CN102133282B

CN102133282B - Medicament for treating femoral head necrosis

Info

Publication number: CN102133282B
Application number: CN201110058566A
Authority: CN
Inventors: 侯希彦
Original assignee: Individual
Current assignee: Individual
Priority date: 2011-03-11
Filing date: 2011-03-11
Publication date: 2012-08-29
Anticipated expiration: 2031-03-11
Also published as: CN102133282A

Abstract

The invention relates to a medicine, in particular to a medicament for treating femoral head necrosis, which is prepared from the following raw material medicaments: eucommia bark, corydalis root, aerofloat, Chinese angelica, pubescent angelica, seed of common monkshood prepared daughter root, monkshood, cinnamon twig, szechuan lovage rhizome, liquoric root, peach kernel, salvia root, moutan bark and kapok seed. The invention has the advantages that the medicament has the effects of promoting blood circulation and removing blood stasis, relieving swelling and pain, tonifying liver and kidney, strengthening bones and muscles, improving immunity, warming pulse and inducing menstrual flow, dispelling wind and eliminating cold, dispelling arthralgia factors at hip joints and inguinal regions, recovering blood supply of caput femoris, promoting the regeneration of bone trabecula and repairing necrotic bone tissue, and has obvious curative effect on the femoral head necrosis. By observation, the medicament does not have toxic or side effect, has the characteristics of readily available materials, low cost, wide application range and the like, and is easy to prepare and convenient to use, so that the medicament has the high using value and excellent market prospect.

Description

A kind of medicine of treating femur head necrosis

Technical field

The present invention relates to a kind of medicine, promptly a kind of medicine of treating femur head necrosis.

Background technology

Femur head necrosis is also claimed ischemic necrosis of femoral head, or a bone thigh bland necrosis, and the traditional Chinese medical science is also claimed " thigh pivot numbness ", " rheumatism involving the bone ", " bone withers ".Be a kind of comparatively common osteoarthritis, show as Thigh bone upper end and the bonded bulb superior articular facet of acetabular bone and adjacent tissue's blood supply obstacle, and then cause bone necrosis.Because of belonging to weight-bearing joint, it is bigger downright bad harm to occur, and gently then affected part pain is uncomfortable for the patient, and muscle spasm, joint motion are limited, weight person the disable limping even the walking of can not standing.At present, the origin cause of formation of this osteopathia is still not fully aware of, and lacks specific drug, and clinical many methods with the hyperphoric metal succedaneum of operation not only spend higherly, and the patient is relatively more painful, and postoperative status is also undesirable.

Summary of the invention

The purpose of this invention is to provide and a kind of femur head necrosis is had definite curative effect, and medicine easy to use, with low cost.

Above-mentioned purpose is realized by following technical scheme: a kind of medicine of treating femur head necrosis is provided, is characterized in: this medicine is to be processed by following crude drug by weight: stone is thought first 10-20 part, Rhizoma Corydalis 12-18 part, black powder 12-18 part; Driedly return 8-12 part, solely shake careless 12-18 part, Odontobutis obscura (T. Et S.) 8-12 part, Aconitum carmichjaelii Debx. 8-12 part; Liu Gui 18-22 part, tongue rhizome of chuanxiong 8-12 part, well-informed 4-8 part, Semen Persicae 10-20 part; Radix Salviae Miltiorrhizae 10-20 part, DANGEN 12-18 part, Semen gossypii 35-45 part.

Said medicine is to be processed by following crude drug by weight: stone is thought 15 parts earlier, 15 parts of Rhizoma Corydalis, and 15 parts of black powder are driedly returned 10 parts, solely shake 15 parts of grass; 10 parts of Odontobutis obscura (T. Et S.)s, 10 parts of Aconitum carmichjaelii Debx.s, 20 parts of Liu Gui, 10 parts of tongue rhizomes of chuanxiong, well-informed 6 parts; 15 parts of Semen Persicae, 15 parts of Radix Salviae Miltiorrhizae, 15 parts of DANGEN, 40 parts of Semen gossypiis.

Said medicine is to be processed by following crude drug by weight: stone is thought first 15g, Rhizoma Corydalis 15g, and black powder 15g, the dried 10g that returns solely shakes careless 15g; Odontobutis obscura (T. Et S.) 10g, Aconitum carmichjaelii Debx. 10g, Liu Gui 20g, tongue rhizome of chuanxiong 10g, well-informed 6g; Semen Persicae 15g, Radix Salviae Miltiorrhizae 15g, DANGEN 15g, Semen gossypii 40g.

The concocting method of said medicine: the above-mentioned raw materials medicine is dropped in the decoction vessel, warm water soaking 2-6 hour, boil with high heat, the fried 30-50 of reuse slow fire minute, the taking-up decoction added clear water again and decocts, and twice fried decoction is total to the 450-550 milliliter.

The concocting method of said medicine is through fried, the concentrated solid dosage forms that forms.

The invention has the beneficial effects as follows: clinical experiment confirms; This medicament has tangible recovery femoral head blood fortune, promotes bone trabecula regeneration, the effect of repairing the necrotic bone tissue; Has significant curative effect for femur head necrosis; Do not find toxic and side effects through observing, and have easy, the characteristics such as making is simple, with low cost, easy to use, wide accommodation of drawing materials, thereby have higher use value and good market prospect.

The specific embodiment

First kind of embodiment: get the raw material YAOSHI and think first 20g, Rhizoma Corydalis 18g, black powder 18g, the dried 12g that returns solely shakes careless 18g, Odontobutis obscura (T. Et S.) 12g, Aconitum carmichjaelii Debx. 12g, Liu Gui 22g, tongue rhizome of chuanxiong 12g, well-informed 8g, Semen Persicae 20g, Radix Salviae Miltiorrhizae 18g, DANGEN 18g, Semen gossypii 45g.The entry of above-mentioned raw materials medicine was soaked 2-6 hour, again water is boiled the back literary composition and fried in shallow oil 35 minutes, the taking-up decoction adds clear water again and decocts, with twice fried decoction totally 500 milliliters of merging use.

Usage: each obeys once severe patient sooner or later, and each 250 milliliters, 15 is a course of treatment.

Clinical giving an example: the Fuxin City grandson, make a definite diagnosis the trouble femur head necrosis through the CT image, lean on the crutches walking, because of family's medical history is arranged, doubting is the heritability disease.Begin to take medicine in April, 2010, and pain relief on the 7th can remove one and turn, and the crutches of dropping back course of treatment can be stood, and need not lean on after four courses of treatment and turn and can recover normal behind one hundred days at stair activity, do not have repeatedly so far.

Second kind of embodiment: get the raw material YAOSHI and think first 15g, Rhizoma Corydalis 15g, black powder 15g, the dried 10g that returns solely shakes careless 15g, Odontobutis obscura (T. Et S.) 10g, Aconitum carmichjaelii Debx. 10g, Liu Gui 20g, tongue rhizome of chuanxiong 10g, well-informed 6g, Semen Persicae 15g, Radix Salviae Miltiorrhizae 15g, DANGEN 15g, Semen gossypii 40g.The entry of above-mentioned raw materials medicine was soaked 2-6 hour, again water is boiled the back literary composition and fried in shallow oil 35 minutes, take out decoction and add clear water again and decoct, with totally 500 milliliters of twice fried decoctions.

Usage: each obeys once each 250 milliliters to moderate patient sooner or later.15 is a course of treatment.

Clinical giving an example: Yi County, Liaoning Province patient Lee suffers from femur head necrosis, can not walk, and can not ride vehicle; Begin to take medicine in August, 2010; Can walk by motorcycle two courses of treatment, the walking of can standing after three courses of treatment, and assert through the film making of former diagnosis hospital five courses of treatment: bone density distributes rationally; The skeleton gap is normal, and focus disappears basically.

The third embodiment: get the raw material YAOSHI and think first 12g, Rhizoma Corydalis 12g, black powder 12g, the dried 8g that returns solely shakes careless 12g, Odontobutis obscura (T. Et S.) 8g, Aconitum carmichjaelii Debx. 8g, Liu Gui 18g, tongue rhizome of chuanxiong 8g, well-informed 4g, Semen Persicae 10g, Radix Salviae Miltiorrhizae 10g, DANGEN 12g, Semen gossypii 35g.The entry of above-mentioned raw materials medicine was soaked 2-6 hour, again water is boiled the back literary composition and fried in shallow oil 35 minutes, the taking-up decoction adds clear water again and decocts, with twice fried decoction totally 500 milliliters of merging.

Usage: each obeys once each 250 milliliters to patients with mild sooner or later.15 is a course of treatment.

Clinical giving an example: Fuxin City patient Chen is one-sided femur head necrosis after diagnosing, and pain is difficult to walk, the work of can not going to work.9 months Augusts in 2010 began to take medicine, and through four courses of treatment, pain disappears, and walking is normal, has recovered operate as normal.

The experiment situation: this medicine is inventor's secret recipe handed down in the family, and the past only supplies the insider to ask for as folk remedy for many years, and is better because of curative effect, and certain influence is arranged in the locality.Since 2008, under professional's assistance, carried out clinical experiment and observed, institute is following according to data and accumulation data:

Diagnostic criteria: press working standard divide light, in, heavy, serious four degree.

Gently: clinical symptoms is not obvious, the hip discomfort only after fatigue, occurs.At the X line, the last change of CT is not obvious or have drop density to change, nuclear magnetic resonance, NMR and bone radioisotope scan can be found.

In: occur hip discomfort or pain after the fatigue, the back of having a rest takes a turn for the better, can be to the inboard radiation of knee joint.X line, CT are last to have density to change, and changes obvious on bone scanning and the nuclear magnetic resonance, NMR.

Heavy: pain is heavier, and pain is arranged when static, and the limited of function can be arranged.X line, CT are last to have the bone trabecula fracture not to be connected with cortical bone, or changes such as meniscus sign, the change of capsule appearance, density unevenness occur.Though the cracking of femoral head this moment, profile changes little.

Seriously: sharp ache, with dysfunction.Last femoral head distortion of X line, CT and gapped variation or with the deformation of hip joint.

Curative effect determinate standard:

Produce effects: hip joint function takes a turn for the better, and pain disappears during heavy burden.X line prompting femoral head density, bone trabecula are obviously repaired, and the cryptomere shadow dwindles or disappears, and recover normal life and do not bear a heavy burden work.

Effectively: hip joint function takes a turn for the better to some extent, and the back idol of bearing a heavy burden has slight pain, and the X line discloses femur head necrosis has reparation, and life can be taken care of oneself, and can be competent at light work.

Invalid: the contrast of treatment before and after look, function, symptom, sign takes a turn for the better not obvious, and the X line discloses femur head necrosis does not have improvement.

Clinical experiment 120 examples, severe patient 4 examples wherein, severe patient 8 people, moderate patient 71 people, patients with mild 37 examples.Average 4 courses of treatment, therapeutic effect such as following table:

Classification	The example number	Produce effects	Effectively	Invalid
					Seriously	4	2		2
Severe	8	2	3	3
					Moderate	71	4	59	8
Slightly	37	3	29	5
					Add up to (%)	120(100)	11(9.17)	91(75.83)	18(15)

Pharmacodynamic analysis: motherland's medical science thinks that femur head necrosis is because of the imbalance of liver,spleen,kidney organ function, causes in the anemofrigid-damp arthralgia invasion and attack body, and hyperamization fortune is silted up, and arthralgia is decreased.Thereby when adopting liver heat removing, spleen reinforcing, kidney tonifying, Therapeutic Principle cold, that remove arthralgia chiefly caused by damp pathogen, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, benefit bone granulation promoting dispels the wind.Shi Sixian in the side has another name called the Cortex Eucommiae, is the dry bark of the Eucommiaceae plant Cortex Eucommiae, sweet in the mouth, little suffering, and property is flat, dry, blunt, heavy, gentle, soft, and the effect of heat clearing away synthetism is arranged.Rhizoma Corydalis is the dried pieces footpath of papaveraceae plant corydalis, contains nearly 20 kinds of alkaloid, and wherein stronger with the plain biological activity of tetrahydropalmatine, first element, ugly element and dehydrogenation Rhizoma Corydalis first, acrid in the mouth is bitter; Warm in nature, GUIXIN, liver, spleen channel can be invigorated blood circulation promoting the circulation of QI; Hypnosis, anti-hat, pain relieving, analgesic activity is strong especially.Black powder another name copper foot Radix Clematidis, leaf Radix Notoginseng are the root of Yunnan, samphire river sanicle, and sweet and slightly bitter taste is warm in nature.But invigorating the lung and the kidney cures mainly lumbago due to renal deficiency.Dried returning is Radix Angelicae Sinensis, and another name Radix Angelicae Sinensis, cloud are returned, western Radix Angelicae Sinensis, Min Radix Angelicae Sinensis, are the root of umbelliferae angelica.Sweet, acrid, bitter, including ligustilide is butylidenephthalide, ferulic acid, nicotinic acid, sugar and amino acids and sesquiterpene compounds, sweet, acrid, warm, hearts , liver, spleen can be blood circulation, relieving pain, laxative, commonly used in blood deficiency chlorosis, dizziness, palpitations, irregular menstruation, amenorrhea dysmenorrhea, cold abdominal pain, intestinal dry constipation, rheumatism, or flutter injury, ulcer sore.Solely shake grass and have another name called Radix Angelicae Pubescentis, solely sliding, Sempervivum tectorum.Root and rhizome for the heavy peristome Radix Angelicae Sinensis of samphire, Angelica pubescens, Xingan's Radix Angelicae Dahuricae, purple stem Radix Angelicae Pubescentis, Radix Heraclei hemsleyani, fur Radix Angelicae Pubescentis and Araliaceae Shi Yong Cortex araliae chinensis etc.Can search wind prevailing over dampness, dispersing cold for relieving pain is opened expectorant, detumescence.Odontobutis obscura (T. Et S.) has another name called Radix Aconiti Lateralis Preparata, is the root of ranunculaceae plant Radix Aconiti Kusnezoffii with Aconitum carmichjaelii Debx., and parent root is spasmolytic Aconitum carmichjaelii Debx., smelting wind low, rheumatism neuralgia.Lateral root has recuperating depleted YANG, pursues effect cold, wind-damp dispelling Radix Aconiti Lateralis Preparata.Control faint contrary, cramp caused by acute vomiting and diarrhea, weak chills and pain of the waist and kness, the cold physique of kidney yang of the sun of profuse sweating, extremity and like diseases such as cold, lassitude and wind-cold-dampness ache, beriberi.Liu Gui also claims Ramulus Cinnamomi, is the cinnamomic twig of canella.The diaphoresis expelling pathogenic factors from muscles is arranged, the effect of warming the meridian and promoting blood circulation.Be usually used in treating exterior syndrome due to wind-cold, shoulder back of the body podomere ache, thoracic obstruction phlegm retention, amenorrhea and mass in the abdomen, between podomere the expectorant blood coagulation stagnate, migratory arthralgia joint spasm and pain etc.Moss, also known as Chuan Xiong Xiong, mountain Ju poor, Chuanxiong, allspice, Hu Qiong, Ma title, Chuanxiong, bird brain Xiong, Jing Xiong, Guan Xiong, Fu Xiong, Taiwan Xiong, West Xiong, Umbelliferae Chuanxiong rhizomes.Suffering, temperature is returned liver, gallbladder, pericardium channel.Blood-activating and qi-promoting, wind-expelling pain-stopping.Be used to pacify nerve, positive wind syndrome of head headache, lump in the abdomen stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.Having quick access to information has another name called Radix Glycyrrhizae, is the root and the root stock of dicotyledon medicine glycyrrhizic legume.Contain glycyrrhizic acid, liquiritin, isoliquiritin, liquiritigenin, isoliquiritin unit, Radix Glycyrrhizae coumarin, Radix Glycyrrhizae pyrans coumarin, licocoumarone, licocoumarone, licoricidin (+)-Licoricidin., the sharp ketone of Radix Glycyrrhizae, glycyol, 5-O-methyl glycyol etc.Radix Glycyrrhizae property is flat, and sweet in the mouth is returned 12 warps.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription, spasmolytic is so that pharmacological action such as anticancer grade.Semen Persicae has another name called Semen Persicae, is the seed of rosaceous plant peach or mountain peach, and bitter in the mouth property is flat.Cure mainly congestion, blood closes the abdominal mass heresy, kills small worm, ends cough with dyspnea, the hardness in the epigastrium that disappears removes the sudden blood that hits cruelly, broken lump in the abdomen, Tong Yueshui, pain relieving.Radix Salviae Miltiorrhizae has another name called Radix Salviae Miltiorrhizae, SHANSHEN, Radix Salviae Miltiorrhizae, Arisaema balansae Engl., purple Radix Codonopsis, mountain Radix Dauci Sativae etc., these article are the labiate Radix Salviae Miltiorrhizae. dry root and rhizome.Bitter in the mouth, cold nature.GUIXIN, Liver Channel have stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.DANGEN another name moutan root bark, Cortex Moutan are the root bark of ranunculaceae peony.Contain paeonol, paeonolide, paeonolide, paeoniflorin.Still contain volatile oil 0.15～0.4% and plant sterol etc.Heat clearing away is arranged, removing heat from blood, and blood, the effect of repercussive.Semen gossypii has another name called Semen gossypii, Cotton Gossypii nuclear.Seed for Malvaceae plant cotton etc.But the kidney warming, tonify deficiency, hemostasis, warm waist is controlled damage.In the above-mentioned raw materials medicine, with Rhizoma Corydalis, driedly return, the leading blood circulation promoting and blood stasis dispelling of medicine, reducing swelling and alleviating pain such as Semen Persicae, Radix Salviae Miltiorrhizae, DANGEN, with Shi Sixian, Semen gossypii, well-informed invigorating the liver and kidney, bone and muscle strengthening, raising immunity; With Liu Gui, tongue rhizome of chuanxiong temperature beniol warp, use black powder, solely shake grass; Odontobutis obscura (T. Et S.), Aconitum carmichjaelii Debx., dispeling the wind, it is cold to remove; Dispel the arthralgia pain factor of hip joint, groin one band, all medicines are collaborative, so that the outer pain that disappears is levied, the interior purpose of removing evil fraud, restore funcitons.

Toxic and side effects: crude drug Odontobutis obscura (T. Et S.), Aconitum carmichjaelii Debx. are slightly toxic in the side, except that limiting the quantity of by relevant pharmacopeia, and dissolve with the well-informed grass of heavy dose, guarantee safety.Other tastes are all by general dosage, and are nontoxic no anti-.In addition, before clinical experiment,, take 15 times of phase, carry out the rabbit zoopery, all no abnormality seen with 100 times of ordinary person's per weight consumption.

The dosage form experiment: the mode that is decocted in water for oral dose is all adopted in existing clinical experiment, in order to adapt to the following remote demand that supplies medicine, since 2010, under multidigit expert's assistance, the dosage form of this medicine has been carried out improvement explored.Wherein, through fried concentrate process ball, loose, multiple solid dosage formss such as cream, pellet, capsule, also have certain curative effect through the preliminary experiment proof, be expected to become the new embodiment of this medicine.

Claims

1. medicine of treating femur head necrosis, it is characterized in that: this medicine is to be processed by following crude drug by weight: Cortex Eucommiae 10-20 part, Rhizoma Corydalis 12-18 part, copper foot Radix Clematidis 12-18 part; Radix Angelicae Sinensis 8-12 part, Radix Angelicae Pubescentis 12-18 part, Radix Aconiti Lateralis Preparata 8-12 part, Aconitum carmichjaelii Debx. 8-12 part; Ramulus Cinnamomi 18-22 part, Rhizoma Chuanxiong 8-12 part, Radix Glycyrrhizae 4-8 part, Semen Persicae 10-20 part; Radix Salviae Miltiorrhizae 10-20 part, Cortex Moutan 12-18 part, Semen gossypii 35-45 part.

2. the medicine of treatment femur head necrosis according to claim 1 is characterized in that: said medicine is to be processed by following crude drug by weight: 15 parts of the Cortexs Eucommiae, 15 parts of Rhizoma Corydalis, 15 parts of copper foot Radix Clematidis; 10 parts of Radix Angelicae Sinensis, 15 parts of Radix Angelicae Pubescentiss, 10 parts of Radix Aconiti Lateralis Preparatas, 10 parts of Aconitum carmichjaelii Debx.s; 20 parts of Ramulus Cinnamomi, 10 parts of Rhizoma Chuanxiongs, 6 parts in Radix Glycyrrhizae, 15 parts in Semen Persicae; 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of Cortex Moutans, 40 parts of Semen gossypiis.

3. the medicine of treatment femur head necrosis according to claim 1 is characterized in that: said medicine is to be processed by following crude drug by weight: Cortex Eucommiae 15g, Rhizoma Corydalis 15g, copper foot Radix Clematidis 15g; Radix Angelicae Sinensis 10g, Radix Angelicae Pubescentis 15g, Radix Aconiti Lateralis Preparata 10g, Aconitum carmichjaelii Debx. 10g; Ramulus Cinnamomi 20g, Rhizoma Chuanxiong 10g, Radix Glycyrrhizae 6g, Semen Persicae 15g; Radix Salviae Miltiorrhizae 15g, Cortex Moutan 15g, Semen gossypii 40g.

4. the medicine of treatment femur head necrosis according to claim 1; It is characterized in that: the above-mentioned raw materials medicine is dropped in the decoction vessel; Warm water soaking 2-6 hour, boil the fried 30-50 of reuse slow fire minute with high heat; The taking-up decoction adds clear water again to be repeated to decoct, and gets twice fried decoction and is total to the 450-550 milliliter.

5. the medicine of treatment femur head necrosis according to claim 1 is characterized in that: with crude drug through fried, concentrate and to form solid dosage forms.