CN102131918A - 牙髓髓相似细胞(dpmsc)和分离和使用的方法 - Google Patents

牙髓髓相似细胞(dpmsc)和分离和使用的方法 Download PDF

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CN102131918A
CN102131918A CN2009801335654A CN200980133565A CN102131918A CN 102131918 A CN102131918 A CN 102131918A CN 2009801335654 A CN2009801335654 A CN 2009801335654A CN 200980133565 A CN200980133565 A CN 200980133565A CN 102131918 A CN102131918 A CN 102131918A
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cells
dpmscs
population
cell
differentiation
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F·费罗
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Universita degli Studi di Udine
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    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
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  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN2009801335654A 2008-06-26 2009-06-26 牙髓髓相似细胞(dpmsc)和分离和使用的方法 Pending CN102131918A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITRM2008A000342 2008-06-26
IT000342A ITRM20080342A1 (it) 2008-06-26 2008-06-26 Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso.
PCT/EP2009/058015 WO2009156495A1 (en) 2008-06-26 2009-06-26 Dental pulp marrow similar cells (dpmsc) and methods of isolating and using

Publications (1)

Publication Number Publication Date
CN102131918A true CN102131918A (zh) 2011-07-20

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CN2009801335654A Pending CN102131918A (zh) 2008-06-26 2009-06-26 牙髓髓相似细胞(dpmsc)和分离和使用的方法

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US (2) US20110158962A1 (enExample)
EP (1) EP2313493A1 (enExample)
JP (1) JP2011525798A (enExample)
CN (1) CN102131918A (enExample)
IT (1) ITRM20080342A1 (enExample)
WO (1) WO2009156495A1 (enExample)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106471371A (zh) * 2014-12-05 2017-03-01 宣捷生物科技股份有限公司 区别间充质干细胞的方法
CN109219441A (zh) * 2016-03-09 2019-01-15 阿威他国际有限公司 表达间充质和神经元标志物的牙髓干细胞及其组合物治疗神经疾病的用途
CN112469815A (zh) * 2018-07-31 2021-03-09 Jcr制药股份有限公司 牙髓来源细胞的制造方法
CN114736957A (zh) * 2022-04-15 2022-07-12 中国人民解放军空军军医大学 外泌体介导rna casc15干预阿尔茨海默症突触损失的应用
CN117363565A (zh) * 2023-09-28 2024-01-09 南方医科大学口腔医院 一种用于骨再生的血管化干细胞球的构建方法

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20080342A1 (it) 2008-06-26 2009-12-27 Univ Degli Studi Udine Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso.
US20150335400A1 (en) * 2009-06-17 2015-11-26 The Trustees Of Columbia University In The City Of New York Tooth scaffolds
US9550975B2 (en) * 2009-07-15 2017-01-24 Mari Dezawa SSEA-3 pluripotent stem cell isolated from body tissue
ES2360434B1 (es) * 2009-07-21 2012-04-12 Universitat Internacional De Catalunya Celulas madre pluripotenciales obtenidas a partir de la pulpa dental.
JP5608927B2 (ja) * 2010-04-13 2014-10-22 国立大学法人名古屋大学 歯髄幹細胞を用いた神経疾患治療用組成物
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP2633870B1 (en) 2012-02-29 2018-08-01 Technische Universität Berlin Method of preparing an artificial tooth primordium in vitro and artificial tooth primordium derived therefrom
US10106773B2 (en) * 2012-03-01 2018-10-23 University Of Miami Isolation and use of pluripotent stem cell population from adult neural crest-derived tissues
WO2013146992A1 (ja) * 2012-03-29 2013-10-03 日本ケミカルリサーチ株式会社 歯髄由来の多能性幹細胞の製造方法
US10709741B2 (en) 2013-02-13 2020-07-14 National University Corporation Nagoya University Composition for preventing or treating inflammatory disease
US9790468B2 (en) * 2013-03-15 2017-10-17 Avita Iinternational Ltd. Multifunctional immature dental pulp stem cells and therapeutic applications
US11278574B2 (en) * 2013-03-15 2022-03-22 Avita International Ltd. Use of stem cells expressing mesenchymal and neuronal markers and compositions thereof to treat neurological disease
US11306290B2 (en) 2013-03-15 2022-04-19 Avita International Ltd. Stem cells expressing mesenchymal and neuronal markers, compositions thereof, and methods of preparation thereof
US11207352B2 (en) 2013-03-15 2021-12-28 Avita International Ltd. Compositions comprising stem cells expressing mesenchymal and neuronal markers and uses thereof to treat neurological disease
SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
EP3936609A1 (en) * 2014-08-14 2022-01-12 Avita International Ltd. Stem cell compositions and methods of producing stem cells for therapeutic applications
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
CN105063089A (zh) * 2015-05-19 2015-11-18 西安交通大学 hTERT重组慢病毒永生化人脱落乳牙牙髓干细胞系的方法
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
US20200270579A1 (en) * 2017-02-03 2020-08-27 Kyushu University, National University Corporation Method for preparing dental pulp stem cells from cells derived from dental pulp tissue
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
CA3082368A1 (en) * 2017-11-09 2019-05-16 Sapporo Medical University Medicine for tissue regeneration, and preparation method therefor
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
WO2023227972A1 (en) * 2022-05-24 2023-11-30 Iceta - Instituto De Ciências, Tecnologias E Agroambiente Da Universidade Do Porto Process for preparation and cryopreservation of dental pulp from definitive teeth and products thereof based on isolated mesenchymal stem cells
EP4600350A1 (en) * 2022-10-03 2025-08-13 Kidswell Bio Corporation Novel dental pulp stem cell population
WO2024075145A1 (ja) * 2022-10-03 2024-04-11 キッズウェル・バイオ株式会社 新規な歯髄幹細胞集団
TW202434721A (zh) * 2023-02-14 2024-09-01 國立大學法人山口大學 細胞群、三維細胞培養體、醫藥組成物、胞泌體及製作此細胞群的方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003206844B2 (en) 2002-02-06 2010-04-08 Tissuedent Gmbh & Co. Kg Pluripotent embryonic-like stem cells derived from teeth and uses thereof
AU2003231015B2 (en) 2003-04-19 2009-10-08 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health Postnatal stem cells and uses thereof
AU2004293841B2 (en) * 2003-11-20 2009-10-08 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Multipotent postnatal stem cells from human periodontal ligament and uses thereof
ITNA20040043A1 (it) * 2004-07-28 2004-10-28 Francesco Carinci Tecnica di ingegneria tissutale ottenibile mediante isolamento di una nuova sottopopolazione di cellule staminali mbp-shed ed mbp-dpsc, isolate da polpa di denti decidui e permanenti in grado di produrre in vitro tessuto osseo umano.
EP1705245B1 (en) 2005-03-23 2009-05-20 Stiftung CAESAR Neural stem cells
US20070258957A1 (en) * 2006-05-04 2007-11-08 Russell Bowermaster Method for obtaining and storing multipotent stem cells
DE602005012081D1 (de) * 2005-07-29 2009-02-12 Univ Bonn Verfahren zur Isolierung von Stammzellen aus ein kissenformiges Gewebe der Zähne
US20070280907A1 (en) * 2006-04-07 2007-12-06 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Adult bone marrow cell transplantation to testes creation of transdifferentiated testes germ cells, leydig cells and sertoli cells
CN101501185A (zh) * 2006-06-09 2009-08-05 人类起源公司 胎盘巢(placental niche)及其培养干细胞的用途
ITRM20080342A1 (it) 2008-06-26 2009-12-27 Univ Degli Studi Udine Cellule di polpa dentale midollo-simili, metodi per isolamento ed uso.

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106471371A (zh) * 2014-12-05 2017-03-01 宣捷生物科技股份有限公司 区别间充质干细胞的方法
CN106471371B (zh) * 2014-12-05 2018-05-04 宣捷生物科技股份有限公司 区别间充质干细胞的方法
CN109219441A (zh) * 2016-03-09 2019-01-15 阿威他国际有限公司 表达间充质和神经元标志物的牙髓干细胞及其组合物治疗神经疾病的用途
CN109312303A (zh) * 2016-03-09 2019-02-05 阿威他国际有限公司 表达间充质和神经元标志物的干细胞、其组合物及其制备方法
CN109219441B (zh) * 2016-03-09 2022-06-10 阿威他国际有限公司 表达间充质和神经元标志物的牙髓干细胞及其组合物治疗神经疾病的用途
CN109312303B (zh) * 2016-03-09 2024-03-26 阿威他国际有限公司 表达间充质和神经元标志物的干细胞、其组合物及其制备方法
CN112469815A (zh) * 2018-07-31 2021-03-09 Jcr制药股份有限公司 牙髓来源细胞的制造方法
CN114736957A (zh) * 2022-04-15 2022-07-12 中国人民解放军空军军医大学 外泌体介导rna casc15干预阿尔茨海默症突触损失的应用
CN114736957B (zh) * 2022-04-15 2024-03-12 中国人民解放军空军军医大学 外泌体介导rna casc15干预阿尔茨海默症突触损失的应用
CN117363565A (zh) * 2023-09-28 2024-01-09 南方医科大学口腔医院 一种用于骨再生的血管化干细胞球的构建方法
CN117363565B (zh) * 2023-09-28 2024-05-17 南方医科大学口腔医院 一种用于骨再生的血管化干细胞球的构建方法

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EP2313493A1 (en) 2011-04-27
US10421947B2 (en) 2019-09-24
US20110158962A1 (en) 2011-06-30

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