CN102134232B - 同位素取代的质子泵抑制剂 - Google Patents
同位素取代的质子泵抑制剂 Download PDFInfo
- Publication number
- CN102134232B CN102134232B CN2011100224850A CN201110022485A CN102134232B CN 102134232 B CN102134232 B CN 102134232B CN 2011100224850 A CN2011100224850 A CN 2011100224850A CN 201110022485 A CN201110022485 A CN 201110022485A CN 102134232 B CN102134232 B CN 102134232B
- Authority
- CN
- China
- Prior art keywords
- methoxyl group
- pyridyl
- benzoglyoxaline
- group
- methoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/69—Two or more oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05106868 | 2005-07-26 | ||
EP05106868.2 | 2005-07-26 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800345034A Division CN101268051B (zh) | 2005-07-26 | 2006-07-26 | 同位素取代的质子泵抑制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN102134232A CN102134232A (zh) | 2011-07-27 |
CN102134232B true CN102134232B (zh) | 2012-11-21 |
Family
ID=35734406
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800345034A Expired - Fee Related CN101268051B (zh) | 2005-07-26 | 2006-07-26 | 同位素取代的质子泵抑制剂 |
CN2011100224850A Expired - Fee Related CN102134232B (zh) | 2005-07-26 | 2006-07-26 | 同位素取代的质子泵抑制剂 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2006800345034A Expired - Fee Related CN101268051B (zh) | 2005-07-26 | 2006-07-26 | 同位素取代的质子泵抑制剂 |
Country Status (17)
Country | Link |
---|---|
EP (1) | EP1910293A1 (xx) |
JP (1) | JP5448448B2 (xx) |
KR (1) | KR101358509B1 (xx) |
CN (2) | CN101268051B (xx) |
AR (1) | AR054584A1 (xx) |
AU (1) | AU2006274036B2 (xx) |
BR (1) | BRPI0614039A2 (xx) |
CA (1) | CA2615670C (xx) |
EA (1) | EA016814B1 (xx) |
HK (2) | HK1125098A1 (xx) |
IL (1) | IL188773A (xx) |
MX (1) | MX2008000901A (xx) |
NO (1) | NO20080839L (xx) |
NZ (1) | NZ565078A (xx) |
TW (1) | TWI394750B (xx) |
WO (1) | WO2007012650A1 (xx) |
ZA (1) | ZA200800303B (xx) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1912947A1 (en) * | 2005-07-26 | 2008-04-23 | Nycomed GmbH | Isotopically substituted pantoprazole |
CN101309917B (zh) * | 2005-10-06 | 2013-09-11 | 奥斯拜客斯制药有限公司 | 具有增强治疗性质的胃h+,k+-atp酶氘代抑制剂 |
WO2008127640A2 (en) * | 2007-04-11 | 2008-10-23 | Auspex Pharmaceuticals, Inc. | Substituted benzimidazoles |
WO2008130863A2 (en) * | 2007-04-11 | 2008-10-30 | Auspex Pharmaceuticals, Inc. | Substituted benzimidazoles |
CN102770423B (zh) | 2010-02-12 | 2014-10-15 | 埃斯特维化学股份有限公司 | 艾美拉唑的钠盐的制备方法 |
CN104530003A (zh) * | 2014-06-10 | 2015-04-22 | 广东东阳光药业有限公司 | 吡啶甲基亚磺酰基-1h-苯并咪唑类化合物的盐的制备方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0005129A1 (en) * | 1978-04-14 | 1979-10-31 | Aktiebolaget Hässle | Substituted pyridylsulfinylbenzimidazoles having gastric acid secretion properties, pharmaceutical preparations containing same, and intermediates for their preparation |
EP0254588A1 (en) * | 1986-07-25 | 1988-01-27 | Tokyo Tanabe Company Limited | Imidazo[4,5-b] pyridine compounds, process for preparing same and pharmaceutical compositions containing same |
US6818200B2 (en) * | 1994-03-25 | 2004-11-16 | Isotechnika Inc. | Method of using deuterated calcium channel blockers |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE372966T1 (de) * | 1994-03-25 | 2007-09-15 | Isotechnika Inc | Verbesserung der effektivität von arzneimitteln duren deuterierung |
US6884429B2 (en) * | 1997-09-05 | 2005-04-26 | Isotechnika International Inc. | Medical devices incorporating deuterated rapamycin for controlled delivery thereof |
NO309305B1 (no) * | 1999-02-19 | 2001-01-15 | Norsk Hydro As | Anvendelse av benzaldehydderivater ved fremstilling av farmasöytiske preparater for forebygging og/eller behandling av kreft, samt visse nye benzaldehydderivater |
DE10123129A1 (de) * | 2001-05-02 | 2002-11-14 | Berolina Drug Dev Ab Svedala | Deuterierte 3-Piperidinopropiophenone sowie diese Verbindungen enthaltende Arzneimittel |
DE10162121A1 (de) * | 2001-12-12 | 2003-06-18 | Berolina Drug Dev Ab Svedala | Deuterierte substituierte Pyrazolyl-Benzolsulfonamide sowie diese Verbindungen enthaltende Arzneimittel |
EP1912947A1 (en) * | 2005-07-26 | 2008-04-23 | Nycomed GmbH | Isotopically substituted pantoprazole |
-
2006
- 2006-07-26 EP EP06764258A patent/EP1910293A1/en not_active Withdrawn
- 2006-07-26 CA CA2615670A patent/CA2615670C/en not_active Expired - Fee Related
- 2006-07-26 NZ NZ565078A patent/NZ565078A/en not_active IP Right Cessation
- 2006-07-26 JP JP2008523354A patent/JP5448448B2/ja not_active Expired - Fee Related
- 2006-07-26 TW TW095127340A patent/TWI394750B/zh not_active IP Right Cessation
- 2006-07-26 WO PCT/EP2006/064666 patent/WO2007012650A1/en active Application Filing
- 2006-07-26 EA EA200800203A patent/EA016814B1/ru not_active IP Right Cessation
- 2006-07-26 CN CN2006800345034A patent/CN101268051B/zh not_active Expired - Fee Related
- 2006-07-26 AR ARP060103224A patent/AR054584A1/es unknown
- 2006-07-26 KR KR1020087003989A patent/KR101358509B1/ko not_active IP Right Cessation
- 2006-07-26 BR BRPI0614039-4A patent/BRPI0614039A2/pt not_active IP Right Cessation
- 2006-07-26 MX MX2008000901A patent/MX2008000901A/es active IP Right Grant
- 2006-07-26 CN CN2011100224850A patent/CN102134232B/zh not_active Expired - Fee Related
- 2006-07-26 AU AU2006274036A patent/AU2006274036B2/en not_active Ceased
-
2008
- 2008-01-10 ZA ZA2008/00303A patent/ZA200800303B/en unknown
- 2008-01-15 IL IL188773A patent/IL188773A/en not_active IP Right Cessation
- 2008-02-18 NO NO20080839A patent/NO20080839L/no not_active Application Discontinuation
-
2009
- 2009-03-12 HK HK09102398.5A patent/HK1125098A1/xx not_active IP Right Cessation
-
2012
- 2012-01-18 HK HK12100603.5A patent/HK1160126A1/xx not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0005129A1 (en) * | 1978-04-14 | 1979-10-31 | Aktiebolaget Hässle | Substituted pyridylsulfinylbenzimidazoles having gastric acid secretion properties, pharmaceutical preparations containing same, and intermediates for their preparation |
EP0254588A1 (en) * | 1986-07-25 | 1988-01-27 | Tokyo Tanabe Company Limited | Imidazo[4,5-b] pyridine compounds, process for preparing same and pharmaceutical compositions containing same |
US6818200B2 (en) * | 1994-03-25 | 2004-11-16 | Isotechnika Inc. | Method of using deuterated calcium channel blockers |
Also Published As
Publication number | Publication date |
---|---|
WO2007012650A1 (en) | 2007-02-01 |
AU2006274036A2 (en) | 2008-03-20 |
IL188773A (en) | 2014-02-27 |
AR054584A1 (es) | 2007-06-27 |
EP1910293A1 (en) | 2008-04-16 |
HK1125098A1 (en) | 2009-07-31 |
CA2615670A1 (en) | 2007-02-01 |
CN101268051A (zh) | 2008-09-17 |
NZ565078A (en) | 2010-03-26 |
HK1160126A1 (en) | 2012-08-10 |
KR20080037676A (ko) | 2008-04-30 |
KR101358509B1 (ko) | 2014-02-05 |
CN102134232A (zh) | 2011-07-27 |
NO20080839L (no) | 2008-02-18 |
BRPI0614039A2 (pt) | 2011-03-09 |
ZA200800303B (en) | 2009-01-28 |
CA2615670C (en) | 2015-01-20 |
TW200714596A (en) | 2007-04-16 |
EA200800203A1 (ru) | 2008-08-29 |
CN101268051B (zh) | 2011-08-31 |
JP2009502871A (ja) | 2009-01-29 |
EA016814B1 (ru) | 2012-07-30 |
IL188773A0 (en) | 2008-08-07 |
AU2006274036B2 (en) | 2012-05-24 |
MX2008000901A (es) | 2008-03-26 |
JP5448448B2 (ja) | 2014-03-19 |
TWI394750B (zh) | 2013-05-01 |
AU2006274036A1 (en) | 2007-02-01 |
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Owner name: TAKEDA GMBH Free format text: FORMER NAME: NYCOMED INC. |
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CP01 | Change in the name or title of a patent holder |
Address after: Konstanz Patentee after: Nycomed GmbH Address before: Konstanz Patentee before: Nycomed GmbH |
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CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20121121 Termination date: 20150726 |
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EXPY | Termination of patent right or utility model |