核酸传递系统的可释放的偶联物

Country Status (7)

Country Link
US (1) US20110230420A1 (https=)
EP (1) EP2362729A1 (https=)
JP (1) JP2012509066A (https=)
CN (1) CN102231951A (https=)
CA (1) CA2742842A1 (https=)
TW (1) TW201029668A (https=)
WO (1) WO2010057154A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017025057A1 (en) * 2015-08-11 2017-02-16 Coherent Biopharma Multi-ligand drug conjugates and uses thereof
CN106466484A (zh) * 2015-08-11 2017-03-01 同宜医药开曼有限公司 一种具有细胞内吞介导功能的多靶向配体-药物偶联体
CN107629118A (zh) * 2017-10-31 2018-01-26 天津大学 基于组氨酸的靶向性穿膜肽载体及用途

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014055754A1 (en) * 2012-10-05 2014-04-10 The University Of Kansas Conformationally-constrained kinked endosomal-disrupting peptides
US10766928B2 (en) 2012-10-05 2020-09-08 The University Of Kansas Targeted conformationally-constrained kinked endosomal disrupting peptides
US9365599B2 (en) 2012-10-26 2016-06-14 Korea Atomic Energy Research Institute N3S1 chelator-folate derivatives, preparation method thereof and composition for diagnosis or treatment of cancer containing the same as an active ingredient
JP6882782B2 (ja) 2015-08-04 2021-06-02 デューク ユニバーシティ 遺伝子コードされた本質的に無秩序な送達用ステルスポリマーおよびその使用方法
US11752213B2 (en) 2015-12-21 2023-09-12 Duke University Surfaces having reduced non-specific binding and antigenicity
WO2017210476A1 (en) 2016-06-01 2017-12-07 Duke University Nonfouling biosensors
RU2019110848A (ru) 2016-09-14 2020-10-15 Дьюк Юниверсити Наночастицы на основе триблочных полипептидов для доставки гидрофильных лекарственных средств
EP3515928B1 (en) 2016-09-23 2026-01-28 Duke University Unstructured non-repetitive polypeptides having lcst behavior
WO2018132732A1 (en) 2017-01-12 2018-07-19 Duke University Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly
WO2018213320A1 (en) 2017-05-15 2018-11-22 Duke University Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents
WO2019006374A1 (en) 2017-06-30 2019-01-03 Duke University ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS
US12296018B2 (en) 2018-01-26 2025-05-13 Duke University Albumin binding peptide-drug (AlBiPeD) conjugates and methods of making and using same
EP3788343B1 (en) 2018-04-30 2024-03-27 Duke University Stimuli-responsive peg-like polymer-based drug delivery platform
EP3829622A4 (en) 2018-08-02 2022-05-11 Duke University DOUBLE AGONIST FUSION PROTEINS
WO2020051541A1 (en) 2018-09-07 2020-03-12 Duke University Nanoparticulate drug delivery systems
US11512314B2 (en) 2019-07-12 2022-11-29 Duke University Amphiphilic polynucleotides
US20250297258A1 (en) * 2021-07-07 2025-09-25 Ractigen Therapeutics Oligonucleotide-based delivery vehicle for oligonucleotides agents and methods of use thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008034124A2 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999042091A2 (en) * 1998-02-19 1999-08-26 Massachusetts Institute Of Technology Use of polycations as endosomolytic agents
EP1389209B1 (en) * 2001-04-24 2009-04-08 Purdue Research Foundation Folate mimetics and folate-receptor binding conjugates thereof
WO2003085110A2 (en) * 2002-04-05 2003-10-16 Santaris Pharma A/S Oligomeric compounds for the modulation hif-1alpha expression
US7713738B2 (en) * 2003-02-10 2010-05-11 Enzon Pharmaceuticals, Inc. Oligomeric compounds for the modulation of survivin expression
EP1640452A4 (en) * 2003-05-30 2009-12-23 Nippon Shinyaku Co Ltd OLIGOBICATENARY RNA INHIBITING BCL-2 EXPRESSION AND MEDICINAL COMPOSITION CONTAINING THE SAME
AU2005207026A1 (en) * 2004-01-22 2005-08-04 Immunomedics, Inc. Folate conjugates and complexes
GB0415263D0 (en) * 2004-07-07 2004-08-11 Norwegian Radium Hospital Res Method
AU2005310131A1 (en) * 2004-11-17 2006-06-08 University Of Maryland, Baltimore Highly branched HK peptides as effective carriers of siRNA
EP1841867A1 (en) * 2005-01-24 2007-10-10 Avaris AB COMPLEX CONTAINING SiRNA, ShRNA OR ANTISENSE MOLECULE AND FUNCTIONAL ENTITY, FOR IMPROVED SPECIFICITY AND DELIVERY
EP2076257A4 (en) * 2006-09-15 2014-04-16 Belrose Pharma Inc POLYMER CONJUGATES WITH POSITIVELY LOADED PARTS

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008034124A2 (en) * 2006-09-15 2008-03-20 Enzon Pharmaceuticals, Inc. Targeted polymeric prodrugs containing multifunctional linkers
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017025057A1 (en) * 2015-08-11 2017-02-16 Coherent Biopharma Multi-ligand drug conjugates and uses thereof
CN106466484A (zh) * 2015-08-11 2017-03-01 同宜医药开曼有限公司 一种具有细胞内吞介导功能的多靶向配体-药物偶联体
CN108135881A (zh) * 2015-08-11 2018-06-08 同宜医药开曼有限公司 多配体药物偶联体及其用途
CN108135881B (zh) * 2015-08-11 2020-11-13 同宜医药（苏州）有限公司 多配体药物偶联体及其用途
CN106466484B (zh) * 2015-08-11 2021-05-04 同宜医药（苏州）有限公司 一种具有细胞内吞介导功能的多靶向配体-药物偶联体
CN107629118A (zh) * 2017-10-31 2018-01-26 天津大学 基于组氨酸的靶向性穿膜肽载体及用途

Also Published As

Publication number Publication date
JP2012509066A (ja) 2012-04-19
TW201029668A (en) 2010-08-16
EP2362729A1 (en) 2011-09-07
WO2010057154A1 (en) 2010-05-20
US20110230420A1 (en) 2011-09-22
CA2742842A1 (en) 2010-05-20

Similar Documents

Publication Publication Date Title
CN102231951A (zh) 用于核酸传递系统的可释放的偶联物
US20110105413A1 (en) Polymeric systems containing intracellular releasable disulfide linker for the delivery of oligonucleotides
TW201021853A (en) Releasable cationic lipids for nucleic acids delivery systems
US20090202573A1 (en) Polymeric conjugates containing positively-charged moieties
TW201019969A (en) Branched cationic lipids for nucleic acids delivery system
US20110305770A1 (en) Releasable polymeric lipids for nucleic acids delivery system
CN102215820A (zh) 用于核酸输送系统的可释放融合脂质
US20110111044A1 (en) Nanoparticle compositions for nucleic acids delivery system
JP2010510810A (ja) ポリマー低分子干渉ｒｎａ複合体
WO2023029928A1 (zh) 一种氨基脂质及其应用
JP2023504186A (ja) 標的化された核酸送達のためのペプチドドッキング賦形剤
CN110650742A (zh) 使用经结构强化的S-TuD的新的癌症治疗方法
CN101516362A (zh) 含有带正电荷部分的聚合物的缀合物
CZ430399A3 (cs) Nová třída kationtových činidel pro přenos nukleových kyselin a farmaceutické prostředky, které je obsahují

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20111102