CN102188590B - A kind of Zengshengping dispersing tablet composition and preparation method thereof - Google Patents
A kind of Zengshengping dispersing tablet composition and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine preparation, particularly to a kind of Zengshengping dispersing tablet composition and preparation method thereof, the compositions of the present invention, formed what raw material of Chinese medicine medicine was prepared from by formula as below: Radix Sophorae Tonkinensis 210-630g, Rhizoma Bistortae 210-630g, Sonchus brachyotus DC. 210-630g, Cortex Dictamni 105-315g, Spica Prunellae 210-630g, Rhizoma Dioscoreae Bulbiferae 50-150g, the compositions of the present invention, preparation method is as follows: takes Radix Sophorae Tonkinensis boiling and filters, filtrate concentrates, and is dried, standby；Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae boiling, leaching medicinal liquid, medicinal residues add Cortex Dictamni, boiling, collecting decoction, filters, filtrate reduced in volume, add Radix Sophorae Tonkinensis dried cream powder, mixing, dry, prepared composition discrete piece.
Description
Technical field:
The present invention relates to a kind of Chinese medicine preparation, particularly to the Chinese medicine Zengshengping dispersing tablet composition for the treatment of proliferative disease.
Background technology:
Chinese patent 90109821.3 entitled " preparation technology of canceration shutoff agent " zengshengping tablet " " describes the preparation technology of a kind of zengshengping tablet, becomes extractum through extraction with aqueous solution effective ingredient, then makes different dosage form and form.Through rat and the experiment of dog and the observation of 2531 example esophageal epithelium proliferation patients, result shows, " zengshengping tablet " is the tumor prevention agent of a kind of novel blocking-up carcinogenesis.Consisting of of each component of hypertrophy plain film that this patent describes: Rhizoma Dioscoreae Bulbiferae 3-6, Spica Prunellae 18-25, Rhizoma Bistortae 17-21, Herba Patriniae 17-23, Radix Sophorae Tonkinensis 18-24, Cortex Dictamni 8-12.
Separately there is an application of preparation technology and the Xin following patents describing " zengshengping tablet ":
At present, " hypertrophy plain film " has listed, and its indication includes:
Heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating.Being applicable to esophagus and cardia epithelial proliferation, have singultus, take food the heat-phlegm interior knot showers such as dysphagia, xerostomia, bitter taste, the pharyngalgia dry stool dark stringy and rolling pulse of tongue.
Formula consists of: Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g.
The taken Chinese crude drug of zengshengping tablet confirms through modern pharmacology drug effect, and have antimicrobial antiphlogistic effect is: Rhizoma Bistortae, Cortex Dictamni, Spica Prunellae, Herba Patriniae, Rhizoma Dioscoreae Bulbiferae；There is having of antitumor antitumaous effect: Radix Sophorae Tonkinensis, Cortex Dictamni, Rhizoma Dioscoreae Bulbiferae；There is regulation immunization, having of enhancing immunologic function: Radix Sophorae Tonkinensis, Cortex Dictamni, Spica Prunellae.
In the disclosedest data, the preparation method of zengshengping tablet mainly uses some drugs to pulverize and uses, some drugs water extraction uses, owing to the medicine pulverized is in dissolubility, in mouthfeel and mobility defective, therefore there is necessity of improvement, the present invention is found surprisingly that and the preparation technology of zengshengping tablet is transformed, obtain a kind of brand-new extractum, this extractum is in terms of preparation process, stability aspect, particularly dissolubility, mouthfeel aspect and mobility aspect all have good effect, better effect can be obtained in terms for the treatment of mammary gland tumor simultaneously, it it is below present disclosure.
Summary of the invention:
The present invention provides a kind of dispersible tablets of Chinese medicine compositions and preparation method thereof.
The dispersible tablets of Chinese medicine compositions of the present invention, is formed what raw material of Chinese medicine medicine was prepared from by formula as below:
Radix Sophorae Tonkinensis 210-630g, Rhizoma Bistortae 210-630g, Sonchus brachyotus DC. 210-630g, Cortex Dictamni 105-315g, Spica Prunellae 210-630g, Rhizoma Dioscoreae Bulbiferae 50-150g
The dispersible tablets of Chinese medicine compositions of the present invention, preferred formula composition is as follows:
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
In composition described above, weight calculates with crude drug, can increase according to corresponding proportion when producing or reduce, as large-scale production can by kilogram in units of, or in units of ton, small-scale production can also by gram or milligram in units of, weight can increase or reduce, but the constant rate of the raw medicinal herbs weight proportion between each composition.
The ratio of above weight proportion obtains through science screening, for especial patient, such as serious symptom or mild, fat or modest patient, can adjust the proportioning of the amount of composition accordingly, be increased or decreased less than 100%, and drug effect is constant.
Single medicinal material in composition described above, especially ministerial drug and adjuvant drug, it is also possible to replaced by the suitable Chinese medicine with the identical property of medicine, its medicine effect of the Chinese medicine preparation after replacement is constant.
The dispersible tablets of Chinese medicine compositions of the present invention, its Chinese medicine crude drug is through processing as pharmaceutically active substance, it is prepared as dispersible tablets of Chinese medicine compositions through galenic pharmacy routine techniques, this dispersible tablets of Chinese medicine compositions, wherein pharmaceutically active substance shared percentage by weight in the formulation is 0.01-99.9%, and remaining is pharmaceutically acceptable carrier.Pharmaceutically active substance, exists in a unit, and described unit dosage form refers to the unit of preparation, such as dispersible tablet every etc..
The Chinese medicine preparation of the present invention is dispersible tablet, determines usage and dosage according to the situation of patient in use, can often taken three times per day, each 1-20 sheet.
The dispersible tablets of Chinese medicine compositions of the present invention, its preparation method obtains through screening, and preferred preparation method is as follows:
Formula:
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Taking Radix Sophorae Tonkinensis boiling to filter, filtrate concentrates, and is dried, standby.
Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae boiling, leaching medicinal liquid, medicinal residues add Cortex Dictamni, boiling, collecting decoction, filter, filtrate reduced in volume to relative density is the clear paste of 1.30-1.35 (50 DEG C), adds Radix Sophorae Tonkinensis dried cream powder, mixing, dry (less than 80 DEG C), pulverize, add the pharmaceutically acceptable auxiliary materials and mixing being suitable for preparing dispersible tablet, pelletize, tabletting, to obtain final product.
Wherein it is suitable for preparing the pharmaceutically acceptable carrier of dispersible tablet, the wherein said pharmaceutically acceptable carrier preparing dispersible tablet that is suitable for is selected from following component: lactose, microcrystalline Cellulose, cross-linking sodium carboxymethyl cellulose, sodium lauryl sulphate, starch, magnesium stearate, carboxymethyl starch sodium, polyvidone, Pulvis Talci, magnesium stearate etc..Preferably composition is lactose, microcrystalline Cellulose, carboxymethyl starch sodium, polyvidone, magnesium stearate.
The most preferred preparation method of the present invention is as follows:
Formula:
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Take Radix Sophorae Tonkinensis and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.
Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae add the soak by water secondary of 8 times amount, 1 hour for the first time, leaching medicinal liquid, add Cortex Dictamni in medicinal residues, add the water of 8 times amount, decoct 1 hour, collecting decoction, filter, filtrate reduced in volume to relative density is the clear paste of 1.30-1.35 (50 DEG C), adds Radix Sophorae Tonkinensis dried cream powder, mixing, dry (less than 80 DEG C), pulverize, add lactose, microcrystalline Cellulose, carboxymethyl starch sodium, the adjuvant such as polyvidone, pelletize, tabletting, to obtain final product.
Preferably formula composition is as follows:
The dispersible tablets of Chinese medicine compositions of the present invention has following functions to cure mainly:
Heat-clearing and toxic substances removing, blood stasis-eliminating and stagnation-dissipating.Being applicable to esophagus and cardia epithelial proliferation, have singultus, take food the heat-phlegm interior knot showers such as dysphagia, xerostomia, bitter taste, the pharyngalgia dry stool dark stringy and rolling pulse of tongue.
Can also be used for treating following disease:
The precancerous lesion such as esophagocardial carcinoma, gastric cancer is such as: esophageal epithelial proliferation, atypical hyperplasia of gastric mucosa, gastric intestinal metaplasia, dysplasia, the sickness rate of the esophageal carcinoma and gastric cancer can be significantly reduced, the toxic and side effects of Radiotherapy chemotherapy can be alleviated, prevent recurrence and the transfer of cancerous cell.Oral leukoplakia and buccal cavity white spot, stomach chronic inflammatory disease accompanied by intestinal epithelial metaplasia, intraepithelial neoplasia.
Mammary gland tumor, described mammary gland tumor includes: cyclomastopathy, breast tumor, galactocele, and wherein, cyclomastopathy includes normal breast hypertrophy and the cyclomastopathy that is not true to type, and breast tumor includes mammary gland benign tumor and breast carcinoma.
Craft screening:
Granule draws moist investigation
Investigating the extract of different process, variable is extraction time, the amount of Extraction solvent and extraction time and the extraction time of Cortex Dictamni.
Weigh each 10g of extractum that different extraction process by water obtains respectively, be positioned under natural conditions (temperature 35 DEG C, relative humidity 70%), within every 24 hours, survey its water absorption rate once, the results are shown in Table 1.
Table 1 different process draws moist test
A01 technique is
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in container, adding water of 8 times amount, decoct 3 hours, leaching medicinal liquid, medicinal residues, add the water of 8 times amount, decoct 3 hours, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.
A02 technique is
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in container, adding water of 8 times amount, decoct 2 hours, leaching medicinal liquid, medicinal residues, add the water of 8 times amount, decoct 2 hours, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.
A03 technique is
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in container, adding water of 8 times amount, decoct 1 hour, leaching medicinal liquid, medicinal residues add the water of 8 times amount, decoct 1 hour, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.
A04 technique is
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in container, adding water of 8 times amount, decoct 3 hours, leaching medicinal liquid, medicinal residues add Cortex Dictamni 210g, adds the water of 8 times amount, decoct 3 hours, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.
A05 technique is
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in container, adding water of 8 times amount, decoct 2 hours, leaching medicinal liquid, medicinal residues add Cortex Dictamni 210g, adds the water of 8 times amount, decoct 2 hours, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.
A06 technique is
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in container, adding water of 8 times amount, decoct 1 hour, leaching medicinal liquid, medicinal residues add Cortex Dictamni 210g, adds the water of 8 times amount, decoct 1 hour, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.
A07 technique is
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in container, adding water of 8 times amount, decoct 2 hours, leaching medicinal liquid, medicinal residues, add the water of 8 times amount, decoct 2 hours, leaching medicinal liquid, medicinal residues, add the water of 8 times amount, decoct 2 hours, leaching medicinal liquid, three filtrates are merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.
A08 technique is
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in container, adding water of 8 times amount, decoct 1 hour, leaching medicinal liquid, medicinal residues, add the water of 8 times amount, decoct 1 hour, leaching medicinal liquid, medicinal residues, add the water of 8 times amount, decoct 1 hour, leaching medicinal liquid, three filtrates are merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.
A09 technique is
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take Cortex Dictamni 210g, Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and each 420g of Spica Prunellae, put in container, adding water of 8 times amount, decoct 1.5 hours, leaching medicinal liquid, medicinal residues, add the water of 8 times amount, decoct 1.5 hours, leaching medicinal liquid, medicinal residues, add the water of 8 times amount, decoct 1.5 hours, leaching medicinal liquid, three filtrates are merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.
By upper table result it can be seen that its mean water absorption rate of finished product prepared by A06 technique changes little, the stability of sample is preferable.
Mobility of particle is investigated
By self-control " funnel " method to A04, the mobility of the shaped granule that A05, A06 technique is made checks, the results are shown in Table 2,3.
Table 2 different process fluidity testing
Table 3 different process content measurement result angle of repose
By upper table result it can be seen that the finished particle mobility prepared of A06 technique is preferable, it is easy to tabletting, it is suitable for large-scale production.
As can be seen from the above table, different disposal results sample hygroscopicity A06 of extraction process by water is minimum；Mobility of particle, A06 is best.
The research of A06 antiinflammatory action: anti-chronic inflammatory disease test (rat cotton balls hypodermic implantation)
Test medicine:
Title: zengshengping tablet extractum, the extractum prepared by the method for embodiment 1
Character: for tan powder；Feeble QI, mildly bitter flavor.
Animal:
Wistar rat, quality: 200-250g male and female half and half.Medical courses in general institute Experimental Animal Center provides.
Experimental technique and result:
Take rat 50, male and female half and half, be randomly divided into 5 groups, often group 10.1st group is blank group, to isometric(al) normal saline；2nd group is positive controls (prednisone sheet 8mg/kg)；3rd, 4,5 groups is zengshengping tablet group (0.2g, 0.4g, 0.8g/kg crude drug).Under the shallow fiber crops of ether, cropping is sterilized.Sterile working, in hypogastric region medisection skin, implants both sides groin by the sterilizing cotton balls of weight 50mg subcutaneous, then skin suture, sterilization,.Start ig from operation consent 3d to be administered, 2ml/100g, 1 times/day, continuous 10d.D11 puts to death rat, and careful stripping takes out cotton balls and the granulation tissue of parcel, weighs, deducts raw cotton ball weight and be granulation tissue weight, represent with granulation tissue weight (bilateral) contained by 100g body weight after 60 DEG C of dry 12h.Check through t.The results are shown in Table 4.
The impact (X ± S) on rat chronic hypertrophy inflammation of table 4 zengshengping tablet
* P ＜ 0.05**P ＜ 0.01 is compared with blank group
The zengshengping tablet therapeutic effect to cyclomastopathy
Use E2The rabbit hyperplasia of mammary gland model observation the replicated impact on morphological change:
1) three red, swollen, big does not all have the person to be +++.
2) swollen, big both persons of having are ++.
3) simple become big person into+.
4) unchanged person be-.
Table 5 zengshengping tablet increases the impact of degree to mammary gland
It addition, the granule of the present invention has also carried out multinomial relevant test, including herein below:
1. inhibition test: result of the test result shows, zengshengping tablet is respectively less than 30% to S-180 without obvious inhibitory action, tumour inhibiting rate.As merged application with CTX, though not demonstrating synergism in terms of tumour inhibiting rate, but the application of zengshengping tablet can substantially alleviate the inhibitory action (P ＜ 0.05) that host's body weight is increased by CTX.
2. mice net is knitted the impact of endothelial system phagocytic function: zengshengping tablet can be remarkably reinforced mice net and knit the function of endothelial system phagocytosis foreign body.
3. the impact on mouse lymphocyte conversion reaction: zengshengping tablet group CPM value all apparently higher than matched group (P ＜ 0.05), illustrates that zengshengping tablet can remarkably promote the answering of T lymphocyte.
4. mouse boosting cell is produced the impact of IL-2: zengshengping tablet group mouse boosting cell produces the ability of IL-2. in 5 dilution measurement results of curve, all apparently higher than matched group (P ＜ 0.05), show that zengshengping tablet can significantly improve mouse boosting cell and produce the ability of IL-2.
5. the impact on mouse skin delayed hypersensitivity: matched group compares with the response strength of zengshengping tablet group, both have significant at difference
6. experiment in vitro proves, zengshengping tablet has obvious anti-cause and dashes forward and Anti-oxytocin serum, and can substantially suppress the in-vitro multiplication of K562 cancerous cell.
7. zoopery proves, zengshengping tablet can substantially suppress the rat esophagus epithelium of Induced by Carcinogen, mice model of forestomach epithelium, suslik oral mucous epithelia, rat nasopharyngeal epithelium and the hypertrophy of rat bladder epithelium and canceration, and the transfer to tumor has obvious inhibitory action.
8. pharmacological experiment proves, the zengshengping tablet phagocytic function to net matter endothelial system, LT respond, the killing vigor of NK cell, the generation ability of splenocyte IL-2, the ability of skin delayed hypersensitivity and hemolysin level etc. all have significant potentiation.Illustrate that zengshengping tablet can significantly improve cell and the humoral immune function of body, there is the effect of BRM sample material.
9., in clinical trial, zengshengping tablet is to esophagus, cardia stomach function regulating. precancerous lesion and the treatment of inflammation, total effective rate reaches 91.9%.Clinical observation to oral lichen planus patient, it was demonstrated that have preferable therapeutic effect, effective percentage reaches 90%, especially the more remarkable treatment effect to rotten to the corn atrophic type.
Having the beneficial effect that of dispersible tablets of Chinese medicine compositions for the present invention:
Several factors is depended in the selection of the extracting method of middle the effective elements of the medicine, such as raw material availability, curative effect, the simplification of production process, stability etc..
Why Cortex Dictamni pulverizing is used as medicine by prior art, it is primarily due to it is generally acknowledged that Cortex Dictamni boiling is extracted, the ingredient that some alkaloidss are more bitter can be extracted, also can extract the compositions such as some starch, protein, tannin simultaneously, and the easy moisture absorption of water extract, be not suitable for the dosage forms such as dispersible tablet.
The present invention is in order to improve the resolvability of zengshengping tablet medicine, change existing medicining mode, Cortex Dictamni has been carried out decocting extraction, it is found surprisingly that the fresh water (FW) by the present invention carries Cortex Dictamni, the problem not causing the water extract moisture absorption, can be prepared into the oral administration of soluble preparation in good taste that dissolubility is good simultaneously.
Detailed description of the invention:
Further illustrate the present invention by the following examples, but not as limitation of the present invention.
Embodiment 1
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in container, adding water of 8 times amount, decoct 1 hour, leaching medicinal liquid, medicinal residues add Cortex Dictamni 210g, adds the water of 8 times amount, decoct 1 hour, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.Being merged by extractum, and lactose 100g, microcrystalline Cellulose 100g, carboxymethyl starch sodium 50g, polyvidone 10g, magnesium stearate 2g mixes, and pelletizes, tabletting and get final product.
Embodiment 2
Radix Sophorae Tonkinensis 210g, Rhizoma Bistortae 210g, Sonchus brachyotus DC. 210g, Cortex Dictamni 105g, Spica Prunellae 210g, Rhizoma Dioscoreae Bulbiferae 50g
Preparation:
Take Radix Sophorae Tonkinensis and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in container, adding water of 8 times amount, decoct 1 hour, leaching medicinal liquid, medicinal residues add Cortex Dictamni, adds the water of 8 times amount, decoct 1 hour, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.Being merged by extractum, and lactose 100g, microcrystalline Cellulose 100g, carboxymethyl starch sodium 50g, polyvidone 10g, magnesium stearate 2g mixes, and pelletizes, tabletting and get final product.
Embodiment 3
Radix Sophorae Tonkinensis 630g, Rhizoma Bistortae 630g, Sonchus brachyotus DC. 630g, Cortex Dictamni 315g, Spica Prunellae 630g, Rhizoma Dioscoreae Bulbiferae 150g
Preparation:
Take Radix Sophorae Tonkinensis and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take Rhizoma Dioscoreae Bulbiferae, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in container, adding water of 8 times amount, decoct 1 hour, leaching medicinal liquid, medicinal residues add Cortex Dictamni, adds the water of 8 times amount, decoct 1 hour, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.Being merged by extractum, and lactose 100g, microcrystalline Cellulose 100g, carboxymethyl starch sodium 50g, polyvidone 10g, magnesium stearate 2g mixes, and pelletizes, tabletting and get final product.
Embodiment 4
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in container, adding water of 8 times amount, decoct 1 hour, leaching medicinal liquid, medicinal residues add Cortex Dictamni 210g, adds the water of 8 times amount, decoct 1 hour, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.Being merged by extractum, and lactose 200g, microcrystalline Cellulose 200g, carboxymethyl starch sodium 50g, polyvidone 10g, magnesium stearate 2g mixes, and pelletizes, tabletting and get final product.
Embodiment 5
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in container, adding water of 8 times amount, decoct 1 hour, leaching medicinal liquid, medicinal residues add Cortex Dictamni 210g, adds the water of 8 times amount, decoct 1 hour, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.Being merged by extractum, and lactose 100g, microcrystalline Cellulose 100g, carboxymethyl starch sodium 20g, polyvidone 20g, magnesium stearate 3g mixes, and pelletizes, tabletting and get final product.
Embodiment 6
Radix Sophorae Tonkinensis 420g, Rhizoma Bistortae 420g, Sonchus brachyotus DC. 420g, Cortex Dictamni 210g, Spica Prunellae 420g, Rhizoma Dioscoreae Bulbiferae 100g
Preparation:
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density is the thick paste of 1.30-1.35 (50 DEG C), and drying under reduced pressure (60 DEG C) becomes dry cream, pulverizes, standby.Take each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in container, adding water of 8 times amount, decoct 1 hour, leaching medicinal liquid, medicinal residues add Cortex Dictamni 210g, adds the water of 8 times amount, decoct 1 hour, leaching medicinal liquid waste.Twice filtrate is merged, is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30.Being merged by extractum, and lactose 200g, microcrystalline Cellulose 200g, carboxymethyl starch sodium 20g, polyvidone 20g, magnesium stearate 4g mixes, and pelletizes, tabletting and get final product.
Claims (3)
1. the dispersible tablets of Chinese medicine compositions treating mammary gland tumor, it is characterised in that be prepared from by following raw material of Chinese medicine medicine:
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density 50 DEG C surveys the thick paste for 1.30-1.35, and 60 DEG C of drying under reduced pressure become dry cream, pulverizes, standby；Take each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in container, adding water of 8 times amount, decoct 1 hour, leaching medicinal liquid, adds Cortex Dictamni 210g, adds the water of 8 times amount in medicinal residues, decoct 1 hour, leaching medicinal liquid waste, twice filtrate is merged, it is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30, extractum is merged, with lactose 100g, microcrystalline Cellulose 100g, carboxymethyl starch sodium 50g, polyvidone 10g, magnesium stearate 2g mixes, and pelletizes, tabletting and get final product.
2. the preparation method of the dispersible tablets of Chinese medicine compositions treating mammary gland tumor, it is characterised in that comprise the following steps:
Take Radix Sophorae Tonkinensis 420g and add the soak by water 2 times of 8 times amount, each 1.5 hours, collecting decoction, filter, filtrate reduced in volume to relative density 50 DEG C surveys the thick paste for 1.30-1.35, and 60 DEG C of drying under reduced pressure become dry cream, pulverizes, standby；Take each 420g of Rhizoma Dioscoreae Bulbiferae 100g, Sonchus brachyotus DC., Rhizoma Bistortae and Spica Prunellae, put in container, adding water of 8 times amount, decoct 1 hour, leaching medicinal liquid, adds Cortex Dictamni 210g, adds the water of 8 times amount in medicinal residues, decoct 1 hour, leaching medicinal liquid waste, twice filtrate is merged, it is evaporated to relative density 60 DEG C and surveys the extractum of 1.20 to 1.30, extractum is merged, with lactose 100g, microcrystalline Cellulose 100g, carboxymethyl starch sodium 50g, polyvidone 10g, magnesium stearate 2g mixes, and pelletizes, tabletting and get final product.
3. the application in the medicine of preparation treatment mammary gland tumor of the compositions described in claim 1.
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| CN101670034A (en) * | 2009-10-21 | 2010-03-17 | 天津普瑞森医药贸易有限公司 | Application of traditional Chinese drug Zengshengping to treating mammary gland tumor |
| CN101940696A (en) * | 2010-09-10 | 2011-01-12 | 天津康晨瑞信医药集团有限公司 | Method for preparing Chinese medicinal compound Zengshengping |
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| CN101670034A (en) * | 2009-10-21 | 2010-03-17 | 天津普瑞森医药贸易有限公司 | Application of traditional Chinese drug Zengshengping to treating mammary gland tumor |
| CN101966272A (en) * | 2009-10-21 | 2011-02-09 | 天津康晨瑞信医药集团有限公司 | Chinese medicinal composition for treating proliferative diseases |
| CN101940696A (en) * | 2010-09-10 | 2011-01-12 | 天津康晨瑞信医药集团有限公司 | Method for preparing Chinese medicinal compound Zengshengping |
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