CN102210630A - System and method for preparing nosiheptide premix particles - Google Patents
System and method for preparing nosiheptide premix particles Download PDFInfo
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- CN102210630A CN102210630A CN2011101494522A CN201110149452A CN102210630A CN 102210630 A CN102210630 A CN 102210630A CN 2011101494522 A CN2011101494522 A CN 2011101494522A CN 201110149452 A CN201110149452 A CN 201110149452A CN 102210630 A CN102210630 A CN 102210630A
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- nosiheptide
- vacuum rake
- carrier
- rake style
- style drier
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- FPTCMHOCGKKRGQ-WYOWUDGCSA-N Multhiomycin Natural products CC=C1NC(=O)[C@@H](NC(=O)c2csc(n2)c3cc(O)c(nc3c4csc(n4)[C@H]5CSC(=O)c6[nH]c7cccc(COC(=O)[C@@H](O)C[C@H](NC(=O)c8csc1n8)c9nc(cs9)C(=O)N5)c7c6C)c%10nc(cs%10)C(=O)N[C@@H](C)C(=O)N)[C@H](C)O FPTCMHOCGKKRGQ-WYOWUDGCSA-N 0.000 title claims abstract description 118
- 101800003864 Nosiheptide Proteins 0.000 title claims abstract description 118
- MQWDKYHFGBWGQZ-JQTJYXGUSA-N nosiheptide Chemical compound N([C@H](C(=O)N\C(C=1SC=C(N=1)C(=O)N[C@@H]1CC(O)C(=O)OCC=2C=CC=C3NC(=C(C3=2)C)C(=O)SC[C@H](NC(=O)C=2N=C1SC=2)C=1SC=C(N=1)C1=N2)=C/C)[C@@H](C)O)C(=O)C(N=3)=CSC=3C1=CC(=O)\C2=C1/NC(C(=O)NC(=C)C(N)=O)=CS1 MQWDKYHFGBWGQZ-JQTJYXGUSA-N 0.000 title claims abstract description 118
- 229950006423 nosiheptide Drugs 0.000 title claims abstract description 118
- 238000000034 method Methods 0.000 title claims abstract description 19
- 239000002245 particle Substances 0.000 title abstract description 5
- 239000007788 liquid Substances 0.000 claims abstract description 40
- 238000000855 fermentation Methods 0.000 claims abstract description 34
- 230000004151 fermentation Effects 0.000 claims abstract description 34
- 238000003860 storage Methods 0.000 claims abstract description 34
- 239000011230 binding agent Substances 0.000 claims abstract description 27
- 239000003795 chemical substances by application Substances 0.000 claims description 35
- 238000003756 stirring Methods 0.000 claims description 18
- 238000002156 mixing Methods 0.000 claims description 13
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 11
- 235000012054 meals Nutrition 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 9
- 239000000230 xanthan gum Substances 0.000 claims description 7
- 229920001285 xanthan gum Polymers 0.000 claims description 7
- 229940082509 xanthan gum Drugs 0.000 claims description 7
- 235000010493 xanthan gum Nutrition 0.000 claims description 7
- 229920002472 Starch Polymers 0.000 claims description 6
- 240000008042 Zea mays Species 0.000 claims description 6
- 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 claims description 6
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 6
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 6
- 235000009973 maize Nutrition 0.000 claims description 6
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 6
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 6
- 239000008107 starch Substances 0.000 claims description 6
- 235000019698 starch Nutrition 0.000 claims description 6
- 235000007164 Oryza sativa Nutrition 0.000 claims description 5
- 244000046052 Phaseolus vulgaris Species 0.000 claims description 5
- 235000010627 Phaseolus vulgaris Nutrition 0.000 claims description 5
- 235000019779 Rapeseed Meal Nutrition 0.000 claims description 5
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 claims description 5
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 claims description 5
- 235000012343 cottonseed oil Nutrition 0.000 claims description 5
- 239000004456 rapeseed meal Substances 0.000 claims description 5
- 235000009566 rice Nutrition 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 238000005507 spraying Methods 0.000 claims description 3
- 240000007594 Oryza sativa Species 0.000 claims 1
- 239000000243 solution Substances 0.000 description 28
- 239000000203 mixture Substances 0.000 description 17
- 239000008187 granular material Substances 0.000 description 13
- 238000002360 preparation method Methods 0.000 description 13
- 238000007789 sealing Methods 0.000 description 10
- 238000001035 drying Methods 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 239000000428 dust Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- 239000000843 powder Substances 0.000 description 5
- 241000209094 Oryza Species 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 238000004821 distillation Methods 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000005550 wet granulation Methods 0.000 description 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000008394 flocculating agent Substances 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000003910 polypeptide antibiotic agent Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
The invention provides a system and method for preparing nosiheptide premix particles. The system comprises a storage tank, a vacuum rake dryer and an air compressor, wherein a concentrated solution obtained by removing partial moisture from a nosiheptide fermentation liquid and a binder mixed uniformly with the concentrated solution are filled in the storage tank; a carrier is stored in the vacuum rake dryer; the storage tank and the vacuum rake dryer are connected by the air compressor; the uniformly mixed liquid of the nosiheptide and the binder in the storage tank is delivered into the vacuum rake dryer by the air compressor; then the mixed liquid is uniformly sprayed onto the carrier in the vacuum rake dryer by a nozzle on the vacuum rake dryer; and the carrier with the mixed liquid is dried and mixed in the vacuum rake dryer.
Description
Technical field
The invention belongs to field of biological pharmacy, relate to the antibiotic particulate preparation method of a kind of animal specific, be specifically related to the particulate preparation method of a kind of sulfur-bearing polypeptide antibiotics nosiheptide.
Background technology
Nosiheptide is a kind of fabulous promoting animal growth agent that French scientist is found, the back is developed as product by MIT with it, and is added for legal feedstuff by Japan's approval.China was the new veterinary drug of national three classes in 1998 with the nosiheptide approval, and permission interpolation in feedstuff is used to promote growth of animal.Nosiheptide is owing to be the animal specific antibiotic, and have noresidue, safety, to characteristics such as environment do not influence, obtained general application at home.
At present, preparation to nosiheptide preparation both at home and abroad has following several method: the one, and adopt the solvent method that nosiheptide is directly extracted from the nosiheptide fermentation liquid, make the pre-mixing agent of all size then, concrete steps are for adding equal-volume ethanol, homogenate then, centrifugal, collect supernatant, concentrate, with n-butanol extraction, concentrate evaporate to dryness, add the dioxane dissolving, add the water precipitation nosiheptide again, sedimentary nosiheptide washes with water, dries, and adds adjuvant then.Stepwise dilution mixes, and is prepared into pulverous Nosiheptide premixed agent of all size.As patent publication No. is CN1899599A " a kind of method for preparing Nosiheptide premixed agent ".The 2nd, the fermentation liquid of nosiheptide is carried out metal membrane filter by the metal pipe type membrane separator, remove in the fermentation liquid 25%～30% moisture, obtain concentrated solution, then concentrated solution is carried out spray drying and obtain nosiheptide powder.As patent publication No. is CN101624418A " preparing nosiheptide powder ".The 3rd, in the nosiheptide fermentation liquid, add flocculating agent or filter aid, squeeze after the stirring or filter pressing, obtain the nosiheptide wet cake, again wet cake is carried out drying and obtain nosiheptide mycelium dry product, pulverize then and obtain nosiheptide mycelium fine powder, in fine powder, add powder carrier again, mix obtaining the powdery Nosiheptide premixed agent; Or with the nosiheptide mycelium by wet granulation, obtain the graininess Nosiheptide premixed agent.First method is that refabrication became Nosiheptide premixed agent after nosiheptide was purified, and whole process steps is many, and technology is loaded down with trivial details, and the cost height is unfavorable for the large-scale production Nosiheptide premixed agent.And the Nosiheptide premixed agent of producing is Powdered, and it has mobile poor, shortcoming that dust is big.The Nosiheptide premixed agent of second method preparation still is Powdered, very easily produces a large amount of dust in production and adding feedstuff, influences operator's health, also is unfavorable for environmental conservation.Though the third method has been mentioned preparation nosiheptide granule, this method is that the nosiheptide fermentation liquid is made powdered nosiheptide mycelium earlier, and then the adding adjuvant is made the powdery Nosiheptide premixed agent or passed through wet granulation graininess Nosiheptide premixed agent.Prepare this graininess Nosiheptide premixed agent and need pass through plurality of processes, more loaded down with trivial details, and have the generation of dust.
Summary of the invention
The purpose of this invention is to provide a kind of direct preparation method by nosiheptide fermentation liquid production graininess Nosiheptide premixed agent.This method has that production technology is simple, easy to operate, advantage of high production efficiency, and nosiheptide particle premix good fluidity, no dust, more helps mix homogeneously in feedstuff.
The preparation technology of graininess Nosiheptide premixed agent of the present invention concentrates the nosiheptide fermentation liquid, directly is sprayed onto on the graininess carrier then, and drying makes.Do not need through once more drying, sieve and mix simple, the operation easily of production technology.
On the one hand, the invention provides the particulate system of a kind of preparation Nosiheptide premixed agent, comprising:
(1), storage tank, in storage tank, be equipped with the concentrated solution of from the nosiheptide fermentation liquid, being removed part moisture and with the binding agent of concentrated solution mix homogeneously;
(2), vacuum rake style drier, in vacuum rake style drier, store carrier;
(3), the air compressor that connects storage tank and vacuum rake style drier;
Wherein the nosiheptide of mix homogeneously in the storage tank and the mixed liquor of binding agent are input in the vacuum rake style drier by air compressor, this mixing material is sprayed on the carrier in the vacuum rake style drier equably by the shower nozzle on the vacuum rake style drier then, in vacuum rake style drier the carrier that has mixing material is carried out dry mixed again.
In a preferred mode, when spraying mixing material, allow carrier speed with 4-10 rev/min in vacuum rake style drier rotate; Preferably, the speed of rotation is 5-9 rev/min, is more preferably 5 rev/mins.
Preferably, the pressure that air compressor produced is 0.5-0.6MPa.
Preferably, in the vacuum rake style drier carrier being carried out exsiccant temperature is 50 ℃-60 ℃, and the time is 20-100 minute.
Preferably, binding agent can be one or more in alphalise starch, beta-schardinger dextrin-, Carboxymethyl cellulose sodium, sodium carboxymethyl cellulose or the xanthan gum.
Preferably, carrier can be one or more in the maize cob meal, bean cake, Testa oryzae, cottonseed meal, rapeseed meal, Testa Tritici, powdered rice hulls of 0.60～0.25mm.
On the other hand, the particulate preparation method of Nosiheptide premixed agent of the present invention comprises:
(1) by equipment the nosiheptide fermentation liquid that stops fermentation is concentrated, in the storage tank of then the nosiheptide concentrated solution being packed into, add binding agent, stir.
(2) carrier is dropped into vacuum rake style drier.
(3) adopt air compressor that the nosiheptide that stirs is imported in the vacuum rake style drier by pipeline with the mixed liquor of binding agent, be sprayed at equably on the carrier by the shower nozzle on the vacuum rake style drier then, in vacuum rake style drier, the carrier that has mixing material carried out drying, mixing again.
Wherein,
The described equipment of step (1) can select those to remove the equipment of a part of liquid from the nosiheptide fermentation liquid, for example remove a part of liquid with the reaction pot distillation, perhaps adopt centrifugal fermentation liquid to be concentrated, perhaps carry out metal membrane filter and remove a part of liquid through the metal pipe type separator.Preferably, spissated equipment can be selected reaction pot distillation for use, centrifugally concentrate or use metal membrane filter, 25～70% moisture in the removal fermentation liquid.
The described binding agent of step (1) can be one or more in alphalise starch, beta-schardinger dextrin-, Carboxymethyl cellulose sodium, sodium carboxymethyl cellulose or the xanthan gum.
The described carrier of step (2) can be one or more in maize cob meal, bean cake, Testa oryzae, cottonseed meal, rapeseed meal, Testa Tritici, the powdered rice hulls, and the granularity of carrier can be 30 orders～60 orders (0.60～0.25mm).
Exsiccant temperature in the step (3) is 50 ℃～60 ℃, mixes 20～100 minutes, and promptly getting granularity is 24 orders～60 orders (Nosiheptide premixed agent granules of 0.70～0.25mm).
Preferably, when mixed liquor sprayed, carrier speed with 4-10 rev/min in vacuum rake style drier was rotated; Preferably, the speed of rotation is 5-9 rev/min, is more preferably 5-8 rev/min.
Can prepare content by the inventive method is 0.25%～2% Nosiheptide premixed agent granule.
The particulate preparation method of Nosiheptide premixed agent of the present invention is further described below:
After the nosiheptide fermentation stops, after the nosiheptide fermentation liquid concentrated, measure the content of nosiheptide in the concentrated solution, use vacuum pump (Hangzhou Xin'anjiang Industrial Pump Co., Ltd. then, model: RB-65-280) with nosiheptide concentrated solution suction storage tank (the conspicuous mechanical ﹠ electronic equipment corporation, Ltd of Shanghai generation, model: SJBF-1000), the pressure of setting vacuum pump is 0.08～0.09MPa; In the nosiheptide concentrated solution, add a spot of binding agent again, binding agent can be selected one or more in alphalise starch, beta-schardinger dextrin-, Carboxymethyl cellulose sodium, sodium carboxymethyl cellulose and the xanthan gum, with the stirring paddle (West Lake, Hangzhou glass-lined equipment company limited, anchor formula BXH k1000) nosiheptide concentrated solution and binding agent are stirred, mixing speed is 15～45 rev/mins; Be that (one or more carriers in 0.60～0.25mm) maize cob meal, bean cake, Testa oryzae, cottonseed meal, rapeseed meal, Testa Tritici, the powdered rice hulls drop into vacuum rake style drier (Qianjiang Drying Equipment Co., Ltd., Hangzhou to 30 orders～60 orders then with granularity, model: ZPD1000), close dog-house; Use air compressor, under the pressure of 0.5～0.6MPa, with in the storage tank with the nosiheptide concentrated solution of binding agent mix homogeneously by line transportation in vacuum rake style drier, and be sprayed on the carrier equably, when mixed liquor sprayed, carrier speed with 5 rev/mins in vacuum rake style drier was rotated; After mixed liquor is carried and finished, with the vacuum rake style drier sealing, begin to heat up, temperature is 50～60 ℃, and the time is 20～100 minutes; Promptly obtain the content specification and be 0.25%～2% Nosiheptide premixed agent granule, its fineness of the particles is 24 orders～60 orders (0.70～0.25mm).
Beneficial effect of the present invention
It is very simple that the present invention prepares the particulate method technology of Nosiheptide premixed agent, can directly produce the graininess Nosiheptide premixed agent by the nosiheptide fermentation liquid, do not need through once more mixing, step such as sieve, and its production efficiency height, easy to operate; And nosiheptide particle premix good fluidity, no dust pollution, more help mix homogeneously in feedstuff.
Description of drawings
Fig. 1 and 2 is the preparation system connection layout in specific embodiment of invention.Equipment among Fig. 1 couples together by the equipment among pipeline 6 and Fig. 2.Ferment liquid concentration jar 3 is connected with fermented liquid holding vessel 5, by vacuum compressor 7 liquid compression in the fermented liquid concentration tank is entered in the fermented liquid holding vessel 5, also fermented liquid is dropped in the vacuum rake style driers 16 with wherein carrier by dog-house 13 simultaneously and mix, and carry out drying therein by vacuum compressor.Simultaneously, work for these equipment, they can connect the cooling processing that condenser 4 carries out these equipment respectively, for example in fermented liquid concentration tank 3, be connected with shell and tube condenser 4, vacuum rake style drier 16 also can be connected with shell and tube condenser 17 simultaneously, the connection of these equipment can connect by pipe, and these connections are that one of ordinary skill in the art can be known, and do not do too much narration at this.
Description of reference numerals
The condensation-water drain 1 of fermented liquid concentration tank 3; The charging aperture 2 of fermented liquid concentration tank 3; Fermented liquid concentration tank 3; Shell and tube condenser 4,7; Fermented liquid holding vessel 5; Vacuum compressor 7; The pipeline 6 that the fermented liquid holding vessel is connected with vacuum rake style drier 16; The shower nozzle 11 of vacuum rake style drier; The dog-house 13 of vacuum rake style drier; The discharging opening 14 of vacuum rake style drier; Vacuum rake style drier 16; The steam that enters vacuum rake style drier enters pipe 12; Condensed water pans 18; Liquid-ring type vacuum 19 connects pipe 6.
The specific embodiment
Embodiment 1:
After the nosiheptide fermentation stops, fermentation liquid is input to the reaction pot (West Lake, Hangzhou glass-lined equipment company limited by pipeline, model: K2000), heat up while stirring, the speed that stirs is 80 rev/mins, temperature is set at 100 ℃, remove about 20% moisture, reduce the temperature to room temperature, the content of measuring nosiheptide is 13.18mg/ml, be that the vacuum pump 7 of 0.08MPa is with 100L nosiheptide concentrated solution suction fermentation liquid storage tank 5 (Hangzhou Xin'anjiang Industrial Pump Co., Ltd. with pressure then, model: RB-65-280), add the 0.2kg Carboxymethyl cellulose sodium, employing speed is that 25 rev/mins stirring arm (West Lake, Hangzhou glass-lined equipment company limited, anchor formula BXH k1000) stirred 8 minutes; The maize cob meal 520.7kg that with granularity is 40 orders (0.42mm) drops into vacuum rake style drier 16 (Qianjiang Drying Equipment Co., Ltd., Hangzhou, models: ZPD1000), close dog-house by dog-house 13; Use air compressor under the pressure of 0.5MPa with storage tank in the nosiheptide concentrated solution of binding agent mix homogeneously by line transportation in the vacuum rake style drier 16, and be sprayed on the carrier equably, when mixed liquor sprayed, carrier speed with 5 rev/mins in vacuum rake style drier was rotated; After mixed liquor is carried and finished, with the vacuum rake style drier sealing, begin to heat up, temperature is set 50 ℃, 20 minutes time; Obtaining granularity is that 24 orders～60 orders are (about 0.70～0.25mm) 0.25% Nosiheptide premixed agent granule 527.2kg (concrete structure is seen Fig. 1).
Embodiment 2:
Identical device name is identical with manufacturer and model among the embodiment 1.
After the nosiheptide fermentation stops, (rich medicine machinery plant is contained in the Zhangjiagang to adopt centrifuge, model: SB1000) carry out centrifugal, remove general 25% moisture, the content of measuring nosiheptide is 14.11mg/ml, then with pressure be the vacuum pump of 0.09MPa with in the 200L nosiheptide concentrated solution suction storage tank, add the 0.05kg xanthan gum, employing speed is that 30 rev/mins stirring arm stirred 8 minutes; With granularity is in the bean cake 551.4kg input vacuum rake style drier of 60 orders (0.25mm), closes dog-house; Use air compressor under the pressure of 0.6MPa with storage tank in the nosiheptide concentrated solution of binding agent mix homogeneously by line transportation in vacuum rake style drier, and be sprayed on the carrier equably, when mixed liquor sprayed, carrier speed with 5 rev/mins in vacuum rake style drier was rotated; After mixed liquor is carried and finished, with the vacuum rake style drier sealing, begin to heat up, temperature is set 60 ℃, 45 minutes time; Obtaining granularity is that 24 orders～60 orders are (about 0.70～0.25mm) 0.5% Nosiheptide premixed agent granule 564.4kg.
Embodiment 3:
After the nosiheptide fermentation stops, fermentation liquid is filtered through metal film (Hefei Fengyun Membrane Technology Co., Ltd.), remove general 30% moisture, the content of measuring nosiheptide is 15.17mg/ml, be that the vacuum pump of 0.09MPa is with in the 400L nosiheptide concentrated solution suction storage tank with pressure then, add the 0.1kg beta-schardinger dextrin-, employing speed is that 30 rev/mins stirring arm stirred 10 minutes; With granularity is in the cottonseed meal 580.8kg input vacuum rake style drier of 50 orders (0.35mm), closes dog-house; Use air compressor under the pressure of 0.6MPa with storage tank in the nosiheptide concentrated solution of binding agent mix homogeneously by line transportation in vacuum rake style drier, and be sprayed on the carrier equably, when mixed liquor sprayed, carrier speed with 5 rev/mins in vacuum rake style drier was rotated; After mixed liquor is carried and finished, with the vacuum rake style drier sealing, begin to heat up, temperature is set 60 ℃, 100 minutes time; Obtaining granularity is that 24 orders～60 orders are (about 0.70～0.25mm) 1% Nosiheptide premixed agent granule 606.8kg.
Embodiment 4:
Identical device name is identical with manufacturer and model among the embodiment 1.
After the nosiheptide fermentation stops, adopt centrifuge to carry out centrifugal, remove general 35% moisture, the content of measuring nosiheptide is 16.17mg/ml, be that the vacuum pump of 0.09MPa is with in the 400L nosiheptide concentrated solution suction storage tank with pressure then, add the 0.4kg sodium carboxymethyl cellulose, employing speed is that 45 rev/mins stirring arm stirred 5 minutes; With granularity is in the Testa Tritici 620.8kg input vacuum rake style drier of 60 orders (0.25mm), closes dog-house; Use air compressor under the pressure of 0.6MPa with storage tank in the nosiheptide concentrated solution of binding agent mix homogeneously by line transportation in vacuum rake style drier, and be sprayed on the carrier equably, when mixed liquor sprayed, carrier speed with 5 rev/mins in vacuum rake style drier was rotated; After mixed liquor is carried and finished, with the vacuum rake style drier sealing, begin to heat up, temperature is set 60 ℃, 95 minutes time; Obtaining granularity is that 24 orders～60 orders are (about 0.70～0.25mm) 1% Nosiheptide premixed agent granule 646.8kg.
Embodiment 5:
Identical device name is identical with manufacturer and model among the embodiment 1.
After the nosiheptide fermentation stops, adopt centrifuge to carry out centrifugal, remove general 40% moisture, the content of measuring nosiheptide is 17.28mg/ml, be that the vacuum pump of 0.09MPa is with in the 400L nosiheptide concentrated solution suction storage tank with pressure then, add the alphalise starch of 0.2kg, employing speed is that 35 rev/mins stirring arm stirred 8 minutes; With granularity is in the Testa oryzae 665.2kg input vacuum rake style drier of 60 orders (0.25mm), closes dog-house; Use air compressor under the pressure of 0.6MPa with storage tank in the nosiheptide concentrated solution of binding agent mix homogeneously by line transportation in vacuum rake style drier, and be sprayed on the carrier equably, when mixed liquor sprayed, carrier speed with 5 rev/mins in vacuum rake style drier was rotated; After mixed liquor is carried and finished, with the vacuum rake style drier sealing, begin to heat up, temperature is set 60 ℃, 90 minutes time; Obtaining granularity is that 24 orders～60 orders are (about 0.70～0.25mm) 1% Nosiheptide premixed agent granule 691.2kg.
Embodiment 6:
Identical device name is identical with manufacturer and model among the embodiment 1.
After the nosiheptide fermentation stops, adopt centrifuge to carry out centrifugal, remove general 45% moisture, the content of measuring nosiheptide is 19.25mg/ml, be that the vacuum pump of 0.09MPa is with in the 400L nosiheptide concentrated solution suction storage tank with pressure then, add the 0.1kg xanthan gum, employing speed is that 30 rev/mins stirring arm stirred 12 minutes; With granularity is in the powdered rice hulls 744kg input vacuum rake style drier of 60 orders (0.25mm), closes dog-house; Use air compressor under the pressure of 0.6MPa with storage tank in the nosiheptide concentrated solution of binding agent mix homogeneously by line transportation in vacuum rake style drier, and be sprayed on the carrier equably, when mixed liquor sprayed, carrier speed with 5 rev/mins in vacuum rake style drier was rotated; After mixed liquor is carried and finished, with the vacuum rake style drier sealing, begin to heat up, temperature is set 60 ℃, 90 minutes time; Obtaining granularity is that 24 orders～60 orders are (about 0.70～0.25mm) 1% Nosiheptide premixed agent granule 770kg.
Embodiment 7:
Identical device name is identical with manufacturer and model among the embodiment 1.
After the nosiheptide fermentation stops, adopt centrifuge to carry out centrifugal, remove general 50% moisture, the content of measuring nosiheptide is 21.24mg/ml, be that the vacuum pump of 0.09MPa is with in the 400L nosiheptide concentrated solution suction storage tank with pressure then, add the 0.4kg sodium carboxymethyl cellulose, employing speed is that 45 rev/mins stirring arm stirred 5 minutes; With granularity is in the rapeseed meal 823.6kg input vacuum rake style drier of 60 orders (0.25mm), closes dog-house; Use air compressor under the pressure of 0.6MPa with storage tank in the nosiheptide concentrated solution of binding agent mix homogeneously by line transportation in vacuum rake style drier, and be sprayed on the carrier equably, when mixed liquor sprayed, carrier speed with 5 rev/mins in vacuum rake style drier was rotated; After mixed liquor is carried and finished, with the vacuum rake style drier sealing, begin to heat up, temperature is set 60 ℃, 90 minutes time; Obtaining granularity is that 24 orders～60 orders are (about 0.70～0.25mm) 1% Nosiheptide premixed agent granule 849.6kg.
Embodiment 8:
Identical device name is identical with manufacturer and model among the embodiment 1.
After the nosiheptide fermentation stops, adopt centrifuge to carry out centrifugal, remove general 60% moisture, the content of measuring nosiheptide is 26.45mg/ml, be that the vacuum pump of 0.09MPa is with in the 400L nosiheptide concentrated solution suction storage tank with pressure then, add the alphalise starch of 0.2kg, employing speed is that 35 rev/mins stirring arm stirred 15 minutes; With granularity is in the Testa oryzae 503kg input vacuum rake style drier of 60 orders (0.25mm), closes dog-house; Use air compressor under the pressure of 0.6MPa with storage tank in the nosiheptide concentrated solution of binding agent mix homogeneously by line transportation in vacuum rake style drier, and be sprayed on the carrier equably, when mixed liquor sprayed, carrier speed with 5 rev/mins in vacuum rake style drier was rotated; After mixed liquor is carried and finished, with the vacuum rake style drier sealing, begin to heat up, temperature is set 60 ℃, 85 minutes time; Obtaining granularity is that 24 orders～60 orders are (about 0.70～0.25mm) 2% Nosiheptide premixed agent granule 529kg.
Embodiment 9:
Identical device name is identical with manufacturer and model among the embodiment 1.
After the nosiheptide fermentation stops, adopt centrifuge to carry out centrifugal, remove general 70% moisture, the content of measuring nosiheptide is 35.43mg/ml, be that the vacuum pump of 0.09MPa is with in the 400L nosiheptide concentrated solution suction storage tank with pressure then, add the 0.1kg xanthan gum, employing speed is that 30 rev/mins stirring arm stirred 15 minutes; With granularity is in the maize cob meal 682.5kg input vacuum rake style drier of 60 orders (0.25mm), closes dog-house; Use air compressor under the pressure of 0.6MPa with storage tank in the nosiheptide concentrated solution of binding agent mix homogeneously by line transportation in vacuum rake style drier, and be sprayed on the carrier equably, when mixed liquor sprayed, carrier speed with 5 rev/mins in vacuum rake style drier was rotated; After mixed liquor is carried and finished, with the vacuum rake style drier sealing, begin to heat up, temperature is set 60 ℃, 90 minutes time; Obtaining granularity is that 24 orders～60 orders are (about 0.70～0.25mm) 2% Nosiheptide premixed agent granule 708.5kg.
Claims (10)
1. one kind prepares the particulate system of Nosiheptide premixed agent, and this system comprises:
(1), storage tank, in storage tank, be equipped with the concentrated solution of from the nosiheptide fermentation liquid, being removed part moisture and with the binding agent of concentrated solution mix homogeneously;
(2), vacuum rake style drier, in vacuum rake style drier, store carrier;
(3), the air compressor that connects storage tank and vacuum rake style drier;
Wherein the nosiheptide of mix homogeneously in the storage tank and the mixed liquor of binding agent are input in the vacuum rake style drier by air compressor, this mixing material is sprayed on the carrier in the vacuum rake style drier equably by the shower nozzle on the vacuum rake style drier then, in vacuum rake style drier the carrier that has mixing material is carried out dry mixed again.
2. according to the system of claim 1, wherein when spraying mixing material, allow carrier speed with 5 rev/mins in vacuum rake style drier rotate.
3. according to the system of claim 1, the pressure that air compressor produced is 0.5-0.6MPa.
4. according to the system of claim 1, wherein, exsiccant temperature is 50 ℃-60 ℃.
5. according to the system of claim 1, wherein, binding agent can be one or more in alphalise starch, beta-schardinger dextrin-, Carboxymethyl cellulose sodium, sodium carboxymethyl cellulose or the xanthan gum.
6. according to the system of claim 1, wherein, described carrier can be one or more in the maize cob meal, bean cake, Testa oryzae, cottonseed meal, rapeseed meal, Testa Tritici, powdered rice hulls of 0.60～0.25mm.
7. one kind prepares the particulate method of Nosiheptide premixed agent, comprising:
(1), by equipment the nosiheptide fermentation liquid that stops fermentation is concentrated; Add binding agent, stir;
(2), carrier is dropped into vacuum rake style drier;
(3), adopt air compressor that the nosiheptide that stirs and the mixed liquor of binding agent are imported in the described vacuum rake style drier by pipeline, equably mixed liquor is sprayed on this carrier by the shower nozzle on the vacuum rake style drier then, in vacuum rake style drier, the carrier that has mixing material is carried out dry mixed again.
8. according to the method for claim 7, wherein, the equipment in the step (1) can select to remove from the nosiheptide fermentation liquid equipment of portion of water.
9. according to the method for claim 7, wherein, when spraying mixing material, allow carrier speed with 5 rev/mins in vacuum rake style drier rotate.
10. according to the method for claim 7, wherein, also comprise earlier the nosiheptide fermentation liquid after concentrating is packed in the storage tank, and then add described binding agent and stir.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104524586A (en) * | 2014-12-15 | 2015-04-22 | 山东齐发药业有限公司 | Preparation method of premix product |
| CN111961098A (en) * | 2020-08-28 | 2020-11-20 | 山东胜利生物工程有限公司 | Method for preparing high-content avilamycin premix by solvent method |
| CN112353774A (en) * | 2020-11-17 | 2021-02-12 | 浙江汇能生物股份有限公司 | Nascitide flavor chewable tablet, preparation method thereof and application thereof to clostridium welchii disease of dog |
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| CN1899599A (en) * | 2005-07-19 | 2007-01-24 | 复旦大学 | Method for preparing Nosiheptide premixed agent |
| CN101302247A (en) * | 2008-06-24 | 2008-11-12 | 浙江汇能动物药品有限公司 | Method for extracting nosipeptide crude product |
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| CN101624418A (en) * | 2009-08-03 | 2010-01-13 | 安徽省皖北药业股份有限公司 | Method for preparing nosiheptide powder |
| CN101869188A (en) * | 2010-06-11 | 2010-10-27 | 濮阳泓天威药业有限公司 | Preparation method of nosiheptide premix |
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| CN1899599A (en) * | 2005-07-19 | 2007-01-24 | 复旦大学 | Method for preparing Nosiheptide premixed agent |
| CN101302247A (en) * | 2008-06-24 | 2008-11-12 | 浙江汇能动物药品有限公司 | Method for extracting nosipeptide crude product |
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| CN101624418A (en) * | 2009-08-03 | 2010-01-13 | 安徽省皖北药业股份有限公司 | Method for preparing nosiheptide powder |
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| CN104524586A (en) * | 2014-12-15 | 2015-04-22 | 山东齐发药业有限公司 | Preparation method of premix product |
| CN111961098A (en) * | 2020-08-28 | 2020-11-20 | 山东胜利生物工程有限公司 | Method for preparing high-content avilamycin premix by solvent method |
| CN112353774A (en) * | 2020-11-17 | 2021-02-12 | 浙江汇能生物股份有限公司 | Nascitide flavor chewable tablet, preparation method thereof and application thereof to clostridium welchii disease of dog |
| CN112353774B (en) * | 2020-11-17 | 2022-08-23 | 浙江汇能生物股份有限公司 | Nascitide flavor chewable tablet, preparation method thereof and application thereof to clostridium welchii disease of dog |
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| CN102210630B (en) | 2014-01-15 |
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