CN102159249A - 具有低滥用潜在性的聚乙二醇化阿片样物质 - Google Patents

具有低滥用潜在性的聚乙二醇化阿片样物质 Download PDF

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Publication number
CN102159249A
CN102159249A CN2009801360891A CN200980136089A CN102159249A CN 102159249 A CN102159249 A CN 102159249A CN 2009801360891 A CN2009801360891 A CN 2009801360891A CN 200980136089 A CN200980136089 A CN 200980136089A CN 102159249 A CN102159249 A CN 102159249A
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China
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chemical compound
opioid
less
oligomer
compound
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CN2009801360891A
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Chinese (zh)
Inventor
C·S·诸得-菲斯伯恩
T·A·瑞丽
A·扎卡利斯
H·瓜萨哈尼
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Nektar Therapeutics
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Nektar Therapeutics
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Priority claimed from US12/558,395 external-priority patent/US8173666B2/en
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of CN102159249A publication Critical patent/CN102159249A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Addiction (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Inorganic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2009801360891A 2008-09-16 2009-09-16 具有低滥用潜在性的聚乙二醇化阿片样物质 Pending CN102159249A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19224708P 2008-09-16 2008-09-16
US61/192,247 2008-09-16
US12/558,395 2009-09-11
US12/558,395 US8173666B2 (en) 2007-03-12 2009-09-11 Oligomer-opioid agonist conjugates
PCT/US2009/005174 WO2010033195A1 (en) 2008-09-16 2009-09-16 Pegylated opioids with low potential for abuse

Publications (1)

Publication Number Publication Date
CN102159249A true CN102159249A (zh) 2011-08-17

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Application Number Title Priority Date Filing Date
CN2009801360891A Pending CN102159249A (zh) 2008-09-16 2009-09-16 具有低滥用潜在性的聚乙二醇化阿片样物质

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Country Link
US (2) US20110237614A1 (enExample)
EP (2) EP2340044A1 (enExample)
JP (1) JP5827123B2 (enExample)
KR (1) KR101660996B1 (enExample)
CN (1) CN102159249A (enExample)
AU (1) AU2009292631A1 (enExample)
CA (1) CA2734333A1 (enExample)
IL (1) IL211762A (enExample)
MX (1) MX347741B (enExample)
WO (1) WO2010033195A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017129046A1 (zh) * 2016-01-29 2017-08-03 北京键凯科技股份有限公司 具有低成瘾作用的聚乙二醇化阿片样物质
CN107033154A (zh) * 2016-02-02 2017-08-11 苏州派格生物科技有限公司 阿片受体拮抗剂缀合物及其应用
WO2018113581A1 (zh) * 2016-12-22 2018-06-28 北京键凯科技股份有限公司 一种地佐辛与聚乙二醇的结合物
CN111107849A (zh) * 2017-07-20 2020-05-05 苏州润鑫达泰生物医药有限公司 抗滥用长效释放阿片样前药
CN115181109A (zh) * 2021-04-02 2022-10-14 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法

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US20130023553A1 (en) * 2010-01-12 2013-01-24 Nektar Therapeutics Pegylated opioids with low potential for abuse and side effects
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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107019803B (zh) * 2016-01-29 2020-09-15 北京键凯科技股份有限公司 具有低成瘾作用的聚乙二醇化阿片样物质
CN107019803A (zh) * 2016-01-29 2017-08-08 北京键凯科技股份有限公司 具有低成瘾作用的聚乙二醇化阿片样物质
WO2017129046A1 (zh) * 2016-01-29 2017-08-03 北京键凯科技股份有限公司 具有低成瘾作用的聚乙二醇化阿片样物质
CN107033154A (zh) * 2016-02-02 2017-08-11 苏州派格生物科技有限公司 阿片受体拮抗剂缀合物及其应用
US11311533B2 (en) 2016-02-02 2022-04-26 Shanghai Hanmai Bio-Pharma Co., Ltd. Opioid receptor antagonist conjugate and use thereof
CN107033154B (zh) * 2016-02-02 2020-02-04 上海瀚迈生物医药科技有限公司 阿片受体拮抗剂缀合物及其应用
WO2018113581A1 (zh) * 2016-12-22 2018-06-28 北京键凯科技股份有限公司 一种地佐辛与聚乙二醇的结合物
CN108210933B (zh) * 2016-12-22 2021-05-04 北京键凯科技股份有限公司 一种地佐辛与聚乙二醇的结合物
CN108210933A (zh) * 2016-12-22 2018-06-29 北京键凯科技股份有限公司 一种地佐辛与聚乙二醇的结合物
CN111107849A (zh) * 2017-07-20 2020-05-05 苏州润鑫达泰生物医药有限公司 抗滥用长效释放阿片样前药
CN111107849B (zh) * 2017-07-20 2024-03-29 苏州润鑫达泰生物医药有限公司 抗滥用长效释放阿片样前药
CN115181109A (zh) * 2021-04-02 2022-10-14 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法
CN115181109B (zh) * 2021-04-02 2024-06-04 南京正大天晴制药有限公司 吗啡喃衍生物的晶体及其制备方法

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Publication number Publication date
IL211762A (en) 2016-06-30
MX347741B (es) 2017-05-10
MX2011002748A (es) 2011-04-21
KR101660996B1 (ko) 2016-09-28
US20110237614A1 (en) 2011-09-29
JP5827123B2 (ja) 2015-12-02
WO2010033195A1 (en) 2010-03-25
CA2734333A1 (en) 2010-03-25
EP3342427A1 (en) 2018-07-04
JP2012502904A (ja) 2012-02-02
EP2340044A1 (en) 2011-07-06
IL211762A0 (en) 2011-06-30
US20160243111A1 (en) 2016-08-25
KR20110058783A (ko) 2011-06-01
AU2009292631A1 (en) 2010-03-25

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