CN102188682A - Chinese medicinal composition for treating biliary calculus and preparation method thereof - Google Patents
Chinese medicinal composition for treating biliary calculus and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a Chinese medicinal composition for treating biliary calculus and a preparation method thereof. The Chinese medicinal composition is prepared from the following Chinese herbal medicines in part by weight: 5 to 10 parts of largehead atractylodes rhizome, 5 to 10 parts of white paeony root, 5 to 10 parts of stir-fried white hyacinth bean, 5 to 10 parts of astragalus, 5 to 10 parts of Indian buead, 5 to 10 parts of liquoric root, 5 to 20 parts of ginger and 5 to 10 parts of red date. The Chinese medicinal composition for treating biliary calculus has the effects of invigorating spleen, relieving pain, regulating qi and blood, clearing heat, detoxicating, normalizing gallbladder, dehumidifying, eliminating factors which cause biliary calculus in bodies, dissolving and discharging existing biliary calculus.
Description
Technical field
The invention belongs to the Chinese medicine composition field, specifically, relate to a kind of Chinese medicine composition for the treatment of cholelithiasis and preparation method thereof.
Background technology
Cholelithiasis is common clinically choledocholithiasis, calculus of intrahepatic duct, a cholelithiasis.Because the position difference that calculus generates.Clinical manifestation is also different.But the typical characteristic of choledocholithiasis is angor, shiver with cold hyperpyrexia, jaundice, early stage shock; Calculus of intrahepatic duct is the vexed bloated pain in right upper quadrant of the abdomen hepatic region to show effect repeatedly then, can be with fear of cold, heating etc.But symptom is not true to type more, often mistaken diagnosis; The violent angor that gall stone occurs breaking out after with heavy meal is difficult to stand and is feature, and clinically in conjunction with blood, X ray or auxiliary examinations such as cholangiography, B ultrasonic, analysis-by-synthesis is the diagnosis of being not difficult to make cholelithiasis.Cholelithiasis is in the past all based on operative treatment, but effect is not satisfied, uses therapy of combining Chinese and Western medicine in recent years, has obtained gratifying curative effect.
In the successive dynasties TCM Document, there is no the name of cholelithiasis.But its sign performance: hypochondriac pain, feeling of fullness, subcutaneous ulcer card etc. early have detailed description." knotted chest with jaundice " particularly described in the treatise on Febrile Diseases is similar to the performance of cholelithiasis.The traditional Chinese medical science is thought, coerces the dividing line into gallbladder.Two side of body portions are that Liver Channel is led.Though so sick giving birth to and gallbladder, concern with liver in fact, Jing-Yue Complete Works is said: " disease of costalgia, this genus liver and gall two warps all follow rib with the arteries and veins of two warps and put also." because of gallbladder depends on liver, be subjected to gas after the liver and be bile.Liver controlling conveyance and dispersion, can fortune blood, regulating spirit and emotion by oneself, thus stagnation of liver-QI then the bile catharsis be obstructed, be stone with fixed attention; Or because of the liver failing to maintain the normal flow of QI, the fortuneization of spleen is also influenced, and heat is given birth in the water retention removing dampness, damp and hot evil fumigation liver and gall, and to gallbladder is also got involved, then bile pulls the devil by the tail for a long time, condenses into stone.Calculus is blocked intestinal, right flank feeling of fullness, distending pain occur, or enclosed mass is easily irritated by pain body order yellowish urine, the xerostomia hardship; Or a series of liver and gall such as vomiting anorexia etc. are symptom." Ling Shu Miraculous Pivot or Divine Axis: opinion expands " cloud: " the gallbladder-distention person, distending pain in the hypochondrium, bitter in mouthful, sighing frequently." become endlessly " sensible opinion " also cloud: " the full person of the side of body ... hard-fullness in the hypochondrium, unable to take food due to retching, alternate attacks of chills and fever, its large pulse heavily fortified point of deep and tense pulse is with puckery ... ... .. " " danxi's experiential therapy " said: hypochondriac pain, and liver-fire is contained, and wood gas is real, and dead blood is arranged, and the expectorant multiple abscess is arranged, and liver is anxious.Wood gas is real, with Rhizoma Atractylodis, Rhizoma Chuanxiong, Pericarpium Citri Reticulatae Viride, Radix Angelicae Sinensis and so on; The patient, liver-fire is contained, and with danggui longhui pills, danggui longhui wan, under the Sucus Zingberis, is the key medicine of pathogenic fire purging; Dead blood is with made from peach kernel, safflower, Rhizoma Chuanxiong; The expectorant multiple abscess adds Rhizoma Arisaematis, Rhizoma Atractylodis, Rhizoma Chuanxiong with ERCHEN TANG; Liver is bitter anxious, and anxious food is hot to loose it, with Ligusticum slnense, Rhizoma Atractylodis.Disorders of blood is gone into promoting the circulation of blood in the blood medicine.Control the cough hypochondriac pain, add Rhizoma Arisaematis, Rhizoma Cyperi, Pericarpium Citri Reticulatae Viride, Indigo Naturalis, go into Sucus Zingberis with ERCHEN TANG.Hypochondriac pain has blood stasis, and add Semen Persicae in the qi-activating drug and do not remove point, and Rhizoma Cyperi and so on.Fiery Sheng person is arranged, when checking hyperfunction of the liver wood.Zuojin Wan treating the liver fire has the stagnation of QI and the chest and hypochondrium person sees its deep and hesitant pulse, is used as Yu Zhi.Must not stretch the person's honeyed pill that relaxes bitterly, imperial luxuriant growth is fast.There is one of food stagnation to lift with hands under the side of body, with Fructus Evodiae, Rhizoma Coptidis (parched).Kongxian Dan, pain due to disorder of QI, and hypochondriac pain all over the body, expectorant is held dead blood under the arm, Semen Persicae mud, ball clothes.Pain in the right hypochondrium looses with pushing away gas, goes out Yan Shi side; Pain in the left hypochondrium is that monarch adds Radix Bupleuri or little Radix Bupleuri with prodrug, also can.So it will be argued that: control and should let out dampness-heat of the liver clearly, happy mechanism of qi, cholagogic and lithagogue, special wound is controlled it in order to changing experience soup: Herba Lysimachiae, Herba Artemisiae Scopariae, Herba Hedyotidis Diffusae, Radix Et Rhizoma Rhei, Fructus Aurantii Immaturus, Radix Curcumae, Semen Persicae ... Radix Salviae Miltiorrhizae.The patient adds Rhizoma Cyperi, Pollen Tyjphae, the Radix Paeoniae Alba; Heating person adds Folium Isatidis, Fructus Forsythiae, Herba Taraxaci; The obvious person of distension adds the Radix Aucklandiae, Fructus Toosendan, Endothelium Corneum Gigeriae Galli.In the side with Herba Lysimachiae sweetly lightly ooze profit, the heat clearing away that is slightly cold, be the key medicine of cholagogic and lithagogue; The heat of the kind liver heat removing gallbladder of Herba Artemisiae Scopariae, the reason of holding concurrently liver and gall strongly fragrant, " Records of Tradition Chinese and Western Medicine in Combination " said: " it is also unseparated that heat strongly fragrant the opening that disappear, bile are gone into the road of small intestinal." both are our principal agent altogether.The Radix Et Rhizoma Rhei jaundice eliminating that purges heat, it contains emodin and aloe-emodin to suppress bacterial body sugar and glycometabolic oxidation, dehydrogenation, and deamination can make gallbladder shrink again, and Oddi's sphincter is lax, and impelling bile to discharge increases, so stronger antiinflammatory, calculus effect are arranged; Fructus Aurantii Immaturus, the Radix Curcumae resolving depression of regulating the flow of vital energy; Semen Persicae, Radix Salviae Miltiorrhizae clots absorbing removing food stagnancy; Sal Nitri removing dampness diuresis; Radix Aucklandiae fragrance a surname is logical, can rise and can fall, the stagnant gas of the three warmers that pass through, and it contains volatile oil and alkaloid can alleviate the spasm of biliary tract and pain relieving; The Fructus Toosendan promoting the circulation of QI to relieve pain, processed with vinegar is used as medicine, and can go into the liver medicine by priming.All medicine combinations, the effect of playing function of gallbladder promoting, damp eliminating heat, fossil altogether.So we's treating both the principal and the secondary aspects of a disease at the same time is the effect person invariably of throwing.
CN1172691C discloses " a kind of medicine for the treatment of cholelithiasis ", and this level is made up of 22 flavor Chinese medicines such as raw material of Chinese medicine Herba Glechomae, Herba Swertiae Mileensis, Herba Artemisiae Scopariae, Spora Lygodii, Rhizoma Curcumae Longae, Radix Et Rhizoma Rhei, Herba Taraxaci, Radix Vladimiriae, Herba Lysimachiae, Rhizoma Chuanxiong, Radix Gentianae, Radix Curcumae, Rhizoma Corydalis, Herba Andrographis, Rhizoma Polygoni Cuspidati, Fructus Gardeniae, Radix Clematidis, Spica Prunellae, Radix Scutellariae, Radix Bupleuri, Pericarpium Citri Reticulatae Viride, fevervine.Prescription is too numerous and jumbled, and not clear specifically is which medical material is in the performance effect; The multi-flavor medicine is difficult in the side, is difficult to carry out; The prescription contained drug is too much simultaneously, is difficult for amplifying producing.
The medicine of existing treatment cholelithiasis such as Danshixiao medicine for treating cholelithiasis, concentrated medicine-Danshikang for removing cholelith, Sal Nitri loose, calculus eliminating pill etc., though the treatment of cholelithiasis is had certain help, slower for dissolving, discharge, the relieving spasm to stop pain effect of cholelithiasis, curative effect is not good enough.
Summary of the invention
In order to address the above problem, the present invention aims to provide a kind of Chinese medicine composition for the treatment of cholelithiasis and preparation method thereof.
An object of the present invention is to provide a kind of Chinese medicine composition for the treatment of cholelithiasis.
Another object of the present invention provides a kind of preparation method for the treatment of the Chinese medicine composition of cholelithiasis.
The present invention treats the Chinese medicine composition of cholelithiasis, and its active ingredient is made by following bulk drugs: the Rhizoma Atractylodis Macrocephalae 5～10, the Radix Paeoniae Alba 5～10, Semen Lablab Album (parched) 5～10, the Radix Astragali 5～10, Poria 5～10, Radix Glycyrrhizae 5～10, Rhizoma Zingiberis Recens 5～20, Fructus Jujubae 5～10.
Preferably, its active ingredient is made by following bulk drugs: the Rhizoma Atractylodis Macrocephalae 5～8, the Radix Paeoniae Alba 5～8,5～8 parts of Semen Lablab Album (parched), the Radix Astragali 5～8, Poria 5～8, Radix Glycyrrhizae 5～8, Rhizoma Zingiberis Recens 5～15, Fructus Jujubae 5～8.
Preferred, its active ingredient is made by following bulk drugs: the Rhizoma Atractylodis Macrocephalae 5～7, the Radix Paeoniae Alba 5～7, Semen Lablab Album (parched) 5～7, the Radix Astragali 5～7, Poria 5～7, Radix Glycyrrhizae 5～7, Rhizoma Zingiberis Recens 8～12, Fructus Jujubae 5～7.
Most preferred, its active ingredient is made by following bulk drugs: the Rhizoma Atractylodis Macrocephalae 6, the Radix Paeoniae Alba 6, Semen Lablab Album (parched) 6, the Radix Astragali 6, Poria 6, Radix Glycyrrhizae 6, Rhizoma Zingiberis Recens 10, Fructus Jujubae 6.
The Chinese medicine composition of treatment cholelithiasis of the present invention can also contain pharmaceutically acceptable carrier, is prepared into conventional formulation, as decoction, mixture, capsule, tablet or granule, is preferably decoction.
The preparation method of the Chinese medicine composition of treatment cholelithiasis of the present invention, it comprises step: take by weighing the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Semen Lablab Album (parched), the Radix Astragali, Poria, Radix Glycyrrhizae, Rhizoma Zingiberis Recens and Fructus Jujubae in proportion, the water that adds 5～15 times of volumes, decoct 2～3 times in 80 ℃, filter, filtrate merges and is concentrated into 2 times of volumes, is prepared into the acceptable preparation of pharmacy more according to a conventional method.
The present invention treats the Chinese medicine composition of cholelithiasis, has the following advantages and effect:
(1) raw material of Chinese medicine composition of the present invention is formed: the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba are monarch, have invigorating the spleen and benefiting QI, nourishing blood to suppress the hyperactive liver, slow middle pain relieving, and yin fluid astringing is received antiperspirant; Minister is with Semen Lablab Album (stir-fry), the Radix Astragali, Poria, and spleen invigorating QI invigorating, sharp key dry; Assistant is with the Radix Glycyrrhizae spleen invigorating; Make with Rhizoma Zingiberis Recens, Fructus Jujubae hepatoprotective.
(2) Chinese medicine composition of the present invention is without the operative treatment cholelithiasis, and drug effect is remarkable.
(3) for chemical drugs, untoward reaction and side effect are less when the treatment cholelithiasis for Chinese medicine composition of the present invention.
(4), cure 14 examples (17.9%), produce effects 24 examples (30.8%), effective 31 examples (39.7%), total effective rate (88.5%), invalid 9 examples (11.5%) through taking the medicine that the present invention treats cholelithiasis
The specific embodiment
Following examples are used to illustrate the present invention, but are not used for limiting the scope of the invention.
Embodiment 1 Chinese medicine composition decoction of the present invention
(1) takes by weighing raw materials of traditional Chinese medicinal materials according to the following weight proportioning: Rhizoma Atractylodis Macrocephalae 6g, Radix Paeoniae Alba 6g, Semen Lablab Album (parched) 6g, Radix Astragali 6g, Poria 6g, Radix Glycyrrhizae 6g, Rhizoma Zingiberis Recens 10g, Fructus Jujubae 6g;
(2) with the above-mentioned Rhizoma Atractylodis Macrocephalae that takes by weighing, the Radix Paeoniae Alba, Semen Lablab Album (parched), the Radix Astragali, Poria, Radix Glycyrrhizae, Rhizoma Zingiberis Recens and Fructus Jujubae add water (10 times of volumes), in 80 ℃ of decoctions 3 times, filter, and filtrate is closed the back and is concentrated into 2 times of volumes, is concentrated into 2 times of volumes, divides to be filled in the bottle, promptly gets decoction.
Embodiment 2 Chinese medicine composition mixture of the present invention
(1) takes by weighing raw materials of traditional Chinese medicinal materials according to the following weight proportioning: Rhizoma Atractylodis Macrocephalae 6g, Radix Paeoniae Alba 6g, Semen Lablab Album (parched) 6g, Radix Astragali 6g, Poria 6g, Radix Glycyrrhizae 6g, Rhizoma Zingiberis Recens 8g, Fructus Jujubae 6g;
(2) with the above-mentioned Rhizoma Atractylodis Macrocephalae that takes by weighing, the Radix Paeoniae Alba, Semen Lablab Album (parched), the Radix Astragali, Poria, Radix Glycyrrhizae, Rhizoma Zingiberis Recens and Fructus Jujubae add water (10 times of volumes), in 80 ℃ of decoctions 3 times, filter, and filtrate is concentrated into 2 times of volumes after merging, and adds sodium benzoate 0.25g branch and is filled in the bottle, promptly gets mixture.
Embodiment 3 Chinese medicinal composition granules of the present invention
(1) takes by weighing raw materials of traditional Chinese medicinal materials according to the following weight proportioning: Rhizoma Atractylodis Macrocephalae 8g, Radix Paeoniae Alba 8g, Semen Lablab Album (parched) 8g, Radix Astragali 8g, Poria 8g, Radix Glycyrrhizae 8g, Rhizoma Zingiberis Recens 12g, Fructus Jujubae 8g;
(2) with the above-mentioned Rhizoma Atractylodis Macrocephalae that takes by weighing, the Radix Paeoniae Alba, Semen Lablab Album (parched), the Radix Astragali, Poria, Radix Glycyrrhizae, Rhizoma Zingiberis Recens, Fructus Jujubae add water (10 times of volumes), in 80 ℃ of decoctions 2 times, filter, and filtrate merges, and is condensed into clear paste;
(3) (2) are added ethanol and make and contain the alcohol amount and reach 70% and stir evenly, cold preservation 20 hours filters decompression filtrate recycling ethanol;
(4) (3) being continued be concentrated into relative density is 1.40 thick paste, and vacuum drying gets dry extract;
(5) (4) are ground into fine powder, add water-wet, granulate, volatile oil is sneaked into after measuring the beta cyclodextrin enclose with 4 times, promptly.
Embodiment 4 Chinese medicinal composition capsules agent of the present invention
(1) takes by weighing raw materials of traditional Chinese medicinal materials according to the following weight proportioning: Rhizoma Atractylodis Macrocephalae 5g, Radix Paeoniae Alba 5g, Semen Lablab Album (parched) 5g, Radix Astragali 5g, Poria 5g, Radix Glycyrrhizae 5g, Rhizoma Zingiberis Recens 10g, Fructus Jujubae 5g;
(2) with the Rhizoma Atractylodis Macrocephalae that takes by weighing, the Radix Paeoniae Alba, Semen Lablab Album (parched), the Radix Astragali, Poria, Radix Glycyrrhizae, Rhizoma Zingiberis Recens, Fructus Jujubae add water (10 times of volumes), in 80 ℃ of decoctions 2 times, filter, and filtrate merges, and is condensed into clear paste;
(3) (2) are added ethanol and make and contain the alcohol amount and reach 80% and stir evenly, cold preservation 24 hours filters decompression filtrate recycling ethanol;
(4) (3) being continued be concentrated into relative density is 1.34 thick paste;
(5) make wetting agent with 70% ethanol after fully the mixing after drying is ground into fine powder with (4), mix agent and become soft material, cross 16 mesh sieves and make granule;
(6) with (5) in 60 ℃ of oven dryings, granulate, dry grain, be sub-packed in No. 1 capsule promptly.
Test example 1.
1 test material and method
1.1 laboratory animal and grouping
Select 60 of healthy guinea pigs for use, male and female half and half, body weight 350～450g is provided by Anhui Province's medical experiment animal center.Be divided into 5 groups at random: blank group (A), cause stone matched group (B), the embodiment of the invention 1 Chinese medicine composition low dosage (0.58g/kgd) group (C), Chinese medicine composition embodiment 1 high dose of the present invention (1.17g/kgd) group (D), Hepatolytic calculus sheet (0.5g/kgd) group (E).
1.2 the making of animal calculus model
After animal is bought back, after normal nursing observed for 1 week, begin to apply the processing factor, adopt Scott (1976) method, except that the blank group, surplus 4 groups respectively to Cavia porcellus subcutaneous injection lincomycin 60g/kgd, continuously 7d.Injection back the 3rd day, Cavia porcellus begins to occur loss of appetite, and the loose tarnish of fur is become thin.To the 5th weekend, dead 6 altogether, B, C organize each dead 2, each 1 of D, E group.
1.3 medicine and consumption
Lincomycin hydrochloride injection (lot number 990917), bridge pharmaceutical factory in Guangzhou produces.Hepatolytic calculus sheet is produced main component by Xuhua Pharmaceutical Co., Ltd., Sichuan: ox bile extract, Endothelium Corneum Gigeriae Galli, Fructus Aurantii, Rhizoma Cyperi, Fructus Evodiae, Rhizoma Alpiniae Officinarum, Massa Medicata Fermentata etc., function: depressed liver-energy dispersing and function of gallbladder promoting, promoting the circulation of QI to relieve pain, molten cholelithiasis disappears.
The beginning of the 6th week, A, B group routine is raised with normal diet and greenfeed, every day 2 times, feed at regular time and quantity, the C group is pressed 0.58g/kgd, the D group gives Chinese medicine composition sheet of the present invention by 1.17g/kgd, and the E group gives Hepatolytic calculus sheet by 0.5g/kgd, and tablet pours in the Cavia porcellus stomach with syringe after grinding molten water into powder.
1.4 sample is drawn materials
After the 11st week, fasting 24h can't help water, every Cavia porcellus extracts the 2mL cardiac blood earlier, and it is deadly to tap the head then, cuts the breast abdomen rapidly open, block cystic duct with vascular forceps, take off gallbladder, perusal gallbladder profile, become the stone situation, and with the whole bile of syringe sucking-off, collect all animal cholelithiasiss, send respectively after drawing materials and test.
1.5 cholelithiasis analysis
Adopt pellet technique, test instrunment is a drug-beam infrared spectrophotometer.
1.6 bile analysis and hepatic and renal function are measured
Adopt the CL-7200 automatic clinical chemistry analyzer, measure glutamate pyruvate transaminase (SGPT) in total bilirubin in the bile, calcium, bile acid content and the blood, alkali phosphatase (AKP), blood urea nitrogen (BUN), serum creatinine (Cr) immediately.
2 results
2.1 the general situation of Cavia porcellus
Each treated animal all has losing weight in various degree during modeling except that the blank group, on average alleviate 16.4g.During treating, cause only average weight gain 7.2g of stone matched group, and Chinese medicine composition group of the present invention and Hepatolytic calculus sheet group on average increase 25.3g.
2.2 gallbladder wall situation
A group only 1 thickening of capsule wall of gallbladder appears, and B group (9/10), C group (4/10), D group (2/11), E group (3/11) exist thickening of capsule wall of gallbladder in various degree, coarse, gallbladder distortion.
2.3 become the stone situation in the gallbladder
There is not 1 routine Cheng Shi in blank group 12 examples, causing stone matched group gallstone formation rate is 80% (8/10), the low agent group of Chinese medicine composition of the present invention is 40% (4/10), and Chinese medicine composition object height agent group of the present invention is 27.27% (3/11), and Hepatolytic calculus sheet group is 36.36% (4/11).Naked eyes are seen: calculus is single or multiple brown or black calculus in the gallbladder, diameter 5～3mm, and out-of-shape, quality is soft frangible.
Check through V2, Chinese medicine composition object height agent group of the present invention and Hepatolytic calculus sheet group are compared and are had significant difference (P＜0.05) with causing stone matched group gallstone formation rate, the low agent group of Chinese medicine composition of the present invention with cause stone matched group gallstone formation rate and compare there was no significant difference (P＞0.05).
2.4 bile situation and bile component analysis
The intracapsular bile of gallbladder that causes the stone control animals is how muddy, deep yellow, and much more limpid transparent each treatment group and blank treated animal intracapsular bile of gallbladder be.
The bile measurement result sees Table 1.
Table 1 bile measurement result
| The experiment group | cTBIL/(umol/L) | cBA/(umol/L) | cCa 2+/(mmol/L) |
| Blank group (A) | 20.26/2.64 | 421.99/31.52 | 0.73/0.20 |
| Cause stone matched group (B) | 46.58/7.46 vv | 411.89/27.13 | 1.91/0.29 vv |
| The low clearly agent group (C) of cholelithiasis | 26.29/4.34 v* | 451.97/20.18 v* | 0.75/0.24 ** |
| Aloof from politics and material pursuits dose of group of cholelithiasis (D) | 25.60/4.71 v** | 473.99/24.28 vv** | 0.62/0.17 ** |
| Hepatolytic calculus sheet group (E) | 27.59/4.34 vv** | 468.55/28.26 v** | 0.68/0.73 ** |
Statistical method: student_t check; V and blank group be than P＜0.05, vvP＜0.01;
*With cause the stone matched group than P＜0.05,
*P＜0.001
Table 1 shows, high and low dose of group of Chinese medicine composition of the present invention and liver and bile stone sheet group bile acid (BA) content are apparently higher than causing stone matched group and blank group (P＜0.05 or P＜0.001), and total bilirubin (TBIL) and Ca
2+Content then is starkly lower than and causes stone matched group (P＜0.05 or P＜0.001), reaches between high and low dose of group of Chinese medicine composition of the present invention and compares no significant difference (P＞0.05) with Hepatolytic calculus sheet group bile situation.
2.5 hepatic and renal function is measured
After 6 weeks, the hepatic and renal function of high and low dose of group of Chinese medicine composition of the present invention Cavia porcellus is compared there was no significant difference (P＞0.05) with the blank group through medicine feed.
2.6 cholelithiasis qualitative analysis
Qualitative for being the bile pigment calculus of main component through infrared spectrum with the bile pigments.
The result shows that Chinese medicine composition of the present invention has the calculus dissolving and excreting effect to the Cavia porcellus cholelithiasis.
Test example 2
One, cholelithiasis diagnostic criteria: all are observed cases and are B ultrasonic and turn out to be the cholelithiasis diagnosis, symptoms such as the acute onset clinical symptoms comprises abdominal pain, feels sick, vomiting, heating, jaundice, the back untoward reaction of oils and fats eggs food.
Two, Therapeutic Method:
Take the medicine three times of the treatment cholelithiasis of the embodiment of the invention 1 every day, each 1 bag; Be 1 hour before the meal and take, period in a medicine is not avoided greasy; Take continuously, be interrupted (every 2-4 week) biliary tract ultrasonic monitoring, discharge unless confirmed calculus, taking medicine should be more than 4 week.
Three, efficacy assessment standard
1, cure: clinical symptom disappearance has no adverse reaction after the oils and fats eggs food; The ultrasound diagnosis calculus disappears.
2, produce effects: clinical symptom disappearance has no adverse reaction after the oils and fats eggs food; The ultrasound diagnosis calculus reduces or major diameter dwindles.
3, clinical effective: clinical symptoms is complete obiteration not, but seizure frequency obviously reduces; Still responding of oils food, but degree obviously alleviates; The ultrasound diagnosis calculus changes little.
4, invalid: adhere to taking medicine more than 4 weeks, clinical symptoms and outbreak frequency still do not have significant change before and after taking medicine.
Four, therapeutic effect:
Clinical observation is totally 78 examples, wherein male 31 examples, women 47 examples, and in age 16-81 year, the course of disease (the conscious symptom that occurs) is more than the 15-2; The diagnosis of ultrasound diagnosis cholelithiasis.Through taking the medicine that the present invention treats cholelithiasis, cure 14 examples (17.9%), produce effects 24 examples (30.8%), effective 31 examples (39.7%), total effective rate (88.5%), invalid 9 examples (11.5%).
The similar mixture of taking embodiment 2, the granule of embodiment 3 and the capsule of embodiment 4 of experiment showed, also can effectively be treated cholelithiasis.
Though above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (8)
1. Chinese medicine composition for the treatment of cholelithiasis, its active ingredient is made by following bulk drugs: the Rhizoma Atractylodis Macrocephalae 5～10, the Radix Paeoniae Alba 5～10, Semen Lablab Album (parched) 5～10, the Radix Astragali 5～10, Poria 5～10, Radix Glycyrrhizae 5～10, Rhizoma Zingiberis Recens 5～20, Fructus Jujubae 5～10.
2. Chinese medicine composition as claimed in claim 1 is characterized in that, its active ingredient is made by following bulk drugs: the Rhizoma Atractylodis Macrocephalae 5～8, the Radix Paeoniae Alba 5～8,5～8 parts of Semen Lablab Album (parched), the Radix Astragali 5～8, Poria 5～8, Radix Glycyrrhizae 5～8, Rhizoma Zingiberis Recens 5～15, Fructus Jujubae 5～8.
3. Chinese medicine composition as claimed in claim 2 is characterized in that, its active ingredient is made by following bulk drugs: the Rhizoma Atractylodis Macrocephalae 5～7, the Radix Paeoniae Alba 5～7, Semen Lablab Album (parched) 5～7, the Radix Astragali 5～7, Poria 5～7, Radix Glycyrrhizae 5～7, Rhizoma Zingiberis Recens 8～12, Fructus Jujubae 5～7.
4. important composition as claimed in claim 3 is characterized in that, its active ingredient is made by following bulk drugs: the Rhizoma Atractylodis Macrocephalae 6, the Radix Paeoniae Alba 6, Semen Lablab Album (parched) 6, the Radix Astragali 6, Poria 6, Radix Glycyrrhizae 6, Rhizoma Zingiberis Recens 10, Fructus Jujubae 6.
5. as each described Chinese medicine composition of claim 1～4, it also contains pharmaceutically acceptable carrier.
6. Chinese medicine composition as claimed in claim 5, it is decoction, mixture, capsule, tablet or granule.
7. Chinese medicine composition as claimed in claim 6, it is a decoction.
8. method for preparing the arbitrary described Chinese medicine composition of claim 1～7, it comprises step: take by weighing the Rhizoma Atractylodis Macrocephalae, the Radix Paeoniae Alba, Semen Lablab Album (parched), the Radix Astragali, Poria, Radix Glycyrrhizae, Rhizoma Zingiberis Recens and Fructus Jujubae in proportion, the water that adds 5～15 times of volumes, decoct 2～3 times in 80 ℃, filter, filtrate is closed the back and is concentrated into 2 times of volumes, is prepared into the acceptable preparation of pharmacy more according to a conventional method.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491206A (en) * | 2015-01-15 | 2015-04-08 | 王金强 | Traditional Chinese medicine preparation for treating calculus of bile duct and preparation method thereof |
| CN107929399A (en) * | 2017-11-30 | 2018-04-20 | 郭氏博信中医科技(北京)股份有限公司 | A kind of pharmaceutical composition for treating calculus and its preparation method and application |
| CN111617228A (en) * | 2020-07-21 | 2020-09-04 | 刘仁海 | Traditional Chinese medicine for treating gallstones, preparation method and application thereof |
| CN111643653A (en) * | 2020-07-21 | 2020-09-11 | 刘仁海 | Traditional Chinese medicine for treating kidney stone and gall-stone, preparation method and application thereof |
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| CN102000307A (en) * | 2009-09-01 | 2011-04-06 | 高瑜杰 | Medicament for treating cholecystitis |
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| CN102000307A (en) * | 2009-09-01 | 2011-04-06 | 高瑜杰 | Medicament for treating cholecystitis |
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| 《实用中医药杂志》 20100531 郑荣林 胆石症中医治疗进展 358-359 1-8 第26卷, 第05期 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491206A (en) * | 2015-01-15 | 2015-04-08 | 王金强 | Traditional Chinese medicine preparation for treating calculus of bile duct and preparation method thereof |
| CN107929399A (en) * | 2017-11-30 | 2018-04-20 | 郭氏博信中医科技(北京)股份有限公司 | A kind of pharmaceutical composition for treating calculus and its preparation method and application |
| CN111617228A (en) * | 2020-07-21 | 2020-09-04 | 刘仁海 | Traditional Chinese medicine for treating gallstones, preparation method and application thereof |
| CN111643653A (en) * | 2020-07-21 | 2020-09-11 | 刘仁海 | Traditional Chinese medicine for treating kidney stone and gall-stone, preparation method and application thereof |
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