CN111249439A - anti-HPV biological protein gel and preparation method thereof - Google Patents
anti-HPV biological protein gel and preparation method thereof Download PDFInfo
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- CN111249439A CN111249439A CN202010218312.5A CN202010218312A CN111249439A CN 111249439 A CN111249439 A CN 111249439A CN 202010218312 A CN202010218312 A CN 202010218312A CN 111249439 A CN111249439 A CN 111249439A
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- A61K38/02—Peptides of undefined number of amino acids; Derivatives thereof
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
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- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/04—Antipruritics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract
The invention discloses an anti-HPV bioprotein gel, which comprises the following raw materials in percentage by mass: biological protein, carbomer and the balance of water; the invention also discloses a preparation method of the anti-HPV bioprotein gel; the anti-HPV bioprotein gel prepared by the invention is prepared by adding bioprotein, bioprotein (molecular formula C)118H197N35O21S1) Negative charges carried on the surface are electrostatically adsorbed with positive charges of Human Papilloma Virus (HPV), so that the HPV is blocked from entering host target cells outside cells to a certain extent, and the aim of reducing the local HPV load is fulfilled; the carbomer can adsorb and wrap inactivated HPV to be discharged out of a body, accelerate the rapid repair and regeneration of an erosion tissue and promote healing, so that the safe and effective anti-HPV medicine without side effects is obtained.
Description
Technical Field
The invention relates to the field of medicines, in particular to an anti-HPV bioprotein gel and a preparation method thereof.
Background
Human papilloma virus is a papilloma vacuolatum virus A belonging to papovaviridae, is a spherical DNA virus and can cause squamous epithelial proliferation of human skin mucosa; the symptoms of common wart, genital wart (condyloma acuminatum) and the like; human Papillomavirus (HPV) infection is attracting more and more attention with the rapidly increasing incidence rate of condyloma acuminatum in venereal diseases and the increasing of cervical cancer, anal cancer and the like.
However, the existing medicines for treating HPV virus comprise ointment which is a medicine for smearing, the ointment contains arsenic and red lead, arsenic is a raw material for preparing the arsenic with strong toxicity, the use risk is high, and the red lead contains lead elements, so that lead poisoning is easily caused, and the ointment has the large side effect and the risk of easy poisoning.
Disclosure of Invention
The invention aims to provide an anti-HPV bioprotein gel and a preparation method thereof, so as to solve the problems in the background technology.
In order to achieve the purpose, the invention provides the following technical scheme:
an anti-HPV bioprotein gel comprises the following raw materials in percentage by mass: 0.02-0.08% of bioprotein, 0.2-0.5% of carbomer and the balance of water.
As a further scheme of the invention: the composite material comprises the following raw materials in percentage by mass: 0.03-0.07% of bioprotein, 0.25-0.45% of carbomer and the balance of water.
As a still further scheme of the invention: the composite material comprises the following raw materials in percentage by mass: 0.04-0.06% of bioprotein, 0.28-0.42% of carbomer and the balance of water.
As a still further scheme of the invention: the composite material comprises the following raw materials in percentage by mass: 0.05-0.055% of bioprotein, 0.3-0.4% of carbomer and the balance of water.
As a still further scheme of the invention: the composite material comprises the following raw materials in percentage by mass: 0.055% of biological protein, 0.35% of carbomer and the balance of water.
As a still further scheme of the invention: the water is purified water.
A method for preparing anti-HPV bioprotein gel comprises the following steps:
1) according to the mass percentage, adding carbomer into part of purified water under the condition of continuously stirring, and stirring to completely dissolve carbomer to obtain a solution A;
2) transferring the solution A into a vacuum emulsification tank, adding the residual purified water into the vacuum emulsification tank, stirring, vacuumizing and degassing to obtain a mixture B;
3) and after the mixture B is completely dissolved, wiping the feeding port of the vacuum emulsification tank with alcohol for disinfection, starting an ozone machine to disinfect the emulsification environment for 30-40 min, naturally ventilating after disinfection, adding biological protein, continuously stirring for 30-35 min, vacuumizing and degassing until the product in the vacuum emulsification tank is bubble-free and transparent, and cooling to room temperature.
Compared with the prior art, the invention has the beneficial effects that:
the anti-HPV bioprotein gel prepared by the invention is prepared by adding bioprotein, bioprotein (molecular formula C)118H197N35O21S1) Negative charges carried on the surface are electrostatically adsorbed with positive charges of Human Papilloma Virus (HPV), so that the HPV is blocked from entering host target cells outside cells to a certain extent, and the aim of reducing the local HPV load is fulfilled; can be used for treating infection of high risk type HPV in genital tract; for the treatment of low-grade cervical lesions (CIN grade I) caused by high-risk HPV infection; blocking genital tract HPV infection, preventing cervical precancerous lesion (CIN) and cervical cancer; the vaginal microenvironment is improved, the vaginal inflammatory reaction is relieved, the abnormal vaginal secretion amount is reduced, and the vaginal cleanliness is effectively improved; can be used for treating vaginal odor and pruritus caused by various vaginal inflammations; the carbomer can adsorb and wrap inactivated HPV to be discharged out of a body, accelerate the rapid repair and regeneration of an erosion tissue and promote healing, so that the safe and effective anti-HPV medicine without side effects is obtained.
Detailed Description
The technical solution of the present invention will be described in further detail with reference to specific embodiments.
Example 1
An anti-HPV bioprotein gel comprises the following raw materials in percentage by mass: 0.055% of biological protein, 0.2% of carbomer and the balance of water.
Wherein the water is purified water.
The preparation method of the anti-HPV bioprotein gel is characterized by comprising the following steps:
1) according to the mass percentage, adding carbomer into part of purified water under the condition of continuously stirring, and stirring to completely dissolve carbomer to obtain a solution A;
2) transferring the solution A into a vacuum emulsification tank, adding the residual purified water into the vacuum emulsification tank, stirring, vacuumizing and degassing to obtain a mixture B;
3) and after the mixture B is completely dissolved, wiping the feeding port of the vacuum emulsification tank with alcohol for disinfection, starting an ozone machine to disinfect the emulsification environment for 35min, naturally ventilating after disinfection, adding biological protein, continuously stirring for 32min, vacuumizing and degassing until the product in the vacuum emulsification tank is bubble-free and transparent, and cooling to room temperature.
Example 2
An anti-HPV bioprotein gel comprises the following raw materials in percentage by mass: 0.02% of biological protein, 0.5% of carbomer and the balance of water.
Wherein the water is purified water.
The preparation method of the anti-HPV bioprotein gel is characterized by comprising the following steps:
1) according to the mass percentage, adding carbomer into part of purified water under the condition of continuously stirring, and stirring to completely dissolve carbomer to obtain a solution A;
2) transferring the solution A into a vacuum emulsification tank, adding the residual purified water into the vacuum emulsification tank, stirring, vacuumizing and degassing to obtain a mixture B;
3) and after the mixture B is completely dissolved, wiping the feeding port of the vacuum emulsification tank with alcohol for disinfection, starting an ozone machine to disinfect the emulsification environment for 30min, naturally ventilating after disinfection, adding biological protein, continuously stirring for 35min, vacuumizing and degassing until the product in the vacuum emulsification tank is bubble-free and transparent, and cooling to room temperature.
Example 3
An anti-HPV bioprotein gel comprises the following raw materials in percentage by mass: 0.08% of biological protein, 0.25% of carbomer and the balance of water.
Wherein the water is purified water.
The preparation method of the anti-HPV bioprotein gel is characterized by comprising the following steps:
1) according to the mass percentage, adding carbomer into part of purified water under the condition of continuously stirring, and stirring to completely dissolve carbomer to obtain a solution A;
2) transferring the solution A into a vacuum emulsification tank, adding the residual purified water into the vacuum emulsification tank, stirring, vacuumizing and degassing to obtain a mixture B;
3) and after the mixture B is completely dissolved, wiping the feeding port of the vacuum emulsification tank with alcohol for disinfection, starting an ozone machine to disinfect the emulsification environment for 40min, naturally ventilating after disinfection, adding biological protein, continuously stirring for 30min, vacuumizing and degassing until the product in the vacuum emulsification tank is bubble-free and transparent, and cooling to room temperature.
Example 4
An anti-HPV bioprotein gel comprises the following raw materials in percentage by mass: 0.03% of biological protein, 0.45% of carbomer and the balance of water.
Wherein the water is purified water.
The preparation method of the anti-HPV bioprotein gel is characterized by comprising the following steps:
1) according to the mass percentage, adding carbomer into part of purified water under the condition of continuously stirring, and stirring to completely dissolve carbomer to obtain a solution A;
2) transferring the solution A into a vacuum emulsification tank, adding the residual purified water into the vacuum emulsification tank, stirring, vacuumizing and degassing to obtain a mixture B;
3) and after the mixture B is completely dissolved, wiping the feeding port of the vacuum emulsification tank with alcohol for disinfection, starting an ozone machine to disinfect the emulsification environment for 30min, naturally ventilating after disinfection, adding biological protein, continuously stirring for 30min, vacuumizing and degassing until the product in the vacuum emulsification tank is bubble-free and transparent, and cooling to room temperature.
Example 5
An anti-HPV bioprotein gel comprises the following raw materials in percentage by mass: 0.07% of biological protein, 0.28% of carbomer and the balance of water.
Wherein the water is purified water.
The preparation method of the anti-HPV bioprotein gel is characterized by comprising the following steps:
1) according to the mass percentage, adding carbomer into part of purified water under the condition of continuously stirring, and stirring to completely dissolve carbomer to obtain a solution A;
2) transferring the solution A into a vacuum emulsification tank, adding the residual purified water into the vacuum emulsification tank, stirring, vacuumizing and degassing to obtain a mixture B;
3) and after the mixture B is completely dissolved, wiping the feeding port of the vacuum emulsification tank with alcohol for disinfection, starting an ozone machine to disinfect the emulsification environment for 40min, naturally ventilating after disinfection, adding biological protein, continuously stirring for 35min, vacuumizing and degassing until the product in the vacuum emulsification tank is bubble-free and transparent, and cooling to room temperature.
Example 6
An anti-HPV bioprotein gel comprises the following raw materials in percentage by mass: 0.06% of biological protein, 0.42% of carbomer and the balance of water.
Wherein the water is purified water.
The preparation method of the anti-HPV bioprotein gel is characterized by comprising the following steps:
1) according to the mass percentage, adding carbomer into part of purified water under the condition of continuously stirring, and stirring to completely dissolve carbomer to obtain a solution A;
2) transferring the solution A into a vacuum emulsification tank, adding the residual purified water into the vacuum emulsification tank, stirring, vacuumizing and degassing to obtain a mixture B;
3) and after the mixture B is completely dissolved, wiping the feeding port of the vacuum emulsification tank with alcohol for disinfection, starting an ozone machine to disinfect the emulsification environment for 30min, naturally ventilating after disinfection, adding biological protein, continuously stirring for 35min, vacuumizing and degassing until the product in the vacuum emulsification tank is bubble-free and transparent, and cooling to room temperature.
Example 7
An anti-HPV bioprotein gel comprises the following raw materials in percentage by mass: 0.04% of biological protein, 0.3% of carbomer and the balance of water.
Wherein the water is purified water.
The preparation method of the anti-HPV bioprotein gel is characterized by comprising the following steps:
1) according to the mass percentage, adding carbomer into part of purified water under the condition of continuously stirring, and stirring to completely dissolve carbomer to obtain a solution A;
2) transferring the solution A into a vacuum emulsification tank, adding the residual purified water into the vacuum emulsification tank, stirring, vacuumizing and degassing to obtain a mixture B;
3) and after the mixture B is completely dissolved, wiping the feeding port of the vacuum emulsification tank with alcohol for disinfection, starting an ozone machine to disinfect the emulsification environment for 40min, naturally ventilating after disinfection, adding biological protein, continuously stirring for 35min, vacuumizing and degassing until the product in the vacuum emulsification tank is bubble-free and transparent, and cooling to room temperature.
Example 8
An anti-HPV bioprotein gel comprises the following raw materials in percentage by mass: 0.055% of biological protein, 0.4% of carbomer and the balance of water.
Wherein the water is purified water.
The preparation method of the anti-HPV bioprotein gel is characterized by comprising the following steps:
1) according to the mass percentage, adding carbomer into part of purified water under the condition of continuously stirring, and stirring to completely dissolve carbomer to obtain a solution A;
2) transferring the solution A into a vacuum emulsification tank, adding the residual purified water into the vacuum emulsification tank, stirring, vacuumizing and degassing to obtain a mixture B;
3) and after the mixture B is completely dissolved, wiping the feeding port of the vacuum emulsification tank with alcohol for disinfection, starting an ozone machine to disinfect the emulsification environment for 35min, naturally ventilating after disinfection, adding biological protein, continuously stirring for 35min, vacuumizing and degassing until the product in the vacuum emulsification tank is bubble-free and transparent, and cooling to room temperature.
Example 9
An anti-HPV bioprotein gel comprises the following raw materials in percentage by mass: 0.05% of biological protein, 0.35% of carbomer and the balance of water.
Wherein the water is purified water.
The preparation method of the anti-HPV bioprotein gel is characterized by comprising the following steps:
1) according to the mass percentage, adding carbomer into part of purified water under the condition of continuously stirring, and stirring to completely dissolve carbomer to obtain a solution A;
2) transferring the solution A into a vacuum emulsification tank, adding the residual purified water into the vacuum emulsification tank, stirring, vacuumizing and degassing to obtain a mixture B;
3) and after the mixture B is completely dissolved, wiping the feeding port of the vacuum emulsification tank with alcohol for disinfection, starting an ozone machine to disinfect the emulsification environment for 30min, naturally ventilating after disinfection, adding biological protein, continuously stirring for 35min, vacuumizing and degassing until the product in the vacuum emulsification tank is bubble-free and transparent, and cooling to room temperature.
The anti-HPV bioprotein gel prepared by the invention is prepared by adding bioprotein, bioprotein (molecular formula C)118H197N35O21S1) Negative charges carried on the surface are electrostatically adsorbed with positive charges of Human Papilloma Virus (HPV), so that the HPV is blocked from entering host target cells outside cells to a certain extent, and the aim of reducing the local HPV load is fulfilled; can be used for treating genital tractInfection of high risk HPV; for the treatment of low-grade cervical lesions (CIN grade I) caused by high-risk HPV infection; blocking genital tract HPV infection, preventing cervical precancerous lesion (CIN) and cervical cancer; the vaginal microenvironment is improved, the vaginal inflammatory reaction is relieved, the abnormal vaginal secretion amount is reduced, and the vaginal cleanliness is effectively improved; can be used for treating vaginal odor and pruritus caused by various vaginal inflammations; the carbomer can adsorb and wrap inactivated HPV to be discharged out of a body, accelerate the rapid repair and regeneration of an erosion tissue and promote healing, so that the safe and effective anti-HPV medicine without side effects is obtained.
While the preferred embodiments of the present invention have been described in detail, the present invention is not limited to the above embodiments, and various changes can be made without departing from the spirit of the present invention within the knowledge of those skilled in the art.
Claims (7)
1. The anti-HPV bioprotein gel is characterized by comprising the following raw materials in percentage by mass: 0.02-0.08% of bioprotein, 0.2-0.5% of carbomer and the balance of water.
2. The anti-HPV bioprotein gel of claim 1 comprising the following raw materials in mass percent: 0.03-0.07% of bioprotein, 0.25-0.45% of carbomer and the balance of water.
3. The anti-HPV bioprotein gel of claim 2 comprising the following raw materials in mass percent: 0.04-0.06% of bioprotein, 0.28-0.42% of carbomer and the balance of water.
4. The anti-HPV bioprotein gel of claim 3 comprising the following raw materials in mass percent: 0.05-0.055% of bioprotein, 0.3-0.4% of carbomer and the balance of water.
5. The anti-HPV bioprotein gel of claim 4 comprising the following raw materials in mass percent: 0.05% of biological protein, 0.35% of carbomer and the balance of water.
6. The anti-HPV bioprotein gel of any one of claims 1-5, wherein the water is purified water.
7. A method of preparing an anti-HPV bioprotein gel of claim 6, comprising the steps of:
1) according to the mass percentage, adding carbomer into part of purified water under the condition of continuously stirring, and stirring to completely dissolve carbomer to obtain a solution A;
2) transferring the solution A into a vacuum emulsification tank, adding the residual purified water into the vacuum emulsification tank, stirring, vacuumizing and degassing to obtain a mixture B;
3) and after the mixture B is completely dissolved, wiping the feeding port of the vacuum emulsification tank with alcohol for disinfection, starting an ozone machine to disinfect the emulsification environment for 30-40 min, naturally ventilating after disinfection, adding biological protein, continuously stirring for 30-35 min, vacuumizing and degassing until the product in the vacuum emulsification tank is bubble-free and transparent, and cooling to room temperature.
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Cited By (7)
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| CN112402559A (en) * | 2020-11-26 | 2021-02-26 | 通化仁生源生物科技股份有限公司 | Compositions for the prevention and treatment of HPV viral infections and methods for their preparation |
| CN113476396A (en) * | 2021-06-15 | 2021-10-08 | 四川滋兴生物科技有限公司 | anti-HPV gel and production process thereof |
| CN113577244A (en) * | 2021-08-09 | 2021-11-02 | 高丽莉 | Traditional Chinese medicine anti-HPV gel containing biological protein and preparation method thereof |
| CN114129553A (en) * | 2020-09-04 | 2022-03-04 | 安徽德莱康生物医疗科技有限公司 | anti-HPV bioprotein gel containing garlic extract |
| CN114159614A (en) * | 2021-12-13 | 2022-03-11 | 河南汇博医疗股份有限公司 | anti-HPV protein dressing and preparation method thereof |
| CN114767921A (en) * | 2022-03-03 | 2022-07-22 | 吉林省国大生物工程有限公司 | Preparation method and application of negatively charged anti-HPV biological protein gel dressing |
| CN116808275A (en) * | 2023-05-09 | 2023-09-29 | 辽宁美滋林药业有限公司 | HPV (human papilloma Virus) resistant biological protein dressing and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114129553A (en) * | 2020-09-04 | 2022-03-04 | 安徽德莱康生物医疗科技有限公司 | anti-HPV bioprotein gel containing garlic extract |
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| CN114767921A (en) * | 2022-03-03 | 2022-07-22 | 吉林省国大生物工程有限公司 | Preparation method and application of negatively charged anti-HPV biological protein gel dressing |
| CN116808275A (en) * | 2023-05-09 | 2023-09-29 | 辽宁美滋林药业有限公司 | HPV (human papilloma Virus) resistant biological protein dressing and preparation method thereof |
| CN116808275B (en) * | 2023-05-09 | 2024-03-22 | 辽宁美滋林药业有限公司 | HPV (human papilloma Virus) resistant biological protein dressing and preparation method thereof |
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