CN207430431U - Organize shear - Google Patents
Organize shear Download PDFInfo
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- CN207430431U CN207430431U CN201721352931.3U CN201721352931U CN207430431U CN 207430431 U CN207430431 U CN 207430431U CN 201721352931 U CN201721352931 U CN 201721352931U CN 207430431 U CN207430431 U CN 207430431U
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- stationary knife
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Abstract
A kind of tissue shear, including cover, the first cutting member, the second cutting member and driving mechanism etc..Cover includes body and through hole.First cutting member includes stationary knife, and stationary knife includes the first cut part, moved by ontology-driven, and the second cutting member includes connecting rod and moving knife, and moving knife includes turning end and the second cut part；Driving mechanism includes actuating arm and driving wheel, and actuating arm is arranged in through hole, and the driven swing arm of driving wheel drives and rotates, and turning end is connected to driving wheel, and is offset to the axis at wheel center of overdriving.Moving knife and stationary knife are pivotally connected, and moving knife is driven by connecting rod and rotated, and are coordinated with stationary knife and implemented shearing.With hand-held operating scissors tissue is carried out shearing repeatedly realize it is broken compared with, tissue shear provided by the utility model can be easy to operate in a manner of the rotation operation that motor drove or held actuating arm, laborsaving.
Description
Technical field
The utility model is related to a kind of for broken device more particularly to a kind of shear, for tissue, especially
The shearing of the tissues such as umbilical cord and placenta, in order to which clostridiopetidase A is using being digested.
Background technology
By in September, 2017, in the global mescenchymal stem cell of U.S. www.clinicaltrials.gov websites registration
Clinical research encloses production mescenchymal stem cell and occupies larger proportion wherein up to 759.Mescenchymal stem cell correlative study and
The extensive development of application, has also driven the construction and development of mesenchyma stem cell.By taking prepared by placenta mesenchyma stem cell as an example,
Its shear history mainly includes the following steps that：Separation placental villi membrane tissue simultaneously cleans, and is cut into 1mm3~2mm3Size
Fragment, collagenase digesting simultaneously centrifuge, cell count and inoculated and cultured.Wherein, chorion tissue is shredded is to improve collagen
Enzymic digestion efficiency improves mescenchymal stem cell and prepares yield.Moreover, it is next in nearly all tissue to shred this operation for tissue
Also all it is necessary step in the primary cell preparation process in source.
At present, primary cell, such as：Widely used tissue shreds mode as operation in the preparation process of mescenchymal stem cell
Shearing.Exemplified by enclosing production mescenchymal stem cell and prepare, i.e., villus membrane tissue or umbilical cord tissue are first placed in 50mL sterile centrifugations
In pipe (volume of an example sample is 15mL~20mL), technical staff holds operating scissors, deeply centrifuges bottom of the tube, comes repeatedly
It is sheared back into row.Under this traditional cut mode, operating scissors are opened about 30 degree~40 degree angles and will be done with the wall of container
It relates to, working space is narrow and small.Preparation an example sample generally requires continuous shear stress and can be only achieved appropriate digested group in 5 minutes~10 minutes
Size requirements are knitted, are links the most laborious in entire preparation flow.In addition, the common automation historrhexis being currently known sets
It is standby, such as：Electric hand tissue homogenizer and by motor-driven homogenization apparatus (CN205576112U), advantage exists
In can smash tissue to pieces, shortcoming is that homogenizer runs at high speed organization center's temperature is caused quickly to raise, and nothing with fast power-saving
Method controls the granular size of tissue, and the tissue smashed to pieces through homogenizer is usually homogenate state, can destroy primary cell or stem cell
Integrality and activity, thus be not suitable for preparing fragile and precious primary cell or stem cell.In addition, such as：It is Chinese practical
The tissue shear of the reports such as new patent CN205817926U and CN206154357U all continues traditional finger and is inserted in finger
The mode that ring is sheared can not fundamentally change the finger that technical staff occurs by long working or the shape that wrist is ached
Condition.Therefore, it is still necessary to it is a kind of for placenta, the shear of umbilical cord tissue, to improve the safety and reliability prepared.
Utility model content
One of the utility model is designed to provide a kind of tissue shear, by mesh when being prepared suitable for primary cell
Mark tissue shreds, and the tissue shearing of placenta, umbilical cord mesenchymal stem cells preparation process is particularly suitable for, in order to which clostridiopetidase A utilizes
It is digested.
Another of the utility model is designed to provide a kind of tissue shear, has both avoided electrical shear rate too fast
And target cell activity is influenced, and the working space of operating personnel is expanded, alleviate the lower operating personnel's wrist of shearing manually and ache.
A kind of tissue shear provided by the utility model, including：
Cover, including body and through hole；
First cutting member, including stationary knife, stationary knife includes the first cut part, is moved by ontology-driven；
Second cutting member, including connecting rod and moving knife, moving knife includes turning end and the second cut part；
Driving mechanism, including actuating arm and driving wheel, actuating arm is arranged in through hole, the driving of driving wheel driven swing arm and
It rotates, turning end is connected to driving wheel, and is offset to the axis at wheel center of overdriving；
Moving knife and stationary knife are pivotally connected, and moving knife is driven by connecting rod and rotated, and are coordinated with stationary knife and implemented shearing.
The tissue shear of the utility model, driving wheel include connecting rod, and connecting rod is offset to wheel center of overdriving
Axis, turning end are fixed in connecting rod.
The tissue shear of the utility model, further includes container, including opening, body closing opening.
The tissue shear of the utility model, further includes connecting component, and its one end is fixed on the lower edge of body, the other end
It is connected with stationary knife, stationary knife (in container) height and position to be adjusted, expands shearing inclination, avoid and container wall
Interference increases shear efficiency.
The tissue shear of the utility model, further includes adjusting mechanism, is connected respectively with body and container activities, right
The height of stationary knife in a reservoir is adjusted, to adapt to the demand of the shearing of different sample sizes.
The tissue shear of the utility model, adjusting mechanism are threadedly coupled respectively with body and container activities, are rotated and are adjusted
Mechanism is saved, so that relative displacement occurs for body and container, the height of stationary knife in a reservoir is adjusted, to adapt to different samples
The demand of the shearing of amount.
The advantageous effect that technical solutions of the utility model are realized：
With hand-held operating scissors tissue is carried out shearing repeatedly realize it is broken compared with, tissue shearing dress provided by the utility model
It puts, can be easy to operate in a manner of the rotation operation that motor drove or held actuating arm, it is laborsaving.
Compared with the cut mode of operating scissors, tissue shear provided by the utility model expands the behaviour of shearing work
Make space, avoid the interference with container wall so that the shearing inclination bigger of cutting member increases shear efficiency.
In shear history, shearing work can be made to implement under air-tight state, avoid the mutual of tissue samples and external environment
It is logical, the contaminated risk of shear history tissue is reduced, improves seed cell security.
The tissue shear of the utility model shreds process control, and tissue will not overheat, and can maintain cell well
Activity.
The tissue shear of the utility model, the high and low position of cutting member is adjustable, suitable for different sample throughputs
Needs, application range is wider.
Description of the drawings
Fig. 1 is the structure diagram of one embodiment of the utility model tissue shear；
Fig. 2 is the structure diagram that tissue shear shown in Fig. 1 assembles an embodiment with container；
Fig. 3 is the enlarged structure schematic diagram of one embodiment of driving wheel of the utility model tissue shear.
Specific embodiment
The technical solution of the utility model is described in detail below in conjunction with attached drawing.The utility model embodiment is only to illustrate this
The technical solution of utility model and it is unrestricted, although the utility model is described in detail with reference to preferred embodiment, ability
Domain it is to be appreciated by one skilled in the art that can be modified or replaced equivalently to the technical solution of utility model, without de-
Spirit and scope from technical solutions of the utility model should all cover in the right of the utility model.
Fig. 1 is the structure diagram of one embodiment of the utility model tissue shear, and Fig. 2 is tissue shearing shown in Fig. 1
Device assembles the structure diagram of an embodiment with container.As depicted in figs. 1 and 2, the tissue shear of the present embodiment, including
Cover 100, the first cutting member 300 and the second cutting member 500.Cover 100 includes body 110 and through hole 120.Container 200
Including opening (not shown), the closing opening of body 110.
First cutting member 300 includes stationary knife 310, and stationary knife 310 includes the first cut part 311.400 one end of connecting component is consolidated
Due to the lower edge of body 110, the other end is connected with stationary knife 310, and stationary knife is moved by driving body, with to stationary knife in container
Position be adjusted, expand shearing inclination, avoid the interference with container wall, increase shear efficiency.
Second cutting member 500 includes connecting rod 520 and moving knife 510, and moving knife 510 includes 512 and second cut part of turning end
511.Moving knife 510 and stationary knife 310 are pivotally connected, and moving knife 510 is driven by connecting rod 520 and rotated, and implement to cut with the cooperation of stationary knife 310
It cuts.
Driving mechanism 600 includes actuating arm 610 and driving wheel 620, and actuating arm is arranged in through hole 120, and driving wheel is driven
Swing arm drives and rotates, and turning end 512 is connected to driving wheel 620.Fig. 3 is the driving wheel one of the utility model tissue shear
The enlarged structure schematic diagram of embodiment, with reference to Fig. 1, as shown in figure 3, driving wheel 620 further includes connecting rod 621, connecting rod 621 is inclined
The axis at wheel center of overdriving is placed in, into eccentric stiffener, turning end 512 is fixed in connecting rod 621.Actuating arm is applied and is made
Firmly so that stationary knife is fixed compared with chamber wall, and actuating arm drives link motion by driving wheel, so that moving knife
510 realize folding with stationary knife 310, and tissue samples are sheared.
Tissue shear provided in this embodiment, further includes adjusting mechanism 700, respectively with body and container activities screw thread
Connection rotates adjusting mechanism, so that relative displacement occurs for body and container, the height of stationary knife in a reservoir is adjusted, with
Adapt to the demand of the shearing of different sample sizes.
Biological organization sample to be sheared e.g., but is not limited to Chorionic villi of placenta, umbilical cord, is placed in outer spiral shell by technical staff
In the tissue container of line, such as：50mL sterile centrifugation tubes, rocking tissue container makes tissue deposition be packed into adjusting mechanism in tube bottom
Container upper end is then packed into cover, reversely rotates adjusting mechanism and container in the shear height of needs, will load the container of tissue
Centrifuge tube shelf is placed in, actuating arm is held, rotates clockwise or counterclockwise, the driving of driven swing arm, driving wheel is driven to rotate, and is made
Connecting rod in through hole in being moved so that stationary knife and moving knife folding cooperation carry out shearing work to tissue.Treat that tissue samples shred
To target sizes, the main body of shear, location nut are removed successively, the mode with operating scissors is cleaned and sterilized, and is cut
Cutting apparatus can Reusability.In shear history, shearing work can be made to implement under air-tight state, avoid tissue samples and outside
The intercommunication of environment reduces the contaminated risk of shear history tissue, improves seed cell security.
Compared with the cut mode of operating scissors, tissue shear provided in this embodiment expands the operation of shearing work
Space avoids the interference with container wall so that the shearing inclination bigger of cutting member increases shear efficiency.With hand-held operation
Cut tissue is carried out shearing repeatedly realize it is broken compare, tissue shear provided in this embodiment can be driven or hand with motor
The rotation operation mode of actuating arm is held, it is easy to operate, it is laborsaving.
Claims (6)
1. a kind of tissue shear, it is characterised in that including：
Cover, including body and through hole；
First cutting member, including stationary knife, the stationary knife includes the first cut part, is moved by the ontology-driven；
Second cutting member, including connecting rod and moving knife, the moving knife includes turning end and the second cut part；
Driving mechanism, including actuating arm and driving wheel, the actuating arm is arranged in the through hole, the driving wheel
It is driven and rotated by the actuating arm, the turning end is connected to the driving wheel, and is offset to wheel center of overdriving
Axis；
The moving knife and the stationary knife are pivotally connected, and the moving knife is driven by the connecting rod and rotated, and with it is described
Stationary knife cooperation implement shearing.
2. tissue shear according to claim 1, it is characterised in that the driving wheel further includes connecting rod, described
Connecting rod be offset to the axis at wheel center of overdriving, the turning end is fixed in the connecting rod.
3. tissue shear according to claim 1, it is characterised in that further include container, the container includes opening
Mouthful, the body closing opening.
4. tissue shear according to claim 3, it is characterised in that further include adjusting mechanism, the adjusting mechanism
It is connected respectively with the body and the container activities, height of the stationary knife in the container is adjusted
Section.
5. tissue shear according to claim 4, it is characterised in that the adjusting mechanism respectively with body and appearance
Device movable whorl connects, and rotates the adjusting mechanism, so that relative displacement occurs for the body and the container, to institute
The height of the stationary knife stated in the above-described container is adjusted.
6. tissue shear according to claim 1, it is characterised in that further include connecting component, the connecting component
The lower edge of the body is fixed in one end, and the other end is connected with the stationary knife, to be carried out to the height and position of the stationary knife
It adjusts.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721352931.3U CN207430431U (en) | 2017-10-19 | 2017-10-19 | Organize shear |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201721352931.3U CN207430431U (en) | 2017-10-19 | 2017-10-19 | Organize shear |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN207430431U true CN207430431U (en) | 2018-06-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201721352931.3U Active CN207430431U (en) | 2017-10-19 | 2017-10-19 | Organize shear |
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| Country | Link |
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| CN (1) | CN207430431U (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107716013A (en) * | 2017-10-19 | 2018-02-23 | 章毅 | Organize cutting method and its device and purposes |
| CN109261306A (en) * | 2018-08-15 | 2019-01-25 | 嘉兴塘东汽车配件有限公司 | It is a kind of to shred device for file process |
-
2017
- 2017-10-19 CN CN201721352931.3U patent/CN207430431U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107716013A (en) * | 2017-10-19 | 2018-02-23 | 章毅 | Organize cutting method and its device and purposes |
| CN109261306A (en) * | 2018-08-15 | 2019-01-25 | 嘉兴塘东汽车配件有限公司 | It is a kind of to shred device for file process |
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