CN102178056B - Dihydropyridine clathrate compound - Google Patents
Dihydropyridine clathrate compound Download PDFInfo
- Publication number
- CN102178056B CN102178056B CN2011101153693A CN201110115369A CN102178056B CN 102178056 B CN102178056 B CN 102178056B CN 2011101153693 A CN2011101153693 A CN 2011101153693A CN 201110115369 A CN201110115369 A CN 201110115369A CN 102178056 B CN102178056 B CN 102178056B
- Authority
- CN
- China
- Prior art keywords
- dihydropyridine
- oil
- parts
- clathrate compound
- tower
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical compound C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title claims abstract description 54
- 150000001875 compounds Chemical class 0.000 title claims abstract description 13
- 238000000034 method Methods 0.000 claims abstract description 13
- 239000007921 spray Substances 0.000 claims abstract description 12
- 239000000843 powder Substances 0.000 claims abstract description 10
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 230000008569 process Effects 0.000 claims abstract description 7
- 238000010438 heat treatment Methods 0.000 claims abstract description 4
- 238000002156 mixing Methods 0.000 claims abstract description 3
- 238000005984 hydrogenation reaction Methods 0.000 claims description 13
- 239000012467 final product Substances 0.000 claims description 4
- 238000003801 milling Methods 0.000 claims description 2
- 239000002994 raw material Substances 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 238000003756 stirring Methods 0.000 claims description 2
- 239000007787 solid Substances 0.000 abstract description 6
- 238000001816 cooling Methods 0.000 abstract description 5
- 239000002245 particle Substances 0.000 abstract description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- 238000003860 storage Methods 0.000 abstract description 3
- 230000008901 benefit Effects 0.000 abstract description 2
- 238000002844 melting Methods 0.000 abstract 2
- 230000008018 melting Effects 0.000 abstract 2
- 238000009776 industrial production Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 description 11
- 239000000243 solution Substances 0.000 description 10
- 230000000694 effects Effects 0.000 description 4
- 244000144977 poultry Species 0.000 description 4
- 238000013019 agitation Methods 0.000 description 3
- 230000003064 anti-oxidating effect Effects 0.000 description 3
- 125000004925 dihydropyridyl group Chemical group N1(CC=CC=C1)* 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 239000004519 grease Substances 0.000 description 3
- 244000144972 livestock Species 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 229920000858 Cyclodextrin Polymers 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 2
- 239000000725 suspension Substances 0.000 description 2
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 208000008964 Chemical and Drug Induced Liver Injury Diseases 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 208000004930 Fatty Liver Diseases 0.000 description 1
- 206010019708 Hepatic steatosis Diseases 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 235000019730 animal feed additive Nutrition 0.000 description 1
- 239000003674 animal food additive Substances 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 230000003026 anti-oxygenic effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 230000008827 biological function Effects 0.000 description 1
- 235000010410 calcium alginate Nutrition 0.000 description 1
- 239000000648 calcium alginate Substances 0.000 description 1
- 229960002681 calcium alginate Drugs 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 208000010706 fatty liver disease Diseases 0.000 description 1
- 230000003031 feeding effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 231100000240 steatosis hepatitis Toxicity 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
Images
Landscapes
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011101153693A CN102178056B (en) | 2011-05-05 | 2011-05-05 | Dihydropyridine clathrate compound |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2011101153693A CN102178056B (en) | 2011-05-05 | 2011-05-05 | Dihydropyridine clathrate compound |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102178056A CN102178056A (en) | 2011-09-14 |
CN102178056B true CN102178056B (en) | 2012-08-08 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN2011101153693A Expired - Fee Related CN102178056B (en) | 2011-05-05 | 2011-05-05 | Dihydropyridine clathrate compound |
Country Status (1)
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CN (1) | CN102178056B (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN109432045B (en) * | 2018-11-29 | 2021-11-23 | 佛山市正典生物技术有限公司 | Dihydropyridine microcapsule preparation and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1559407A (en) * | 2004-02-23 | 2005-01-05 | 沈阳药科大学 | Self-micro emulsion solft capsule of dihydropyridine type calcium ion agonist, and its prepn. method |
CN101548715A (en) * | 2009-05-13 | 2009-10-07 | 西北农林科技大学 | Dihydropyridine clathrate compound and preparation method thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1325941B1 (en) * | 1995-10-13 | 2005-06-01 | Crompton Vinyl Additives GmbH | Stabiliser combinations for chlorinated polymers |
US6593350B2 (en) * | 2001-04-26 | 2003-07-15 | Wyeth | Antidepressant indoletetrahydropyridine derivatives of 2,3-dihydro-7H-[1,4]dioxino[2,3-e]indole |
-
2011
- 2011-05-05 CN CN2011101153693A patent/CN102178056B/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1559407A (en) * | 2004-02-23 | 2005-01-05 | 沈阳药科大学 | Self-micro emulsion solft capsule of dihydropyridine type calcium ion agonist, and its prepn. method |
CN101548715A (en) * | 2009-05-13 | 2009-10-07 | 西北农林科技大学 | Dihydropyridine clathrate compound and preparation method thereof |
Non-Patent Citations (2)
Title |
---|
邹晓庭 等.二氢吡啶对产蛋鸡的作用效果及机理研究.《浙江大学学报(农业与生命科学版)》.1998,(第3期),298-302. * |
陈菊芳 等.新颖的饲料添加剂-二氢吡啶.《饲料研究》.1987,21-22. * |
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CN102178056A (en) | 2011-09-14 |
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SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Free format text: FORMER OWNER: CAO SHENGYAN Effective date: 20140915 Owner name: HENAN SHUANGCHENG BIOTECHNOLOGY CO., LTD. Free format text: FORMER OWNER: WANG HONGYAN Effective date: 20140915 |
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C41 | Transfer of patent application or patent right or utility model | ||
COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 450052 ZHENGZHOU, HENAN PROVINCE TO: 463900 ZHUMADIAN, HENAN PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20140915 Address after: 463900, Henan, Xiping County, Zhumadian province Jinfeng Road West Section of the road south Patentee after: Henan Shuangcheng Biotechnology Co., Ltd. Address before: 450052 No. 385 Longhai West Road, Henan, Zhengzhou Patentee before: Wang Hongyan Patentee before: Cao Shengyan |
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CF01 | Termination of patent right due to non-payment of annual fee | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20120808 Termination date: 20200505 |