CN102119999A - Preparation method of oral solution capable of tonifying qi and nourishing blood - Google Patents
Preparation method of oral solution capable of tonifying qi and nourishing blood Download PDFInfo
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- CN102119999A CN102119999A CN201110051323XA CN201110051323A CN102119999A CN 102119999 A CN102119999 A CN 102119999A CN 201110051323X A CN201110051323X A CN 201110051323XA CN 201110051323 A CN201110051323 A CN 201110051323A CN 102119999 A CN102119999 A CN 102119999A
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Abstract
The invention belongs to the technical field of traditional Chinese medicine, and relates to a preparation method of an oral solution capable of tonifying qi and nourishing the blood. The preparation method comprises the following steps of: taking 12 traditional Chinese medicines including dangshen and the like except antler, adding water for decocting (for 3 hours for the first time and for 2 hours for the second time), mixing the decoctions, filtering, concentrating until the relative density is 1.03-1.05, adding the antler, and extracting clear cream for dissolving; carrying out ultrafiltration with an ultrafiltration membrane the molecular weight of which is 300000, wherein the temperature of the liquid medicine is 20-25 DEG C, the inlet pressure of an ultrafiltration column is 1.2bar, the return pressure of the ultrafiltration column is 0.7bar, and the penetration outlet pressure of the ultrafiltration column is 0.5bar; and adding 133g of sucrose and 267g of refined honey into ultrafiltrate, heating and boiling for 30 minutes, cooling, adding auxiliary materials, adjusting the total quantity to be 1000ml, stirring, filtering and filling to obtain the oral solution. By using an ultrafiltration technology for preparing a mixture, macromolecular substances in the liquid medicine are effectively removed, the molecular weight of the medicament is obviously lowered, the clarity of the medicament is obviously improved, the stability of the preparation is enhanced, and the product quality is ensured.
Description
Technical field
The invention belongs to technical field of Chinese medicines, be specifically related to the preparation method of benefiting QI and nourishing blood oral liquid.
Background technology
In the prior art, a lot of mixture products in the market circulate, after but standing time is long, precipitation or turbid phenomenon appear in the capital, therefore, many productions or research and development department adopt the various ways that the mixture clarity is improved to change this present situation, and common processing method is decoction and alcohol sedimentation technique, clarifier method, supercentrifugal process, resin column partition method etc., but these methods all have problems.Decoction and alcohol sedimentation technique increases production cost, and ethanol can be taken away a large amount of active ingredients; The clarifier method can be introduced new impurity; Supercentrifugal process can only be removed the impurity that molecular weight is big and can estimate; Resin column method cost is too high, and also can lose a large amount of active ingredients.As 2005 editions benefiting QI and nourishing blood oral liquids of Chinese Pharmacopoeia prescription: Radix Ginseng 5.53g, Radix Astragali 83.4g, Radix Codonopsis 75g, Radix Ophiopogonis 50g, Radix Angelicae Sinensis 33.3g, Rhizoma Atractylodis Macrocephalae 33.3g, Radix Rehmanniae 33.3g, Radix Polygoni Multiflori Preparata 30g, Fructus Schisandrae Chinensis 25g, Pericarpium Citri Reticulatae 33.3g, Cortex Lycii 25g, Cornu Cervi Pantotrichum 1.7g, Herba Epimedii 50g; Method for making: above 13 flavors, the Cornu Cervi Pantotrichum section decocts with water secondary, and each 3 hours, collecting decoction filtered, and it is 1.20-1.25 (20 ℃) that filtrate is concentrated into relative density, adds triplication ethanol, leaves standstill 24 hours, filters, and reclaims ethanol, standby; 12 flavors such as all the other Radix Codonopsis decoct with water secondary, 3 hours each time, 2 hours for the second time, collecting decoction filtered, filtrate is concentrated in right amount, merges with Cornu Cervi Pantotrichum extracting solution, adds sucrose 133g, refined honey 267g boiled 30 minutes, put cold, add Fructus Citri tangerinae essence 0.5ml, ethyl hydroxybenzoate 1g, add water to 1000ml, stir evenly, filter, promptly.Function with cure mainly: benefiting QI and nourishing blood, be used for the cardiopalmus of breathing hard due to the insufficiency of vital energy and blood, lustreless complexion, body void is weak.Its shortcoming be standing time long after, precipitation or turbid phenomenon can appear, influence the clarity of mixture.
Summary of the invention
The objective of the invention is to provide a kind of advanced Chinese medicine hyperfiltration technique that adopts, remove a large amount of macromolecular substances in the mixture, make the steady quality of mixture, the preparation method of benefiting QI and nourishing blood oral liquid evident in efficacy at above-mentioned deficiency.
The technology of the present invention solution is: the preparation method of benefiting QI and nourishing blood oral liquid:
(1) raw material is 2005 editions benefiting QI and nourishing blood oral liquids of Chinese Pharmacopoeia prescriptions: Radix Ginseng 5.53g, Radix Astragali 83.4g, Radix Codonopsis 75g, Radix Ophiopogonis 50g, Radix Angelicae Sinensis 33.3g, Rhizoma Atractylodis Macrocephalae 33.3g, Radix Rehmanniae 33.3g, Radix Polygoni Multiflori Preparata 30g, Fructus Schisandrae Chinensis 25g, Pericarpium Citri Reticulatae 33.3g, Cortex Lycii 25g, Cornu Cervi Pantotrichum 1.7g, Herba Epimedii 50g;
(2) get Cornu Cervi Pantotrichum section, decoct with water secondary, each 3 hours, collecting decoction, filtering filtrate, to be concentrated into relative density be 1.2~1.3 cream, adds 3 times of amount ethanol, left standstill 24 hours, filters, and reclaims ethanol, clear paste is standby;
(3) get 12 flavor medicines such as Radix Codonopsis, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and being concentrated into relative density is 1.03~1.05, added Cornu Cervi Pantotrichum and extracted clear paste and make dissolving; The ultrafilter membrane of crossing 300,000 molecular weight carries out ultrafiltration, 20~25 ℃ of fluid temperature, and ultrafiltration post inlet pressure 1.2bar, ultrafiltration post return pressure 0.7bar, the ultrafiltration post sees through outlet pressure 0.5bar;
(4) add sucrose 133g, refined honey 267g in the ultrafiltrate, heated and boiled 30min is put coldly, adds adjuvant, and adjustments total amount is 1000ml, stir, and filtration, fill, promptly.The polyether sulfone organic membrane that adopts U.S. Millipore Corp. to produce.
Advantage of the present invention is: 1, adopted advanced hyperfiltration technique, overcome the shortcoming that traditional mixture clarity processing method exists, on the basis that keeps the original composition of medicinal liquid, impurity such as the resin of removal macromolecule, tannin, Denatured protein, small molecular weight material is big to the adhesive attraction of intestinal wall, and the time of staying prolongs in intestinal, and bioavailability obviously improves, therefore, easier being absorbed by the body of medicinal liquid of handling through hyperfiltration technique.2, the present invention with the medicinal liquid hyperfiltration treatment, does not need to be condensed into cream and dissolves in preparation process, reuses after the while ultrafiltration apparatus is capable of washing, and technology is simple, and cost is low, and is free from environmental pollution, do not bring impurity into.3, the present invention adopts hyperfiltration technique to make mixture, effectively removed the macromolecular substances in the medicinal liquid, the molecular weight of medicine obviously diminishes, the clarity of medicine obviously improves, even long-time the placement do not contain yet and precipitation or muddy occurs, that has avoided using other defecation method to bring is residual, so adopt the present invention to strengthen stability of formulation, guaranteed product quality.
The medicine long term test detects data and sees the following form:
Table 1 long-time stability experimental data (0 month)
Table 2 long-time stability experimental data (3 months)
Table 3 long-time stability experimental data (6 months)
Table 4 long-time stability experimental data (12 months)
Table 5 long-time stability experimental data (24 months)
Below in conjunction with embodiment embodiments of the present invention are described in further detail.
The specific embodiment
Embodiment
The preparation method of benefiting QI and nourishing blood oral liquid:
(1) raw material is 2005 editions benefiting QI and nourishing blood oral liquids of Chinese Pharmacopoeia prescriptions: Radix Ginseng 5.53g, Radix Astragali 83.4g, Radix Codonopsis 75g, Radix Ophiopogonis 50g, Radix Angelicae Sinensis 33.3g, Rhizoma Atractylodis Macrocephalae 33.3g, Radix Rehmanniae 33.3g, Radix Polygoni Multiflori Preparata 30g, Fructus Schisandrae Chinensis 25g, Pericarpium Citri Reticulatae 33.3g, Cortex Lycii 25g, Cornu Cervi Pantotrichum 1.7g, Herba Epimedii 50g;
(2) get Cornu Cervi Pantotrichum section, decoct with water secondary, each 3 hours, collecting decoction, filtering filtrate, to be concentrated into relative density be 1.2~1.3 cream, adds 3 times of amount ethanol, left standstill 24 hours, filters, and reclaims ethanol, clear paste is standby;
(3) get 12 flavor medicines such as Radix Codonopsis, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and being concentrated into relative density is 1.03~1.05, added Cornu Cervi Pantotrichum and extracted clear paste and make dissolving; The ultrafilter membrane of crossing 300,000 molecular weight carries out ultrafiltration, 20~25 ℃ of fluid temperature, and ultrafiltration post inlet pressure 1.2bar, ultrafiltration post return pressure 0.7bar, the ultrafiltration post sees through outlet pressure 0.5bar;
(4) add sucrose 133g, refined honey 267g in the ultrafiltrate, heated and boiled 30min is put coldly, adds flavoring orange essence 0.5ml, ethyl hydroxybenzoate 1g, the adjustment total amount is 1000ml, stirs, and filters, fill to 10ml control oral liquid bottle, 105 ℃ the sterilization 30min, promptly.
Claims (1)
1. the preparation method of a benefiting QI and nourishing blood oral liquid may further comprise the steps:
(1) raw material: Radix Ginseng 5.53g, Radix Astragali 83.4g, Radix Codonopsis 75g, Radix Ophiopogonis 50g, Radix Angelicae Sinensis 33.3g, Rhizoma Atractylodis Macrocephalae 33.3g, Radix Rehmanniae 33.3g, Radix Polygoni Multiflori Preparata 30g, Fructus Schisandrae Chinensis 25g, Pericarpium Citri Reticulatae 33.3g, Cortex Lycii 25g, Cornu Cervi Pantotrichum 1.7g, Herba Epimedii 50g;
(2) get Cornu Cervi Pantotrichum section, decoct with water secondary, each 3 hours, collecting decoction, filtering filtrate, to be concentrated into relative density be 1.2~1.3 cream, adds 3 times of amount ethanol, left standstill 24 hours, filters, and reclaims ethanol, clear paste is standby;
(3) get 12 flavor medicines such as Radix Codonopsis, decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and being concentrated into relative density is 1.03~1.05, added Cornu Cervi Pantotrichum and extracted clear paste and make dissolving; The ultrafilter membrane of crossing 300,000 molecular weight carries out ultrafiltration, 20~25 ℃ of fluid temperature, and ultrafiltration post inlet pressure 1.2bar, ultrafiltration post return pressure 0.7bar, the ultrafiltration post sees through outlet pressure 0.5bar;
(4) add sucrose 133g, refined honey 267g in the ultrafiltrate, heated and boiled 30min is put coldly, adds adjuvant, and adjustments total amount is 1000ml, stir, and filtration, fill, promptly.
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CN102920903A (en) * | 2012-09-27 | 2013-02-13 | 潘首德 | New method for preparing oral liquid for reinforcing qi and nourishing blood |
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CN101310751A (en) * | 2007-05-23 | 2008-11-26 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for replenishing qi and blood, preparation method and quality control method thereof |
CN101953986A (en) * | 2009-07-21 | 2011-01-26 | 通药制药集团股份有限公司 | Method for preparing Chinese medicinal preparation for treating Qi deficiency and blood deficiency |
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CN101310751A (en) * | 2007-05-23 | 2008-11-26 | 北京亚东生物制药有限公司 | Traditional Chinese medicine composition for replenishing qi and blood, preparation method and quality control method thereof |
CN101953986A (en) * | 2009-07-21 | 2011-01-26 | 通药制药集团股份有限公司 | Method for preparing Chinese medicinal preparation for treating Qi deficiency and blood deficiency |
Non-Patent Citations (4)
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《世界科学技术-中医药现代化*现代中药制剂装备现代化》 20091231 苏薇薇等 《现代中药制药生产中的膜分离技术及其装备》 906-911 1 第11卷, 第6期 2 * |
《中华人民共和国药典2005年版一部》 20051231 国家药典委员会 《益气养血口服液》 576 1 , 1 * |
《实用中药制剂新技术》 20021031 韩丽 《超滤》 201-215 1 , 1 * |
《陕西中医》 20091031 田继义等 《益气养血口服液的薄层鉴别研究》 1399-1240 1 第30卷, 第10期 2 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN102920903A (en) * | 2012-09-27 | 2013-02-13 | 潘首德 | New method for preparing oral liquid for reinforcing qi and nourishing blood |
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Application publication date: 20110713 |