CN102512583B - Preparation method of Jinguoyin oral liquid - Google Patents
Preparation method of Jinguoyin oral liquid Download PDFInfo
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- CN102512583B CN102512583B CN2011104317322A CN201110431732A CN102512583B CN 102512583 B CN102512583 B CN 102512583B CN 2011104317322 A CN2011104317322 A CN 2011104317322A CN 201110431732 A CN201110431732 A CN 201110431732A CN 102512583 B CN102512583 B CN 102512583B
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Abstract
The invention belongs to the field of pharmacy, and relates to a Jinguoyin oral liquid. A prescription of the oral liquid comprises components of: 73g of rehmannia, 55g of figwort, 18g of immature chebula fruit, 27g of black cicada slough, 55g of creeping liriope, 18g of boat-fruited sterculia seed, 55g of fourleaf ladybell root, 55g of different leaves pseudostellaria root tuber, 36g of tangerine peel, and 0.5ml of peppermint oil. A preparation method comprises steps that: 1, raw rehmannia and figwort are decocted three times by using water; other medicine materials except the tangerine peel are decocted 2 times; obtained medicine liquids are combined and concentrated; ethanol is added to the combined medicine liquid, and the solution is stood; a supernatant is adopted, and ethanol is recovered until no alcohol smell is left; the supernatant is concentrated, such that a clear paste is obtained for later use; 2, ethanol is added to the tangerine peel medicine material, and the mixture is subject to reflux extraction; ethanol in the extraction liquid is recovered by vacuum concentration, until no ethanol smell is left; the pH value of the extraction is regulated by using an NaOH solution, until hesperidin is completely dissolved; an obtained clear paste is preserved for later use; 3, clear pastes obtained in the steps 1 and 2 are combined; the combination is dissolved by using water, such that the oral liquid is prepared.
Description
Technical field
The present invention relates to a kind of gold fruit and drink oral liquor, the particularly optimization of Chinese crude drug extraction process in the side.
Background technology
It is to add the oral liquid that appropriate amount of auxiliary materials is made by ten flavor medical materials such as Radix Rehmanniae, Radix Scrophulariae, table winter, Pericarpium Citri Reticulatae that the gold fruit drinks oral liquid, record in " one one of Chinese Pharmacopoeia version in 2010, be used for YIN nourishing and the production of body fluid promoting, relieving sore-throat by clearing away heat, red swelling of the pharynx, pharyngalgia, dry mouth and throat due to being used for that lung-heat is cloudy and hindering; Acute and chronic pharyngitis is seen above-mentioned patient.Also can be used for the dry pharynx discomfort that radiotherapy causes.Pericarpium Citri Reticulatae medical material effect regulating qi-flowing for strengthening spleen wherein, drying dampness to eliminate phlegm.Be used for distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.Usage and dosage is oral, a 15ml, 3 times on the one or follow the doctor's advice.But the gold fruit has drunk oral liquid since 2010 editions standards of pharmacopoeia promote, increased Determination of Hesperidin Content in this product test item, therefore improve the extraction rate of transform of Hesperidin in the Pericarpium Citri Reticulatae medical material, thereby be conducive to the performance of drug effect, promote product quality, in both citrus (Cirtus), the flourishing system person of mesocarp (platinum sponge shape tissue) contains narigin more, and the thinner system person of mesocarp contains hesperidin more.Hesperidin is almost insoluble in water, often can not be fully that extracts active ingredients is complete with the method that decocts, so the effective ingredient Hesperidin extraction rate of transform is low.
Summary of the invention
The object of the invention is to provide a kind of gold fruit to drink oral liquor.
Purpose of the present invention is exactly in order to provide a kind of gold fruit to drink oral liquor.Solve Hesperidin and extract inadequate problem, improve the rate of transform of medical material effective ingredient.Utilize certain density ethanol to extract the effective ingredient of Hesperidin in the Pericarpium Citri Reticulatae medical material as solvent, clear paste adds aqueous slkali again and transfers PH to certain scope, has namely solved the Hesperidin solubility, has solved the clarity problem of this kind again.
The invention provides the preparation method that a kind of gold fruit drinks oral liquid, wherein the extracting method of Pericarpium Citri Reticulatae glycosides also is applicable to other oral formulations that contain Pericarpium Citri Reticulatae.
The present invention seeks to be achieved through the following technical solutions.
[prescription]: Radix Rehmanniae 73g Radix Scrophulariae 55g FRUCTUS TERMINALIAE IMMATURUS 18g
Periostracum Cicadae 27g 55g Radix Ophiopogonis Semen Sterculiae Lychnophorae 18g
Radix Adenophorae 55g Radix Pseudostellariae 55g Pericarpium Citri Reticulatae 36g
Oleum menthae 0.5ml
[preparation method]:
Step 1, the Radix Rehmanniae, Radix Scrophulariae decocting boil three times, and all the other medical materials (except Pericarpium Citri Reticulatae) decocting boils 2 times, and medicinal liquid merges, and concentrate to add ethanol and leave standstill, and get supernatant and reclaim ethanol to obtain clear paste not standby to having the alcohol flavor, concentrating.
Step 2, get the Pericarpium Citri Reticulatae medical material, add alcohol reflux, the extracting solution concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, adds NaOH solution and transfers PH all to dissolve to Hesperidin, and clear paste is standby.
Step 3, merging 1,2 clear paste are dissolved in water and are mixed with oral liquid.
Preferred preparation method of the present invention is as follows:
Step 1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings and decoct three times, and each 2 hours, merging filtrate filtered; All the other medical materials (except Pericarpium Citri Reticulatae) add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, it is standby to receive cream.
Step 2, get the Pericarpium Citri Reticulatae medical material, add 60% alcoholic solution reflux, extract, three times, each 1.5h, add for the first time 8 times of amount 60% ethanol, 60% ethanol of 6 times of amount preparations of second and third time usefulness, concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, and clear paste adds 20%NaOH solution and transfers PH to 12.0 all to dissolve to Hesperidin, and clear paste is standby.
Step 3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
Step 4, filtrate add sucrose 200g, citric acid 1g,, boiling sterilization 30 minutes is put cold, adjusting total amount with purified water is 1000ml, puts coldly, adds Oleum menthae (using earlier dissolve with ethanol), stirs, filter with the rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
Method of the present invention obtains through screening, and screening process is as follows:
Method one,
1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings decoctions three times, and each 2 hours, merging filtrate filtered; All the other medical materials (except Pericarpium Citri Reticulatae) add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, it is standby to receive cream.
2, get the Pericarpium Citri Reticulatae medical material, add 60 alcoholic solution reflux, extract, three times, each 1.5h adds 8 times of amount 60% ethanol for the first time, and 60% ethanol of 6 times of amount preparations of second and third time usefulness, concentrating under reduced pressure reclaim ethanol to there not being the alcohol flavor, and clear paste is standby.
3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
4, filtrate adds sucrose 200g, citric acid 1g,, boiling sterilization 30 minutes; Put coldly, adjusting total amount with purified water is 1000ml, puts coldly, adds Oleum menthae (use earlier dissolve with ethanol), stirs, and with the filtration of rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
Method two,
1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings decoctions three times, and each 2 hours, merging filtrate filtered; All the other medical materials add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, it is standby to receive cream.
2, get the Pericarpium Citri Reticulatae medical material, add 80% alcoholic solution reflux, extract, three times, each 1.5h adds 8 times of amount 60% ethanol for the first time, and 60% ethanol of 6 times of amount preparations of second and third time usefulness, concentrating under reduced pressure reclaim ethanol to there not being the alcohol flavor, and clear paste is standby.
3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
4, filtrate adds sucrose 200g, citric acid 1g,, boiling sterilization 30 minutes; Put coldly, adjusting total amount with purified water is 1000ml, puts coldly, adds Oleum menthae (use earlier dissolve with ethanol), stirs, and with the filtration of rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
Method three,
1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings decoctions three times, and each 2 hours, merging filtrate filtered; All the other medical materials add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, clear paste is standby.
2, get the Pericarpium Citri Reticulatae medical material, add 60% alcoholic solution percolation, left standstill 24 hours, with the speed of 3ml/kg/min percolation slowly, collect percolate heating evaporation ethanol, being concentrated into proportion is 1.30, crosses 200 order filter clothes, and clear paste is standby.
3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
4, filtrate adds sucrose 200g, citric acid 1g,, boiling sterilization 30 minutes; Put coldly, adjusting total amount with purified water is 1000ml, puts coldly, adds Oleum menthae (use earlier dissolve with ethanol), stirs, and with the filtration of rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
Method four,
1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings decoctions three times, and each 2 hours, merging filtrate filtered; All the other medical materials add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, clear paste is standby.
2, get the Pericarpium Citri Reticulatae medical material, add 80% alcoholic solution percolation, left standstill 24 hours, with the speed of 3ml/kg/min percolation slowly, collect percolate heating evaporation ethanol, being concentrated into proportion is 1.30, crosses 200 order filter clothes, and clear paste is standby.
3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
4, filtrate adds sucrose 200g, citric acid 1g,, boiling sterilization 30 minutes; Put coldly, adjusting total amount with purified water is 1000ml, puts coldly, adds Oleum menthae (use earlier dissolve with ethanol), stirs, and with the filtration of rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
Method five,
1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings decoctions three times, and each 2 hours, merging filtrate filtered; All the other medical materials (except Pericarpium Citri Reticulatae) add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, it is standby to receive cream.
2, get the Pericarpium Citri Reticulatae medical material, add 60% alcoholic solution reflux, extract, three times, each 1.5h, add for the first time 8 times of amount 60% ethanol, 60% ethanol of 6 times of amount preparations of second and third time usefulness, concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, and clear paste adds 20%NaOH solution and transfers PH to 12.0 all to dissolve to Hesperidin, and clear paste is standby.
3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
4, filtrate adds sucrose 200g, citric acid 1g,, boiling sterilization 30 minutes is put cold, adjusting total amount with purified water is 1000ml, puts coldly, adds Oleum menthae (using earlier dissolve with ethanol), stirs, filter with the rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
Method six,
1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings decoctions three times, and each 2 hours, merging filtrate filtered; All the other medical materials add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, clear paste is standby.
2, get the Pericarpium Citri Reticulatae medical material, add 60% alcoholic solution percolation, left standstill 24 hours, with the speed of 3ml/kg/min percolation slowly, collect percolate heating evaporation ethanol, concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, clear paste adds 20%NaOH solution and transfers PH to 12.0 all to dissolve to Hesperidin, and clear paste is standby.
3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
4, filtrate adds sucrose 200g, citric acid 1g,, boiling sterilization 30 minutes; Put coldly, adjusting total amount with purified water is 1000ml, puts coldly, adds Oleum menthae (use earlier dissolve with ethanol), stirs, and with the filtration of rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
Method seven,
1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings decoctions three times, and each 2 hours, merging filtrate filtered; All the other medical materials (except Pericarpium Citri Reticulatae) add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, it is standby to receive cream.
2, get the Pericarpium Citri Reticulatae medical material, add 80% alcoholic solution reflux, extract, three times, each 1.5h, add for the first time 8 times of amount 60% ethanol, 60% ethanol of 6 times of amount preparations of second and third time usefulness, concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, and clear paste adds 20%NaOH solution and transfers PH to 12.0 all to dissolve to Hesperidin, and clear paste is standby.
3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
4, filtrate adds sucrose 200g, citric acid 1g, and boiling sterilization 30 minutes is put coldly, and adjusting total amount with purified water is 1000ml, put coldly, add Oleum menthae (use earlier dissolve with ethanol), stir, filter with the rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
The selection of table one, Pericarpium Citri Reticulatae extracting method
Conclusion: investigate the result according to above seven kinds of Pericarpium Citri Reticulatae medicinal material extract methods, method five, six all meets the requirements, and wherein the extraction rate of transform of Pericarpium Citri Reticulatae glycosides is the highest in the method five, and each test item is all up to specification.
The specific embodiment
The following embodiment of the present invention all can reach the effect of above-mentioned experimental example.
Embodiment 1: a kind of gold fruit of the present invention drinks oral liquor
[prescription]: Radix Rehmanniae 73g Radix Scrophulariae 55g FRUCTUS TERMINALIAE IMMATURUS 18g
Periostracum Cicadae 27g 55g Radix Ophiopogonis Semen Sterculiae Lychnophorae 18g
Radix Adenophorae 55g Radix Pseudostellariae 55g Pericarpium Citri Reticulatae 36g
Oleum menthae 0.5ml sucrose 200g citric acid 1g
Sodium benzoate 2g
Above-mentioned raw materials is mixed with oral liquid 1000ml as follows;
[preparation method]:
1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings decoctions three times, and each 2 hours, merging filtrate filtered; All the other medical materials (except Pericarpium Citri Reticulatae) add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, it is standby to receive cream.
2, get the Pericarpium Citri Reticulatae medical material, add 60% alcoholic solution reflux, extract, three times, each 1.5h, add for the first time 8 times of amount 60% ethanol, 60% ethanol of 6 times of amount preparations of second and third time usefulness, concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, and clear paste adds 20%NaOH solution and transfers PH to 12.0 all to dissolve to Hesperidin, and clear paste is standby.
3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
4, filtrate adds sucrose 200g, and boiling sterilization 30 minutes is put coldly, and adjusting total amount with purified water is 1000ml, puts coldly, adds Oleum menthae (use earlier dissolve with ethanol), stirs, and with the filtration of rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
Embodiment 2: a kind of gold fruit of the present invention drinks oral liquor
[prescription]: Radix Rehmanniae 73g Radix Scrophulariae 55g FRUCTUS TERMINALIAE IMMATURUS 18g
Periostracum Cicadae 27g 55g Radix Ophiopogonis Semen Sterculiae Lychnophorae 18g
Radix Adenophorae 55g Radix Pseudostellariae 55g Pericarpium Citri Reticulatae 36g
Oleum menthae 0.5ml sucrose 200g citric acid 1g
Sodium benzoate 2g
Above-mentioned raw materials is mixed with oral liquid 1000ml as follows;
[preparation method]:
1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings decoctions three times, and each 2 hours, merging filtrate filtered; All the other medical materials add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, clear paste is standby.
2, get the Pericarpium Citri Reticulatae medical material, add 60% alcoholic solution percolation, left standstill 24 hours, with the speed of 3ml/kg/min percolation slowly, collect percolate heating evaporation ethanol, concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, clear paste adds 20%NaOH solution and transfers PH to 12.0 all to dissolve to Hesperidin, and clear paste is standby.
3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
4, filtrate adds sucrose 200g, boiling sterilization 30 minutes; Put coldly, adjusting total amount with purified water is 1000ml, puts coldly, adds Oleum menthae (use earlier dissolve with ethanol), stirs, and with the filtration of rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
Embodiment 3: a kind of gold fruit of the present invention drinks oral liquor
[prescription]: Radix Rehmanniae 73g Radix Scrophulariae 55g FRUCTUS TERMINALIAE IMMATURUS 18g
Periostracum Cicadae 27g 55g Radix Ophiopogonis Semen Sterculiae Lychnophorae 18g
Radix Adenophorae 55g Radix Pseudostellariae 55g Pericarpium Citri Reticulatae 36g
Oleum menthae 1ml steviosin 1g sodium benzoate 2g
Above-mentioned raw materials is mixed with oral liquid 1000ml as follows;
[preparation method]:
1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings decoctions three times, and each 2 hours, merging filtrate filtered; All the other medical materials (except Pericarpium Citri Reticulatae) add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, it is standby to receive cream.
2, get the Pericarpium Citri Reticulatae medical material, add 60% alcoholic solution reflux, extract, three times, each 1.5h, add for the first time 8 times of amount 60% ethanol, 60% ethanol of 6 times of amount preparations of second and third time usefulness, concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, and clear paste adds 20%NaOH solution and transfers PH to 12.0 all to dissolve to Hesperidin, and clear paste is standby.
3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
4, filtrate adds sucrose 200g, and boiling sterilization 30 minutes is put coldly, and adjusting total amount with purified water is 1000ml, puts coldly, adds Oleum menthae (use earlier dissolve with ethanol), stirs, and with the filtration of rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
Embodiment 4: a kind of gold fruit of the present invention drinks oral liquor
[prescription]: Radix Rehmanniae 73g Radix Scrophulariae 55g FRUCTUS TERMINALIAE IMMATURUS 18g
Periostracum Cicadae 27g 55g Radix Ophiopogonis Semen Sterculiae Lychnophorae 18g
Radix Adenophorae 55g Radix Pseudostellariae 55g Pericarpium Citri Reticulatae 36g
Oleum menthae 1ml steviosin 1g sodium benzoate 2g
Above-mentioned raw materials is mixed with oral liquid 1000ml as follows;
[preparation method]:
1, the Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings decoctions three times, and each 2 hours, merging filtrate filtered; All the other medical materials add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into relative density 1.15 (60 ℃ of surveys), clear paste adds 7 times of amounts and reclaims ethanol (from minuent to height), makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration is received cream to relative density 1.30 (80 ℃ of surveys), cross 200 order filter clothes, clear paste is standby.
2, get the Pericarpium Citri Reticulatae medical material, add 80% alcoholic solution percolation, left standstill 24 hours, with the speed of 3ml/kg/min percolation slowly, collect percolate heating evaporation ethanol, concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, clear paste adds 20%NaOH solution and transfers PH to 12.0 all to dissolve to Hesperidin, and clear paste is standby.
3, merging 1,2 clear paste are put and are boiled 10-15 minute (pressure 0.2MPa), add 7 times of water gagings and sodium benzoate (using earlier water dissolution), precipitate 48 hours, get supernatant liquid filtering.
4, filtrate adds steviosin 1g, boiling sterilization 30 minutes; Put coldly, adjusting total amount with purified water is 1000ml, puts coldly, adds Oleum menthae (use earlier dissolve with ethanol), stirs, and with the filtration of rustless steel sheet frame, fill, sterilization, packing, that is, 15ml/ props up.
Claims (2)
1. a gold fruit drinks oral liquid, and its prescription is:
Preparation method is:
Step 1, Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings and decoct three times, and each 2 hours, merging filtrate filtered; All the other medical materials except Pericarpium Citri Reticulatae add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into 60 ℃ and survey relative densities 1.15, clear paste adds 7 times of amounts and reclaims ethanol, makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration to 80 ℃ survey relative density 1.30 is received cream, cross 200 order filter clothes, it is standby to receive cream;
Step 2, get the Pericarpium Citri Reticulatae medical material, add 60% alcoholic solution reflux, extract, three times, each 1.5h, add for the first time 8 times of amount 60% ethanol, 60% ethanol of 6 times of amount preparations of second and third time usefulness, concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, and clear paste adds 20%NaOH solution and transfers PH to 12.0 all to dissolve to Hesperidin, and clear paste is standby;
Step 3, combining step 1,2 clear paste are put and are boiled 10-15 minute, add 7 times of water gagings and sodium benzoate, precipitate 48 hours, get supernatant liquid filtering;
Step 4, filtrate add sucrose 200g, citric acid 1g, and boiling sterilization 30 minutes is put coldly, and adjusting total amount with purified water is 1000ml, put coldly, add Oleum menthae, stir, filter with the rustless steel sheet frame, and fill, sterilization, packing, that is, 15ml/ props up.
2. preparation method that gold fruit drinks oral liquid, be processed into by following composition:
Preparation method is:
Step 1, Radix Rehmanniae, Radix Scrophulariae add 8 times of water gagings and decoct three times, and each 2 hours, merging filtrate filtered; All the other medical materials except Pericarpium Citri Reticulatae add 8 times of water gagings and decoct 2 times, each 30 minutes, filter, filtrate and the Radix Rehmanniae, Radix Scrophulariae medicinal liquid merge, be concentrated into 60 ℃ and survey relative densities 1.15, clear paste adds 7 times of amounts and reclaims ethanol, makes to contain the alcohol amount and reach 60%, left standstill 72 hours, get the supernatant decompression recycling ethanol to there not being the alcohol flavor, reconcentration to 80 ℃ survey relative density 1.30 is received cream, cross 200 order filter clothes, it is standby to receive cream;
Step 2, get the Pericarpium Citri Reticulatae medical material, add 60% alcoholic solution reflux, extract, three times, each 1.5h, add for the first time 8 times of amount 60% ethanol, 60% ethanol of 6 times of amount preparations of second and third time usefulness, concentrating under reduced pressure reclaims ethanol to there not being the alcohol flavor, and clear paste adds 20%NaOH solution and transfers PH to 12.0 all to dissolve to Hesperidin, and clear paste is standby;
Step 3, merging 1,2 clear paste are put and are boiled 10-15 minute, add 7 times of water gagings and sodium benzoate, precipitate 48 hours, get supernatant liquid filtering;
Step 4, filtrate add sucrose 200g, citric acid 1g, and boiling sterilization 30 minutes is put coldly, and adjusting total amount with purified water is 1000ml, put coldly, add Oleum menthae, stir, filter with the rustless steel sheet frame, and fill, sterilization, packing, that is, 15ml/ props up.
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| 中华人民共和国卫生部药典委员会.金果饮口服液.< * |
| 中华人民共和国卫生部药典委员会.金果饮口服液.<中华人民共和国药典2010年版>.2010,827. |
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