CN1754566A - Oral capsule and plaster for treating femoral head ischemic necrosis, and its preparation method - Google Patents

Abstract

The invention discloses an oral capsule and plaster for treating femoral head ischemic necrosis, wherein the oral preparation is prepared from 24 kinds of Chinese medicinal materials including Chinese angelica root, safflower, Chinese ephedra, Chinese flowering quince, black catechu, ledebouriella root, tetrandra root, achyranthes and cyathula root, Sichuan aconite root, rhubarb, capsule of weeping forsythia, frankincense, dragon's blood resin, dipsacus root, cucumber seeds, myrrh, notopterygium root, drynaria, Kusnezoff monkshood root, native copper and baras camphor. The plaster is prepared from 33 kinds of Chinese medicinal materials including Sichuan aconite root, dipsacus root, futokadsura stem, silver flower, licorice root, puncturevine, mentha, ledebouriella root, capsule of weeping forsythia, Loranthus mulberry mistletoe, gastrodia tuber, speranskia herb, musk, Cinnamomum cassia, dragon's blood resin, myrrh, Kusnezoff monkshood root, notopterygium root, Clematis chinensis, batryticated silkworm, galangal, achyranthes and cyathula root, eucommia bark, cimicifuga rhizome, Chinese angelica root, pubescent angelica root, safflower, buck grass, native copper, boneol, clove and frankincense.

Description

Oral capsule and the plaster preparation and the preparation method of treatment ischemic necrosis of femoral head

Affiliated technical field

The present invention relates to a kind of oral capsule and plaster preparation and preparation method for the treatment of ischemic necrosis of femoral head, specifically is exactly oral medicine and the preparation of externally applied plaster and the method for preparation for the treatment of ischemic necrosis of femoral head, belongs to field of pharmaceutical technology.

Background technology

Ischemic necrosis of femoral head is the orthopedics department difficult disease, this disease many by wound, take amcinonide or reason such as drink causes venation block, QI and blood is obstructed, it is foster that bone is become homeless, bone marrow is withered, sends out to be primary disease; At present, sickness rate day by day increases, though this sick method of treatment is a lot of both at home and abroad, unsatisfactory curative effect, doctor trained in Western medicine lays particular emphasis on operative treatment, but late result is also unsatisfactory, particularly centering, adolescence more feel a delicacy about, and often make the patient that the lifelong disability disability is arranged, even can't take care of oneself, cause very big burden for individual and society.

Summary of the invention

In order to overcome above-mentioned deficiency, the invention provides a kind of working along both lines, the oral capsule of internal and external application and externally applied plaster preparation, these two kinds of preparations are the several generations of my family secret prescriptions handed down in the family from generation to generation for many years, I am improved on the study basis of putting into practice, knowing from experience during practising medicine for many years and am improved in addition again, draw the length of crowd families and the new results of some modern Chinese medicine Chinese medicines simultaneously and extract.Its advantage is that short treating period, good effect, healing are fast, never recurrence, and without any side effects, easy to use, the patient suffering is little, and special centering, young curative effect are more remarkable, can effect a radical cure and not stay sequela.

Oral capsule medicine of the present invention, make (consumption is a weight portion) by following component:

Radix Angelicae Sinensis 10-15 Radix Stephaniae Tetrandrae 2-3 Olibanum 5-7 Rhizoma Et Radix Notopterygii 3-4

Flos Carthami 1-2 Radix Achyranthis Bidentatae 4-5 Sanguis Draxonis 10-15 Rhizoma Drynariae 1-2

Herba Ephedrae 7-9 Radix Aconiti 1-2 Radix Dipsaci 6-10 Radix Aconiti Kusnezoffii 1-2

Fructus Chaenomelis 1-2 Concretio silicea Bambusae seu schizostachyi 4-5 Semen Cucumidis sativi 6-10 worm 2-5

Catechu 2-3 Radix Et Rhizoma Rhei 4-5 Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 3-4 Pyritum 3-5

Radix Saposhnikoviae 1-2 Fructus Forsythiae 4-5 Myrrha 3-5 Borneolum Syntheticum 1.5-2

The preparation method of this oral capsule medicine is:

With the weight proportion of above-mentioned each tcm components after by oven dry, metering respectively, mixed powder is broken into 120 order powderies, and mix homogeneously incapsulates then, and dress 0.45g in each capsule is standby by the false proof bottle capping of packing into of quantitative grain number.

The plaster of treatment ischemic necrosis of femoral head is concocted and is formed by 33 kinds of Chinese medicines and an amount of Plumbum preparatium, Oleum Sesami, and it is formed and divides is (consumption is a weight portion):

Radix Aconiti 3-5 Rhizoma Gastrodiae 4-7 Radix Achyranthis Bidentatae 2-4

Radix Dipsaci 2-4 Herba speranskiae tuberculatae 7-10 Cortex Eucommiae 3-5

Semen Persicae 2-4 Moschus 0.3-0.5 Rhizoma Cimicifugae 3-4

Caulis Piperis Kadsurae Teng 2-4 Cortex Cinnamomi 3-5 Radix Angelicae Sinensis 2-6

Flos Lonicerae 2-4 Sanguis Draxonis 0.5-0.8 Radix Angelicae Pubescentis 3-4

Radix Glycyrrhizae 3-6 Myrrha 0.5-0.7 Flos Carthami 4-6

Fructus Tribuli 3-5 Radix Aconiti Kusnezoffii 2-4 Herba Lycopodii 4-7

Herba Menthae 2-4 Rhizoma Et Radix Notopterygii 3-5 processs Pyritum 5-8

Radix Saposhnikoviae 3-4 Radix Clematidis 2-5 Borneolum Syntheticum 0.5-1

Fructus Forsythiae 2-5 Bombyx Batryticatus 2-6 Flos Caryophylli 3-5

Herba Taxilli 1-2 Rhizoma Alpiniae Officinarum 2-5 Olibanum 0.6-0.7

Plumbum preparatium Oleum Sesami is an amount of.

The preparation method of this plaster is: at first with Moschus, Borneolum Syntheticum, Cortex Cinnamomi, Flos Caryophylli, Sanguis Draxonis, Olibanum, seven kinds of medicines of Myrrha, pulverizing by the composition weight proportioning is that 120 order powder are deposited; Other 26 kinds of Chinese medicines are dropped in the Oleum Sesami by the composition weight proportioning soaked 36 hours, it serves as an amount of that the ratio of Oleum Sesami and 26 kinds of medicines can be soaked whole Chinese medicines with Oleum Sesami, with slow fire with the medicine that soaks fried to the medicine complexion changed be sallow being advisable, can not explode black, it is clean then medicine to be pulled out filter, remaining Oleum Sesami is measured, carry out compatibility in the ratio of every jin, a traditional unit of weight of Oleum Sesami and 250g Plumbum preparatium again and concoct, must under slow fire, slowly concoct during the process of preparing Chinese medicine, and ceaselessly stir, after Plumbum preparatium is stirred in Oleum Sesami, could behind fire, Plumbum preparatium and the Oleum Sesami cream for preparing be washed 96 hours with running water from fire, or soak 120 little with cold water, changed water once in per 8 hours, after again it being reheated fusing at last, seven kinds of medicamental pulverata will pulverizing earlier are blended into again, stir evenly, spread out on cloth or oilpaper, be plaster, can come into operation.

Characteristics of the present invention are that Radix Angelicae Sinensis in the oral capsule medicament, Flos Carthami, Sanguis Draxonis, Radix Dipsaci, Rhizoma Drynariae are monarch drug, with tonifying liver and kidney and strengthening bones and muscles benefit marrow, the poison during promoting blood circulation and stopping pain is boned; Pyritum, Olibanum, Myrrha, worm, Herba Ephedrae, Radix Et Rhizoma Rhei are ministerial drug, stagnate eliminating stasis to stop pain with promoting the circulation of bloodization; Fructus Forsythiae, Radix Saposhnikoviae, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Radix Aconiti, Radix Aconiti Kusnezoffii are adjuvant drug, with warming YANG eliminating impediment coronary circulation-promoting pain-relieving; Radix Achyranthis Bidentatae, Fructus Chaenomelis priming are descending, and with the Borneolum Syntheticum priming to the marrow, Radix Stephaniae Tetrandrae, Semen Cucumidis sativi, catechu, Concretio silicea Bambusae seu schizostachyi are messenger drug, with tonifying liver, kidney, and relaxing muscles and tendons and activating QI and blood in the collateral removing dampness, promoting granulation and relieving pain; All medicine reasonable compatibilities are played the effect of blood circulation promoting and blood stasis dispelling, tissue regeneration promoting, circulation of qi promoting, collateral dredging the kidney invigorating, bone strengthening altogether, improve and reconstruction femoral head blood fortune, in order to new bone formation.

The effect of oral capsule preparation of the present invention is: the liver and the kidney tonifying, bone and muscle strengthening, blood circulation promoting and blood stasis dispelling, and removing obstruction in the collateral to relieve pain, its effect is an anticoagulant, blood viscosity lowering quickens erythrocyte electrophoresis, eliminates the blood stasis state, improve blood and in blood vessel, flow and microcirculation, have important function; To blood vessel dilating, reduction vascular resistance, the alleviating vascular spasm is improved the weary oxygen of ischemia, improve femoral head focal zone ischemia, to stoping the disease progression in femur head necrosis district, make the reparation of necrotic lesion, new osteanagenesis, increase blood capillary quantity and bone density and have important function.

The effect that the present invention treats the externally applied plaster of ischemic necrosis of femoral head is: plaster is affixed on the affected part, infiltration by pore, make the efficacy of a drug sick institute that goes directly, with dredging the meridian, relieving rigidity of joints, strong muscles and bones, prevent muscles and bones, amyotrophy, joint accretion makes the blood supply in femur head necrosis district full, improve the blood supply problem of ischemic necrosis of femoral head, make disease rehabilitation as early as possible.Oral capsule and externally applied plaster are also with playing short treating period, the purpose that curative effect is fast, without any side effects.

Medicine of the present invention shows that through clinical use result following advantage is arranged:

1, the various Chinese crude drugs selected for use of the present invention are raw material, do not have the relation of " on the contrary " and " mutual inhibition " between its compatibility; Each component meets the pharmaceutical control law regulation, utilizes the comprehensive function of the Chinese medicine of respectively distinguishing the flavor of, and the treatment ischemic necrosis of femoral head is nontoxic to human body.

2, the present invention need not decoct, and uses oral capsule convenient and easy, and pasting plaster need only scrub skin, after the fusing is Pasting, easy to use.

Excellent beneficial effect of the present invention was: from-calendar year 2001 in 1999, through treatment statistics to 206 routine ischemic necrosis of femoral head patients, wherein male 145 examples, women 61 examples, at minimum 6 years old of age, maximum 64 years old, the course of disease was the longest 25 years, the shortest 4 months, belong to fracture of femoral neck 71 examples, dislocation of hip joint 4 examples, wound 83 examples; Life-time service hormonal medicaments person 39 examples do not have obvious inducement 9 examples.In early days (1,2 phase) 34 examples, mid-term (3,4 phase) 129 examples, late period (5,6 phase) 43 examples.

Therapeutic Method:

Alleviating the joint bears a heavy burden, be intended to avoid or alleviate the femoral head deformity, accomplish to be association of activity and inertia, not definitely braking, only restriction is born a heavy burden with tired, with hip joint subluxation or muscle spasm person, can suitably draw embolia, after spasm is alleviated, remove traction, the state of an illness alleviates stable back and strengthens functional exercise such as hip bends and stretches, takes down the exhibits and rotates and increase range of motion, does exercises but must guard against roughness.

Drug therapy, oral capsule of the present invention, day clothes 3 times, each 5, per 60 days is a course of treatment, external application plaster of the present invention, paste position is: Ipsilateral hip and groin, respectively paste a card at every turn, changed once in 3 days.

Therapeutic outcome: recovery from illness: the hip arthralgia disappears, functional rehabilitation, activity freely, the X-ray sheet shows that joint space, acetabular bone and femoral head form and bone structure recover normally substantially, the sclerotin reparation is good; Be almost recovered: the hip arthralgia disappears, and it is normal or slightly limited that function is recovered substantially, and the X-ray sheet shows that femoral head profile and bone have obvious reparation, and bone trabecula is arranged comparatively neat; Effectively: the hip arthralgia alleviates, and function takes a turn for the better to some extent, but still partly limited, and the X-ray sheet shows that the femur head necrosis district enlarges again, or sequestrum has fusion slightly, but makes slow progress; Invalid: the hip arthralgia and function limitation all do not have improvement, and the X-ray sheet shows that the femoral head pathological changes remains unchanged or carrying out property increases the weight of.

The result:

Phase is other	Patient's number	Recovery from illness		Be almost recovered		Effectively		Invalid		Effective percentage
											Number	％	Number	％	Number	％	Number	％
		In early days	34	29	85.2	4	11.8	1	3										0		100％
Mid-term	129									48	37.2	59	45.7	18	14	4	3.1	97％
		Late period	43	14	32.5	15	34.8	6	13.9										8	19	81％
	206									91		78		25		12

Several generations' my kidney of telling handed down through generations is the source of whole body yang-energy for many years, cold-evil's impairment of YANG, thus the treatment ischemic necrosis of femoral head, necessary the liver and the kidney tonifying, eliminating impediment blood stasis dispelling; It is smart by force that oral capsule of the present invention has the kidney invigorating, blood circulation promoting and blood stasis dispelling, and the merit of Fuzheng Jiedu cooperates externally applied plaster simultaneously, and in conjunction with local braking, traction alleviates heavy burden, and internal and external application is association of activity and inertia, and could really improve curative effect; Advocate early to open now, early treatment reaches the healing purpose with relieving the pain caused by diseases.

Specific embodiments

The present invention is further described now to lift most preferred embodiment:

Take by weighing raw material (kilogram) by following proportioning:

Radix Angelicae Sinensis 12 Radixs Stephaniae Tetrandrae 2.5 Olibanums 6.5 Rhizoma Et Radix Notopterygiis 3.5

Flos Carthami 1.5 Radix Achyranthis Bidentataes 4.5 Sanguis Draxonis 13 Rhizoma Drynariae 1.5

Herba Ephedrae 7.5 Radix Aconitis 1.5 Radix Dipsaci 8 Radix Aconiti Kusnezoffii 1.5

Fructus Chaenomelis 1.5 Concretio silicea Bambusae seu schizostachyis 4.5 Semen Cucumidis sativi 7.5 worms 3.5

Catechu 2.5 Radix Et Rhizoma Rhei 4.5 Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 3.5 Pyritums 4.5

Radix Saposhnikoviae 1.5 Fructus Forsythiaes 4.5 Myrrhas 4.5 Borneolum Syntheticums 1.5

Above-mentioned 24 kinds of Chinese medicines are dried respectively, and metering is ground into 120 orders respectively, and mix homogeneously incapsulates then, and dress 0.45g makes oral capsule of the present invention in every capsule, and is standby by the capping of packing in the imitative pseudo-bottle of a fixing grain number.

Take by weighing raw material (kilogram) by following proportioning:

Radix Aconiti 3.5 Fructus Forsythiaes 3.5 Rhizoma Et Radix Notopterygiis 3.5 Flos Carthamis 4.5

Radix Dipsaci 3.5 Herba Taxillis 1 Radix Clematidis 3.5 Herba Lycopodiis 4.5

Semen Persicae 3.5 Rhizoma Gastrodiaes 5.5 Bombyx Batryticatus 3.5 are processed Pyritum 5.5

Caulis Piperis Kadsurae Teng 3.5 Herba speranskiae tuberculataes 8.5 Rhizoma Alpiniae Officinarum 3.5 Borneolum Syntheticums 0.6

Flos Lonicerae 3.5 Moschus 0.3 N of sunset 3.5 Flos Caryophylli 3.5

Radix Glycyrrhizae 3.5 Cortex Cinnamomis 3.5 Cortexs Eucommiae 3.5 Olibanums 0.6

Fructus Tribuli 3.5 Sanguis Draxonis 0.6 Rhizoma Cimicifugae 3.5 Herba Menthaes 3.5

Myrrha 0.6 Radix Angelicae Sinensis 3.5 Radix Saposhnikoviaes 3.5 Radix Aconiti Kusnezoffii 3.5

Radix Angelicae Pubescentis 3.5 Plumbum preparatium, Oleum Sesami are an amount of.

Manufacture externally applied plaster.Its preparation method is: at first with Moschus, Borneolum Syntheticum, Cortex Cinnamomi, Flos Caryophylli, Sanguis Draxonis, Olibanum, seven kinds of Chinese medicines of Myrrha, the amount pulverizing is that 120 order powder are deposited standby in proportion, other 26 kinds of Chinese medicines are measured to drop in the Oleum Sesami in proportion soaked 36 hours, it serves as an amount of that the ratio of Oleum Sesami and 26 kinds of Chinese medicines can be soaked whole Chinese medicines with Oleum Sesami, it is sallow with slow fire the medicine that soaks being exploded to the medicine complexion changed, can not explode black, it is clean then Chinese medicine to be pulled out filter, remaining Oleum Sesami is measured, the compatibility process of preparing Chinese medicine is carried out in every jin, a traditional unit of weight of ratio with 250g Plumbum preparatium in the metering back, must slowly concoct under slow fire during the process of preparing Chinese medicine, and ceaselessly stir, after Plumbum preparatium stirs in Oleum Sesami, could be from fire.Behind fire, Plumbum preparatium and the Oleum Sesami cream for preparing was washed 96 hours with running water, or soaked 120 hours, changed water once in per 8 hours with cold water, after at last it being reheated fusing, seven kinds of medicamental pulverata pulverizing earlier are blended into, stir evenly, spreading out on cloth or oilpaper, both has been externally applied plaster of the present invention.

Claims (4)

1, a kind of oral capsule and plaster preparation for the treatment of ischemic necrosis of femoral head is characterized in that it is the oral capsule medicament of being made by following weight percentages:

Radix Angelicae Sinensis 10%-15% Radix Stephaniae Tetrandrae 2%-3% Olibanum 5%-7%

Rhizoma Et Radix Notopterygii 3%-4% Flos Carthami 1%-2% Radix Achyranthis Bidentatae 4%-5%

Sanguis Draxonis 10%-15% Rhizoma Drynariae 1%-2% Herba Ephedrae 7%-9%

Radix Aconiti 1%-2% Radix Dipsaci 6%-10% Radix Aconiti Kusnezoffii 1%-2%

Fructus Chaenomelis 1%-2% Concretio silicea Bambusae seu schizostachyi 4%-5% Semen Cucumidis sativi 6%-10%

worm 2%-5% catechu 2%-3% Radix Et Rhizoma Rhei 4%-5%

Radix Angelicae Dahuricae (Radix Heraclei Scabridi) 3%-4% Pyritum 3%-5% Radix Saposhnikoviae 1%-2%

Fructus Forsythiae 4%-5% Myrrha 3%-5% Borneolum Syntheticum 1.5%-2%.

2, a kind of preparation method for the treatment of the oral capsule of ischemic necrosis of femoral head according to claim 1, it is characterized in that each tcm components by the weight proportion after drying, metering respectively, mixed powder is broken into 120 order powderies, mix homogeneously incapsulates then, dress 0.45g in each capsule, standby by bottle interior capping of packing into of quantitative grain number.

3, a kind of plaster preparation for the treatment of ischemic necrosis of femoral head according to claim 1 is characterized in that it is the plaster preparation of being made by following weight percentages.

Radix Aconiti 3%-5% Rhizoma Gastrodiae 4%-7% Radix Achyranthis Bidentatae 2%-4%

Radix Dipsaci 2%-4% Herba speranskiae tuberculatae 7%-10% Cortex Eucommiae 3%-5%

Semen Persicae 2%-4% Moschus 0.3%-0.5% Rhizoma Cimicifugae 3%-4%

Caulis Piperis Kadsurae Teng 2%-4% Cortex Cinnamomi 3%-5% Radix Angelicae Sinensis 2%-6%

Flos Lonicerae 2%-4% Sanguis Draxonis 0.5%-0.8% Radix Angelicae Pubescentis 3%-4%

Radix Glycyrrhizae 3%-6% Myrrha 0.5%-0.7% Flos Carthami 4%-6%

Fructus Tribuli 3%-5% Radix Aconiti Kusnezoffii 2%-4% Herba Lycopodii 4%-7%

Herba Menthae 2%-4% Rhizoma Et Radix Notopterygii 3%-5% processs Pyritum 5%-8%

Radix Saposhnikoviae 3%-4% Radix Clematidis 2%-5% Borneolum Syntheticum 0.5%-1%

Fructus Forsythiae 2%-5% Bombyx Batryticatus 2%-6% Flos Caryophylli 3%-5%

Herba Taxilli 1%-2% Rhizoma Alpiniae Officinarum 2%-5% Olibanum 0.6%-0.7% Plumbum preparatium, Oleum Sesami are an amount of.

4, according to claim 1, the preparation method of the plaster preparation of 3 described a kind of ischemic necrosis of femoral head, it is characterized in that at first with Moschus, Borneolum Syntheticum, Cortex Cinnamomi, Flos Caryophylli, Sanguis Draxonis, Olibanum, seven kinds of Chinese medicines of Myrrha, pulverizing by the composition weight proportioning is that 120 order powder are deposited, the set of dispense of other 26 kinds of Chinese medicines was soaked 36 hours than dropping in the Oleum Sesami, it serves as an amount of that the ratio of Oleum Sesami and 26 kinds of Chinese medicines can be soaked whole Chinese medicines with Oleum Sesami, with slow fire with the medicine that soaks fried to the medicine complexion changed be sallow being advisable, can not explode black, it is clean then Chinese medicine to be pulled out filter, remaining Oleum Sesami is measured, carrying out compatibility in the ratio of every jin, a traditional unit of weight of Oleum Sesami and 250g Plumbum preparatium again concocts, must under slow fire, slowly concoct during the process of preparing Chinese medicine, and ceaselessly stir, after Plumbum preparatium is stirred in Oleum Sesami, could be from fire, behind fire, Plumbum preparatium and the Oleum Sesami cream for preparing was washed 96 hours with running water, or soaked 120 hours with cold water, changed one time water in per 8 hours, after again it being reheated fusing at last, seven kinds of powder of Chinese herbs to pulverizing earlier are blended into again, stir, spread out on cloth or oilpaper, be the plaster of treatment ischemic necrosis of femoral head.