CN102166250A - Liquid biological medicament for treating esophagus cancer, cardiac cancer and diseases of digestive tract - Google Patents
Liquid biological medicament for treating esophagus cancer, cardiac cancer and diseases of digestive tract Download PDFInfo
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- CN102166250A CN102166250A CN2011100358431A CN201110035843A CN102166250A CN 102166250 A CN102166250 A CN 102166250A CN 2011100358431 A CN2011100358431 A CN 2011100358431A CN 201110035843 A CN201110035843 A CN 201110035843A CN 102166250 A CN102166250 A CN 102166250A
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- carcinoma
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- digestive tract
- hericium erinaceus
- sojae atricolor
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Abstract
The invention provides a preparation method of a liquid biological medicament for treating esophagus cancer, cardiac cancer and diseases of the digestive tract, which comprises the following steps: taking soybeans, hericium erinaceus, molasses and effective microorganisms as raw materials; proportioning and combining the raw materials; sealing; carrying out anaerobic fermentation at normal pressure; and then, carrying out pressure filtration and acid regulating treatment to prepare a liquid pure biological medicament. The invention has the advantages of simple process, low cost and no discharge of waste materials in production, and residual solid matters obtained by pressure filtration of a pressure filter can be used for preparing solid pure biological medicaments. The invention also has the advantage that the soybeans, the effective microorganisms and the medicinal and edible hericium erinaceus are combined and fermented to form ultra-strong colonial synergetic fermenting power, thereby strengthening the biological activity of various types of beneficial components in the soybeans and hericium erinaceus. Thus, the medicament provided by the invention has obvious and reliable effects on treating esophagus cancer, cardiac cancer and common diseases of the digestive tract, can be used for medicinal and edible purposes, does not have toxic side effects after being taken for a long time, and can comprehensively and greatly improve the immunity of a human body.
Description
Technical field
The present invention relates to a kind of liquid biological medicine for the treatment of digestive system disease, a kind of specifically liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease.
Background technology
Esophageal carcinoma is one of modal malignant tumor of China, and China is the esophageal carcinoma district occurred frequently, occupies second because of esophageal carcinoma death person is only second to gastric cancer; Carcinoma of gastric cardia is the specific type of gastric cancer, and the M ﹠ M of carcinoma of gastric cardia ranks among the best in all kinds of malignant tumor.For esophageal carcinoma and carcinoma of gastric cardia, doctor trained in Western medicine preferentially adopts operative treatment, and has lost the preferable opportunity of operative treatment during the clinical accurate diagnosis of many patients; But rely on non-operative treatment side effect such as radiotherapy chemotherapy big and have little effect, especially the harm to liver, renal function is bigger, and cure rate and survival rate are very low.Chinese traditional treatment is based on decoction, and its prescription complexity is taken trouble, and the course of treatment of making slow progress is long, and cure rate is not high yet, and the part composition also has certain toxic and side effects, takes for a long time to make people worried.
Summary of the invention
Purpose of the present invention just provides a kind of liquid biological medicine that is used for the treatment of digestive tract common diseases such as esophageal carcinoma, carcinoma of gastric cardia and gastric ulcer, esophagitis, duodenal ulcer, reach without any side effects again in the treatment disease, and can also significantly improve body immunity comprehensively.To achieve these goals, the invention provides following technical solution:
A kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease is characterized in that:
Its quality prescription is as follows:
Semen sojae atricolor 12-22%, Hericium erinaceus (Bull. Ex Fr.) Pers. 26-52%, molasses 1-3%, effective microorganisms 1-3%, water 30-50%, total 100%.
Its processing technology is as follows:
(1) measures the Semen sojae atricolor that screens out behind the granule that goes mouldy by prescription and clean the container of packing into, add whole moisture immersions by formula ratio again and made it abundant expansion in 8-10 hour, behind the processed (employing is boiled, steamed or other ripening means are processed as ripe Semen sojae atricolor) to ripe Semen sojae atricolor moisture content≤20%, the moisture of pressing filterable ripe Semen sojae atricolor and filter pressing to go out is respectively charged into containers for future use through the pressure filter filter pressing.
(2) measure molasses by prescription and dissolve in the moisture that (1) filter pressing goes out, be stirred to molasses and fully dissolve.
(3) measure effective microorganisms by prescription and add in (2), be stirred to abundant fusion.
(4) measuring Hericium erinaceus (Bull. Ex Fr.) Pers. by prescription is refrigerated to-10 ℃ of pulverizing again and crosses 10 mesh sieves after the filterable ripe Semen sojae atricolor mixing of (1) pressure together.
(5) packed in (3) (4) fermentation tank and to replenish moisture to the total amount of losing in the aforementioned operation be 100%, mix, 28 ℃ ± 2 ℃ temperature conditions lower seal anaerobic fermentations 5 days, therebetween after abundant stirring in 8 hours 6 minutes and discharging unnecessary gas, the row sealing keeps normal pressure again, continues anaerobic fermentation.
(6) material that ferments is all taken out, through the pressure filter filter pressing, make the solids moisture content drop to≤6%, again the liquid object that leaches is adjusted acidity value to PH≤4.0 with 56% edible ice acetic acid, get final product sealed packaging, become a kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease of the present invention.Remaining solids will be used to make solid-state pure biological medicine separately after the pressure filter filter pressing.
Semen sojae atricolor in the quality prescription of the present invention is Semen Glycines or Semen sojae atricolor, Hericium erinaceus (Bull. Ex Fr.) Pers. in the described quality prescription is the Hericium erinaceus (Bull. Ex Fr.) Pers. mycelium of liquid submerged fermentation or the Hericium erinaceus of cultivation, molasses in the described quality prescription are Mel, brown sugar or brown sugar, effective microorganisms in the described quality prescription is the EM liquid composite bacteria agent capable (EM is the english abbreviation of effective microorganisms) of foodstuff sanitation-stage, and domestic morning, existing product emerged as the EM original solution of foodstuff sanitation-stage etc.
The present invention has following technical advantage:
1, advantage of the present invention is to adopt the Hericium erinaceus (Bull. Ex Fr.) Pers. combined fermentation of Semen sojae atricolor, effective microorganisms and medicine-food two-purpose, form superpower colony and even take fermenting power, defectives such as the flatulence factor that Semen sojae atricolor contains, antinutritional factor are overcome, and strengthened the biological activity of soybean lecithin, coenzyme Q10, isoflavone and oligosaccharide, multiple enzyme, aminoacid, vitamin, antibacterial peptide and other nutrient and biological active substances have been synthesized in secretion again in the fermented soybean process; Also strengthened simultaneously the effect of multiple beneficial compositions such as the polysaccharide in the Hericium erinaceus (Bull. Ex Fr.) Pers., polypeptide, gland glycoside, enzyme, make product of the present invention curative effect significantly reliably all be arranged, have auxiliary treatment effect simultaneously concurrently other disease to digestive tract common diseases such as esophageal carcinoma, carcinoma of gastric cardia and esophagitis, gastric ulcer, duodenal ulcers.
2, advantage of the present invention also is to adopt freezing and pulverizing, the loss of beneficiating ingredients such as the polysaccharide in soybean lecithin, coenzyme Q10, isoflavone, oligosaccharide and the Hericium erinaceus (Bull. Ex Fr.) Pers. that avoids room temperature to pulverize causing, polypeptide, gland glycoside, enzyme, help improving biological value and absorption rate, the operation of acid adjustment has simultaneously also facilitated the shelf-life of liquid biological medicine can reach the setting requirement.
3, the selected raw material of the present invention all belongs to human general food, very closes the true essence of integration of edible and medicinal herbs; The product of being produced belongs to pure biologics, takes also without any side effectsly for a long time, simultaneously can also significantly improve body immunity comprehensively; And production technology is simply with low cost, can correspondingly alleviate the economic pressures in the patient treatment.
4. the present invention does not have any refuse trash discharge aborning, and remaining solids can be used to make solid-state pure biological medicine separately after the pressure filter filter pressing; Described prescription does not have significant difference in raw material type and weight proportion scope, the quantum of output of adjusting liquid object and solids is just measured in the variation of prescription according to demand, does not influence therapeutic effect.
The specific embodiment
Embodiment 1:
A kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease, its quality prescription is as follows:
Each 1.5kg of Hericium erinaceus 52kg, Mel and brown sugar of Semen Glycines 12kg, cultivation is 3kg, EM original solution 3kg, water 30kg altogether, adds up to 100kg.
Its processing technology is as follows:
(1) measures the Semen Glycines 12kg that screens out behind the granule that goes mouldy by prescription and clean the container of packing into, add whole moisture 30kg immersions by formula ratio again and made it abundant expansion in 10 hours, cook after the pressure filter filter pressing to ripe Semen sojae atricolor moisture content≤20%, press the filterable ripe Semen sojae atricolor containers for future use of packing into, the moisture that filter pressing goes out and the residual moisture of soaking soybean another containers for future use of packing into jointly.
(2) by prescription measure Mel and each 1.5kg of brown sugar altogether 3kg dissolve in the mix moisture of residual moisture of moisture that (1) filter pressing goes out and soaking soybean, be stirred to Mel and brown sugar fully dissolves.
(3) measure EM original solution 3kg by prescription and add in (2), be stirred to abundant fusion.
(4) be refrigerated to-10 ℃ again after the Hericium erinaceus 52kg of measuring cultivation by prescription presses filterable ripe Semen sojae atricolor to mix with (1) and pulverize and cross 10 mesh sieves.
(5) packed in (3) (4) fermentation tank and to replenish moisture to the total amount of losing in the aforementioned operation be 100kg, mix, 28 ℃ ± 2 ℃ temperature conditions lower seal anaerobic fermentations 5 days, therebetween after abundant stirring in 8 hours 6 minutes and discharging unnecessary gas, the row sealing keeps normal pressure again, continues anaerobic fermentation.
(6) material that ferments is all taken out, through the pressure filter filter pressing, make the solids moisture content drop to≤6%, again the liquid object that leaches is adjusted acidity value to PH≤4.0 with 56% edible ice acetic acid, get final product sealed packaging, become a kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease of the present invention.Remaining solids will be used to make solid-state pure biological medicine separately after the pressure filter filter pressing.
Embodiment 2:
A kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease, its quality prescription is as follows:
Each 8kg of Semen Glycines and Semen sojae atricolor is total to the Hericium erinaceus (Bull. Ex Fr.) Pers. mycelium of 16kg, liquid submerged fermentation and each 20kg of Hericium erinaceus of cultivation is total to 40kg, Mel and each 1kg of brown sugar 2kg, EM original solution 2kg, water 40kg altogether, adds up to 100kg.
Its processing technology is as follows:
(1) by prescription measure the Semen Glycines that screens out behind the granule that goes mouldy and each 8kg of Semen sojae atricolor altogether 16kg clean the container of packing into, add whole moisture 40kg immersions by formula ratio again and made it abundant expansion in 8 hours, ripe after the pressure filter filter pressing of Zhu is to ripe Semen sojae atricolor moisture content≤20%, and the moisture of pressing filterable ripe Semen sojae atricolor and filter pressing to go out is respectively charged into containers for future use.
(2) by prescription measure Mel and each 1kg of brown sugar altogether 2kg dissolve in the moisture that (1) filter pressing goes out, be stirred to Mel and brown sugar fully dissolves.
(3) measure EM original solution 2kg by prescription and add in (2), be stirred to abundant fusion.
(4) be refrigerated to-10 ℃ again after measuring each 20kg of Hericium erinaceus of the Hericium erinaceus (Bull. Ex Fr.) Pers. mycelium of liquid submerged fermentation and cultivation 40kg presses filterable ripe Semen sojae atricolor to mix with (1) altogether by prescription and pulverize and cross 10 mesh sieves.
(5) packed in (3) (4) fermentation tank and to replenish moisture to the total amount of losing in the aforementioned operation be 100kg, mix, 28 ℃ ± 2 ℃ temperature conditions lower seal anaerobic fermentations 5 days, therebetween after abundant stirring in 8 hours 6 minutes and discharging unnecessary gas, the row sealing keeps normal pressure again, continues anaerobic fermentation.
(6) material that ferments is all taken out, through the pressure filter filter pressing, make the solids moisture content drop to≤6%, again the liquid object that leaches is adjusted acidity value to PH≤4.0 with 56% edible ice acetic acid, get final product sealed packaging, become a kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease of the present invention.Remaining solids will be used to make solid-state pure biological medicine separately after the pressure filter filter pressing.
Embodiment 3:
A kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease, its quality prescription is as follows:
The Hericium erinaceus (Bull. Ex Fr.) Pers. mycelium 26kg of Semen sojae atricolor 22kg, liquid submerged fermentation, brown sugar 1kg, EM original solution 1kg, water 50kg add up to 100kg.
Its processing technology is as follows:
(1) measures the Semen sojae atricolor 22kg that screens out behind the granule that goes mouldy by prescription and clean the container of packing into, add whole moisture 50kg immersions by formula ratio again and made it abundant expansion in 9 hours, processed after the pressure filter filter pressing to ripe Semen sojae atricolor moisture content≤20%, the moisture of pressing filterable ripe Semen sojae atricolor and filter pressing to go out is respectively charged into containers for future use.
(2) measure brown sugar 1kg by prescription and dissolve in the moisture that (1) filter pressing goes out, be stirred to brown sugar and fully dissolve.
(3) measure EM original solution 1kg by prescription and add in (2), be stirred to abundant fusion.
(4) be refrigerated to-10 ℃ again after the Hericium erinaceus (Bull. Ex Fr.) Pers. mycelium 26kg of measuring liquid submerged fermentation by prescription presses filterable ripe Semen sojae atricolor to mix with (1) and pulverize and cross 10 mesh sieves.
(5) packed in (3) (4) fermentation tank and to replenish moisture to the total amount of losing in the aforementioned operation be 100kg, mix, 28 ℃ ± 2 ℃ temperature conditions lower seal anaerobic fermentations 5 days, therebetween after abundant stirring in 8 hours 6 minutes and discharging unnecessary gas, the row sealing keeps normal pressure again, continues anaerobic fermentation.
(6) material that ferments is all taken out, through the pressure filter filter pressing, make the solids moisture content drop to≤6%, again the liquid object that leaches is adjusted acidity value to PH≤4.0 with 56% edible ice acetic acid, get final product sealed packaging, become a kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease of the present invention.Remaining solids will be used to make solid-state pure biological medicine separately after the pressure filter filter pressing.
More than the technical solution of each embodiment all can reach purpose of the present invention.
A kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease, the finished product of making according to above proportioning carries out practical application: from 2004-2009, observe number 22 examples altogether, effective percentage reaches more than 90%, and the patient takes medicine promptly produce effects in 6-22 days; 18 people that return to one's perfect health, cure rate reaches more than 81%.
Below list the several instantiations of the present invention in the treatment patient:
Laohekou Sophora japonica L. gulf Korea Spro * * father 2004 67 years old, suffered from esophageal carcinoma at that time and had a surplus in 1 year, obstinate and gradually serious, hiccough and dysphagia, can only take food fluidity food, severe malnutrition; Dripping clothes liquid medicine of the present invention only after 6 days, the hiccough phenomenon reduces, and the symptom of dysphagia is also alleviated to some extent after 17 days, and the general food of having taken food after month is adhered to after treatment in about 2 years, and it is fine to feel health in the return visit.
Yuan * * 2008, peaceful town, Zaoyang year 51 years old are diagnosed as carcinoma of gastric cardia through hospital, and the cardia place thing that swell is seen in gastroscopy, and sense of obstruction is serious, nauseating, vomitus band blood, significantly become thin; Because of the gob-struck unable hospitalization of family financial situation, it is main in conjunction with oral dripping clothes through liquid drug of the present invention, behind the sky alleviation is arranged slightly surplus in the of ten, feels sick after 21 days, vomits significantly and reduce, and the readme sense of obstruction also alleviates to some extent; Feed is tending towards normal after three months, drug withdrawal voluntarily after a year, and the readme health recovers fully in the return visit.
Ban Qiao town, Yicheng Huang * * 2006 years 49 years old, suffer from rectal cancer, the visible tumor of microscopic examination of rectum is with abdominal distension, paroxysmal colic and dense hemafecia symptom, through with the biological medicine coloclysis of liquid state of the present invention, and the solid-state biological Drug Capsule of making in conjunction with the solids after the filter pressing among oral the present invention, paroxysmal colic alleviates after 7 days, dense hemafecia doing well,improving after 28 days, feeling tumor after half a year disappears, health recovers normally substantially, again through after treatment half a year, and recurrence more so far.
Claims (5)
1. liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease is characterized in that:
Its quality prescription is as follows:
Semen sojae atricolor 12-22%, Hericium erinaceus (Bull. Ex Fr.) Pers. 26-52%, molasses 1-3%, effective microorganisms 1-3%, water 30-50%, total 100%;
Its processing technology is as follows:
(1) measures the Semen sojae atricolor that screens out behind the granule that goes mouldy by prescription and clean the container of packing into, add whole moisture immersions by formula ratio again and made it abundant expansion in 8-10 hour, processed after the pressure filter filter pressing to ripe Semen sojae atricolor moisture content≤20%, the moisture of pressing filterable ripe Semen sojae atricolor and filter pressing to go out is respectively charged into containers for future use;
(2) measure molasses by prescription and dissolve in the moisture that (1) filter pressing goes out, be stirred to molasses and fully dissolve;
(3) measure effective microorganisms by prescription and add in (2), be stirred to abundant fusion;
(4) measuring Hericium erinaceus (Bull. Ex Fr.) Pers. by prescription is refrigerated to-10 ℃ of pulverizing again and crosses 10 mesh sieves after the filterable ripe Semen sojae atricolor mixing of (1) pressure together;
(5) packed in (3) (4) fermentation tank and to replenish moisture to the total amount of losing in the aforementioned operation be 100%, mix, 28 ℃ ± 2 ℃ temperature conditions lower seal anaerobic fermentations 5 days, therebetween after abundant stirring in 8 hours 6 minutes and discharging unnecessary gas, the row sealing keeps normal pressure again, continues anaerobic fermentation;
(6) material that ferments is all taken out, through the pressure filter filter pressing, make the solids moisture content drop to≤6%, again the liquid object that leaches is adjusted acidity value to PH≤4.0 with 56% edible ice acetic acid, get final product sealed packaging, become a kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease of the present invention.
2. a kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease according to claim 1, it is characterized in that: the Semen sojae atricolor in the described quality prescription is Semen Glycines or Semen sojae atricolor.
3. a kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease according to claim 1 is characterized in that: the Hericium erinaceus (Bull. Ex Fr.) Pers. in the described quality prescription is the Hericium erinaceus (Bull. Ex Fr.) Pers. mycelium of liquid submerged fermentation or the Hericium erinaceus of cultivation.
4. a kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease according to claim 1, it is characterized in that: the molasses in the described quality prescription are Mel, brown sugar or brown sugar.
5. a kind of liquid biological medicine for the treatment of esophageal carcinoma, carcinoma of gastric cardia and digestive tract disease according to claim 1 is characterized in that: the effective microorganisms in the described quality prescription is the EM liquid composite bacteria agent capable of foodstuff sanitation-stage.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100358431A CN102166250B (en) | 2011-01-20 | 2011-01-20 | Liquid biological medicament for treating esophagus cancer, cardiac cancer and diseases of digestive tract |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100358431A CN102166250B (en) | 2011-01-20 | 2011-01-20 | Liquid biological medicament for treating esophagus cancer, cardiac cancer and diseases of digestive tract |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102166250A true CN102166250A (en) | 2011-08-31 |
| CN102166250B CN102166250B (en) | 2012-06-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2011100358431A Expired - Fee Related CN102166250B (en) | 2011-01-20 | 2011-01-20 | Liquid biological medicament for treating esophagus cancer, cardiac cancer and diseases of digestive tract |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1471952A (en) * | 2003-04-26 | 2004-02-04 | 冯子龙 | Preparation for Chinese medicine multiple fungus mixed fermenting oral liquid and producing process thereof |
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2011
- 2011-01-20 CN CN2011100358431A patent/CN102166250B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1471952A (en) * | 2003-04-26 | 2004-02-04 | 冯子龙 | Preparation for Chinese medicine multiple fungus mixed fermenting oral liquid and producing process thereof |
Non-Patent Citations (2)
| Title |
|---|
| 《中国酿造》 20051220 史先振 现代发酵工程技术在食品领域的应用研究进展 1-4 1-6 , 第12期 2 * |
| 《江苏食品与发酵》 20040331 范贵增等 药用食用真菌营养保健饮品的研制 23-26 1-6 , 第01期 2 * |
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| CN102166250B (en) | 2012-06-20 |
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