CN102119916A - Liquid oxygen in-situ forming gel and preparation method and application thereof - Google Patents
Liquid oxygen in-situ forming gel and preparation method and application thereof Download PDFInfo
- Publication number
- CN102119916A CN102119916A CN2011100254678A CN201110025467A CN102119916A CN 102119916 A CN102119916 A CN 102119916A CN 2011100254678 A CN2011100254678 A CN 2011100254678A CN 201110025467 A CN201110025467 A CN 201110025467A CN 102119916 A CN102119916 A CN 102119916A
- Authority
- CN
- China
- Prior art keywords
- liquid oxygen
- poloxamer
- instant gel
- preparation
- stir
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Landscapes
- Medicinal Preparation (AREA)
Abstract
The invention relates to liquid oxygen in-situ forming gel and a preparation method and application thereof. The liquid oxygen in-situ forming gel comprises the following materials in percentage by weight: 10 to 40 percent of poloxamer, 0.001 to 1 percent of nano silver and 59 to 89.4 percent of solvent. The preparation method comprises the following steps of: adding water into the poloxamer, stirring uniformly, swelling and defoaming to obtain a medicinal base material, adding the nano silver into the base material and stirring uniformly. The liquid oxygen in-situ forming gel can be used for treating vaginitis, rhinitis, otitis and skin tinea diseases. The poloxamer is taken as a temperature sensitive material, and the in-situ forming gel can reside in a human body for more than 20h, so that a medicine taking frequency can be reduced, the compliance of a patient can be improved, a pharmacological treatment effect can be enhanced, and toxic and side effects can be lowered.
Description
Technical field
The present invention relates to a kind of liquid oxygen instant gel and its production and use.
Background technology
Nanometer silver is that particle diameter is accomplished nano level argent simple substance, nano-Ag particles directly enters thalline and (SH) combines with the oxygen metabolism enzyme, the unique effect mechanism that thalline is choked to death can be killed microorganisms such as most of antibacterials of being in contact with it, fungus, mycete, spore.Nanometer silver has been proved to be broad-spectrum antibacterial action, is prepared to solid gel at present, is used for the treatment of gynecological inflammation, rhinitis, otitis, skin ringworm.But common solid gel can't be caught the antibacterial that is hidden in the cavity mucous membrane fold place because flowability is relatively poor, so the outbreak repeatedly easily of these position inflammation.
Instant gel; when temperature is lower than certain gelation temperature (common 30 ℃); the preparation form is a liquid; changed into solid-state in 2-3 minute behind the contact body temperature; instant gel so characteristics have successfully solved the ordinary gel agent and have disperseed uneven problem at patient part; simultaneously also guaranteed to keep within a certain period of time drug level, mucosa has been had the effect of mechanical protection.Its medication is convenient, healthy, can pollution clothes yet, and patient's compliance is higher.
Summary of the invention
Purpose of the present invention is exactly in order to overcome above-mentioned the deficiencies in the prior art part, a kind of liquid oxygen instant gel and its production and use is provided, it utilizes instant gel substrate to cooperate nanometer silver, has improved the flowability of nanometer silver, and has kept gel at partial long-time drug effect.
The present invention relates to the instant gel that a kind of macromolecular material combining nano silvery is equipped with, with the liquid oxygen of catalysis water generates in use.The objective of the invention is to realize by following technical measures.
A kind of liquid oxygen instant gel, this liquid oxygen instant gel is made of by weight percentage following material: 10-40% poloxamer, 0.001-1% nanometer silver, 59-89.4% solvent.
In technique scheme, described poloxamer is also using of poloxamer 407 or poloxamer 407 and poloxamer 188.
In technique scheme, described solvent is also using of water or water and carbomer.
In technique scheme, described carbomer is carbomer 934 GE.
Liquid oxygen instant gel of the present invention can be used for treating vaginitis, rhinitis, otitis, dermatophytosis.
In technique scheme, poloxamer is added water stir, add carbomer again, stir, make substrate behind swelling, the froth breaking, add medicament nano silver and stir, obtain vagina liquid oxygen instant gel preparation after the employing radiation sterilization.
In technique scheme, poloxamer is added water stir, add chitosan again, stir, make substrate behind swelling, the froth breaking, add medicament nano silver and stir, obtain nasal cavity liquid oxygen instant gel preparation after the employing radiation sterilization.
In technique scheme, poloxamer is added water stir, make substrate behind swelling, the froth breaking, add medicament nano silver and stir, obtain vagina liquid oxygen instant gel preparation after the employing radiation sterilization.
Liquid oxygen instant gel of the present invention with poloxamer as temperature sensing material, can make instant gel in vivo the holdup time greater than 20h.Therefore can reduce administration frequency, improve patient's compliance, strengthen medication effect, reduce toxic and side effects.
Description of drawings
Fig. 1 is that common solid gel is detained the 20h experimental result picture in the mice body.
Fig. 2 is detained the 20h experimental result picture for liquid oxygen instant gel of the present invention in the mice body.
Fig. 3 treats the colpitic experimental result picture of little Mycoplasma muris for common nanometer silver solid gel.
Fig. 4 treats the colpitic experimental result picture of little Mycoplasma muris for liquid oxygen instant gel of the present invention.
The specific embodiment
The invention will be further described below in conjunction with drawings and Examples.
Embodiment 1
A kind of liquid oxygen instant gel is made up of 10-40% poloxamer (W/W), 0.001-1% nanometer silver (W/W) and 59-89.4% solvent (W/W).
Above-mentioned solvent can be that water also can be also using of water and carbomer.
Above-mentioned poloxamer can be that poloxamer 407 also can be also using of poloxamer 407 and poloxamer 188.
Embodiment 2
A kind of vagina liquid oxygen instant gel, by 10% poloxamer 407(W/W), 0.3% carbomer 934 GE(W/W), 0.6% nanometer silver (W/W) and 89.1% water (W/W) forms, the poloxamer 407 of above-mentioned amount is added water to stir, add carbomer 934 GE again, stir, make substrate behind swelling, the froth breaking, add medicament nano silver and stir, obtain the vagina instant gel preparation after adopting radiation sterilization, pH is 3.8.
Embodiment 3
A kind of nasal cavity liquid oxygen instant gel, by 16% poloxamer 407(W/W), 24% poloxamer 188(W/W), 1% nanometer silver (W/W) and 59% water (W/W) forms, poloxamer 407 and poloxamer 188 mixing and water addings are stirred, add chitosan again, stir, make substrate behind swelling, the froth breaking, add medicament nano silver and stir, obtain the nasal cavity instant gel preparation after adopting radiation sterilization, pH is 7.2.
Embodiment 4
A kind of vagina liquid oxygen instant gel, by 10% poloxamer 407(W/W), 15% poloxamer 188(W/W), 0.001% nanometer silver (W/W) and 74.999% water (W/W) forms, poloxamer 407 and poloxamer 188 mixing and water addings are stirred, make substrate behind swelling, the froth breaking, adding medicament nano silver stirs, obtain instant gel preparation after adopting radiation sterilization, pH is 8.5.
Embodiment 5
Get the vagina liquid oxygen instant gel that embodiment 2 makes, measure gelation temperature with the magneton paddling process, the gelation temperature of this gel is 25 ℃, gelling time 3min.
It is painted to add 0.01% india ink in the vagina usefulness liquid oxygen instant gel that embodiment 2 makes; Get the solid gel of carbomer substrate, add the painted group in contrast of 0.01% india ink, inject mouse vagina respectively, put to death mice in 0.5h, 1h, 3h, 6h, 12h, 16h, 20h, get vagina and observe gel in the intravital holdup time of mice, the experimental result during its 20h respectively as shown in Figure 1, 2.
As can be seen from Fig. 1 behind the solid gel administration 20h of carbomer substrate, the basic emptying of gel, and also can be observed during vaginal thermosensitive gel 20h of the present invention, so in the body holdup time can realize the therapeutic goal that was administered once in a day greater than 20h.
Embodiment 6
Treat the colpitic comparative experiments of mycoplasma with the vagina that contains 1% nanometer silver with liquid oxygen instant gel and common nanometer silver solid gel.
Get the vagina liquid oxygen instant gel that embodiment 2 makes, with 40 of the female KM mices of SPF level, after the hormone pretreatment, select 30 vagina inoculation Ureaplasma urealyticum bacterium liquid (Uu bacterium liquid) at random, 1 time every other day, each 20ul 2.5 * 105ccu/ml continuous 7 days, makes up mycoplasma infection vaginitis mouse model.After the modeling success, 10 that do not inoculate Uu bacterium liquid are normal group; Postvaccinal 30 are divided into model group, liquid oxygen instant gel group, nanometer silver solid gel group, 10 every group, vagina administration at random.Not administration of normal group, model group give blank gel-type vehicle.Liquid oxygen instant gel group, nanometer silver solid gel group give relative medicine 50ul respectively.1 day 1 time, continuous 7 days, behind last administration 24 h, take off neck and put to death mice, dissect, take out complete vagina and uterus, whether perusal has performances such as hyperemia, edema, observes pathological change.Its experimental result is shown in Fig. 3,4.
Be illustrated in figure 3 as mycoplasma infection after the nanometer silver solid gel is treated uterus, vagina after 7 days, congested, edema alleviates, but does not recover normal.
Be illustrated in figure 4 as mycoplasma infection after liquid oxygen instant gel of the present invention, treat after 7 days uterus, vagina, recover normal substantially.
Show that by above-mentioned experiment the liquid oxygen instant gel preparation makes the uterus of mice and vagina is red and swollen and congestive symptom disappears, the vaginitis effective percentage 80% of treatment mycoplasma infection, its therapeutic effect is better than nanometer silver solid gel group.
The content that this description is not described in detail belongs to this area professional and technical personnel's known prior art.
Claims (8)
1. liquid oxygen instant gel is characterized in that this liquid oxygen instant gel is made of by weight percentage following material: 10-40% poloxamer, 0.001-1% nanometer silver, 59-89.4% solvent.
2. liquid oxygen instant gel according to claim 1 is characterized in that: described poloxamer is also using of poloxamer 407 or poloxamer 407 and poloxamer 188.
3. liquid oxygen instant gel according to claim 1 is characterized in that: described solvent is also using of water or water and carbomer.
4. liquid oxygen instant gel according to claim 3 is characterized in that: described carbomer is carbomer 934 GE.
5. the described liquid oxygen instant gel of claim 1 can be used for treating vaginitis, rhinitis, otitis, dermatophytosis.
6. the preparation method of the described liquid oxygen instant gel of claim 1, it is characterized in that: poloxamer is added water stir, add carbomer again, stir, make substrate behind swelling, the froth breaking, add medicament nano silver and stir, obtain vagina liquid oxygen instant gel preparation after the employing radiation sterilization.
7. the preparation method of the described liquid oxygen instant gel of claim 1, it is characterized in that: poloxamer is added water stir, add chitosan again, stir, make substrate behind swelling, the froth breaking, add medicament nano silver and stir, obtain nasal cavity liquid oxygen instant gel preparation after the employing radiation sterilization.
8. the preparation method of the described liquid oxygen instant gel of claim 1, it is characterized in that: poloxamer is added water stir, make substrate behind swelling, the froth breaking, add medicament nano silver and stir, obtain vagina liquid oxygen instant gel preparation after the employing radiation sterilization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100254678A CN102119916A (en) | 2011-01-24 | 2011-01-24 | Liquid oxygen in-situ forming gel and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100254678A CN102119916A (en) | 2011-01-24 | 2011-01-24 | Liquid oxygen in-situ forming gel and preparation method and application thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102119916A true CN102119916A (en) | 2011-07-13 |
Family
ID=44248644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011100254678A Pending CN102119916A (en) | 2011-01-24 | 2011-01-24 | Liquid oxygen in-situ forming gel and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102119916A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553337A (en) * | 2018-04-27 | 2018-09-21 | 普宁康特生物科技有限公司 | Special type resists antibacterial thimerosal |
| CN114344359A (en) * | 2021-11-15 | 2022-04-15 | 烟台大学 | Colloidal sol respiratory tract protection spray for preventing pneumonia |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062055A (en) * | 2007-06-06 | 2007-10-31 | 崔彬 | Slowly-released type nanometer silver antibacterial gel and the preparing method and the application thereof |
| CN101695473A (en) * | 2009-10-28 | 2010-04-21 | 武汉华纳联合药业有限公司 | Use and preparation method of vaginal thermosensitive gel |
-
2011
- 2011-01-24 CN CN2011100254678A patent/CN102119916A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101062055A (en) * | 2007-06-06 | 2007-10-31 | 崔彬 | Slowly-released type nanometer silver antibacterial gel and the preparing method and the application thereof |
| CN101695473A (en) * | 2009-10-28 | 2010-04-21 | 武汉华纳联合药业有限公司 | Use and preparation method of vaginal thermosensitive gel |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108553337A (en) * | 2018-04-27 | 2018-09-21 | 普宁康特生物科技有限公司 | Special type resists antibacterial thimerosal |
| CN114344359A (en) * | 2021-11-15 | 2022-04-15 | 烟台大学 | Colloidal sol respiratory tract protection spray for preventing pneumonia |
| CN114344359B (en) * | 2021-11-15 | 2023-10-27 | 烟台大学 | Sol respiratory tract protective spray for protective nose |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101695473A (en) | Use and preparation method of vaginal thermosensitive gel | |
| CN101297973B (en) | Highly bioadhesive and thermosensitive hydrogel, and preparation method and application thereof | |
| EP1930002B1 (en) | Use of hydroxybenzoic acid ester compounds for the manufacture of a medicament for the prevention and treatment of hpv infection | |
| CN101062055A (en) | Slowly-released type nanometer silver antibacterial gel and the preparing method and the application thereof | |
| CN100457084C (en) | Nanometer silver type external use antibiotic gel for female external use and its prepn. method | |
| CN104840485A (en) | Active carbon suppository for treating cervical erosion, and preparation method thereof | |
| WO2011127829A1 (en) | Use of carbon nanoparticles as externl applied medicament for treating hemorrhoid | |
| US20240173359A1 (en) | Ammonia oxidizing microorganisms for use and delivery to the urogenital system | |
| CN102119916A (en) | Liquid oxygen in-situ forming gel and preparation method and application thereof | |
| CN101229126A (en) | Tinidazole compound nano silver microemulsion antibacterial medicine | |
| CN101269058B (en) | Spraying agent containing diclofenac acid and uses thereof | |
| CN104138350A (en) | Baicalein temperature-sensitive gel, preparing method thereof and applications of the gel | |
| US6992073B2 (en) | Use of N-acetyl-D-glucosamine in the manufacture of a medicament for treating cervical erosion | |
| CN103520262B (en) | A kind of lipid soluble gynecological gel | |
| CN112022902A (en) | Preparation method and application of carbon-point modified fluconazole eucalyptus oil microemulsion gel | |
| CN102335462A (en) | Nano iodine-chitosan cervical disease treating membrane agent and preparation method of membrane | |
| CN106177900B (en) | A kind of gel of anti-human papilloma virus (anti-HPV) and preparation method thereof | |
| CN101214246B (en) | Palmatine nano particle preparations and preparation method thereof | |
| CN109771595A (en) | A kind of Chinese medicine composition and preparation method thereof for treating gynaecological imflammation | |
| CN103845303B (en) | It is a kind of for high valency silver ion effervescent tablet of gynecological disease and preparation method thereof | |
| CN102462768A (en) | Female nursing solution for external use | |
| CN110025758A (en) | A kind of Xingnaojing oral gel preparation and preparation method thereof | |
| CN103751230A (en) | Application of gingko extract nanometer liposome in gynecological disease treatment | |
| CN103599093A (en) | Novel anti-HPV (Human Papillomavirus) medicinal preparation and application | |
| CN101352454A (en) | External-use gel foamable composition for gynecology inflammation and obesity |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20110713 |