CN102220224A - Automatic medical cell separation device - Google Patents
Automatic medical cell separation device Download PDFInfo
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- CN102220224A CN102220224A CN2011101313940A CN201110131394A CN102220224A CN 102220224 A CN102220224 A CN 102220224A CN 2011101313940 A CN2011101313940 A CN 2011101313940A CN 201110131394 A CN201110131394 A CN 201110131394A CN 102220224 A CN102220224 A CN 102220224A
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Abstract
The invention belongs to the technical field of cell separation, and particularly discloses an automatic medical cell separation device which comprises a separation tube. The separation tube is internally provided with a transmission rod, the transmission rod is provided with a structure which can extrude and crush or smash a medical cell, the top end of the transmission rod is connected with a driving motor, and an outlet is arranged on the bottom part of the separation tube and is provided with a plug cover. By the medical cell separation device, a large cell tissue can be conveniently and easily extruded and crushed or smashed into cell particles, the operation process of cell separation of the separation device and an operation can be simultaneously carried out in an operating room, nonnutritive time after the medical cell separation can be effectively shortened, pollution opportunities and harms of the cell can be reduced, and the quality control of the cell treatment can be convenient; simultaneously, the storage and transportation of samples are greatly convenient, the standard operation can be carried out, and the repeatability of a research can be increased; and automation control and personalized customization can be carried out according to different tissue cells, so that the use is simple and convenient.
Description
Technical field
The invention belongs to medical cell separation technology field.Be particularly related to a kind of medical cell automatic separating apparatus.
Background technology
At present,, the tissue of bulk need be become the fine granularity cell when extracting medical cell in the tissue (as lymphoglandula, spleen, liver and tumor tissues etc.) that cuts from operation, carry out cellular segregation and cultivation then in the cell field of medical technology.In the prior art, way commonly used is: after the tissue block that obtains during operation need be taken Cytology Lab, the tissue of bulk is shredded into cell granulations with scissors, separate and cultivate.Because the sepn process of cell is not in operation or carries out in Operation theatre, could handle but need be transferred to another Cytology Lab, the no nutrition overlong time that medical cell is exsomatized, but also increased the chance that medical cell pollutes in transfer and transportation.Above-mentioned situation all increases medical cells injury and may cause medical cellular segregation and cultivate failure, influences the carrying out of cell diagnosis and treatment.In addition, manual operation has increased the chance of operate miss and crossed contamination, is unfavorable for the quality control of cell medical treatment.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, a kind of medical cell automatic separating apparatus is provided, and the operating process of this medical cell automatic separating apparatus can be carried out simultaneously in Operation theatre and operation, has shortened the no nutrition time after medical cell exsomatizes greatly, reduce opportunities for contamination, reduce damage; In addition, it is convenient to the storage and transport of sample, but but also normalizing operation increases the repeatability of research, can also the pair cell medical treatment carry out quality control effectively simultaneously.
In order to solve the problems of the technologies described above, the present invention realizes by following technical scheme:
A kind of medical cell automatic separating apparatus of the present invention, comprise separator tube, cooperate in the described separator tube and be provided with a transmission rod, this transmission rod is provided with the structure that medical cell extruding is pulverized or smashed, the end of described transmission rod is connected with the small-sized drive-motor of rotation rate-controllable, the bottom of described separator tube is provided with outlet, and this outlet is provided with a gag.
As the further improvement of above-mentioned technology, described transmission rod is a plunger tpe barred body structure, and the structure of on the described transmission rod medical cell being pulverized is that the bottom surface that is located at the transmission rod is rough dentation.The bottom surface of described separator tube is an arc, corresponding with it, the bottom of described transmission rod also is an arc.
In addition, when the mode that adopts extruding to pulverize is pulverized medical cell, the bottom of described separator tube is fixed with a controlled pressurizing device, by the pressure between control separator tube bottom and the transmission rod, adapt to different tissues such as bone source sex organization effectively, liver cancer and lymph node tissue etc. extract the needs of medical cell.On the other hand, controlled pressurizing device also can be arranged at the transmission rod the other end to reach identical pressurization.
Another kind distortion as above-mentioned technology, among the present invention, it is the set of blades that is fixed on transmission rod bottom that medical cell also can carry out the structure that cell is smashed that described transmission rod is provided with by the mode of smashing, drive-motor drives the transmission rod and rotates, and then drive set of blades medical cell is broken into particulate state, control medical cell granulations size by the rotating speed size of control drive-motor.
In the present invention, described separator tube bottom is provided with by heat sink material makes the permanent seat that is used for fixing the separator tube bottom, can reduce the heat of milling or producing when smashing by the thermal conduction of heat sink material, reduces the damage of pair cell.
In the present invention, the gag of described separator tube outlet at bottom mill or smash end after can insert communicating pipe or the interface tube that is connected and replace, this communicating pipe be connected medical cellular segregation culturing bottle and be communicated with, mill or smash after histocyte by entering medical cellular segregation culturing bottle this communicating pipe.Owing to mill or smash and switching process is carried out in airtight space, can prevent from effectively to pollute.
In the present invention, the rotating speed of described drive-motor, the pressure of controlled pressurizing device and the radiating control of permanent seat can be set and programming according to different tissues, are stored in the micro computer, are convenient to user's selection and automatization control.
Compared with prior art, the invention has the beneficial effects as follows:
Medical cellular segregation pipe of the present invention can be easy and convenient the medical cell extruding of bulk pulverized or be broken into the medical cell of fine granularity, the operating process of this tripping device isolated cell can be carried out in Operation theatre with in the operation, effectively shorten the no nutrition time after medical cell exsomatizes, reduce opportunities for contamination, reduce damage; In addition, it is convenient to the storage and transport of sample, but but also automatization and normalizing operation increase the repeatability of studying.
Description of drawings
Below in conjunction with the drawings and specific embodiments the present invention is described in detail:
Fig. 1 is the embodiment of the invention one a described medical cell automatic separating apparatus structural representation;
Fig. 2 is an A place enlarged diagram among above-mentioned Fig. 1;
Fig. 3 separator tube is the described medical cell automatic separating apparatus operating structure synoptic diagram one of above-mentioned Fig. 1;
Fig. 4 is the described medical cell automatic separating apparatus operating structure synoptic diagram two of above-mentioned Fig. 1;
Fig. 5 is the embodiment of the invention two described medical cell automatic separating apparatus structural representations.
Embodiment
As shown in Figure 1, medical cell automatic separating apparatus of the present invention, comprise separator tube 1, cooperate in the described separator tube 1 and be provided with a transmission rod 2 that medical cell extruding can be pulverized, the bottom that the top of transmission rod 2 is connected with small-sized drive-motor 3 described separator tubes 1 is provided with outlet 11, and this outlet 11 is provided with a gag 4.
As shown in Figure 1 and Figure 2, for more easy and convenient pulverizes into the medical cell of small-particle with the medical cell extruding of bulk, the bottom surface of described transmission rod 2 is rough dentalation, can mill to the cell tissue of bulk more easily by rough dentalation, thereby obtain more short grained medical cell.
As Fig. 1, Fig. 3, shown in Figure 4, in the present invention, the bottom surface of described separator tube 1 is an arc, corresponding with it, the bottom of described transmission rod 2 also is an arc.In addition, the bottom of described separator tube 1 is fixed with a controlled pressurizing device 5, and the pressure by between control separator tube 1 bottom and the transmission rod 2 adapts to different tissues such as bone source sex organization effectively, and liver cancer and lymph node tissue etc. extract the needs of medical cell.On the other hand, controlled pressurizing device 5 also can be arranged at the transmission rod the other end to reach identical pressurization.Described separator tube 1 bottom is provided with by heat sink material and makes the permanent seat 6 that is used for fixing the separator tube bottom, can reduce the heat that produces when milling by the thermal conduction of heat sink material, reduces the damage of pair cell.
As shown in Figure 4, the gag 4 of described separator tube 1 outlet at bottom 11 can be connected after the end of milling and manage the replacement of 7 interfaces, this communicating pipe 7 can be connected medical cellular segregation culturing bottle and be communicated with, the histocyte after milling entered in the medical cellular segregation culturing bottle by this communicating pipe 7.Owing to mill or smash and switching process is carried out in airtight space, can prevent from effectively to pollute.
Below specify the operating process of medical cell automatic separating apparatus of the present invention:
As shown in Figure 3, Figure 4, the medical cell 10 of bulk is positioned over the bottom of separator tube 1, open drive-motor 3 drive transmission rods 2 then and rotate and move down, it is pushed bulk tissue 10 mill, thereby this bulk tissue 10 can be pulverized into cell granulations 20; At this moment, at separator tube 1 outlet at bottom place communicating pipe 7 is inserted or replacement gag 4, be communicated with medical cellular segregation culturing bottle by making it communicating pipe 7, the histocyte after so just will milling entered in the medical cellular segregation culturing bottle by this communicating pipe 7.
The present invention can shorten the no nutrition time after cell exsomatizes widely, this cellular segregation process can be carried out with operation in Operation theatre synchronously, and will not carry out separately by cell transfer to Cytology Lab, all swivel link opportunities for contamination have been reduced in the centre, be convenient to the storage and transport of sample, but also but normalizing operation increases the repeatability of studying.In addition, the rotating speed of described drive-motor 3, the radiating control of the pressure of controlled pressurizing device 5 and permanent seat 6 can be set and programmes according to different tissues, is stored in the micro computer, is convenient to that the user selects, automatization control and personalized customization, and is easy to use and reliable.
Embodiment two:
As shown in Figure 5, present embodiment and embodiment one difference are, present embodiment is by the method for smashing bulk tissue to be broken into cell granulations, its structure distinctive points is: the structure that cell is smashed of the bottom of described transmission rod 2 is the set of blades 8 that is fixed on transmission rod bottom, drive-motor 3 drives transmission rod 2 and rotates, thereby drive set of blades 8 motions, and then bulk tissue 10 is broken into the cell granulations that needs particle diameter.
Present embodiment and embodiment one difference also comprise: become cell granulations owing to smashing by 8 pairs of bulk tissue of set of blades, therefore, need not also can finish medical cellular segregation process preferably by controlled pressurizing device 5 among this embodiment.
The present invention is not limited to above-mentioned embodiment, every various changes of the present invention or modification are not broken away from the spirit and scope of the present invention, if these are changed and modification belongs within claim of the present invention and the equivalent technologies scope, then the present invention also means and comprises these changes and modification.
Claims (6)
1. medical cell automatic separating apparatus, it is characterized in that: comprise separator tube, cooperate in the described separator tube and be provided with a transmission rod, this transmission rod is provided with the structure that medical cell extruding is pulverized or smashed, the top of described transmission rod is connected with drive-motor, the bottom of described separator tube is provided with outlet, and this outlet is provided with a gag.
2. medical cell separation apparatus according to claim 1 is characterized in that: described transmission rod is plunger tpe barred body structure, and the structure of on the described transmission rod medical cell being pulverized is that the bottom surface that is located at the transmission rod is rough dentation.
3. medical cell separation apparatus according to claim 1 and 2 is characterized in that: the bottom surface of described separator tube is an arc, corresponding with it, the bottom of described transmission rod also is an arc.
4. medical cell separation apparatus according to claim 3 is characterized in that: the bottom of described separator tube is fixed with a controlled pressurizing device.
5. medical cell separation apparatus according to claim 1 is characterized in that: the structure that cell is smashed that the bottom of described transmission rod is provided with is the set of blades that is fixed on transmission rod bottom.
6. medical cell separation apparatus according to claim 1 is characterized in that: described separator tube bottom is provided with the permanent seat of being made by heat sink material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110131394.0A CN102220224B (en) | 2011-05-19 | 2011-05-19 | Automatic medical cell separation device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110131394.0A CN102220224B (en) | 2011-05-19 | 2011-05-19 | Automatic medical cell separation device |
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| CN102220224A true CN102220224A (en) | 2011-10-19 |
| CN102220224B CN102220224B (en) | 2014-10-01 |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102391946A (en) * | 2011-11-11 | 2012-03-28 | 武汉优视科技有限公司 | Plunger sleeve and automatic cell processor therewith |
| CN102899247A (en) * | 2012-10-26 | 2013-01-30 | 中国科学技术大学 | Blood cell separation device |
| CN105296324A (en) * | 2014-07-08 | 2016-02-03 | 吉林化工学院 | Efficient mitochondrion separator |
| WO2016095390A1 (en) * | 2014-12-16 | 2016-06-23 | 南通市肿瘤医院 | Automatic histocyte separator |
| CN108531392A (en) * | 2018-06-26 | 2018-09-14 | 佛山市第人民医院（中山大学附属佛山医院） | Cell separation machine temperature control system suitable for purification of islet cells |
| JP2019140985A (en) * | 2018-02-21 | 2019-08-29 | エイブル株式会社 | Cell dispersion method and cell dispersion apparatus |
| JP2020048540A (en) * | 2018-09-27 | 2020-04-02 | エイブル株式会社 | Cell dispersion tool and cell dispersion device |
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| CN102391946A (en) * | 2011-11-11 | 2012-03-28 | 武汉优视科技有限公司 | Plunger sleeve and automatic cell processor therewith |
| CN102899247A (en) * | 2012-10-26 | 2013-01-30 | 中国科学技术大学 | Blood cell separation device |
| CN105296324A (en) * | 2014-07-08 | 2016-02-03 | 吉林化工学院 | Efficient mitochondrion separator |
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| JP2019140985A (en) * | 2018-02-21 | 2019-08-29 | エイブル株式会社 | Cell dispersion method and cell dispersion apparatus |
| JP7064191B2 (en) | 2018-02-21 | 2022-05-10 | エイブル株式会社 | Cell dispersal method and cell disperser |
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| CN108531392B (en) * | 2018-06-26 | 2023-06-06 | 佛山市第一人民医院（中山大学附属佛山医院） | Cell separator temperature control system suitable for islet cell purification |
| JP2020048540A (en) * | 2018-09-27 | 2020-04-02 | エイブル株式会社 | Cell dispersion tool and cell dispersion device |
| JP7251008B2 (en) | 2018-09-27 | 2023-04-04 | エイブル株式会社 | Cell dispersion tool and cell dispersion device |
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| CN102220224B (en) | 2014-10-01 |
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Effective date of registration: 20160811 Address after: 510005, Guangzhou International Biological Island, Guangdong, Guangzhou, No. four, road 202, an office area, two, layer, unit Patentee after: Guangzhou Yidai Pharmaceutical Technology Co., Ltd. Address before: 510055 No. 56 cemetery West Road, Guangzhou, Guangdong, Yuexiu District Patentee before: Wang Hua |