CN102205148A - Protein biological filling material for repairing scars and preparation method - Google Patents
Protein biological filling material for repairing scars and preparation method Download PDFInfo
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- CN102205148A CN102205148A CN2011101276208A CN201110127620A CN102205148A CN 102205148 A CN102205148 A CN 102205148A CN 2011101276208 A CN2011101276208 A CN 2011101276208A CN 201110127620 A CN201110127620 A CN 201110127620A CN 102205148 A CN102205148 A CN 102205148A
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Abstract
The invention relates to a protein biological filling material for repairing scars and a preparation method. Hair keratin granules and dermal fibroblasts are mixed to form a soft tissue filling material. By means of a repair system of collagens filled by the hair granules and secreted by the dermal fibroblasts, long-term filling effect is realized and maintained, so that the purposes of beautifying features, removing wrinkles and filling scar depression and gingival atrophy are fulfilled.
Description
Technical field
The present invention relates to a kind of protein biology packing material and preparation method of repairing cicatrix, belong to beauty treatment reduce wrinkle technical field.
Background technology
The intimate friend that likes to be beautiful all has and knows, the beauty treatment reduce wrinkle, goes scar well-known.Keloid is divided into essential and two kinds of keloids of secondary type generally, and essential keloid majority from the beginning of small red dot companion gargalesthesia, changes from small to big gradually in the front or the shoulder back, changes software strategy into software-hardware strategy, and color is red or dark red, rounded, bar rope shape, butterfly shape etc.; Secondary shape keloid (also being hypertrophy type keloid) is many because of factors such as burn, scald, operation, wound, acne infection, edema, foreign body stimulation damage corium causes the subcutaneous connective tissue hyperplasia, and part has tangible outward extending blood capillary.
Go at present the scar product to mainly contain the scar cream, send dream that repair liquid, Artistry etc.Select well-known picture Artistry, though effect is pretty good, price is also somewhat expensive, does not also have the effect of significantly taking stopgap measures.And cicatrix is not too consistent with healthy on every side skin tone after going scar.
Summary of the invention
The invention discloses a kind of protein biology packing material of repairing cicatrix, have the beauty treatment reduce wrinkle, improve therapeutic effect, characteristics such as using method is convenient.
The present invention also provides the preparation method of the protein biology packing material of above-mentioned reparation cicatrix.
Technical solution of the present invention is: mix as soft tissue filling material with dermal fibroblast with the hair-keratin granule, rely on particulate filling of hair and the excretory collagen protein repair system of dermal fibroblast, realize also keeping comparatively secular filling effect, thereby reach the beauty treatment reduce wrinkle, fill up the purpose of cicatrix depression and gingival atrophy.
A kind of protein biology packing material of repairing cicatrix that the present invention constitutes is characterized in that by following raw materials by weight portion than making:
1 ~ 8 part of hair-keratin granule, 1 ~ 4 part of dermal fibroblast.
Preparation method: hair-keratin granule and dermal fibroblast mix in proportion and get final product.
Using method: by state of an illness weight, with hair-keratin granule 1 ~ 8(part): dermal fibroblast is injected in human body (5 ~ 10 ml) in 1 ~ 4 part ratio.
Function cures mainly: the beauty treatment reduce wrinkle, fill up cicatrix depression and gingival atrophy.
Indication: the treatment that striae gravidarum, gingival atrophy and the body contour that the cicatrix depression that burning/scald and postoperative form, facial area wrinkle, puerperal form improves.
Curative effect proves: with the hair-keratin granule as packing material, or mix as soft tissue filling material with the auto derma fibroblast as the biodegradable stent material, rely on the collagen protein repair system of particulate filling of hair and auto derma fibroblasts to secrete, overcome the shortcoming of heterologouss such as collagen and hyaluronic acid, and keep comparatively secular filling effect, thereby seek a kind of novel easy acquisition, long-term, safe and effective soft tissue filling material.
Effect: promote cutis laxa to correct, remove the buccal wrinkle, improve that nasolabial fold is dark excessively, cervical region lines etc.
Dosage: when fibroblast and hair-keratin proportion of particles were 2:1, this kind effect was the most obvious.
Using method: by Wicresoft's skin corium and hypodermic method, allow skin reach at once that omnibearing stereo thickens and rejuvenation, realize facial moulding.
Below test shows medical effect of the present invention:
Seek volunteer's 80 examples, carry out that wrinkle is filled and led up, scar repairing etc., and its effect is estimated effective 72 examples of statistics conclusion; Produce effects 6 examples; Invalid 2 examples.
The several cases of concrete summary further show curative effect of the present invention:
The treatment of case 1 crows-feet
Treat trimestral effective percentage more than 98%.
Treatment step and process:
1. adopt 1 milliliter of syringe, No. 29.5 injection needles.
2. the operator holds syringe, pinpoint inclined plane upwards, left hand is tightened local skin, syringe needle and skin is 15 ° of angles slowly thrusts in wrinkle end or the skin injury district, depth of needle is in the reticular layer of corium.
3. withdraw of the needle limit in limit is evenly injected, and bleaches gradually, swells slightly and be advisable with skin.
4. crows-feet is injected with fan-shaped tiling, the lines of wrinkle deep can be on the basis of fan-shaped tiling vertically injection, the artificial support that causes; The have gentle hands forlement is used in the injection back, the cell uniform distribution canthus that injection is entered, thus reach therapeutic effect effectively.
Consumption: a 2ml injection is total to 4ml twice
See before the injection that Fig. 1 injects and saw Fig. 2 in back three months
Consumption: a 3ml injection is total to 6ml twice
See before the injection that Fig. 3 injects and saw Fig. 4 in back three months
The treatment of case 2 forehead stricture of vaginas
Inject back three months effective percentage more than 98%.
Injecting step and method:
1. adopt 1 milliliter of syringe, No. 29.5 injection needles.
2. the operator holds syringe, pinpoint inclined plane upwards, the left hand taught skin is 15 ° of angles with syringe needle and skin and slowly thrusts in wrinkle end or the skin injury district, depth of needle is in the reticular layer of corium.
3. withdraw of the needle limit in limit is evenly injected, and bleaches gradually, swells slightly and be advisable with skin
4. wrinkle reaches tiling, longitudinal network trellis injection again than comparatively dense as far as possible.
Consumption: a 3ml injection is total to 6ml twice
See before the injection that Fig. 5 injects and saw Fig. 6 in back three months
The treatment of case 3 depressed scars
Effective percentage after three months is effective throughout one's life more than 98%.
Treatment step and process:
1. adopt 1 milliliter of syringe, No. 29.5 injection needles.
2. shuttle at the cicatricial adhesion place with syringe needle and peel off, inject after cicatricial adhesion has all been peeled off, the scope of injection is than wide slightly 2 millimeter of cicatrix.The injection back is the cell uniform distribution with the have gentle hands forlement.
Consumption: a 2ml injection is total to 4ml twice.
See before the injection that Fig. 7 injects and saw Fig. 8 in back three months
The treatment of case 4 decree stricture of vaginas
Effective percentage is more than 95% after three months.The facial relax level of therapeutic effect and therapist has relation.
Consumption: a 4ml injection is total to 8ml twice;
See before the treatment that Fig. 9 treats injection and saw Figure 10 in back 3 months;
Consumption: a 3ml injection is total to 6ml twice
See before the injection that Figure 11 injects and saw Figure 12 in back three months
The pit treatment that case 5 comedos stay
Effective percentage after three months is on 98%.
Consumption: one-sided shot 2ml injection is total to 6ml 3 times
Treatment step and process:
1. adopt 1 milliliter of syringe, No. 29.5 injection needles.
2. shuttle at the cicatricial adhesion place with syringe needle and peel off, inject after cicatricial adhesion has all been peeled off, the scope of injection is than wide slightly 2 millimeter of cicatrix.The injection back makes the cell uniform distribution with the have gentle hands forlement.
See before the injection that Figure 13 injects and saw Figure 14 in back three months
Case 6 chickenpoxs are left over the hole treatment of depression pox
Effective percentage is more than 98% after three months
Treatment step and process:
1. adopt 1 milliliter of syringe, No. 29.5 injection needles.
2. shuttle at the cicatricial adhesion place with syringe needle and peel off, inject after cicatricial adhesion has all been peeled off, the scope of injection is than wide slightly 2 millimeter of cicatrix.The injection back makes the cell uniform distribution with the have gentle hands forlement.
Consumption a: 2ml; Inject 2ml altogether twice.
See before the injection that Figure 15 injects and saw Figure 16 in back three months
The treatment of case 7 lip pits
Inject effective percentage after 3 months 100%.
Treatment step and process:
1. adopt 1 milliliter of syringe, No. 29.5 injection needles.
2. shuttle at the cicatricial adhesion place with syringe needle and peel off, inject after cicatricial adhesion has all been peeled off, the scope of injection is than wide slightly 2 millimeter of cicatrix.The injection back makes the cell uniform distribution with the have gentle hands forlement.
Consumption a: 2ml; Inject 2ml altogether twice.
See before the injection that Figure 17 injects and saw Figure 18 in back three months
The treatment of case 8 neck bands
The effective percentage of injecting after 3 months can reach flat fully effect more than 98%, and pigment print is slower to what recover, according to the individual variation difference.
Consumption: two neck bands of neck band ampoule this guest of 3ml ampoule 6ml, inject 12ml altogether twice, unsteady according to the depth width of wrinkle.
Treatment step and method:
1. adopt 1 milliliter of syringe, No. 29.5 injection needles;
2. the width in when injection is wideer slightly than wrinkle, punctures a little back and forth than broad and dark wrinkle and peels off;
3. the injection back makes the local cells uniform distribution with the have gentle hands forlement.
See before the injection that Figure 19 injects and saw Figure 20 in back three months.
Case 9 facial area evaluation of wrinkle treatment
Inject after three months obvious effective rate more than 98%.
Consumption: shot 3ml double injection is 6ml altogether
Injecting step and method:
1. adopt 1 milliliter of syringe, No. 29.5 injection needles.
2. the operator holds syringe, pinpoint inclined plane upwards, the left hand taught skin is 15 ° of angles with syringe needle and skin and slowly stings
Go in wrinkle end or the skin injury district, certain resistance is arranged, depth of needle is in the reticular layer of corium.
3. withdraw of the needle limit in limit is evenly injected, and bleaches gradually, swells slightly and be advisable with skin.
4. the gap of buccal portion injection wrinkle and wrinkle injection is the smaller the better, reaches tiling as far as possible.
5. the have gentle hands forlement is used in the injection back, and cell is evenly distributed.
See before the injection that Figure 21 injects and saw Figure 22 in back three months.
Good effect of the present invention is: mix as soft tissue filling material with dermal fibroblast with the hair-keratin granule, rely on particulate filling of hair and the excretory collagen protein repair system of dermal fibroblast, realize also keeping comparatively secular filling effect, thereby reach the beauty treatment reduce wrinkle, fill up the purpose of cicatrix depression and gingival atrophy.The division growth that helps the cell fast and stable, and can promote cell to produce and the secretion collagen protein, strengthen the effect of the treatment of facial area reduce wrinkle, the recessed limit of cicatrix and gingival atrophy.
Description of drawings
Fig. 1 is the preceding photo of shot 2ml crows-feet treatment of the present invention;
Fig. 2 is that photo after back three months is injected in shot 2ml crows-feet treatment of the present invention.
Fig. 3 is the preceding photo of shot 3ml crows-feet treatment of the present invention;
Fig. 4 is that photo after back three months is injected in shot 3ml crows-feet treatment of the present invention.
Fig. 5 is the preceding photo of shot 3ml forehead stricture of vagina treatment of the present invention;
Fig. 6 is that photo after back three months is injected in shot 3ml forehead stricture of vagina treatment of the present invention.
Fig. 7 is the preceding photo of shot 2ml depressed scar treatment treatment of the present invention;
Fig. 8 is that photo after back three months is injected in shot 2ml depressed scar treatment of the present invention.
Fig. 9 is the preceding photo of shot 4ml decree stricture of vagina treatment of the present invention;
Figure 10 is shot 4ml decree stricture of vagina of the present invention treatment injection back photo after March.
Figure 11 is the preceding photo of shot 3ml decree stricture of vagina treatment of the present invention;
Figure 12 is that photo after back three months is injected in shot 3ml decree stricture of vagina treatment of the present invention.
Photo before the pit treatment that Figure 13 stays for shot 2ml comedo of the present invention;
The pit treatment injection that Figure 14 stays for shot 2ml comedo of the present invention photo after back three months.
Figure 15 leaves over the preceding photo of depression pox hole treatment for shot 1ml chickenpox of the present invention;
Figure 16 leaves over depression pox hole treatment injection photo after back three months for shot 1ml chickenpox of the present invention.
Figure 17 is the preceding photo of shot 1ml lip pit of the present invention hole treatment;
Figure 18 is that photo after back three months is injected in shot 1ml lip pit of the present invention hole treatment.
Figure 19 is the preceding photo of shot 3ml neck band treatment of the present invention;
Figure 20 is that photo after back three months is injected in shot 3ml neck band treatment of the present invention.
Figure 21 is photo before the shot 3ml facial area evaluation of wrinkle treatment of the present invention;
Figure 22 injects photo after back three months for shot 3ml facial area evaluation of wrinkle treatment of the present invention.
The specific embodiment
Embodiment 1
Take by weighing from chaeta and send out keratin granule 1ml, auto derma fibroblast 1ml, mix homogeneously.
Embodiment 2
Take by weighing from chaeta and send out keratin granule 1ml, auto derma fibroblast 4ml, mix homogeneously.
Embodiment 3
Take by weighing from chaeta and send out keratin granule 1ml, auto derma fibroblast 3ml, mix homogeneously promptly.
Embodiment 4
Take by weighing from chaeta and send out keratin granule 3ml, auto derma fibroblast 1ml, mix homogeneously promptly.
Embodiment 5
Take by weighing from chaeta and send out keratin granule 8ml, auto derma fibroblast 1ml, mix homogeneously promptly.
Embodiment 6
Take by weighing from chaeta and send out keratin granule 4ml, auto derma fibroblast 4ml, mix homogeneously promptly.
Embodiment 7
Take by weighing from chaeta and send out keratin granule 5ml, auto derma fibroblast 3ml, mix homogeneously promptly.
Embodiment 8
Take by weighing from chaeta and send out keratin granule 3ml, auto derma fibroblast 2ml, mix homogeneously promptly.
Claims (2)
1. protein biology packing material of repairing cicatrix is characterized in that by following raw materials by weight portion than making:
Send out keratin granule 1 ~ 2 μ l, auto derma fibroblast 1 ~ 3 μ l from chaeta.
2. the preparation method of the protein biology packing material of claims 1 described reparation cicatrix is characterized in that:
To send out the keratin granule and the auto derma fibroblast mixes according to the above ratio from chaeta according to the above ratio.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101276208A CN102205148A (en) | 2011-05-17 | 2011-05-17 | Protein biological filling material for repairing scars and preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011101276208A CN102205148A (en) | 2011-05-17 | 2011-05-17 | Protein biological filling material for repairing scars and preparation method |
Publications (1)
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| CN102205148A true CN102205148A (en) | 2011-10-05 |
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| CN2011101276208A Pending CN102205148A (en) | 2011-05-17 | 2011-05-17 | Protein biological filling material for repairing scars and preparation method |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016100476A1 (en) * | 2014-12-16 | 2016-06-23 | KeraNetics, LLC | Dermal fillers comprising keratin biomaterials |
| CN106474527A (en) * | 2016-07-21 | 2017-03-08 | 北京东方艾美生物技术股份有限公司 | A kind of preparation method of the engineered dressing of hair-keratin compound cells |
| CN106474532A (en) * | 2016-07-21 | 2017-03-08 | 北京东方艾美生物技术股份有限公司 | A kind of preparation method of through engineering approaches dressing |
| CN110279891A (en) * | 2018-03-19 | 2019-09-27 | 凯利得科技股份有限公司 | Medical composition and its preparation method and application made of human hair |
| CN110478614A (en) * | 2019-09-18 | 2019-11-22 | 彭伟 | A kind of basal cell that human skin extracts is applied to the method and device of the facial depressed scar of reparation |
| CN113855858A (en) * | 2021-09-17 | 2021-12-31 | 北京华宇云生健康科技有限公司 | Protein filling material and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1768857A (en) * | 2004-11-04 | 2006-05-10 | 北京东南医疗美容医院 | Wrinkle- and scar-removing injection |
| CN101530636A (en) * | 2008-03-12 | 2009-09-16 | 章庆国 | Preparation method of injectable human hair keratin soft tissue filling material |
-
2011
- 2011-05-17 CN CN2011101276208A patent/CN102205148A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1768857A (en) * | 2004-11-04 | 2006-05-10 | 北京东南医疗美容医院 | Wrinkle- and scar-removing injection |
| CN101530636A (en) * | 2008-03-12 | 2009-09-16 | 章庆国 | Preparation method of injectable human hair keratin soft tissue filling material |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016100476A1 (en) * | 2014-12-16 | 2016-06-23 | KeraNetics, LLC | Dermal fillers comprising keratin biomaterials |
| CN106474527A (en) * | 2016-07-21 | 2017-03-08 | 北京东方艾美生物技术股份有限公司 | A kind of preparation method of the engineered dressing of hair-keratin compound cells |
| CN106474532A (en) * | 2016-07-21 | 2017-03-08 | 北京东方艾美生物技术股份有限公司 | A kind of preparation method of through engineering approaches dressing |
| CN110279891A (en) * | 2018-03-19 | 2019-09-27 | 凯利得科技股份有限公司 | Medical composition and its preparation method and application made of human hair |
| CN110478614A (en) * | 2019-09-18 | 2019-11-22 | 彭伟 | A kind of basal cell that human skin extracts is applied to the method and device of the facial depressed scar of reparation |
| CN113855858A (en) * | 2021-09-17 | 2021-12-31 | 北京华宇云生健康科技有限公司 | Protein filling material and preparation method thereof |
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Application publication date: 20111005 |