CN102159233A - 使用哺乳动物β防御素的炎性肠病的治疗 - Google Patents

使用哺乳动物β防御素的炎性肠病的治疗 Download PDF

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Publication number
CN102159233A
CN102159233A CN2009801363438A CN200980136343A CN102159233A CN 102159233 A CN102159233 A CN 102159233A CN 2009801363438 A CN2009801363438 A CN 2009801363438A CN 200980136343 A CN200980136343 A CN 200980136343A CN 102159233 A CN102159233 A CN 102159233A
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CN
China
Prior art keywords
defensin
beta
hbd2
tnf
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN2009801363438A
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English (en)
Chinese (zh)
Inventor
坦贾·M·R·凯尔
托马斯·克鲁泽
珀尔·H·迈金德
卡罗琳·S·布林奇
泽伦·凯拉尔夫
伯吉特·安德森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novozymes Biopharma DK AS
Original Assignee
Novozymes Adenium Biotech AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41530820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN102159233(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novozymes Adenium Biotech AS filed Critical Novozymes Adenium Biotech AS
Publication of CN102159233A publication Critical patent/CN102159233A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1729—Cationic antimicrobial peptides, e.g. defensins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2009801363438A 2008-07-18 2009-07-17 使用哺乳动物β防御素的炎性肠病的治疗 Pending CN102159233A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP08160761.6 2008-07-18
EP08160761 2008-07-18
EP08162486.8 2008-08-15
EP08162486 2008-08-15
EP08163614 2008-09-03
EP08163614.4 2008-09-03
PCT/EP2009/059253 WO2010007166A2 (en) 2008-07-18 2009-07-17 Treatment of inflammatory bowel diseases with mammal beta defensins

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201110163184XA Division CN102247591A (zh) 2008-07-18 2009-07-17 使用哺乳动物β防御素的炎性肠病的治疗

Publications (1)

Publication Number Publication Date
CN102159233A true CN102159233A (zh) 2011-08-17

Family

ID=41530820

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2009801363438A Pending CN102159233A (zh) 2008-07-18 2009-07-17 使用哺乳动物β防御素的炎性肠病的治疗
CN201110163184XA Pending CN102247591A (zh) 2008-07-18 2009-07-17 使用哺乳动物β防御素的炎性肠病的治疗

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN201110163184XA Pending CN102247591A (zh) 2008-07-18 2009-07-17 使用哺乳动物β防御素的炎性肠病的治疗

Country Status (20)

Country Link
US (4) US8232242B2 (enExample)
EP (2) EP2399600A1 (enExample)
JP (2) JP2011528333A (enExample)
KR (1) KR20110092325A (enExample)
CN (2) CN102159233A (enExample)
AP (2) AP2011005538A0 (enExample)
AR (2) AR072032A1 (enExample)
AU (1) AU2009272681A1 (enExample)
BR (2) BRPI0915973A2 (enExample)
CA (2) CA2730789A1 (enExample)
CL (1) CL2011000099A1 (enExample)
EA (2) EA201100910A1 (enExample)
IL (2) IL210715A0 (enExample)
MX (1) MX2011000568A (enExample)
NZ (2) NZ593653A (enExample)
PH (1) PH12012501542A1 (enExample)
SG (1) SG172709A1 (enExample)
TW (2) TW201004640A (enExample)
WO (1) WO2010007166A2 (enExample)
ZA (1) ZA201100461B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109414474A (zh) * 2016-04-29 2019-03-01 防御素治疗学公司 肝脏、胆道和胰腺障碍的治疗
CN113684162A (zh) * 2021-06-03 2021-11-23 江南大学 一种表达小鼠防御素mBD14基因的重组植物乳杆菌及其应用

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2011000569A (es) * 2008-07-18 2011-02-23 Novozymes Adenium Biotech As Tratamiento de enfermedades inflamatorias con beta-defensinas de mamifero.
MX2011000567A (es) * 2008-07-18 2011-02-23 Novozymes Adenium Biotech As Tratamiento de artritis reumatoide con beta-defensinas de mamifero.
CN102159233A (zh) 2008-07-18 2011-08-17 诺维信阿德宁生物技术公司 使用哺乳动物β防御素的炎性肠病的治疗
KR101320472B1 (ko) * 2010-06-16 2013-10-23 주식회사 나이벡 항균 또는 항염증 활성을 가지는 펩타이드 및 이를 유효성분으로 함유하는 약제학적 조성물
EP2696680B1 (en) 2011-04-15 2018-11-28 Marine Polymer Technologies, Inc. Treatment of hsv infections with poly-n-acetyl glucosamine nanofibers
JP6219277B2 (ja) * 2011-07-08 2017-10-25 ディフェンシン セラピューティクス アンパルトセルスカブＤｅｆｅｎｓｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｐｓ 炎症性腸疾患の経口治療
WO2013026794A1 (en) 2011-08-19 2013-02-28 Novozymes Novel immunomodulatory peptide
US10257564B2 (en) * 2013-01-24 2019-04-09 Saturn Licensing Llc Distributed non-real-time content
CN104628864B (zh) * 2013-11-14 2020-04-10 中国医学科学院医药生物技术研究所 一种抗肿瘤融合蛋白EL-defensin、其编码基因和用途
CA3045079A1 (en) 2016-12-13 2018-06-21 Defensin Therapeutics Aps Methods for treating inflammatory conditions of the lungs
KR20200095472A (ko) * 2017-11-10 2020-08-10 디펜신 테라퓨틱스 에이피에스 조산아에서의 점막 방어 및 장/폐 기능의 성숙화
KR20200097251A (ko) 2017-11-24 2020-08-18 디펜신 테라퓨틱스 에이피에스 디펜신에 의한 이식편 대 숙주 질환의 예방 및 치료
KR102244161B1 (ko) 2018-08-31 2021-04-26 주식회사 나이벡 다중의 질환 바이오마커의 기능 및 발현을 억제하는 펩타이드의 신규한 용도
WO2024225153A1 (ja) * 2023-04-27 2024-10-31 サントリーホールディングス株式会社 免疫活性化用組成物

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US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
IL99552A0 (en) 1990-09-28 1992-08-18 Ixsys Inc Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof
DE4343591A1 (de) 1993-12-21 1995-06-22 Evotec Biosystems Gmbh Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US6576755B1 (en) * 1997-09-10 2003-06-10 Zymogenetics, Inc. Beta-defensins
DE19957043A1 (de) * 1999-11-26 2001-06-07 Forssmann Wolf Georg Neue Defensine
US7338936B2 (en) * 2000-11-28 2008-03-04 House Ear Institute Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis
US20080194481A1 (en) 2001-12-21 2008-08-14 Human Genome Sciences, Inc. Albumin Fusion Proteins
FR2841556B1 (fr) 2002-07-01 2007-07-20 Centre Nat Rech Scient Peptides ayant des proprietes antimicrobiennes et les compositions les contenant notamment pour la conservation des aliments
US20060115480A1 (en) 2002-12-19 2006-06-01 Yitzchak Hillman Disease treatment via antimicrobial peptide inhibitors
US20070207209A1 (en) 2004-08-27 2007-09-06 Murphy Christopher J Trophic factor combinations for nervous system treatment
GB0514482D0 (en) * 2005-07-14 2005-08-17 Ares Trading Sa Protein
WO2007081486A2 (en) * 2005-12-15 2007-07-19 Ventria Bioscience Oral administration of defensins to treat intestinal diseases
WO2007087557A2 (en) 2006-01-24 2007-08-02 University Of Maryland Biotechnology Institute Surface-layer protein coated microspheres and uses thereof
WO2009046833A1 (en) * 2007-09-11 2009-04-16 Mondobiotech Laboratories Ag Use of a peptide as a therapeutic agent
CN102159233A (zh) 2008-07-18 2011-08-17 诺维信阿德宁生物技术公司 使用哺乳动物β防御素的炎性肠病的治疗
MX2011000569A (es) 2008-07-18 2011-02-23 Novozymes Adenium Biotech As Tratamiento de enfermedades inflamatorias con beta-defensinas de mamifero.
MX2011000567A (es) 2008-07-18 2011-02-23 Novozymes Adenium Biotech As Tratamiento de artritis reumatoide con beta-defensinas de mamifero.
JP6219277B2 (ja) 2011-07-08 2017-10-25 ディフェンシン セラピューティクス アンパルトセルスカブＤｅｆｅｎｓｉｎ Ｔｈｅｒａｐｅｕｔｉｃｓ Ａｐｓ 炎症性腸疾患の経口治療
WO2013026794A1 (en) 2011-08-19 2013-02-28 Novozymes Novel immunomodulatory peptide

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109414474A (zh) * 2016-04-29 2019-03-01 防御素治疗学公司 肝脏、胆道和胰腺障碍的治疗
CN113684162A (zh) * 2021-06-03 2021-11-23 江南大学 一种表达小鼠防御素mBD14基因的重组植物乳杆菌及其应用
CN113684162B (zh) * 2021-06-03 2024-02-27 江南大学 一种表达小鼠防御素mBD14基因的重组植物乳杆菌及其应用

Also Published As

Publication number Publication date
US8232242B2 (en) 2012-07-31
IL213680A0 (en) 2011-07-31
EP2320930A2 (en) 2011-05-18
EA201170219A1 (ru) 2011-08-30
TW201138810A (en) 2011-11-16
US20100016230A1 (en) 2010-01-21
AP2011005755A0 (en) 2011-06-30
WO2010007166A3 (en) 2010-06-03
TW201004640A (en) 2010-02-01
CA2750727A1 (en) 2010-01-21
PH12012501542A1 (en) 2015-11-09
AP2011005538A0 (en) 2011-02-28
CL2011000099A1 (es) 2011-10-07
US20120309678A1 (en) 2012-12-06
CA2730789A1 (en) 2010-01-21
SG172709A1 (en) 2011-07-28
US20140135258A1 (en) 2014-05-15
MX2011000568A (es) 2011-02-23
EP2399600A1 (en) 2011-12-28
BRPI0915973A2 (pt) 2013-05-07
US9279010B2 (en) 2016-03-08
AR072032A1 (es) 2010-07-28
US20110251139A1 (en) 2011-10-13
JP2011225596A (ja) 2011-11-10
NZ590468A (en) 2012-06-29
JP2011528333A (ja) 2011-11-17
CN102247591A (zh) 2011-11-23
BRPI0924481A2 (pt) 2015-08-11
EA201100910A1 (ru) 2012-05-30
WO2010007166A2 (en) 2010-01-21
AR081948A2 (es) 2012-10-31
ZA201100461B (en) 2014-03-26
KR20110092325A (ko) 2011-08-17
IL210715A0 (en) 2011-03-31
US8802621B2 (en) 2014-08-12
NZ593653A (en) 2012-09-28
AU2009272681A1 (en) 2010-01-21

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Application publication date: 20110817