CN106177900B - A kind of gel of anti-human papilloma virus (anti-HPV) and preparation method thereof - Google Patents
A kind of gel of anti-human papilloma virus (anti-HPV) and preparation method thereof Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/04—Rhodophycota or rhodophyta (red algae), e.g. Porphyra
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
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Abstract
A kind of gel of anti-human papilloma virus (anti-HPV) and preparation method thereof, the ingredient of the gel includes：5 10 parts by weight of carbomer, 0.01 0.4 parts by weight of triclosan, 16 parts by weight of glycerine, 0.1 5 parts by weight of protein extract, 0.1 2 parts by weight of brucea fruit oil, 0.01 6 parts by weight of red algae extract, 0.01 0.8 parts by weight of paraben esters, 0.01 2 parts by weight of Phenoxyethanol, surplus is purified water.It is high that the anti-HPV activity of JB albumen is added in the gel of the present invention, and being added for carbomer can adsorb the HPV of inactivation, package excretes, and accelerate the rotten to the corn quick reparation and regeneration organized, promote healing；Brucea fruit oil has apparent destruction to HPV；Red algae extract carrageenan is effective against human papilloma virus, and help prevents the diseases such as cervical carcinoma caused by the virus, and carrageenan can be attached on the albumen of human papilloma virus, just as together " defence line ", preventing cell entry cervical cell.
Description
Technical field
The present invention relates to gel rubber material technical fields, and in particular to a kind of gel of anti-human papilloma virus (anti-HPV) and its preparation side
Method.
Background technology
With the change of philosophy of life and the deterioration of ambient enviroment, reproductive tract infection increasingly becomes common in women
Disease and frequently-occurring disease.And it is a kind of thermophilic epithelial virus that HPV therein, which is also known as " human papilloma virus ", is distributed in humans and animals
Extensively, there is the specificity of height.The tumour and wart that HPV can cause the mankind benign, no matter men and women is likely to infection HPV.HPV diseases
Disease type male cancer of anus, carcinoma of penis, throat lump and reproductive organs condyloma etc. caused by poison is possible；It is son that women is then mostly
Cervical carcinoma, carcinoma of vulva and carcinoma of vagina, cancer of anus, head and neck cancer etc.；Male reproductive system can additionally be had an impact, Nan Xingsheng
Device candidiasis is grown mostly since it is with occasionally sexual partner infection or indirect infection, furthermore due to some patientss redundant prepuce or phimosis,
Part is moist, has more aggravated the infection of candida albicans.Influences of the HPV for male reproductive system is mainly condyloma acuminatum and genitals
Bleb." high risk " virus equally is classified into for example certain HPV viruse types of the influence of female reproductive system, because they cause
Cytometaplasia, and reproductive organs cancer can be caused：Cervix cancer, carcinoma of vagina are likely to caused by HPV.In fact,
It is all as caused by the HPV viruse of these high risks that all cervix cancers, which are more than 99%,.High risk latency HPV viruse type is
HPV16 types and HPV18 types, these virus types can lead to about 70% cervix cancer.
The drug for being presently used for treatment HPV viruse has ointment, a drug for smearing, such as application No. is
03111091.6, it is entitled《Ointment against virus of human papilloma》Just describe a kind of ointment against virus of human papilloma, and by
(it is the raw material for preparing hypertoxic arsenic, application risk is big, records in wherein containing arsenolite：Sad big heat, it is very toxic, enter lung
Through) and red lead (containing lead element, it is easy to generate lead poisoning) etc. contain toxicant, therefore that there are side effects is big, in being easy
The risk of poison.Also there is the medicine that HPV viruse is carried out using vaccine, but the research and development time is long, risk is big.
Invention content
The present invention is directed to the above-mentioned deficiency of the prior art, provides a kind of Small side effects, good effect, and do not easily lead to poisoning,
Anti-human papilloma virus (anti-HPV) gel.
In order to solve the above-mentioned technical problem, the technical solution adopted by the present invention is：A kind of gel of anti-human papilloma virus (anti-HPV),
The ingredient of the gel includes：Carbomer 5-10 parts by weight, triclosan 0.01-0.4 parts by weight, glycerine 1-6 parts by weight, protein extraction
Object (JB albumen) 0.1-5 parts by weight, brucea fruit oil 0.1-2 parts by weight, red algae extract 0.01-6 parts by weight, paraben esters
0.01-0.8 parts by weight, Phenoxyethanol 0.01-2 parts by weight, surplus is purified water.
As further preferred, the gel of above-mentioned anti-human papilloma virus (anti-HPV) of the invention, the ingredient of the gel includes：Card wave
Nurse 6-9 parts by weight, triclosan 0.02-0.3 parts by weight, glycerine 1.5-5.5 parts by weight, protein extract (JB albumen) 0.2-4 weights
Measure part, brucea fruit oil 0.1-1 parts by weight, red algae extract 0.05-3 parts by weight, paraben esters 0.01-0.6 parts by weight, benzene oxygen second
Alcohol 0.01-1.5 parts by weight, surplus are purified water.
The brucea fruit oil of the present invention is the product obtained by following methods：It is used after taking fresh Java brucea, grinding to smash to pieces
Petroleum ether extracts 2-4 times, and it is 1 (g) to extract the ratio between Java brucea and petroleum ether every time:2-4 (ml), time 40-50h,
Then leaching liquor is filtered, heating water bath volatilization removes petroleum ether and obtains brucea fruit oil.
Red algae extract of the present invention is carrageenan.Protein extract of the present invention is JB albumen.
The present invention also provides a kind of preparation method of the gel of above-mentioned anti-human papilloma virus (anti-HPV), preparation process includes：
(1) according to formula rate, in the case where being stirred continuously, carbomer and glycerine are slowly added into part first
In purified water, it is complete to be allowed to dissolving；
(2) said mixture is pumped into vacuum emulsification tank, then by remaining purified water, triclosan, paraben esters and benzene oxygen
Ethyl alcohol is added in vacuum emulsification tank, and stirring vacuumizes degassing；
(3) after the dissolving completely of the above mixture, other surplus stocks is added, continue to vacuumize after stirring evenly, degassing to production
Product bubble-free, is cooled to room temperature.
The advantages of the present invention：
1. being added to JB albumen in the gel of the present invention, there is very high anti-HPV activity, can be good at treating HPV,
And being added for carbomer can adsorb the HPV of inactivation, package excretes, and accelerate the rotten to the corn quick reparation and regeneration organized,
Promote healing；Brucea fruit oil has the effects that clearing heat and detoxicating, corrosion wart, has apparent destruction to HPV；The present invention's is red
Algae extract carrageenan is effective against human papilloma virus, and help prevents the diseases such as cervical carcinoma caused by the virus, carrageenan energy
It is enough attached on the albumen of human papilloma virus, just as together " defence line ", preventing cell entry cervical cell；The addition energy of glycerine
Enough adjust product characteristics so that gel is located at lesions position long action time, good effect；In addition, paraben esters and Phenoxyethanol
Be applied in combination and can play antibacterial, corrosion-resistant effect.
2. the present invention uses brucea fruit oil and red algae extract as anti-HPV drug ingedients for the first time, while taking into account other and have
Component is imitated, synergistic effect is played, the drug of acquisition has good mass effect.
Specific implementation mode
With reference to embodiment, present invention will be explained in further detail, but is not limited only to following embodiment.
Embodiment 1
The ingredient of the gel includes：6 parts by weight of carbomer, 0.02 parts by weight of triclosan, 3 parts by weight of glycerine, protein extraction
Object (JB albumen) 0.5 parts by weight, 0.5 parts by weight of brucea fruit oil, 3 parts by weight of red algae extract, 0.05 parts by weight of paraben esters, benzene
0.06 parts by weight of oxyethanol, surplus are purified water.
The brucea fruit oil of the present invention is the product obtained by following methods：After taking fresh Java brucea 50g, grinding to smash to pieces
It is extracted 3 times with petroleum ether, the ratio for extracting every time between Java brucea and petroleum ether is 150ml, time 45h, then filtering leaching
Extract, heating water bath volatilization remove petroleum ether and obtain brucea fruit oil.
The preparation method of the gel of above-mentioned anti-human papilloma virus (anti-HPV), preparation process include：
(1) in the case where being stirred continuously, carbomer and glycerine is slowly added into part first and gone in purified water, is allowed to
Dissolving is complete；
(2) said mixture is pumped into vacuum emulsification tank, then remaining purified water, triclosan, paraben esters and benzene will be removed
Oxyethanol is added in vacuum emulsification tank, and stirring vacuumizes degassing；
(3) after the dissolving completely of the above mixture, other surplus stocks is added, continue to vacuumize after stirring evenly, degassing to production
Product bubble-free, is cooled to room temperature.
Embodiment 2
The ingredient of the gel includes：9 parts by weight of carbomer, 0.3 parts by weight of triclosan, 4 parts by weight of glycerine, protein extract
(JB albumen) 0.8 parts by weight, 0.3 parts by weight of brucea fruit oil, 4 parts by weight of red algae extract, 0.5 parts by weight of paraben esters, benzene oxygen
1 parts by weight of ethyl alcohol, surplus are purified water.
Method is the same as embodiment 1.
Embodiment 3
The ingredient of the gel includes：6 parts by weight of carbomer, 0.03 parts by weight of triclosan, 2 parts by weight of glycerine, protein extraction
Object (JB albumen) 2 parts by weight, 1 parts by weight of brucea fruit oil, 5 parts by weight of red algae extract, 0.8 parts by weight of paraben esters, benzene oxygen second
2 parts by weight of alcohol, surplus are purified water.
Method is the same as embodiment 1.
Comparative example
The ingredient of the gel includes：6 parts by weight of carbomer, 0.03 parts by weight of triclosan, 2 parts by weight of glycerine, protein extraction
Object (JB albumen) 2 parts by weight, 0.8 parts by weight of paraben esters, 2 parts by weight of Phenoxyethanol, surplus is purified water.The same embodiment of method
1。
Sample prepared by the embodiment of the present invention, using effect：Volunteer is divided into 3 groups, every group of 100 people.First group
After (test group) volunteer cleans vagina every night with warm water, gelling agent 3g prepared by Example 1 is coated on labia week
Enclose with inside vagina；Second group (control group) takes commercially available current therapies HPV medicaments to compare, each dosage 3g；Every group continuously makes
With first time check is carried out after two weeks, checked for second after 10 weeks；Third group (comparative example group) takes medicine prepared by comparative example
Agent compares, each dosage 3g；First time check, second of review result after 10 weeks are carried out after every group of continuous use two weeks
It is shown in Table 1.
1 two groups of patient clinical Comparison of therapeutic of table
As can be known from the above table, the gel that prepared by the present invention has the advantages that cure rate is high, eutherapeutic；And comparative example is shown, no
Using the brucea fruit oil and red algae extract of the present invention, effective percentage is decreased obviously.
Claims (2)
1. a kind of gel of anti-human papilloma virus (anti-HPV), it is characterised in that：
The ingredient of the gel includes：6 parts by weight of carbomer, 0.02 parts by weight of triclosan, 3 parts by weight of glycerine, protein extract 0.5
Parts by weight, 0.5 parts by weight of brucea fruit oil, 3 parts by weight of red algae extract, 0.05 parts by weight of paraben esters, 0.06 weight of Phenoxyethanol
Part is measured, surplus is purified water；
Or
The ingredient of the gel includes：9 parts by weight of carbomer, 0.3 parts by weight of triclosan, 4 parts by weight of glycerine, protein extract 0.8
Parts by weight, 0.3 parts by weight of brucea fruit oil, 4 parts by weight of red algae extract, 0.5 parts by weight of paraben esters, 1 parts by weight of Phenoxyethanol,
Surplus is purified water；
Or
The ingredient of the gel includes：6 parts by weight of carbomer, 0.03 parts by weight of triclosan, 2 parts by weight of glycerine, 2 weight of protein extract
Measure part, 1 parts by weight of brucea fruit oil, 5 parts by weight of red algae extract, 0.8 parts by weight of paraben esters, 2 parts by weight of Phenoxyethanol, surplus
For purified water；
The preparation process of the brucea fruit oil is：Take fresh Java brucea, grinding with petroleum ether extracts 2-4 times after smashing to pieces, often
Ratio between secondary extraction Java brucea and petroleum ether is 1（g）:2-4（ml）, the time be 40-50 h, then filter leaching liquor, water
Bath heating volatilization removes petroleum ether and obtains brucea fruit oil；The red algae extract is carrageenan；
The protein extract is JB albumen.
2. the gel of anti-human papilloma virus (anti-HPV) according to claim 1, it is characterised in that：Preparation process includes：
（1）According to formula rate, in the case where being stirred continuously, part is added in carbomer and glycerine first and is gone in purified water,
It is complete to be allowed to dissolving；
（2）By above-mentioned steps（1）Mixture be pumped into vacuum emulsification tank, then by remaining purified water, triclosan, nipalgin
Ester and Phenoxyethanol are added in vacuum emulsification tank, and stirring vacuumizes degassing；
（3）After the above mixture dissolving completely after, other surplus stocks are added, continue to vacuumize after stirring evenly, degassing to product without
Bubble is cooled to room temperature.
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| CN111249439A (en) * | 2020-03-25 | 2020-06-09 | 重庆旭天生物科技有限公司 | anti-HPV biological protein gel and preparation method thereof |
| CN112190707A (en) * | 2020-09-16 | 2021-01-08 | 河南有为医药科技有限公司 | anti-HPV recombinant human gel and preparation method thereof |
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| CN1355045A (en) * | 2001-11-27 | 2002-06-26 | 王永信 | 'Shiyoushaxing' ointment for treating pointed condyloma and its preparing process |
| CN102178668A (en) * | 2011-03-23 | 2011-09-14 | 广州中医药大学第二附属医院 | Application of linoleic acid in preparing human papillomavirus (HPV) resisting medicament |
| CN102908611A (en) * | 2012-10-26 | 2013-02-06 | 太原锦波生物医药科技有限公司 | Bioprotein dressing and bioprotein invisible film for preventing and controlling human papilloma virus infection |
| CN105542024A (en) * | 2016-01-06 | 2016-05-04 | 上海交通大学 | Red alga gracilariopsis lemaneiformis polysaccharide and preparation thereof, anti-tumor activity detection method and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104491838B (en) * | 2014-12-19 | 2017-04-19 | 海南森瑞谱生命科学药业股份有限公司 | Anti-HPV (human papillomavirus) gel dressing and preparation method thereof |
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- 2016-08-19 CN CN201610694240.5A patent/CN106177900B/en active Active
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|---|---|---|---|---|
| CN1355045A (en) * | 2001-11-27 | 2002-06-26 | 王永信 | 'Shiyoushaxing' ointment for treating pointed condyloma and its preparing process |
| CN102178668A (en) * | 2011-03-23 | 2011-09-14 | 广州中医药大学第二附属医院 | Application of linoleic acid in preparing human papillomavirus (HPV) resisting medicament |
| CN102908611A (en) * | 2012-10-26 | 2013-02-06 | 太原锦波生物医药科技有限公司 | Bioprotein dressing and bioprotein invisible film for preventing and controlling human papilloma virus infection |
| CN105542024A (en) * | 2016-01-06 | 2016-05-04 | 上海交通大学 | Red alga gracilariopsis lemaneiformis polysaccharide and preparation thereof, anti-tumor activity detection method and application |
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| 红藻提取物可预防宫颈癌.《中成药》.2006,(第08期), * |
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