CN102228621B - Astragalus and betel nut mixture - Google Patents
Astragalus and betel nut mixture Download PDFInfo
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- CN102228621B CN102228621B CN 201110171966 CN201110171966A CN102228621B CN 102228621 B CN102228621 B CN 102228621B CN 201110171966 CN201110171966 CN 201110171966 CN 201110171966 A CN201110171966 A CN 201110171966A CN 102228621 B CN102228621 B CN 102228621B
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Abstract
The invention relates to an astragalus and betel nut mixture which is prepared from the following bulk drugs in parts by weight: 0.5-1.5 parts of astragalus, 0.5-1.5 parts of betel nut, 1.5-2.5 parts of snakegourd fruit and 1.5-2.5 parts of fragrant solomonseal rhizome. The astragalus and betel nut mixture has the advantages of less dosage and common and readily available medicaments; the medicaments are easily used, can be taken only through decoction and are convenient to popularize and use in ordinary families; the mixture has an obvious therapeutic effect; normal power of the colon can berestored; and the problem of chronic functional constipation can be substantially solved.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of the chronic functional constipation disease, specifically, is the bulky mixture of a kind of stilbene.
Background technology
Chronic functional constipation (Chronic Functional Constipation CFC) mainly is to defecate to discharge difficulty, defecation sense of discomfort and defecation time and be extended for cardinal symptom, without the organic change of intestinal, and the syndrome of other systemic diseases, its sickness rate has rising trend in recent years.Canadian sickness rate is 14.9% according to the literature, and women's prevalence is 2 times of male.Domestic report sickness rate is lower than this, and Beijing scholar reports that sickness rate is 6.07%.Because constipation and cardiovascular and other system's acute disease are in close relations, even fall ill relevantly with rectal cancer, thereby more and more be subjected to the attention of vast Chinese scholars.
The pathogenesis of CFC is complicated, its cause of disease is still indeterminate, think age, sex, living and diet custom at present, Nervous and Mental Factors, enteric nervous system is unusual, and the gastrointestinal peptide parahormone distributes unusual, intestinal smooth muscle dysfunction, the Cajal Interstitial cell is unusual, and alteration of intestinal flora has dependency in the constipation morbidity.Think that simultaneously the intestinal peptide hormone has important function in the formation of constipation.The diagnosis of CFC is mainly based on clinical symptoms and get rid of organic disease, and Rome II standard is the diagnostic criteria of at present internationally recognized more perfect CFC.Take Comprehensive Treatment at present, comprise diet, psychotherapy, Drug therapy, acupuncture and biofeedback therapy etc.Drug therapy is as most common therapeutic method, so that the choose reasonable medication seems is particularly important.
In recent years, the research of Chinese medicine CFC is increasing, majority is limited to the clinical observation on the therapeutic effect aspect, treatment to be adopted " to rush down; with logical be usefulness " method, not satisfactory to chronic constipation patient's late result, be prone to cathartic colon and colon and deceive change, thereby increase the weight of the state of an illness, inquire into less to its Its Mechanisms.
Chinese patent literature CN 1262116A, open day on August 9th, 2000, denomination of invention is the Chinese patent medicine for the treatment of intractable and habitual constipation, this disclosure of the Invention a kind of Chinese patent medicine for the treatment of intractable and habitual constipation, it is to be raw material with the Radix Astragali, Radix Angelicae Sinensis, Semen Persicae, Radix Curcumae, Cortex Moutan, the Radix Aucklandiae, Fructus Crataegi, Fructus Trichosanthis, Semen Arecae, Fructus Aurantii, Radix Scutellariae, Radix Et Rhizoma Rhei, Rhizoma Coptidis, Pericarpium Citri Reticulatae, Fructus Citri Sarcodactylis, and honeyed pill is made in its pulverizing.This invention can be played the effect for the treatment of intractable and habitual constipation to a certain extent, but this invention dosage is big, the cost height, and not remarkable to the chronic functional constipation curative effect.
Therefore, need badly and want a kind of medication few, the medicine of therapeutic effect can be arranged chronic functional constipation, but about this medicine, yet there are no report.
Summary of the invention
The objective of the invention is at deficiency of the prior art, provide a kind of stilbene bulky mixture.
For achieving the above object, the technical scheme that the present invention takes is: the bulky mixture of a kind of stilbene, the bulky mixture of described stilbene is to be made by following bulk drugs: Radix Astragali 0.5-1.5 part, Semen Arecae 0.5-1.5 part, Fructus Trichosanthis 1.5-2.5 part, Rhizoma Polygonati Odorati 1.5-2.5 part.
The bulky mixture of described stilbene is to be made by following bulk drugs: Radix Astragali 0.8-1.2 part, Semen Arecae 0.8-1.2 part, Fructus Trichosanthis 1.8-2.2 part, Rhizoma Polygonati Odorati 1.8-2.2 part.
The bulky mixture of described stilbene is to be made by following bulk drugs: 1 part of the Radix Astragali, 1 part of Semen Arecae, 2 parts of Fructus Trichosanthis, 2 parts of Rhizoma Polygonati Odorati.
The bulky mixture of described stilbene also comprises Fructus Aurantii Immaturus 0.5-1.5 part.
The bulky mixture of described stilbene also comprises Herba cassiae occidentalis 1.5-2.5 part.
The bulky mixture of described stilbene also comprises Rhizoma Anemarrhenae 0.5-1.5 part.
The bulky mixture of described stilbene is used in preparation treatment chronic functional constipation disease.
The invention has the advantages that:
1, dosage of the present invention is few, and medicine is common, obtains conveniently;
2, drug use method of the present invention is simple, only needs decocting to take, and is convenient to average family and promotes the use of;
3, the present invention is evident in efficacy, can recover the normal power of colon, fundamentally solves the problem of chronic functional constipation.
The specific embodiment
Below in conjunction with embodiment the specific embodiment provided by the invention is elaborated.
Embodiment 1
No. 1, the bulky mixture of stilbene
Get the Radix Astragali 5 grams, Semen Arecae 5 grams, Fructus Trichosanthis 15 grams, Rhizoma Polygonati Odorati 15 grams add water 500ml and decoct, and are standby.
Embodiment 2
No. 2, the bulky mixture of stilbene
Get the Radix Astragali 15 grams, Semen Arecae 15 grams, Fructus Trichosanthis 30 grams, Rhizoma Polygonati Odorati 30 grams add water 500ml and decoct, and are standby.
Embodiment 3
No. 3, the bulky mixture of stilbene
Get the Radix Astragali 15 grams, Semen Arecae 15 grams, Fructus Trichosanthis 45 grams, Rhizoma Polygonati Odorati 45 grams add water 500ml and decoct, and are standby.
Embodiment 4
No. 4, the bulky mixture of stilbene
Get the Radix Astragali 15 grams, Semen Arecae 15 grams, Fructus Trichosanthis 30 grams, Rhizoma Polygonati Odorati 30 grams, Fructus Aurantii Immaturus 15 grams add water 500ml and decoct, and are standby.
Embodiment 5
No. 5, the bulky mixture of stilbene
Get the Radix Astragali 15 grams, Semen Arecae 15 grams, Fructus Trichosanthis 30 grams, Rhizoma Polygonati Odorati 30 grams, Fructus Aurantii Immaturus 15 grams, Herba cassiae occidentalis 30 grams add water 500ml and decoct, and are standby.
Embodiment 6
No. 6, the bulky mixture of stilbene
Get the Radix Astragali 15 grams, Semen Arecae 15 grams, Fructus Trichosanthis 30 grams, Rhizoma Polygonati Odorati 30 grams, Fructus Aurantii Immaturus 15 grams, Herba cassiae occidentalis 30 grams, the Rhizoma Anemarrhenae 15 grams add water 500ml and decoct, and are standby.
Embodiment 7
The clinical trial of the bulky mixture of stilbene
1, test material
Trial drug: Chinese medicinal granule (Radix Astragali, Semen Arecae, Fructus Trichosanthis, Rhizoma Polygonati Odorati, Fructus Aurantii Immaturus etc.) is available from common Chinese market.
No. 2, the bulky mixture of stilbene: the Radix Astragali, Semen Arecae, Fructus Trichosanthis, Rhizoma Polygonati Odorati (adopting embodiment 2 preparation gained medicines).
No. 4, the bulky mixture of stilbene: the Radix Astragali, Semen Arecae, Fructus Trichosanthis, Rhizoma Polygonati Odorati, Fructus Aurantii Immaturus (adopting embodiment 4 preparation gained medicines).
No. 6, the bulky mixture of stilbene: the Radix Astragali, Semen Arecae, Fructus Trichosanthis, Rhizoma Polygonati Odorati, Fructus Aurantii Immaturus, Herba cassiae occidentalis, the Rhizoma Anemarrhenae (adopting embodiment 6 preparation gained medicines).
The Chinese patent medicine MAREN RUANJIAONANG: Arstwyth (Foshan) pharmaceutical Co. Ltd produces.
Case is selected:
The case choice criteria:
(1) according to Rome II standard, get rid of the constipation that intestinal itself and whole body organic disease cause, and continue in 12 months in the past or accumulate at least 12 weeks following symptom more than 2 or 2 to occur:
1.〉1/4 time defecation effort;
2.〉1/4 time feces is agglomerate or scleroma;
3.〉1/4 time defecation is felt not to the utmost;
4.〉time of 1/4 during defecation anus block sense or anal orifice and rectal intestine blocks;
5.〉1/4 time defecation needs to help with Handball Association;
6. defecation＜3 time weekly;
(2) age is more than 15 one full year of life;
(3) all selected patients in one week without the other medicines treatment, can partner treatment take one the course for the treatment of person.
Case grouping: select 80 routine patients, be divided into Chinese drug-treated group and Chinese patent medicine MAREN RUANJIAONANG matched group at random, wherein Chinese medicinal components is three groups, the bulky mixture of stilbene is the A group No. 2, the bulky mixture of stilbene is the B group No. 4, and the bulky mixture of stilbene is the C group No. 6, and every group all has 20 people, all observation items are responsible for filling in by case collection personnel, and signature.
2, medication
No. 6, three groups of Chinese drug-treated group A, B, C take the bulky reagent of isodose stilbene respectively No. 2, No. 4, the bulky mixture of stilbene and the bulky mixture of stilbene taken each group medicine after with the equivalent decocting to the patient, day obey potion, oral at twice, matched group gives Chinese patent medicine MAREN RUANJIAONANG, 1.6g/ time, every day twice, treated for 4 weeks altogether.Period in a medicine is stopped using other relevant Chinese and Western relieving constipation medicines.
3, observation index
Main clinic symptoms comprises the blanking time of defecating, and defecation time, anus block sense, defecation effort, the stool character, abdominal distention stomachache, defecation are felt not to the utmost and are waited six, before the medication and one week of medication, two weeks, the patient goes to a doctor all around, and the same day, each recorded once to symptom integral by the record keeping personnel.
Clinicing symptom observation adopts quantitative integration to mark, and concrete integration standard is as follows:
Defecate blanking time: 0 fen defecation time interval≤24h
1 fen 24＜defecation time interval≤48h
2 fens 48＜defecation time interval≤72h
3 fens defecation times are at interval〉72h
Defecation time: 0 minute≤5 minutes
1 fen 5＜defecation time≤10 minute
2 fens 10＜defecation time≤20 minute
3 minutes〉20 minutes
Anus blocks sense or the defecation effort did not have in 0 minute
Idol had anus to block sense in 1 minute, and slightly firmly stool can be discharged
Had anus to block sense in 2 minutes, the stool of requiring great effort could be discharged
Anus blocked sense obviously in 3 minutes, and the defecation effort need help and could discharge with hands or other ways
The soft molding of excrement in 0 fen of stool character
Feces was dry slightly in 1 minute
Feces scleroma in 2 fens, but slivering
Feces was dry and hard in 3 minutes, was sheep stool shape or chestnut shape
Abdominal distention, stomachache did not have in 0 minute
Idol had in 1 minute, and is slight, but spontaneous remission
2 minutes more obvious, alleviates behind the defecation
Obviously still had sense of discomfort behind the defecation in 3 minutes
Defecation is felt 0 fen nothing not to the utmost
By chance having defecation to feel not to the utmost in one hour in 1 minute can disappear
2 timesharing have defecation to feel not to the utmost in half day can to disappear
3 fens defecations are felt lasting not to the utmost and are not understood
4, efficacy assessment standard
Clinical cure: stool is normal, and the stool malaise symptoms all disappears, and integration reduces by 〉=2 ∕ before the treatment;
Produce effects: constipation obviously improves, and the stool malaise symptoms is most of to disappear, and integration reduces by 〉=1 ∕ before the treatment;
Effectively: the constipation situation makes moderate progress, and the stool malaise symptoms take a favorable turn, and integration treatment reduces by 〉=1 ∕;
Invalid: constipation and stool malaise symptoms all do not have improvement, and integration reduces 1 ∕, 3 following persons before the treatment.
5, statistical method
Use SPSS14.0 software to add up measurement data
± SD represents, relatively adopts one-way ANOVA check between group, relatively adopts paired t-test before and after the treatment; Enumeration data adopts
2Check, P＜0.05 is for there being statistical significance.
6, result
Through treatment and the observation in 4 weeks, as can be seen from Table 1:
Four groups of patients divide relatively indifference (P〉0.05) in the treatment foreset.Receive treatment after 4 weeks, each symptom integral of Chinese drug-treated group and matched group patient all has remarkable decline (P＜0.01), and defecate blanking time, defecation time, defecation effort, stool character, abdominal distention stomachache, defecation of most of patient symptom such as felt not to the utmost and all had and alleviate or disappear; Overall symptom integral reduces the amplitude Chinese drug-treated group and obviously is better than matched group (P=0.015), and statistical significance is arranged.
Table 1. Chinese drug-treated group and treatment group symptom integral are relatively
( ± SD)
As can be seen from Table 2:
Chinese drug-treated group 60 routine patients, total effective 58 examples, invalid two examples, effective percentage 96.67%; Matched group 20 examples, total effective 13 examples, effective percentage 65%, both are through x
2Check has statistical significance (P＜0.05), and illustrating that the bulky mixture of stilbene has improves the symptom effect preferably, and defecating feces excretion is better than the Chinese patent medicine MAREN RUANJIAONANG.
Table 2. clinical efficacy situation is (%) relatively
| Group | The example number | Clinical recovery | Produce effects | Effectively | Invalid | Total effective rate |
| The treatment group | 60 | 30（50.00） | 18（30.00） | 10（16.67） | 2（3.33） | 58（96.67） |
| Matched group | 20 | ?7（35.00） | 4（20.00） | 2（10.00） | 7（35.00） | 13（65.00） |
As can be seen from Table 3:
In Chinese drug-treated group, three groups of most of patients of A, B, C defecate and symptom such as feel blanking time, defecation time, defecation effort, stool character, abdominal distention stomachache, defecation not to the utmost and all have and alleviate or disappear, and integration comparison indifference between each group (P〉0.05), illustrate that A, B, three groups of medicines of C all can produce curative effect to the chronic functional constipation disease, and A group contained drug is the main composition that plays curative effect.
Table 3. Chinese drug-treated group is respectively organized symptom integral relatively
( 
± SD)
Table 3 is continuous. and Chinese drug-treated group is respectively organized symptom integral relatively
( 
± SD)
7, conclusion
By experimental result is analyzed, can reach a conclusion: for chronic functional constipation disease patient, the bulky mixture of Chinese drug-treated group stilbene of the present invention and matched group Chinese patent medicine MAREN RUANJIAONANG all can play certain curative effect, but Chinese patent medicine MAREN RUANJIAONANG drug effect is not obvious, and effective percentage is not high, and in addition, this Chinese patent medicine MAREN RUANJIAONANG price is more expensive, patient's use cost is bigger, and the bulky mixture of Chinese drug-treated group stilbene of the present invention is evident in efficacy, and medicament sources is extensive, and cost is low, take also easily, be fit to promote the use of; Chinese drug-treated group A, B, three groups of medicines of C all produce significant curative effect to the patient, and it is little respectively to organize the curative effect difference, but A group medication composition is less than B group and C group, therefore, can determine that A group Chinese medicine is the main component that plays therapeutic effect, and the bulky mixture of the stilbene under this ratio can reach optimum curative effect.
The above only is preferred implementation of the present invention; should be pointed out that for those skilled in the art, under the prerequisite that does not break away from the inventive method; can also make some improvement and replenish, these improvement and replenish and also should be considered as protection scope of the present invention.
Claims (2)
1. the bulky mixture of stilbene that is used for the treatment of the chronic functional constipation disease is characterized in that the bulky mixture of described stilbene is to be made by following bulk drugs: 1 part of the Radix Astragali, 1 part of Semen Arecae, 2 parts of Fructus Trichosanthis, 2 parts of Rhizoma Polygonati Odorati.
2. the bulky mixture of stilbene that is used for the treatment of the chronic functional constipation disease is characterized in that the bulky mixture of described stilbene is to be made by following bulk drugs: 1 part of the Radix Astragali, 1 part of Semen Arecae, 2 parts of Fructus Trichosanthis, 2 parts of Rhizoma Polygonati Odorati, 1 part of Fructus Aurantii Immaturus.
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| CN 201110171966 CN102228621B (en) | 2011-06-24 | 2011-06-24 | Astragalus and betel nut mixture |
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| CN102228621B true CN102228621B (en) | 2013-09-18 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112528A (en) * | 2007-08-29 | 2008-01-30 | 北京艺信堂医药研究所 | Chinese traditional medicine preparations for treating postpartum constipation |
| CN101647921A (en) * | 2009-09-09 | 2010-02-17 | 苏州世林医药技术发展有限公司 | Traditional Chinese medicine composition for preventing and treating peptic ulcer and chronic gastritis |
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2011
- 2011-06-24 CN CN 201110171966 patent/CN102228621B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101112528A (en) * | 2007-08-29 | 2008-01-30 | 北京艺信堂医药研究所 | Chinese traditional medicine preparations for treating postpartum constipation |
| CN101647921A (en) * | 2009-09-09 | 2010-02-17 | 苏州世林医药技术发展有限公司 | Traditional Chinese medicine composition for preventing and treating peptic ulcer and chronic gastritis |
Non-Patent Citations (10)
| Title |
|---|
| > * |
| < * |
| .2008,第35卷(第7期),1043-1045. * |
| .2010,全文. * |
| 李毅平等.芪榔合剂治疗慢性功能性便秘疗效观察.< * |
| 李毅平等.芪榔合剂治疗慢性功能性便秘疗效观察.<<辽宁中医杂志>>.2008,第35卷(第7期),1043-1045. |
| 辽宁中医杂志> * |
| 辽宁中医药大学硕士学位论文> * |
| 马晓敏.田振国教授治疗慢性功能性便秘的经验总结.< * |
| 马晓敏.田振国教授治疗慢性功能性便秘的经验总结.<<辽宁中医药大学硕士学位论文>>.2010,全文. |
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