CN102231950A - 用于核酸递送系统的可释放聚合脂质 - Google Patents

用于核酸递送系统的可释放聚合脂质 Download PDF

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Publication number
CN102231950A
CN102231950A CN2009801458902A CN200980145890A CN102231950A CN 102231950 A CN102231950 A CN 102231950A CN 2009801458902 A CN2009801458902 A CN 2009801458902A CN 200980145890 A CN200980145890 A CN 200980145890A CN 102231950 A CN102231950 A CN 102231950A
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China
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substituted
group
compound
alkyl radical
nhc
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CN2009801458902A
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English (en)
Chinese (zh)
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赵洪
彦魏丽
史连军
乌德春
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Enzon Pharmaceuticals Inc
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Enzon Pharmaceuticals Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/46—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/49—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a carbon atom of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyethers (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
CN2009801458902A 2008-11-17 2009-11-17 用于核酸递送系统的可释放聚合脂质 Pending CN102231950A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11537108P 2008-11-17 2008-11-17
US11537908P 2008-11-17 2008-11-17
US61/115,371 2008-11-17
US61/115,379 2008-11-17
PCT/US2009/064701 WO2010057150A1 (en) 2008-11-17 2009-11-17 Releasable polymeric lipids for nucleic acids delivery systems

Publications (1)

Publication Number Publication Date
CN102231950A true CN102231950A (zh) 2011-11-02

Family

ID=42170403

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801458902A Pending CN102231950A (zh) 2008-11-17 2009-11-17 用于核酸递送系统的可释放聚合脂质

Country Status (7)

Country Link
US (1) US20110305770A1 (https=)
EP (1) EP2362728A1 (https=)
JP (1) JP2012509366A (https=)
CN (1) CN102231950A (https=)
CA (1) CA2742838A1 (https=)
TW (1) TW201023914A (https=)
WO (1) WO2010057150A1 (https=)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106795096A (zh) * 2014-06-25 2017-05-31 爱康泰生治疗公司 用于递送核酸的新型脂质和脂质纳米颗粒制剂
CN108472358A (zh) * 2015-09-30 2018-08-31 盐野义制药株式会社 具有免疫赋活活性的核酸衍生物
CN109251150A (zh) * 2018-11-02 2019-01-22 宁夏医科大学 一种2,3-二氨基丙酸甲酯的制备方法
CN114634927A (zh) * 2020-12-15 2022-06-17 大邱加图立大学校产学协力团 抑制HIF-1α和STAT5转录因子的合成诱骗寡核苷酸及含有它的药物组合物
WO2022170835A1 (zh) * 2021-02-09 2022-08-18 中山大学 可电离的阳离子脂质类似物材料在作为核酸药物递送载体或转染试剂中的应用
WO2023142168A1 (zh) * 2022-01-27 2023-08-03 中山大学 阳离子脂质类似物在基因编辑核糖核蛋白复合物胞内递送中的应用

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US8450290B2 (en) * 2007-11-26 2013-05-28 Enzon Pharmaceuticals, Inc. Methods for treating androgen receptor dependent disorders including cancers
TW201019969A (en) * 2008-11-17 2010-06-01 Enzon Pharmaceuticals Inc Branched cationic lipids for nucleic acids delivery system
AU2012296950B2 (en) * 2011-08-12 2016-09-22 Ascendis Pharma A/S Polymeric hyperbranched carrier-linked prodrugs
EP2581448B1 (en) * 2011-10-13 2015-01-28 Association Institut de Myologie Tricyclo-phosphorothioate DNA
EP2788006B1 (en) 2011-12-07 2026-01-07 Alnylam Pharmaceuticals, Inc. Biodegradable lipids for the delivery of active agents
US20180303925A1 (en) 2015-04-27 2018-10-25 The Trustees Of The University Of Pennsylvania Nucleoside-Modified RNA For Inducing an Adaptive Immune Response
LT3313829T (lt) 2015-06-29 2024-08-12 Acuitas Therapeutics Inc. Lipidai ir lipidų nanodalelių sudėtys, skirtos nukleorūgščių tiekimui
US10940201B2 (en) 2015-09-30 2021-03-09 Shionogi & Co., Ltd. Nucleic acid derivative having immunostimulatory activity
EP3357514B1 (en) 2015-09-30 2021-04-14 NOF Corporation Lipid derivative in which hydrophilic polymer is bound via cyclic benzylidene acetal linkers
IL307179A (en) 2015-10-28 2023-11-01 Acuitas Therapeutics Inc Novel lipids and lipid nanoparticle formulations for delivery of nucleic acids
US12491261B2 (en) 2016-10-26 2025-12-09 Acuitas Therapeutics, Inc. Lipid nanoparticle formulations
WO2018132537A1 (en) 2017-01-11 2018-07-19 The Trustees Of The University Of Pennsylvania Nucleoside-modified rna for inducing an immune response against zika virus
WO2018191657A1 (en) 2017-04-13 2018-10-18 Acuitas Therapeutics, Inc. Lipids for delivery of active agents
WO2018200943A1 (en) 2017-04-28 2018-11-01 Acuitas Therapeutics, Inc. Novel carbonyl lipids and lipid nanoparticle formulations for delivery of nucleic acids
CA3073020A1 (en) 2017-08-16 2019-02-21 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
WO2019036028A1 (en) 2017-08-17 2019-02-21 Acuitas Therapeutics, Inc. LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS
US11524932B2 (en) 2017-08-17 2022-12-13 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
EP3668834B1 (en) 2017-08-17 2024-10-02 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
IL281615B2 (en) 2018-09-21 2026-01-01 Acuitas Therapeutics Inc Systems and methods for producing lipid nanoparticles and liposomes
US11141491B2 (en) * 2018-10-15 2021-10-12 National Yang Ming Chiao Tung University PH-sensitive lipid nanoparticles for encapsulation of anticancer drugs and microRNA and use thereof
JP7543259B2 (ja) 2018-10-18 2024-09-02 アクイタス セラピューティクス インコーポレイテッド 活性剤の脂質ナノ粒子送達のための脂質
MY202837A (en) 2019-01-11 2024-05-24 Acuitas Therapeutics Inc Lipids for lipid nanoparticle delivery of active agents
WO2022016070A1 (en) 2020-07-16 2022-01-20 Acuitas Therapeutics, Inc. Cationic lipids for use in lipid nanoparticles
CA3211623A1 (en) 2021-05-24 2022-12-01 Bo YING Lipid compounds and lipid nanoparticle compositions
CA3233490A1 (en) * 2021-09-28 2023-04-06 The Trustees Of The University Of Pennsylvania Compositions and methods for t cell targeted delivery of therapeutic agents
EP4408437A4 (en) * 2021-10-01 2025-08-27 Univ Pennsylvania LIPID NANOPARTICLE (LNP) COMPOSITIONS AND METHODS OF USE THEREOF
US20250127719A1 (en) * 2021-12-07 2025-04-24 The Trustees Of The University Of Pennsylvania Anisamide-containing lipids and compositions and methods of use thereof
CA3242402A1 (en) 2021-12-16 2023-06-22 Acuitas Therapeutics, Inc. Lipids for use in lipid nanoparticle formulations
CN114699997B (zh) * 2022-03-28 2022-11-25 山东大学 一种具有高抗盐性的碱基@囊泡复合体及其制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009002855A (es) * 2006-09-15 2009-03-30 Enzon Pharmaceuticals Inc Profarmacos polimericos dirigidos que contienen enlazadores multifuncionales.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008137758A2 (en) * 2007-05-04 2008-11-13 Mdrna, Inc. Amino acid lipids and uses thereof

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106795096A (zh) * 2014-06-25 2017-05-31 爱康泰生治疗公司 用于递送核酸的新型脂质和脂质纳米颗粒制剂
CN106795096B (zh) * 2014-06-25 2020-05-29 爱康泰生治疗公司 用于递送核酸的新型脂质和脂质纳米颗粒制剂
CN108472358A (zh) * 2015-09-30 2018-08-31 盐野义制药株式会社 具有免疫赋活活性的核酸衍生物
CN108472358B (zh) * 2015-09-30 2022-06-24 盐野义制药株式会社 具有免疫赋活活性的核酸衍生物
CN109251150A (zh) * 2018-11-02 2019-01-22 宁夏医科大学 一种2,3-二氨基丙酸甲酯的制备方法
CN109251150B (zh) * 2018-11-02 2021-07-30 宁夏医科大学 一种2，3-二氨基丙酸甲酯的制备方法
CN114634927A (zh) * 2020-12-15 2022-06-17 大邱加图立大学校产学协力团 抑制HIF-1α和STAT5转录因子的合成诱骗寡核苷酸及含有它的药物组合物
WO2022170835A1 (zh) * 2021-02-09 2022-08-18 中山大学 可电离的阳离子脂质类似物材料在作为核酸药物递送载体或转染试剂中的应用
WO2023142168A1 (zh) * 2022-01-27 2023-08-03 中山大学 阳离子脂质类似物在基因编辑核糖核蛋白复合物胞内递送中的应用

Also Published As

Publication number Publication date
EP2362728A1 (en) 2011-09-07
WO2010057150A8 (en) 2011-01-06
JP2012509366A (ja) 2012-04-19
CA2742838A1 (en) 2010-05-20
WO2010057150A1 (en) 2010-05-20
US20110305770A1 (en) 2011-12-15
TW201023914A (en) 2010-07-01

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Application publication date: 20111102