CN102138976A - Preparation method of mulberry particles - Google Patents
Preparation method of mulberry particles Download PDFInfo
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- CN102138976A CN102138976A CN2011100716412A CN201110071641A CN102138976A CN 102138976 A CN102138976 A CN 102138976A CN 2011100716412 A CN2011100716412 A CN 2011100716412A CN 201110071641 A CN201110071641 A CN 201110071641A CN 102138976 A CN102138976 A CN 102138976A
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- fructus mori
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- mulberry
- particles
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Abstract
The invention discloses a preparation method of mulberry particles. The method comprises the following steps of: firstly, extracting the active ingredients of mulberries to obtain a mulberry extract; crushing sucrose in a clean area of 300 thousand level into sucrose powder and mixing the sucrose with the mulberry extract to obtain a soft matter; pelletizing the soft matter, and then drying the prepared wet particles with a negative-pressure boiling drying bed at the temperature between 45 DEG C and 65 DEG C; and stopping drying when moisture is not more than 2.0 percent to obtain mulberry particles. The invention has the advantages that warm soaking is carried out before the first decocting, and the speed for dissolving active ingredients of the decocting mulberries out can be accelerated by means of the water dosage adapted for each decocting so as to improve the proportion of the active ingredients in the mulberry particles. In the invention, the production time can be shortened by adopting a double-effect concentrator for concentration, and the preparation method is pollution-free, has dense medicament smell, convenience in cleaning and energy saving.
Description
Technical field
The present invention relates to a kind of preparation method of Chinese medicine preparation, is the particulate preparation method of Fructus Mori of a kind of nourishing YIN for benefiting the kidney, nourishing blood for moistening dryness specifically.
Background technology
The cloudy dry soreness of the waist and knees that causes easily of blood that loses, dizzy insomnia, blurred vision tinnitus, dryness of the intestine constipation, dry mouth and tougue, diseases such as early whitening of beard and hair, treating this type of disease mainly is to take nourishing YIN for benefiting the kidney, the medicine of nourishing blood for moistening dryness, more common medicine is the Fructus Mori granule at present, but the particulate preparation method of existing Fructus Mori can not be well with the abundant stripping of the effective ingredient in the Fructus Mori, thereby reduces drug effect, therefore need drop into a large amount of Fructus Moris in order to reach requirement, has so just increased production cost greatly.
Summary of the invention
Goal of the invention: the purpose of this invention is to provide the particulate preparation method of a kind of eutherapeutic Fructus Mori.
Technical scheme: in order to solve the problems of the technologies described above, the technical solution adopted in the present invention is:
The particulate preparation method of a kind of Fructus Mori, this method comprise the steps:,
(1) Fructus Mori of 1000 weight portions being added water temperature soaked 2～2.5 hours, decoct secondary then, each 2～2.5 hours, add for the first time 8～10 times of water gagings, add for the second time 6～8 times of water gagings, merge decoction liquor and filter, filtrate decompression concentrates, relative density in the time of 60 ℃ is to stop to concentrate in 1.36～1.38 o'clock, promptly obtains Fructus Mori extractum;
(2) in 300,000 grades of clean areas, the sucrose of 1250 weight portions is broken into Icing Sugar and is placed in the trough type mixing machine, add Fructus Mori extractum then, mix obtaining soft material after 15～25 minutes;
(3) with described soft material granulation, dry between 45 ℃～65 ℃ then with the wet granular that makes with negative-pressure type boiling-bed drying drying, when moisture≤2.0%, stop drying, promptly obtain the Fructus Mori granule of 1500 weight portions.
Modern pharmacological research proves that Fructus Mori contain multivitamin, especially contains abundant phosphorus and ferrum, can enrich blood by kidney tonifying, and the people is had rosy cheeks, and hair is pitch-dark beautiful.The effect of Fructus Mori is: the YIN nourishing of enriching blood, and promote the production of body fluid and moisturize, be mainly used in vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, and interior-heat is quenched one's thirst, blood deficiency and constipation; Tonifying liver, kidney tonifying relieves dizziness, high fever, infantile convulsions, epilepsy, etc., and grows liquid; The treating the liver kidney yin is lost, quenches one's thirst, and constipation, order is dark, tinnitus, scrofula, articular instability.
For can energy savings, shorten the production time, in the step (1), the relative density that filtrate is dropped into earlier when being concentrated into 60 ℃ in the economic benefits and social benefits concentrator is 1.1～1.2, then concentrated solution is moved to the concentrating under reduced pressure jar and concentrates.The economic benefits and social benefits concentrator adopts two to imitate evaporation simultaneously, and indirect steam is fully used and has both been saved the investment of boiler, energy efficient again, and energy consumption is compared with haplo-effect concentrator and is reduced by 50%.
In order to make the raising drug effect, in the step (1), add water temperature and soaked 2 hours.
Beneficial effect: compared with prior art, advantage of the present invention is: carry out warm macerating before decocting for the first time, and each water yield that is adopted that decocts, can both accelerate the stripping of Fructus Mori effective ingredient when decocting, therefore can improve the shared proportion of effective ingredient in the Fructus Mori granule; Adopt the economic benefits and social benefits concentrator to concentrate, can shorten the production time, and pollution-free, flavour of a drug are dense, cleaning is convenient, energy efficient.
The specific embodiment
Further set forth the present invention below by embodiment, should understand these embodiment and only be used to the present invention is described and be not used in and limit the scope of the invention.
Embodiment 1: at first the 1000g Fructus Mori added water temperature and soaked 2 hours, decoct secondary then, and each 2 hours, add 10 times of water gagings for the first time, add 8 times of water gagings for the second time, merge decoction liquor and filter; Relative density is 1.36～1.38 Fructus Mori extractum when being evaporated to 60 ℃, receives cream in 300,000 grades of clean areas; Sucrose with 1250 weight portions in 300,000 grades of clean areas is broken into Icing Sugar, 120 mesh sieves are placed in the trough type mixing machine excessively, add Fructus Mori extractum then, mix obtaining soft material after 15 minutes; With above-mentioned soft material granulation, granulate with YK160 type oscillating granulator.Opening power, the trial run that starts the machine is shut down after the no abnormal situation, installs 18 eye mesh screens, starts shooting after putting receiver well, and an amount of soft material is added in the material bin, rotates extruding through machine drum and forms granule, and granule falls into receiver; With the wet granular that makes, dry between 45 ℃-65 ℃ of the temperature controls with negative-pressure type boiling-bed drying drying, stop drying when moisture≤2.0% (weight); Open drain hole after the drying, usefulness shaking screen 12 mesh sieves (on)/40 mesh sieves (descending) screening.With the granule that filters out, send between total mixing and always mix with the two dimensional motion mixer, mix the Fructus Mori granule that discharging after 15 minutes promptly obtains 1500 weight portions.
Embodiment 2: at first the 1000g Fructus Mori added water temperature and soaked 2.5 hours, decoct secondary then, and each 2 hours, add 8 times of water gagings for the first time, add 6 times of water gagings for the second time, merge decoction liquor and filter; Merging decoction liquor filters; The relative density that filtrate is introduced into when being concentrated into 60 ℃ in the economic benefits and social benefits concentrator is 1.1～1.2, and relative density is 1.36～1.38 Fructus Mori extractum when then concentrated solution being moved to the concentrating under reduced pressure jar and being evaporated to 60 ℃, receives cream in 300,000 grades of clean areas; Sucrose with 1250 weight portions in 300,000 grades of clean areas is broken into Icing Sugar, 120 mesh sieves are placed in the trough type mixing machine excessively, add Fructus Mori extractum then, mix obtaining soft material after 15 minutes; With above-mentioned soft material granulation, granulate with YK160 type oscillating granulator.Opening power, the trial run that starts the machine is shut down after the no abnormal situation, installs 18 eye mesh screens, starts shooting after putting receiver well, and an amount of soft material is added in the material bin, rotates extruding through machine drum and forms granule, and granule falls into receiver; With the wet granular that makes, dry between 45 ℃-65 ℃ of the temperature controls with negative-pressure type boiling-bed drying drying, stop drying when moisture≤2.0% (weight); Open drain hole after the drying, usefulness shaking screen 12 mesh sieves (on)/40 mesh sieves (descending) screening.With the granule that filters out, send between total mixing and always mix with the two dimensional motion mixer, mix the Fructus Mori granule that discharging after 15 minutes promptly obtains 1500 weight portions.
Further specify beneficial effect below by clinical trial.
The Fructus Mori granule that adopts the embodiment of the invention 1 or embodiment 2 to make has significant curative effect through the clinical trial proof, and its clinical data is as follows:
One, select the standard of case:
Every have soreness of the waist and knees at outpatient service or inpatient, dizzy insomnia, and blurred vision tinnitus, the dryness of the intestine constipation, dry mouth and tougue, the cloudy dry feature of blood of losing such as early whitening of beard and hair is all as the standard of selecting case.
Two, diagnostic criteria: the cloudy dry soreness of the waist and knees that causes of blood, dizzy insomnia, blurred vision tinnitus, dryness of the intestine constipation, dry mouth and tougue, the early whitening of beard and hair of losing.
Three, therapeutic scheme:
Each clothes one bag of patient, every bag 15g obeys 3 every day, and one month is a course of treatment, carries out the curative effect inspection after one month, contrasts treatment with commercially available Fructus Mori granule matched group.
Four, statistical disposition
Through 60 patients are compared treatment, random packet, medicine group 30 people wherein of the present invention, contrast groups 30 people take by therapeutic scheme and to check after one month, carry out the curative effect observed result, add up, as following table:
The particulate clinical effectiveness statistics of the practical Fructus Mori of the present invention of table 1
| Clinical effectiveness | Recovery from illness | Produce effects | Effectively | Invalid |
| Product of the present invention | 10 | ?15 | ?3 | ?2 |
| The commercially available prod | 5 | ?11 | ?8 | ?6 |
This shows that the clinical effectiveness of product of the present invention obviously is better than common Fructus Mori granule.
It is to draw the proportioning science through drug test repeatedly that the eutherapeutic reason of Fructus Mori granule of the present invention has the each water yield that is adopted that decocts in two:, the present invention; Two, before decocting for the first time, carry out warm macerating, can accelerate the stripping of Fructus Mori effective ingredient when decocting, so the shared proportion of effective ingredient improves in the Fructus Mori granule, active high.
Claims (3)
1. the particulate preparation method of Fructus Mori is characterized in that this method comprises the steps:
(1) Fructus Mori of 1000 weight portions being added water temperature soaked 2～2.5 hours, decoct secondary then, each 2～2.5 hours, add for the first time 8～10 times of water gagings, add for the second time 6～8 times of water gagings, merge decoction liquor and filter, filtrate decompression concentrates, relative density in the time of 60 ℃ is to stop to concentrate in 1.36～1.38 o'clock, promptly obtains Fructus Mori extractum;
(2) sucrose of 1250 weight portions is broken into Icing Sugar and is placed in the trough type mixing machine, add Fructus Mori extractum then, mix obtaining soft material after 15～25 minutes;
(3) described soft material is granulated in 300,000 grades of clean areas, dry between 45 ℃～65 ℃ then with the wet granular that makes with negative-pressure type boiling-bed drying drying, when moisture≤2.0%, stop drying, promptly obtain the Fructus Mori granule of 1500 weight portions.
2. according to the particulate preparation method of the described Fructus Mori of claim 1, it is characterized in that in the step (1), the relative density that filtrate is dropped into earlier when being concentrated into 60 ℃ in the economic benefits and social benefits concentrator is 1.1～1.2, then concentrated solution is moved to the concentrating under reduced pressure jar and concentrates.
3. according to the particulate preparation method of the described Fructus Mori of claim 1, it is characterized in that, in the step (1), add water temperature and soaked 2 hours.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201110071641 CN102138976B (en) | 2011-03-24 | 2011-03-24 | Preparation method of mulberry particles |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 201110071641 CN102138976B (en) | 2011-03-24 | 2011-03-24 | Preparation method of mulberry particles |
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| CN102138976A true CN102138976A (en) | 2011-08-03 |
| CN102138976B CN102138976B (en) | 2012-10-10 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102998272A (en) * | 2012-08-23 | 2013-03-27 | 江苏苏南药业实业有限公司 | Quality control method of mulberry particles |
| CN103690147A (en) * | 2013-12-23 | 2014-04-02 | 广州医科大学附属第一医院 | Computer-assisted method for classifying snores |
| CN109221570A (en) * | 2018-09-19 | 2019-01-18 | 江西省蚕桑茶叶研究所 | A kind of sorosis functional form nougat and preparation method thereof |
-
2011
- 2011-03-24 CN CN 201110071641 patent/CN102138976B/en active Active
Non-Patent Citations (4)
| Title |
|---|
| 《四川蚕业》 20070228 蒋兆健 桑的药理及临床应用 第60-62页 1-3 , 第2期 2 * |
| 《湖南中医药大学学报》 20100831 李顺祥等 桑的药理研究及应用 第60-63页 1-3 第30卷, 第8期 2 * |
| 《药品标准 中药成方制剂第2册》 19901231 国家药典委员会 桑椹冲剂 第228页 1-3 , * |
| 国家药典委员会: "《药品标准 中药成方制剂第2册》", 31 December 1990 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102998272A (en) * | 2012-08-23 | 2013-03-27 | 江苏苏南药业实业有限公司 | Quality control method of mulberry particles |
| CN103690147A (en) * | 2013-12-23 | 2014-04-02 | 广州医科大学附属第一医院 | Computer-assisted method for classifying snores |
| CN103690147B (en) * | 2013-12-23 | 2015-12-30 | 广州医科大学附属第一医院 | A kind of computer-aid method of sound of snoring typing |
| CN109221570A (en) * | 2018-09-19 | 2019-01-18 | 江西省蚕桑茶叶研究所 | A kind of sorosis functional form nougat and preparation method thereof |
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| Publication number | Publication date |
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| CN102138976B (en) | 2012-10-10 |
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