CN101327314A - Nosiheptide-sulfuric acid colimycin premix and preparation and using method thereof - Google Patents
Nosiheptide-sulfuric acid colimycin premix and preparation and using method thereof Download PDFInfo
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- CN101327314A CN101327314A CNA2008101200353A CN200810120035A CN101327314A CN 101327314 A CN101327314 A CN 101327314A CN A2008101200353 A CNA2008101200353 A CN A2008101200353A CN 200810120035 A CN200810120035 A CN 200810120035A CN 101327314 A CN101327314 A CN 101327314A
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- nosiheptide
- colistin
- carrier
- colimycin
- premix
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Abstract
The invention discloses a nosiheptide-colistin sulfate premixed agent which comprises 0.5-4 portions of nosiheptide, 1-10 portions of colistin, and the carriers of calcium carbonate, zeolite powder, corn flour, etc. for the rest in every 100 weight portions. The preparation method is as following. The raw materials are added in a mixing machine by the sequence of the carriers, the colistin sulfate, the nosiheptide and the carriers, and mixed evenly to make into powdery nosiheptide-colistin sulfate premixed agent. Or the nosiheptide and the carriers can be mixed fully firstly, then the colistin sulfate is dissolved in the water and sprinkled evenly on the mixture of the nosiheptide and the carriers. After being granulated, dried and screened, the mixture is made into the granular-typed nosiheptide-colistin sulfate premixed agent, the granularity of which is 30-60 mesh. The nosiheptide-colistin sulfate premixed agent of the invention is added in feedstuffs. The content range of the nosiheptide in every kilogram of overhead price feedstuff is 0.5-20mg, and the content range of the colistin sulfate in every kilogram of overhead price feedstuff is 2-40mg.
Description
Technical field
The invention belongs to feedstuff medicated premix field, be specifically related to a kind of pre-mixing agent and preparation and using method that contains nosiheptide and colistine sulfate.
Background technology
Nosiheptide (Nosiheptide) is Japan's a kind of novel non-absorptive-type feeding antibiotic that late nineteen eighties is succeeded in developing last century, China is the new veterinary drug of national three classes in approval in 1998, is classified as by the Ministry of Agriculture at present and can add the feedstuff medicated premix that uses for a long time in feedstuff.Nosiheptide is the sulfur-bearing polypeptide antibiotics, and molecular formula is C
51H
43N
13O
12S
6, molecular weight is 1122.35.Nosiheptide all has higher activity to most of gram positive bacterias, and is also very effective to the minority gram negative bacteria, thereby domestic animal, poultry and aquatic animal are all had good growth promotion effect.As feed additive, nosiheptide has animal specific, growth promotion is effective, the macromole intestinal does not absorb, noresidue, no cross resistance, to characteristics such as environmental effect are little, thereby be widely used in countries such as China, Japan, North America and Southeast Asia.
Colistine sulfate (Colistin Sulfate) is a polypeptide antibiotics, and main component is colistin A and B.Molecular formula: colistin A:C
53H
100N
16O
13Colistin B:C
52H
98N
16O
13Colistine sulfate because have efficient, safety and residual few characteristics by many state approvals as feed additive.It has powerful bacteriostasis to gram negative bacteria, can prevent by escherichia coli and salmonellal disease, can promote the growth of poultry simultaneously and improve efficiency of feed utilization.
Nosiheptide has stronger antibacterial activity to gram positive bacteria, and is effective to the minority gram negative bacteria, but to the main pathogenic bacterium of intestinal such as escherichia coli and Salmonella nearly unavailable.And the antimicrobial spectrum of colistine sulfate is narrower, and gram negative bacteria is had stronger antibacterial activity, and to the gram positive bacteria nearly unavailable.Therefore nosiheptide and colistine sulfate are used simultaneously, be added in the animal and fowl fodder, then can enlarge antimicrobial spectrum, all inhibited to gram positive bacteria and negative bacterium, the growth promotion more remarkable effect, and can effectively prevent bacterial diarrhea.The two uses simultaneously, and the growth promotion effects of poultry is had potentiation, and also have good stability, safe, drug residue is little, be difficult for producing drug resistance, to characteristics such as environmental effect are little.
Summary of the invention
The objective of the invention is nosiheptide and colistine sulfate are made the compound recipe pre-mixing agent, make an addition in the animal and fowl fodder, reaching remarkable promotion growth of animals or poultry, and can effectively control the effect of intestinal bacteriosis.
The component of a kind of nosiheptide-sulfuric acid colimycin premix of the present invention is: contain 0.5～4 part of nosiheptide in the nosiheptide-sulfuric acid colimycin premix of per 100 weight portions, and 1～10 part of colistin, surplus is a carrier.
Wherein contained nosiheptide contains 1000 nosiheptide units for every milligram; Colistin contains 30000 colistin units for every milligram; Carrier uses calcium carbonate, zeolite powder or corn starch one, or its any mixing of two kinds.
The preparation method of pre-mixing agent of the present invention is that the nosiheptide of certain weight ratio, colistine sulfate and carrier mix homogeneously are made pre-mixing agent, and this pre-mixing agent can be pulverous, also can be corpuscular.Concrete preparation method is as follows:
The preparation method of Powdered pre-mixing agent: nosiheptide, colistine sulfate and the carrier of the certain weight ratio order according to carrier-colistine sulfate-nosiheptide-carrier is made an addition in the mixer, make Powdered pre-mixing agent behind the mix homogeneously.
The preparation method of granular pattern pre-mixing agent: take by weighing nosiheptide, colistine sulfate and carrier by weight, nosiheptide is fully mixed with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on nosiheptide and the carrier mixture, granulation then, dry, sub-sieve, obtaining granularity is 30～60 purpose granular pattern pre-mixing agents.
The using method of nosiheptide-sulfuric acid colimycin premix of the present invention is: make an addition in the feedstuff, nosiheptide content range in the per kilogram complete feedstuff is 0.5～20 milligram, and colistin content range in the per kilogram complete feedstuff is 2～40 milligrams.
Pre-mixing agent of the present invention can be used for preventing and treating the poultry gram positive bacteria and negative bacterium infects, and has the effect that promotes growth of animals or poultry.
Advantage of the present invention is nosiheptide and colistine sulfate to be made pre-mixing agent make an addition in the animal and fowl fodder, enlarged antimicrobial spectrum, simultaneously inhibited to gram positive bacteria and negative bacterium bacterium, growth promotion more remarkable effect not only, and can effectively prevent bacterial diarrhea.Have in addition good stability, safe, drug residue is little, be difficult for to produce drug resistance, to characteristics such as environmental effect are little and easy to use.The granular pattern pre-mixing agent also has few, the mobile better characteristics of dust in the moisture absorption of being difficult for, the course of processing.
Stability: nosiheptide and colistine sulfate stable performance.Nosiheptide is preserved at shady and cool dry place, deposits 2 years, and vigor does not descend, and room temperature is 2 years in the feedstuff, and vigor descends less than 5%; Colistine sulfate was deposited 2 years at 37 ℃, and vigor descends less than 5%; Used carrier stability is all very high in the pre-mixing agent.Therefore, the nosiheptide-sulfuric acid colimycin premix stable performance, effect duration is 2 years.
Safety: the toxicity of nosiheptide is very little.Acute toxicity test shows that nosiheptide is to the oral LD of rat
50＞13060mg/kg, subcutaneous injection LD
50＞4160mg/kg; Chronic toxicity test is fed rat with the feedstuff of 6000mg/kg and was carried out clinical trial in 3 months, and blood test, biochemical analysis all do not note abnormalities.In addition, nosiheptide does not have mutagenicity, no teratogenecity, and it is all no abnormal to cut open inspection, blood examination, reproductive performance and fertility performance.The oral LD of colistine sulfate rat
50720～725mg/kg, the oral LD of mice
50294～450mg/kg.Add continuously ten times of maximal doses commonly used in pig, chicken, the cattle feedstuff, health status, to cut open inspection, blood examination, reproductive performance and fertility performance all no abnormal.Thereby nosiheptide-sulfuric acid colimycin premix toxicity is little, safe.
Antibacterial activity: nosiheptide has very strong antibacterial activity to gram positive bacteria, particularly staphylococcus aureus, bacillus perfringens, micrococcus scarlatinae, Diplococcus pneumoniae etc., also effective to the minority negative bacterium, but to escherichia coli and Salmonella nearly unavailable.The colistine sulfate antimicrobial spectrum is narrower, and gram negative bacteria is had stronger antibacterial activity, especially escherichia coli, Salmonella and pseudomonas aeruginosa.Nosiheptide-sulfuric acid colimycin premix has enlarged antimicrobial spectrum, and is all effective to most of commonly encountered diseases of poultry and non-common disease pathogen, especially the main pathogenic bacterium escherichia coli of intestinal, Salmonella and bacillus perfringens had very high bacteriostatic activity.Colistine sulfate is respectively 0.01～1.6 μ g/ml and 0.01～1.6 μ g/ml to the minimal inhibitory concentration (MIC) of escherichia coli and Salmonella, and nosiheptide is 0.003 μ g/ml to the MIC of bacillus perfringens.
Drug resistance: nosiheptide is difficult for producing drug resistance, does not have cross resistance with other drug.It is also very low that chemical sproof frequency appears in colistine sulfate, also do not have cross resistance with other antibiotic.Nosiheptide is to play antibacterial and bactericidal action by suppressing the synthetic of bacterioprotein, and colistine sulfate be with bacterial cell membrane on phospholipid produce strong interaction and destroy its permeability and function.When the antimicrbial power of medicine was not enough to inhibition or kill bacteria, antibacterial can be adjusted enzyme system, carries out growth and breeding along another metabolic pathway, that is produced drug resistance.As two or more drug combinations, suppress antibacterial different metabolic link respectively, metabolism just is difficult for adjusting, and just is difficult for producing drug resistance, promptly enables to adapt to and adjusts, and also needs the longer time.Nosiheptide and colistine sulfate suppress the different metabolic link of antibacterial respectively, thereby use the probability that Resistant strain occurs minimum simultaneously.Therefore, nosiheptide-sulfuric acid colimycin premix is difficult for producing drug resistance.
Drug residue: nosiheptide is the macromole antibiotic, does not absorb in the intestinal, excretes with feces, therefore has the characteristics of noresidue in animal body.Add 0～250mg/kg continuous eight weeks of nosiheptide to chicken, add maximal dose (20mg/kg) more than ten times continuous 90 days to pig, butchered in 0～7 day in the middle of administration and after stopping administration, testing result shows that nosiheptide is residual all less than 0.001mg/kg (marginal value is following) in the tissue of liver,kidney,spleen, heart, muscle.Colistine sulfate decomposes inactivation in digestive tract, discharge through feces, so drug residue also seldom.To chicken interpolation 100 and continuous eight weeks of 500mg/kg colistine sulfate, add continuous 12 weeks of 400mg/kg in the baby pig feedstuff, main organs is detected, all be lower than and detect limit the quantity of (0.25mg/kg).Certain pharmaceutical factory of Japan is to the pig 40mg/kg colistine sulfate of feeding, and on drug withdrawal same day, except that liver, do not detect (detection is limited the quantity of and is 0.025mg/kg) in kidney, muscle, the fat; After 1 day, also disappear in the liver.In another test,, disappear after 3 days in the liver to the pig 20mg/kg colistine sulfate of feeding.Therefore Japan and China stipulate, the withdrawal time of colistine sulfate is 7 days.The nosiheptide withdrawal time of China regulation also is 7 days, so the nosiheptide-sulfuric acid colimycin premix withdrawal time is 7 days, uses in accordance with regulations, does not have residue problem.
Influence to environment: the nosiheptide that is discharged from was respectively one month and 20 days in pig and the chicken manure half-life in just, these feces as fertilizer sources are imposed on plant, do not find in plant, to have residual after the results, activity for higher plant herbicide and insecticide does not have inhibitory action yet, and active sludge microorganism is not also hindered and side effect.Therefore nosiheptide is minimum to environmental effect.The colistine sulfate major part is decomposed inactivation in intestinal, small part is decomposed rapidly in excrement composting, thereby does not influence environment.Therefore nosiheptide-sulfuric acid colimycin premix is minimum to environmental effect.
The specific embodiment
Embodiment 1:
Take by weighing nosiheptide 5g (5,000,000 nosiheptide unit), colistine sulfate 10g (300,000,000 colistin unit), all the other are calcium carbonate, add to 1000g.Order according to carrier-colistine sulfate-nosiheptide-carrier is mixed, and makes Powdered pre-mixing agent behind the mix homogeneously.Contain nosiheptide 0.5% and colistin 1% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 100～500mg/kg, and the addition in the pig complete feed is 500～4000mg/kg.
Embodiment 2:
Take by weighing nosiheptide 5g (5,000,000 nosiheptide unit), colistine sulfate 10g (300,000,000 colistin unit), all the other are corn starch, add to 1000g.Nosiheptide is fully mixed with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on nosiheptide and the carrier mixture, granulation then, dry, sub-sieve, obtaining granularity is 30～60 purpose granular pattern pre-mixing agents.Contain nosiheptide 0.5% and colistin 1% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 100～500mg/kg, and the addition in the pig complete feed is 500～4000mg/kg.
Embodiment 3:
Take by weighing nosiheptide 5g (5,000,000 nosiheptide unit), colistine sulfate 20g (600,000,000 colistin unit), all the other are zeolite powder, add to 1000g.Order according to carrier-colistine sulfate-nosiheptide-carrier is mixed, and makes Powdered pre-mixing agent behind the mix homogeneously.Contain nosiheptide 0.5% and colistin 2% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 100～500mg/kg, and the addition in the pig complete feed is 500～2000mg/kg.
Embodiment 4:
Take by weighing nosiheptide 5g (5,000,000 nosiheptide unit), colistine sulfate 20g (600,000,000 colistin unit), all the other are corn starch and calcium carbonate (80: 20), add to 1000g.Nosiheptide is fully mixed with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on nosiheptide and the carrier mixture, granulation then, dry, sub-sieve, obtaining granularity is 30～60 purpose granular pattern pre-mixing agents.Contain nosiheptide 0.5% and colistin 2% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 100～500mg/kg, and the addition in the pig complete feed is 500～2000mg/kg.
Embodiment 5:
Take by weighing nosiheptide 5g (5,000,000 nosiheptide unit), colistine sulfate 40g (1,200,000,000 colistin unit), all the other are calcium carbonate and corn starch (80: 20), add to 1000g.Order according to carrier-colistine sulfate-nosiheptide-carrier is mixed, and makes Powdered pre-mixing agent behind the mix homogeneously.Contain nosiheptide 0.5% and colistin 4% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 100～500mg/kg, and the addition in the pig complete feed is 500～1000mg/kg.
Embodiment 6:
Take by weighing nosiheptide 5g (5,000,000 nosiheptide unit), colistine sulfate 40g (1,200,000,000 colistin unit), all the other are corn starch and calcium carbonate (80: 20), add to 1000g.Nosiheptide is fully mixed with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on nosiheptide and the carrier mixture, granulation then, dry, sub-sieve, obtaining granularity is 30～60 purpose granular pattern pre-mixing agents.Contain nosiheptide 0.5% and colistin 4% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 100～500mg/kg, and the addition in the pig complete feed is 500～1000mg/kg.
Embodiment 7:
Take by weighing nosiheptide 10g (1,000 ten thousand nosiheptide unit), colistine sulfate 10g (300,000,000 colistin unit), all the other are zeolite powder and corn starch (80: 20), add to 1000g.Order according to carrier-colistine sulfate-nosiheptide-carrier is mixed, and makes Powdered pre-mixing agent behind the mix homogeneously.Contain nosiheptide 1% and colistin 1% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 50～250mg/kg, and the addition in the pig complete feed is 250～2000mg/kg.
Embodiment 8:
Take by weighing nosiheptide 10g (1,000 ten thousand nosiheptide unit), colistine sulfate 10g (300,000,000 colistin unit), all the other are corn starch and zeolite powder (80: 20), add to 1000g.Nosiheptide is fully mixed with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on nosiheptide and the carrier mixture, granulation then, dry, sub-sieve, obtaining granularity is 30～60 purpose granular pattern pre-mixing agents.Contain nosiheptide 1% and colistin 1% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 50～250mg/kg, and the addition in the pig complete feed is 250～2000mg/kg.
Embodiment 9:
Take by weighing nosiheptide 10g (1,000 ten thousand nosiheptide unit), colistine sulfate 20g (600,000,000 colistin unit), all the other are calcium carbonate and zeolite powder (50: 50), add to 1000g.Order according to carrier-colistine sulfate-nosiheptide-carrier is mixed, and makes Powdered pre-mixing agent behind the mix homogeneously.Contain nosiheptide 1% and colistin 2% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 50～250mg/kg, and the addition in the pig complete feed is 250～2000mg/kg.
Embodiment 10:
Take by weighing nosiheptide 10g (1,000 ten thousand nosiheptide unit), colistine sulfate 20g (600,000,000 colistin unit), all the other are corn starch and calcium carbonate (80: 20), add to 1000g.Nosiheptide is fully mixed with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on nosiheptide and the carrier mixture, granulation then, dry, sub-sieve, obtaining granularity is 30～60 purpose granular pattern pre-mixing agents.Contain nosiheptide 1% and colistin 2% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 50～250mg/kg, and the addition in the pig complete feed is 250～2000mg/kg.
Embodiment 11:
Take by weighing nosiheptide 10g (1,000 ten thousand nosiheptide unit), colistine sulfate 40g (1,200,000,000 colistin unit), all the other are calcium carbonate and corn starch (70: 30), add to 1000g.Order according to carrier-colistine sulfate-nosiheptide-carrier is mixed, and makes Powdered pre-mixing agent behind the mix homogeneously.Contain nosiheptide 1% and colistin 4% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 50～250mg/kg, and the addition in the pig complete feed is 250～1000mg/kg.
Embodiment 12:
Take by weighing nosiheptide 10g (1,000 ten thousand nosiheptide unit), colistine sulfate 40g (1,200,000,000 colistin unit), all the other are corn starch and calcium carbonate (70: 30), add to 1000g.Nosiheptide is fully mixed with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on nosiheptide and the carrier mixture, granulation then, dry, sub-sieve, obtaining granularity is 30～60 purpose granular pattern pre-mixing agents.Contain nosiheptide 1% and colistin 4% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 50～250mg/kg, and the addition in the pig complete feed is 250～1000mg/kg.
Embodiment 13:
Take by weighing nosiheptide 10g (1,000 ten thousand nosiheptide unit), colistine sulfate 80g (2,400,000,000 colistin unit), all the other are calcium carbonate, add to 1000g.Order according to carrier-colistine sulfate-nosiheptide-carrier is mixed, and makes Powdered pre-mixing agent behind the mix homogeneously.Contain nosiheptide 1% and colistin 8% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 50～250mg/kg, and the addition in the pig complete feed is 250～500mg/kg.This pre-mixing agent uses when being suitable for producing concentrate feed and premix material.
Embodiment 14:
Take by weighing nosiheptide 10g (1,000 ten thousand nosiheptide unit), colistine sulfate 80g (2,400,000,000 colistin unit), all the other are corn starch and calcium carbonate (90: 10), add to 1000g.Nosiheptide is fully mixed with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on nosiheptide and the carrier mixture, granulation then, dry, sub-sieve, obtaining granularity is 30～60 purpose granular pattern pre-mixing agents.Contain nosiheptide 1% and colistin 8% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 50～250mg/kg, and the addition in the pig complete feed is 250～500mg/kg.This pre-mixing agent uses when being suitable for producing concentrate feed and premix material.
Embodiment 15:
Take by weighing nosiheptide 10g (1,000 ten thousand nosiheptide unit), colistine sulfate 100g (3,000,000,000 colistin unit), all the other are calcium carbonate, add to 1000g.Order according to carrier-colistine sulfate-nosiheptide-carrier is mixed, and makes Powdered pre-mixing agent behind the mix homogeneously.Contain nosiheptide 1% and colistin 10% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 50～250mg/kg, and the addition in the pig complete feed is 200～400mg/kg.This pre-mixing agent uses when being suitable for producing concentrate feed and premix material.
Embodiment 16:
Take by weighing nosiheptide 10g (1,000 ten thousand nosiheptide unit), colistine sulfate 100g (3,000,000,000 colistin unit), all the other are corn starch and calcium carbonate (80: 20), add to 1000g.Nosiheptide is fully mixed with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on nosiheptide and the carrier mixture, granulation then, dry, sub-sieve, obtaining granularity is 30～60 purpose granular pattern pre-mixing agents.Contain nosiheptide 1% and colistin 10% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 50～250mg/kg, and the addition in the pig complete feed is 200～400mg/kg.This pre-mixing agent uses when being suitable for producing concentrate feed and premix material.
Embodiment 17:
Take by weighing nosiheptide 20g (2,000 ten thousand nosiheptide unit), colistine sulfate 80g (2,400,000,000 colistin unit), all the other are calcium carbonate, add to 1000g.Order according to carrier-colistine sulfate-nosiheptide-carrier is mixed, and makes Powdered pre-mixing agent behind the mix homogeneously.Contain nosiheptide 2% and colistin 8% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 25～125mg/kg, and the addition in the pig complete feed is 125～500mg/kg.This pre-mixing agent uses when being suitable for producing concentrate feed and premix material.
Embodiment 18:
Take by weighing nosiheptide 20g (2,000 ten thousand nosiheptide unit), colistine sulfate 80g (2,400,000,000 colistin unit), all the other are corn starch and calcium carbonate (80: 20), add to 1000g.Nosiheptide is fully mixed with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on nosiheptide and the carrier mixture, granulation then, dry, sub-sieve, obtaining granularity is 30～60 purpose granular pattern pre-mixing agents.Contain nosiheptide 2% and colistin 8% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 25～125mg/kg, and the addition in the pig complete feed is 125～500mg/kg.This pre-mixing agent uses when being suitable for producing concentrate feed and premix material.
Embodiment 19:
Take by weighing nosiheptide 40g (4,000 ten thousand nosiheptide unit), colistine sulfate 100g (3,000,000,000 colistin unit), all the other are calcium carbonate, add to 1000g.Order according to carrier-colistine sulfate-nosiheptide-carrier is mixed, and makes Powdered pre-mixing agent behind the mix homogeneously.Contain nosiheptide 4% and colistin 10% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 12.5～62.5mg/kg, and the addition in the pig complete feed is 62.5～400mg/kg.This pre-mixing agent uses when being suitable for producing concentrate feed and premix material.
Embodiment 20:
Take by weighing nosiheptide 40g (4,000 ten thousand nosiheptide unit), colistine sulfate 100g (3,000,000,000 colistin unit), all the other are corn starch and calcium carbonate (80: 20), add to 1000g.Nosiheptide is fully mixed with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on nosiheptide and the carrier mixture, granulation then, dry, sub-sieve, obtaining granularity is 30～60 purpose granular pattern pre-mixing agents.Contain nosiheptide 4% and colistin 10% in this pre-mixing agent.The addition of this pre-mixing agent in the fowl complete feed is 12.5～62.5mg/kg, and the addition in the pig complete feed is 62.5～400mg/kg.This pre-mixing agent uses when being suitable for producing concentrate feed and premix material.
Claims (4)
1, a kind of nosiheptide-sulfuric acid colimycin premix is characterized in that: contain 0.5～4 part of nosiheptide in the nosiheptide-sulfuric acid colimycin premix of per 100 weight portions, and 1～10 part of colistin, surplus is a carrier.
2, as the said nosiheptide-sulfuric acid colimycin premix of claim 1, it is characterized in that: contained nosiheptide contains 1000 nosiheptide units for every milligram; Contained colistin contains 30000 colistin units for every milligram; Carrier uses calcium carbonate, zeolite powder or corn starch one, or its any mixing of two kinds.
3, a kind of preparation method of nosiheptide-sulfuric acid colimycin premix is characterized in that following steps:
(1) takes by weighing nosiheptide, colistine sulfate and carrier by weight;
(2) order according to carrier, colistine sulfate, nosiheptide, carrier makes an addition in the mixer, makes the powdery nosiheptide-sulfuric acid colimycin premix behind the mix homogeneously;
(3) or with nosiheptide fully mix with carrier, again that colistine sulfate is water-soluble, evenly be sprayed on the nosiheptide carrier mixture, through granulation, drying, sub-sieve, making granularity is 30～60 purpose granular pattern nosiheptide-sulfuric acid colimycin premixes.
4, as the using method of the said nosiheptide-sulfuric acid colimycin premix of claim 1, it is characterized in that: make an addition in the feedstuff, nosiheptide content range in the per kilogram complete feedstuff is 0.5～20 milligram, and colistin content range in the per kilogram complete feedstuff is 2～40 milligrams.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101200353A CN101327314A (en) | 2008-07-15 | 2008-07-15 | Nosiheptide-sulfuric acid colimycin premix and preparation and using method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101200353A CN101327314A (en) | 2008-07-15 | 2008-07-15 | Nosiheptide-sulfuric acid colimycin premix and preparation and using method thereof |
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| CN101327314A true CN101327314A (en) | 2008-12-24 |
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| CNA2008101200353A Pending CN101327314A (en) | 2008-07-15 | 2008-07-15 | Nosiheptide-sulfuric acid colimycin premix and preparation and using method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210630A (en) * | 2011-06-02 | 2011-10-12 | 浙江汇能动物药品有限公司 | System and method for preparing nosiheptide premix particles |
-
2008
- 2008-07-15 CN CNA2008101200353A patent/CN101327314A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102210630A (en) * | 2011-06-02 | 2011-10-12 | 浙江汇能动物药品有限公司 | System and method for preparing nosiheptide premix particles |
| CN102210630B (en) * | 2011-06-02 | 2014-01-15 | 浙江汇能动物药品有限公司 | System and method for preparing nosiheptide premix particles |
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