CN102215817B - 含前列腺素药物组合物 - Google Patents

含前列腺素药物组合物 Download PDF

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Publication number
CN102215817B
CN102215817B CN2009801458654A CN200980145865A CN102215817B CN 102215817 B CN102215817 B CN 102215817B CN 2009801458654 A CN2009801458654 A CN 2009801458654A CN 200980145865 A CN200980145865 A CN 200980145865A CN 102215817 B CN102215817 B CN 102215817B
Authority
CN
China
Prior art keywords
compound
pharmaceutical composition
hydroxyl
rudimentary
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2009801458654A
Other languages
English (en)
Chinese (zh)
Other versions
CN102215817A (zh
Inventor
原田康弘
川崎淳一
林直
上野隆司
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sucampo GmbH
R Tech Ueno Ltd
Original Assignee
Sucampo GmbH
R Tech Ueno Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sucampo GmbH, R Tech Ueno Ltd filed Critical Sucampo GmbH
Publication of CN102215817A publication Critical patent/CN102215817A/zh
Application granted granted Critical
Publication of CN102215817B publication Critical patent/CN102215817B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
CN2009801458654A 2008-10-07 2009-10-02 含前列腺素药物组合物 Expired - Fee Related CN102215817B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10340308P 2008-10-07 2008-10-07
US61/103403 2008-10-07
PCT/JP2009/067586 WO2010041722A2 (en) 2008-10-07 2009-10-02 Pharmaceutical composition

Publications (2)

Publication Number Publication Date
CN102215817A CN102215817A (zh) 2011-10-12
CN102215817B true CN102215817B (zh) 2013-06-12

Family

ID=41479177

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801458654A Expired - Fee Related CN102215817B (zh) 2008-10-07 2009-10-02 含前列腺素药物组合物

Country Status (10)

Country Link
US (1) US20100087540A1 (cg-RX-API-DMAC7.html)
EP (1) EP2341894B1 (cg-RX-API-DMAC7.html)
JP (2) JP5320388B2 (cg-RX-API-DMAC7.html)
KR (1) KR101166739B1 (cg-RX-API-DMAC7.html)
CN (1) CN102215817B (cg-RX-API-DMAC7.html)
AR (1) AR073781A1 (cg-RX-API-DMAC7.html)
CA (1) CA2739710A1 (cg-RX-API-DMAC7.html)
ES (1) ES2392221T3 (cg-RX-API-DMAC7.html)
TW (1) TWI403324B (cg-RX-API-DMAC7.html)
WO (1) WO2010041722A2 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8952051B2 (en) * 2009-11-05 2015-02-10 Allergan, Inc. Ophthalmic formulations containing substituted gamma lactams and methods for use thereof
TW201141486A (en) * 2010-04-12 2011-12-01 R Tech Ueno Ltd Pharmaceutical composition for treating macular edema
WO2014159679A1 (en) 2013-03-12 2014-10-02 The United States Of America, As Represented By The Secretary, Department Of Health & Human Services Methods for using lubiprostone to absorb fluid from the subretinal space
CN116144620B (zh) * 2022-09-14 2025-08-12 湖南农业大学 一种通过解脂耶氏酵母体外催化合成PGF2α的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208256A (en) * 1990-05-22 1993-05-04 R-Tech Ueno, Ltd. Treatment of ocular hypertension with a synergistic combination for ocular administration

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6770675B2 (en) * 1997-03-17 2004-08-03 Novartis Ag Compositions and methods for reducing ocular hypertension
WO2000003736A1 (en) * 1998-07-14 2000-01-27 Alcon Laboratories, Inc. Prostaglandin product
WO2002022106A2 (en) * 2000-09-14 2002-03-21 Novartis Ag Stable ophthalmic preparation
US20040076678A1 (en) * 2002-08-21 2004-04-22 Sucampo Ag Opthalmic solution
KR101118935B1 (ko) * 2003-08-21 2012-03-13 가부시키가이샤 아루떼꾸 우에노 안과용 조성물
US20050049311A1 (en) * 2003-09-03 2005-03-03 Pharmacia & Upjohn Company Medicinal products comprising prostaglandin compositions and methods of packaging such compositions
BRPI0414149A (pt) * 2003-09-05 2006-10-31 Novartis Ag composições compreendendo derivados de benzo(g)-quinolina e derivados de prostaglandina
US20050287325A1 (en) * 2004-06-25 2005-12-29 Pharmacia & Upjohn Company Pharmaceutical containers with low adsorption/absorption of active ingredients, and a method of testing materials for adsorption/absorption of active ingredients
GB0501192D0 (en) * 2005-01-20 2005-03-02 Resolution Chemicals Ltd Stable prostaglandin-containing compositions
NZ571426A (en) * 2006-03-13 2011-02-25 R Tech Ueno Ltd Aqueous composition comprising castor oil, a 15-keto-prostaglandin compound and a quaternary ammonium cationic surface active agent
JPWO2008096804A1 (ja) * 2007-02-07 2010-05-27 テイカ製薬株式会社 ラタノプロスト含有点眼剤
DK2308466T3 (en) * 2008-03-17 2017-09-11 Novartis Ag Aqueous pharmaceutical compositions containing borate-polyol complexes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5208256A (en) * 1990-05-22 1993-05-04 R-Tech Ueno, Ltd. Treatment of ocular hypertension with a synergistic combination for ocular administration

Also Published As

Publication number Publication date
TWI403324B (zh) 2013-08-01
JP2011509237A (ja) 2011-03-24
EP2341894B1 (en) 2012-08-29
HK1162935A1 (zh) 2012-09-07
TW201016219A (en) 2010-05-01
EP2341894A2 (en) 2011-07-13
ES2392221T3 (es) 2012-12-05
WO2010041722A3 (en) 2011-01-27
CA2739710A1 (en) 2010-04-15
JP2013177446A (ja) 2013-09-09
US20100087540A1 (en) 2010-04-08
CN102215817A (zh) 2011-10-12
KR20100065126A (ko) 2010-06-15
HK1159501A1 (en) 2012-08-03
WO2010041722A2 (en) 2010-04-15
JP5320388B2 (ja) 2013-10-23
AR073781A1 (es) 2010-12-01
KR101166739B1 (ko) 2012-07-23

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