CN102188543B - Tea polyphenol tablet and preparation method thereof - Google Patents
Tea polyphenol tablet and preparation method thereof Download PDFInfo
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- CN102188543B CN102188543B CN2011100765508A CN201110076550A CN102188543B CN 102188543 B CN102188543 B CN 102188543B CN 2011100765508 A CN2011100765508 A CN 2011100765508A CN 201110076550 A CN201110076550 A CN 201110076550A CN 102188543 B CN102188543 B CN 102188543B
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- tea polyphenol
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Abstract
The invention discloses a tea polyphenol tablet, which comprises tea polyphenol powder, soluble starch, vitamin C, artemisia glue, magnesium stearate and absolute ethyl alcohol. The tea polyphenol tablet has the advantages of convenience for carrying, convenience for taking medicine and commonly acceptable price for the public, and has preferable market outlook. The invention also discloses a preparation method for the tea polyphenol tablet, which comprises the steps of: mixing the tea polyphenol powder, the soluble starch, the vitamin C and the artemisia glue; adding the absolute ethyl alcohol for granulation; sifting whole granules; adding the magnesium stearate; mixing; and tabletting. The artemisia glue is used as a disintegrating agent in the invention, thus the tea polyphenol tablet has the advantages of small amount, high disintegration speed and simple process.
Description
Technical field
The present invention relates to a kind of health promoting product and preparation method thereof, especially a kind of is the tea polyphenols sheet and preparation method thereof of disintegrating agent with the artemisia glue.
Technical background
The general name of the polyhydroxyl phenolic compound that tea polyphenols is in the Folium Camelliae sinensis to be contained, main component is catechin, flavone, flavonols, anthocyan, phenolic acid, depside and polymerization phenols etc.Big quantity research shows, tea polyphenols has enhancing body resistance, antioxidation, anti-cancer, antitumor, radioprotective, antibacterial, antiviral, blood sugar lowering and blood fat, angiocardiopathy preventing, the anti-ageing multiple natural bioactive of waiting for a long time.
Patent CN1153019A tea polyphenol health products, disclosing a kind of is major ingredient with the tea polyphenols, is aided with Fructus Lycii, Semen Ziziphi Spinosae makes a kind of health care oral liquid, this oral liquid has the effect that strengthens the autoimmune ability, removes excessive free radicals in the body; Patent CN1358063A effervescent green tea extract formulation discloses a kind of preparation that contains the effervescent formulation of green tea extract; Patent CN1381235 Baokang capsule as natural health-care product discloses a kind of utilization and has utilized tea polyphenols, lecithin, medical dextrin to prepare capsular method, and products obtained therefrom has the metabolic function of the human body of adjusting; Patent CN101049160A radiation resistant coffee formula of polyphenol discloses a kind of powdery that tea polyphenols, plant dust, Herba Saussureae Involueratae, coffee, sugar etc. make or aqueous health product of utilizing, and has effects such as refreshment, memory reinforcing; Patent CN1436551A contains the hourishing capsule of tea polyphenols, discloses a kind of a kind of capsule that utilizes tea polyphenols, Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Fu Ling, Radix Glycyrrhizae, the Radix Astragali, Fructus Lycii extractum etc. to make, and has effects such as eliminating evil, toxin expelling, QI invigorating, spleen invigorating; Patent CN101219123A tea polyphenol pellet and preparation method thereof discloses a kind of micropill that utilizes tea polyphenols, pharmaceutic adjuvant preparation, has good radioprotective, the anti-ageing effect of waiting for a long time; Patent CN101518598A tea oral tablet and preparation method thereof; Disclose a kind of with theaflavin, to remove the caffeine tea polyphenols be major ingredient; With carboxymethyl starch sodium, microcrystalline Cellulose or cross-linking sodium carboxymethyl cellulose is disintegrating agent; With pregelatinized Starch or magnesium stearate is binding agent, and adds the oral tablet method that flavoring agent is processed, and products obtained therefrom has antioxidation and removes the effect that free radical keeps physical function.
At present, many employing carboxymethyl starch sodium, microcrystalline Cellulose or cross-linking sodium carboxymethyl cellulose are disintegrating agent in the preparation of tea polyphenols product, and patent does not see with the artemisia glue to be the documents and materials that disintegrating agent prepares the tea polyphenols tablet both at home and abroad.The problem that prior art exists is that the disintegrating agent consumption is big, disintegration rate slow, complex process, product are not easy to carry, cost an arm and a leg etc.
Summary of the invention
First technical problem that the present invention will solve provides a kind of tea polyphenols sheet; It comprises tea polyphenol powder, soluble starch, vitamin C, artemisia glue, magnesium stearate, dehydrated alcohol; Wherein tea polyphenol powder is a functional component, and soluble starch is a filler, and vitamin C is an antioxidant, and artemisia glue is a disintegrating agent, and magnesium stearate is a lubricant, and dehydrated alcohol is a binding agent; It has characteristics such as the disintegrating agent consumption is little, disintegration rate is fast, product carries easily, low price.
Second technical problem that the present invention will solve provides the method for preparing of tea polyphenols sheet; Its technology is simple, and energy consumption is little, and cost is low.
For solving above-mentioned first technical problem, a kind of tea polyphenols sheet of the present invention, it comprises tea polyphenol powder, soluble starch, vitamin C, artemisia glue, magnesium stearate, dehydrated alcohol.
Further, the weight ratio of said soluble starch and said tea polyphenol powder is 1: 1～1: 2.
Further, 5 ‰～10 ‰ of the said ascorbic weight gross weight that is said tea polyphenol powder and said soluble starch.
Further, the weight of said artemisia glue be said tea polyphenol powder and said soluble starch gross weight 3 ‰～5 ‰.
Further, the weight of said magnesium stearate be said tea polyphenol powder, said soluble starch, said vitamin C, said artemisia glue gross weight 5 ‰～8 ‰.
Further, the volume of said dehydrated alcohol is 4.5ml～5ml: 10g with the ratio of the gross weight of said tea polyphenol powder, said soluble starch, said vitamin C, said artemisia glue.
For solving second technical problem, the method for preparing of a kind of tea polyphenols sheet of the present invention may further comprise the steps:
1) draw materials according to following ratio:
The weight ratio of tea polyphenol powder and soluble starch is 1: 1～1: 2,
Ascorbic weight be tea polyphenol powder and soluble starch gross weight 5 ‰～10 ‰,
The weight of artemisia glue be tea polyphenol powder and soluble starch gross weight 3 ‰～5 ‰,
The weight of magnesium stearate be tea polyphenol powder, soluble starch, vitamin C, artemisia glue gross weight 5 ‰～8 ‰,
The volume of dehydrated alcohol is 4.5ml～5ml: 10g with the ratio of the gross weight of tea polyphenol powder, soluble starch, vitamin C, artemisia glue;
2) with 1) in ready tea polyphenol powder, soluble starch, vitamin C, artemisia glue put into reaction vessel, mix homogeneously, subsequent use;
3) in step 2) add dehydrated alcohol in the mixture that obtains, stir and make mix homogeneously, granulate, be dried to ethanol and volatilize fully, granulate sieves;
4) add magnesium stearate in the material on sieve, mix homogeneously, tabletting obtains goods.
Further, the content of tea polyphenols is 75%～80% in the said tea polyphenol powder.
Further, to sieve be 24 mesh sieves to said granulate.
The invention has the beneficial effects as follows:
(1) tea polyphenols sheet provided by the invention, have disintegration rate fast, be easy to carry, taking convenience, price can be commonly popular characteristics such as accept.
(2) the present invention uses artemisia glue to be disintegrating agent, and consumption is little, and disintegration rate is fast, and artemisia glue is natural materials, makes the bioavailability of tea polyphenols high, and technology is simple.
The specific embodiment
Embodiment 1
A kind of method for preparing of tea polyphenols sheet may further comprise the steps:
1) taking by weighing the 20g polyphenol content is 75～80% tea polyphenol powder, the 20g soluble starch, and the 0.20g vitamin C, the 0.16g artemisia glue, the 0.24g magnesium stearate, the 18.28ml dehydrated alcohol, subsequent use;
2) tea polyphenol powder, soluble starch, vitamin C, artemisia glue are mixed, in mixer, mixed 10 minutes, subsequent use.
3) to step 2) add dehydrated alcohol in the mixture that obtains, stir, to granulate, under the room temperature dry 5 hours, granulate was crossed 24 mesh sieves.
4) add magnesium stearate in the material on sieve, mix homogeneously, tabletting obtains goods.
The tea polyphenols sheet that obtains is got 6 carry out disintegration time mensuration, and compare with Comparative Examples, the result sees table; Get 20 and carry out tablet weight variation mensuration, the result meets the regulation of " Chinese Pharmacopoeia 2005 "; Take out 20 average polyphenol contents of mensuration and be about 40%.
Embodiment 2
A kind of method for preparing of tea polyphenols sheet may further comprise the steps:
1) taking by weighing 20g content is 75～80% tea polyphenol powder, the 30g soluble starch, and the 0.40g vitamin C, the 0.15g artemisia glue, the 0.25g magnesium stearate, the 24.40ml dehydrated alcohol, subsequent use;
2) tea polyphenol powder, soluble starch, vitamin C, artemisia glue are mixed, in mixer, mixed 15 minutes, subsequent use.
3) to step 2) add dehydrated alcohol in the mixture that obtains, stir, to granulate, under the room temperature dry 6 hours, granulate was crossed 24 mesh sieves.
4) add magnesium stearate in the material on sieve, mix homogeneously, tabletting obtains goods.
The tea polyphenols sheet that obtains is got 6 carry out disintegration time mensuration, and compare with Comparative Examples, the result sees table; Get 20 and carry out tablet weight variation mensuration, the result meets the regulation of " Chinese Pharmacopoeia 2005 "; Take out 20 average polyphenol contents of mensuration and be about 40%.
Embodiment 3
A kind of method for preparing of tea polyphenols sheet may further comprise the steps:
1) taking by weighing 30g content is 75～80% tea polyphenol powder, the 60g soluble starch, and the 0.9g vitamin C, the 0.45g artemisia glue, the 0.73g magnesium stearate, the 46.00ml dehydrated alcohol, subsequent use;
2) tea polyphenol powder, soluble starch, vitamin C, artemisia glue are mixed, in mixer, mixed 15 minutes, subsequent use.
3) to step 2) add dehydrated alcohol in the mixture that obtains, stir, to granulate, under the room temperature dry 6 hours, granulate was crossed 24 mesh sieves.
4) add magnesium stearate in the material on sieve, mix homogeneously, tabletting obtains goods.
The tea polyphenols sheet that obtains is got 6 carry out disintegration time mensuration, and compare with Comparative Examples, the result sees table; Get 20 and carry out tablet weight variation mensuration, the result meets the regulation of " Chinese Pharmacopoeia 2005 "; Take out 20 average polyphenol contents of mensuration and be about 40%.
Comparative Examples 1
Use the preparation of microcrystalline Cellulose as the tea polyphenols sheet of disintegrating agent:
1) taking by weighing 30g content is 75% tea polyphenol powder, the 50g soluble starch, and the 0.65g vitamin C, the 8g microcrystalline Cellulose, the 0.4g magnesium stearate, the 50ml dehydrated alcohol, subsequent use;
2) tea polyphenol powder, soluble starch, vitamin C, microcrystalline Cellulose are mixed, in mixer, mixed 15 minutes, subsequent use.
3) to step 2) add dehydrated alcohol in the mixture that obtains, stir, to granulate, under the room temperature dry 6 hours, granulate was crossed 24 mesh sieves.
4) add magnesium stearate in the material on sieve, mix homogeneously, tabletting obtains goods.
The tea polyphenols sheet that obtains is got 6 carry out disintegration time mensuration, the result sees table; Take out 20 average polyphenol contents of mensuration and be about 33.7%.
Comparative Examples 2
Use the preparation of carboxymethyl starch sodium as the tea polyphenols sheet of disintegrating agent:
1) taking by weighing 25g content is 80% tea polyphenol powder, the 40g soluble starch, and the 0.45g vitamin C, the 5g carboxymethyl starch sodium, the 0.5g magnesium stearate, the 40ml dehydrated alcohol, subsequent use;
2) tea polyphenol powder, soluble starch, vitamin C, carboxymethyl starch sodium are mixed, in mixer, mixed 15 minutes, subsequent use.
3) to step 2) add dehydrated alcohol in the mixture that obtains, stir, to granulate, under the room temperature dry 6 hours, granulate was crossed 24 mesh sieves.
4) add magnesium stearate in the material on sieve, mix homogeneously, tabletting obtains goods.
The tea polyphenols sheet that obtains is got 6 carry out disintegration time mensuration, the result sees table; Take out 20 average polyphenol contents of mensuration and be about 35%.
Comparative Examples 3
Use the preparation of cross-linking sodium carboxymethyl cellulose as the tea polyphenols sheet of disintegrating agent:
1) taking by weighing 40g content is 75% tea polyphenol powder, the 45g soluble starch, and the 0.8g vitamin C, the 7g cross-linking sodium carboxymethyl cellulose, the 0.8g magnesium stearate, the 70ml dehydrated alcohol, subsequent use;
2) tea polyphenol powder, soluble starch, vitamin C, cross-linking sodium carboxymethyl cellulose are mixed, in mixer, mixed 15 minutes, subsequent use.
3) to step 2) add dehydrated alcohol in the mixture that obtains, stir, to granulate, under the room temperature dry 6 hours, granulate was crossed 24 mesh sieves.
4) add magnesium stearate in the material on sieve, mix homogeneously, tabletting obtains goods.
The tea polyphenols sheet that obtains is got 6 carry out disintegration time mensuration, the result sees table; Take out 20 average polyphenol contents of mensuration and be about 42.7%.
Show tea polyphenols sheet contrast among the different embodiment
Obviously, the above embodiment of the present invention only be for clearly the present invention is described and is done for example, and be not to be qualification to embodiment of the present invention.For the those of ordinary skill in affiliated field, on the basis of above-mentioned explanation, can also make other multi-form variation or change.Here can't give exhaustive to all embodiments.Everyly belong to the row that conspicuous variation that technical scheme of the present invention extends out or change still are in protection scope of the present invention.
Claims (4)
1. a tea polyphenols sheet is characterized in that, its component is tea polyphenol powder, soluble starch, vitamin C, artemisia glue, magnesium stearate, dehydrated alcohol; Wherein tea polyphenol powder is a functional component, and soluble starch is a filler, and vitamin C is an antioxidant, and artemisia glue is a disintegrating agent, and magnesium stearate is a lubricant, and dehydrated alcohol is a binding agent;
The weight ratio of said soluble starch and said tea polyphenol powder is 1: 1～1: 2;
5 ‰～10 ‰ of the gross weight that said ascorbic weight is said tea polyphenol powder and said soluble starch;
The weight of said artemisia glue be said tea polyphenol powder and said soluble starch gross weight 3 ‰～5 ‰;
The weight of said magnesium stearate be said tea polyphenol powder, said soluble starch, said vitamin C, said artemisia glue gross weight 5 ‰～8 ‰;
The volume of said dehydrated alcohol is 4.5ml～5ml: 10g with the ratio of the gross weight of said tea polyphenol powder, said soluble starch, said vitamin C, said artemisia glue.
2. the method for preparing of a kind of tea polyphenols sheet as claimed in claim 1 is characterized in that, may further comprise the steps:
1) draw materials according to following ratio:
The weight ratio of tea polyphenol powder and soluble starch is 1: 1～1: 2,
Ascorbic weight be tea polyphenol powder and soluble starch gross weight 5 ‰～10 ‰,
The weight of artemisia glue be tea polyphenol powder and soluble starch gross weight 3 ‰～5 ‰,
The weight of magnesium stearate be tea polyphenol powder, soluble starch, vitamin C, artemisia glue gross weight 5 ‰～8 ‰,
The volume of dehydrated alcohol is 4.5ml～5ml: 10g with the ratio of the gross weight of tea polyphenol powder, soluble starch, vitamin C, artemisia glue;
2) with 1) in ready tea polyphenol powder, soluble starch, vitamin C, artemisia glue put into reaction vessel, mix homogeneously, subsequent use;
3) in step 2) add dehydrated alcohol in the mixture that obtains, stir and make mix homogeneously, granulate, be dried to ethanol and volatilize fully, granulate sieves;
4) add magnesium stearate in the material on sieve, mix homogeneously, tabletting obtains goods.
3. the method for preparing of a kind of tea polyphenols sheet according to claim 2 is characterized in that: the content of tea polyphenols is 75%～80% in the said tea polyphenol powder.
4. the method for preparing of a kind of tea polyphenols sheet according to claim 2 is characterized in that: it was 24 mesh sieves that said granulate sieves.
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| CN2011100765508A CN102188543B (en) | 2011-03-29 | 2011-03-29 | Tea polyphenol tablet and preparation method thereof |
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| CN2011100765508A CN102188543B (en) | 2011-03-29 | 2011-03-29 | Tea polyphenol tablet and preparation method thereof |
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| CN102188543B true CN102188543B (en) | 2012-11-14 |
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| CN106668928A (en) * | 2017-03-21 | 2017-05-17 | 深圳市前海州福科技有限公司 | Tea polyphenol chip and preparation method of chip body |
| CN107137373B (en) * | 2017-05-23 | 2020-03-13 | 西北师范大学 | Tea polyphenol effervescent tablet and preparation method thereof |
| CN111108848A (en) * | 2019-12-10 | 2020-05-08 | 亿利资源集团有限公司 | Pelleted seed and seed pelleting method |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1654038A (en) * | 2004-02-10 | 2005-08-17 | 浙江大学药业有限公司 | Buccal tablet of tea polyphenol for preventing and treating colds and resisting inflammation and preparation thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1654038A (en) * | 2004-02-10 | 2005-08-17 | 浙江大学药业有限公司 | Buccal tablet of tea polyphenol for preventing and treating colds and resisting inflammation and preparation thereof |
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