CN102114238A - Ointment for treating herpes zoster and preparation method thereof - Google Patents
Ointment for treating herpes zoster and preparation method thereof Download PDFInfo
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Abstract
The invention relates to an ointment for treating herpes zoster and a preparation method thereof and belongs to the field of external traditional Chinese medicines. The invention aims to solve the technical problems that antibiotic and antiviral medicaments for treating the herpes zoster have a slow medicinal effect, an unsatisfactory effect and high cost at present. The ointment for treating the herpes zoster is prepared from glycerin monostearate, stearic acid, butylated hydroxytoluene, cetyl alcohol, octadecanol, chamomile, squalane, dimethyl silicon oil, hydrogenated polydecylene, borneol, glycerin, Chinese medicinal concentrated solution, superfine lithium Tomalin powder, 0.4 to 6.0 percent of gingerol solution, capsaicin solution, menthol, musk, salicylic acid and deionized water by a decocting method. The ointment has the advantages of quick response of medicinal effects, short using time, ideal effect and low cost.
Description
Technical field
The invention belongs to the external field of Chinese medicines, be specifically related to ointment for the treatment of herpes zoster and preparation method thereof.
Background technology
Herpes zoster is a kind of common acute herpetic dermatosis due to the viral infection, and doctor trained in Western medicine is referred to as " herpes zoster "; The traditional Chinese medical science is referred to as " erysipelas ", claims " skirt-roof HUOLONG ", " herpes zoster " at the costa sternales position; Be called " Aranea pellet ", " herpes zoster " etc. at other position; Its main feature is for bunch catchmenting bubble, along the zonal distribution of trooping of side peripheral nerve do, often with obvious neuralgia.At present, there is the shortcoming that the drug effect onset is slow, effect is undesirable, expense is big in treatments such as clinical employing antibiotic and antiviral drugs.
Summary of the invention
The present invention will solve present employing antibiotic and there is the technical problem that the drug effect onset is slow, effect is undesirable, expense is big in the antiviral treatment herpes zoster; Treat ointment of herpes zoster and preparation method thereof and provide.
The ointment of treatment herpes zoster is by weight percentage by 1.0%～2.0% glyceryl monostearate among the present invention, 1.5%～2.5% stearic acid, 0.05%～0.07% dibenzylatiooluene, 3.0%～5.0% hexadecanol, 2.0%～4.0% octadecanol, 2.0%～4.0% Flos Matricariae chamomillae, 0.1%～0.3% squalane, 2.0%～4.0% dimethicone, 5.0%～7.0% hydrogenated polydecene, 0.05%～0.07% Borneolum Syntheticum, 6.0%～10.0% glycerol, 1.0%～3.0% Chinese medicine concentrated solution, 10.0%～14.0% ultra-fine lithium tourmaline powder, 0.4%～6.0% gingerol liquid, 0.4%～6.0% capsaicin liquid, 2.5%～6.5% Mentholum, 0.01%～0.05% Moschus, 0.05%～0.15% salicylic acid and balance of deionized water are formed; Wherein said Chinese medicine concentrated solution is 20 gram Radix Notoginseng, 30 gram Herba speranskiae tuberculataes, 20 gram Flos Carthamis, 30 gram Rhizoma Chuanxiongs, the 20 gram Radixs Angelicae Dahuricae, 20 gram Radix Angelicae Sinensis, 20 gram Radix Saposhnikoviaes, 20 gram Borneolum Syntheticums, 20 gram Radix Isatidiss and 20 gram Olibanums to be decocted 800 after with 2000 gram water loggings bubbles restrain and make.
The preparation method of ointment of treatment herpes zoster is undertaken by following step among the present invention: one, 20 gram Radix Notoginseng, 30 gram Herba speranskiae tuberculataes, 20 gram Flos Carthamis, 30 gram Rhizoma Chuanxiongs, the 20 gram Radixs Angelicae Dahuricae, 20 gram Radix Angelicae Sinensis, 20 gram Radix Saposhnikoviaes, 20 gram Borneolum Syntheticums, 20 gram Radix Isatidiss, 0.01 gram Moschus and 20 gram Olibanums are decocted into 800 after with 2000 gram water loggings bubbles and restrain, promptly obtain the Chinese medicine concentrated solution;
Two, take by weighing 1.0%～2.0% glyceryl monostearate by weight percentage respectively, 1.5%～2.5% stearic acid, 0.05%～0.07% dibenzylatiooluene, 3.0%～5.0% hexadecanol, 2.0%～4.0% octadecanol, 2.0%～4.0% Flos Matricariae chamomillae, 0.1%～0.3% squalane, 2.0%～4.0% dimethicone, 5.0%～7.0% hydrogenated polydecene, 0.05%～0.07% Borneolum Syntheticum, 6.0%～10.0% glycerol, the Chinese medicine concentrated solution of 1.0%～3.0% step 1 preparation, 10.0%～14.0% ultra-fine lithium tourmaline powder, 0.4%～6.0% gingerol liquid, 0.4%～6.0% capsaicin liquid, 1.5%～3.5% Mentholum, 0.01%～0.05% Moschus, 0.05%～0.15% salicylic acid and balance of deionized water;
Three, the glyceryl monostearate that the Mentholum and the step 2 of the step 2 amount of taking by weighing 10%～40% taken by weighing, stearic acid, dibenzylatiooluene, hexadecanol, octadecanol, Flos Matricariae chamomillae, squalane, dimethicone, hydrogenated polydecene and Borneolum Syntheticum mix, under stirring, 70～80 ℃ of conditions, heat, obtain the A component;
Four, remaining Mentholum and the glycerol that step 2 is taken by weighing, Chinese medicine concentrated solution, ultra-fine lithium tourmaline powder, gingerol liquid, capsaicin liquid, salicylic acid and deionized water are mixed, stir, heating obtains the B component under 70～80 ℃ of conditions;
Five, while hot A component and B component are mixed, agitating heating stops heating, continues to be stirred to room temperature; The ointment of herpes zoster promptly obtains medical treatment.
Chinese crude drug Flos Carthami of the present invention---function cures mainly: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.Be used for amenorrhea, dysmenorrhea, the not all right, WEIJIA of lochia mass in the abdomen, injury from falling down, skin infection swells and ache.
Radix Notoginseng---function cures mainly: hemostasis, dissipating blood stasis, detumescence, analgesic therapy.Be used for spitting of blood, spit blood, epistaxis is had blood in stool, metrorrhagia, traumatic hemorrhage, breast ventral spine pain, tumbling and swelling.
Herba speranskiae tuberculatae---function cures mainly: expelling wind and removing dampness, active blood stasis dispelling, promoting blood circulation and stopping pain, eliminating toxic substances to remove stasis.Be used for rheumatic arthralgia, muscles and bones contracture, the disturbance of lower legs due to pathogenic cold and dampness, lumbar strain, paralysis, amenorrhea, eczema scrotum, furuncle toxic swelling.
The Flos Carthami Flos Carthami---function cures mainly: promoting blood circulation to restore menstrual flow, go the pain relieving of becoming silted up.Control amenorrhea ， mass in the abdomen, difficult labour, stillborn fetus, disease that postpartum lochia can't go, congestion is had a pain, carbuncle, injury from falling down
Rhizoma Chuanxiong---function cures mainly: blood-activating and qi-promoting, wind-expelling pain-stopping is used for menoxenia, amenorrhea dysmenorrhea ， WEIJIA stomachache, the twinge of the breast side of body, tumbling and swelling, headache, rheumatic arthralgia.
The Radix Angelicae Dahuricae---function cures mainly: expelling wind and removing dampness, understand things pain-stopping, detumescence and apocenosis.Be used for headache due to common cold, supraorbital bone pain, nasal obstruction, nasal sinusitis, toothache, leucorrhea, skin infection swells and ache.
Radix Angelicae Sinensis---function cures mainly: enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Radix Saposhnikoviae---function cures mainly: deliver, dispel the wind, win and wet, pain relieving.Control affection of exogenous wind-cold, headache, dizzy, stiffness of the nape, anemofrigid-damp arthralgia, joint is ached, and the extremity contraction is anxious, tetanus.
Borneolum Syntheticum---function cures mainly: the refreshment of having one's ideas straightened out, clearing away heat to alleviate pain.Be used for the calentura coma, faint from fear, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, conjunctival congestion, aphtha, laryngopharynx swelling and pain, auditory meatus is suppurated.
Radix Isatidis---function cures mainly: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving.Be used for maculae caused by violent heat pathogen, crimson tongue is purple dark, mumps, sore throat, scarlet fever, major part pestilence, erysipelas, carbuncle.
Moschus---function cures mainly: the refreshment of having one's ideas straightened out, promoting blood circulation to restore menstrual flow, reducing swelling and alleviating pain.Be used for the calentura coma, the apoplexy syncope due to accumulation of phlegm, stagnation of QI sudden syncope, the attacked by pestiferous factors stupor, amenorrhea ， WEIJIA, the difficult labour stillborn fetus, trusted subordinate's sudden pain, the carbuncle scrofula, laryngopharynx swelling and pain falls and pounces on the pain of injury, the arthralgia pain numbness.
Olibanum---function cures mainly: regulating qi and activating blood, analgesic therapy chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Lithium tourmaline powder far infrared has heat effect.The one, the activity of activation biomacromolecule; The 2nd, the blood circulation of promotion and improvement part and whole body; The 3rd, strengthen metabolism; The 4th, improve immunologic function; The 5th, have antiinflammatory, detumescence effect; The 6th, analgesic activity is arranged.Far infrared has activated water molecule, activation histiocyte, the effect of microcirculation improvement in addition.
Lithium tourmaline powder can automatically for good and all discharge anion.Anion has direct effect to promoting health.The one, make cytoactiveization; The 2nd, purify the blood; The 3rd, set up; The 4th, be that autonomic nervous system is stable; The 5th, strengthen resistance against diseases; The 6th, tumor cell there is inhibitory action; The 7th, can improve the resistivity of body to radioactive substance and electromagnetic radiation; The 8th, analgesic activity; The 9th, change allergic constitution; The tenth, anti-aging effects is arranged.
The electric current (0.06mA) of lithium tourmaline powder is complementary with the bioelectric current (0.06mA) of human body, must cause bioelectric biological effect.As, enhance metabolism, regulate the central nervous system autonomic nervous system of unifying, regulate corticocerebral function, the improvement effect all useful to cardiac rhythm and blood circulation, particularly microcirculation.
Lithium tourmaline powder contains and can disengage 11 kinds of mineral and trace element in water.Tourmaline contains sodium, magnesium, ferrum, manganese, lithium, aluminum, boron, silicon, oxygen, hydrogen, 11 kinds of mineral of fluorine and trace element.The trace element of ferrum, manganese, silicon, fluorine and needed by human wherein, all the other sodium, lithium, aluminum, magnesium, boron are mineral.
Gingerol liquid has pain relieving, antipruritic, deodorization, cold-resistant, anti-aging effect, and vitiligo, alopecia areata, the tinea manuum are had certain therapeutic effect.
Capsaicin liquid has the effect of parasite killing dampness removing to stop itchin.
Mentholum is a kind of aromatic drug.Function mainly is the chafe mucosa, and in antipruritic, pain relieving, antiinflammatory, the refrigerant sensation of local generation is to alleviate discomfort.
Borneolum Syntheticum has fragrance, has the breath of similar Camphora and wood.The refrigerant stimulation of fragrance.
Salicylic acid is a kind of dermatologic, is used for softening sclerderm or dissolving cutin.The multinomial effect such as aging that the desalination pigmented spots is arranged, dwindle pore, removes wrinkle and improve that Exposure to Sunlight causes.
Medicine of the present invention has the advantage that drug effect is rapid-action, satisfactory for result, expense is little, has the effect of sterilization, antipruritic, blood circulation promoting and blood stasis dispelling, antiinflammatory, pain relieving, detumescence, speckle dispelling, the pox that disappears, wrinkle-chasing stricture of vagina simultaneously, allows skin is whitened, smooth high resilience.The inventive method is simple, is convenient to operation.Through medicine of the present invention treatment, herpes obviously disappears in the lighter's medication 2 days, and 2～4 days herpess of heavy person's medication disappear to some extent, and pain alleviates, and as seen this medicine is rapid-action; Generally can cure at 4～14 days, the effective percentage of this medicine is more than 97%, and cure rate is more than 88.8%.
The specific embodiment
The specific embodiment one: treat the ointment of herpes zoster in the present embodiment among the present invention by weight percentage by 1.0%～2.0% glyceryl monostearate, 1.5%～2.5% stearic acid, 0.05%～0.07% dibenzylatiooluene, 3.0%～5.0% hexadecanol, 2.0%～4.0% octadecanol, 2.0%～4.0% Flos Matricariae chamomillae, 0.1%～0.3% squalane, 2.0%～4.0% dimethicone, 5.0%～7.0% hydrogenated polydecene, 0.05%～0.07% Borneolum Syntheticum, 6.0%～10.0% glycerol, 1.0%～3.0% Chinese medicine concentrated solution, 10.0%～14.0% ultra-fine lithium tourmaline powder, 0.4%～6.0% gingerol liquid, 0.4%～6.0% capsaicin liquid, 2.5%～6.5% Mentholum, 0.01%～0.05% Moschus, 0.05%～0.15% salicylic acid and balance of deionized water are formed; Wherein said Chinese medicine concentrated solution is 20 gram Radix Notoginseng, 30 gram Herba speranskiae tuberculataes, 20 gram Flos Carthamis, 30 gram Rhizoma Chuanxiongs, the 20 gram Radixs Angelicae Dahuricae, 20 gram Radix Angelicae Sinensis, 20 gram Radix Saposhnikoviaes, 20 gram Borneolum Syntheticums, 20 gram Radix Isatidiss and 20 gram Olibanums to be decocted after with 2000 gram water loggings bubbles be condensed into 800 medicinal liquids that restrain.
Through the treatment of the described medicine of present embodiment, herpes obviously disappears in the lighter's medication 2 days, and 2～4 days herpess of heavy person's medication disappear to some extent, and pain alleviates, and as seen this medicine is rapid-action; Generally can cure at 4～14 days, the effective percentage of this medicine is more than 97.2%, and cure rate is more than 88.88%.
The specific embodiment two: what present embodiment and the specific embodiment one were different is: the granularity of described ultra-fine lithium tourmaline powder is less than 0.5 μ m.Other is identical with the specific embodiment one.
The specific embodiment three: what present embodiment was different with the specific embodiment one or two is: described gingerol liquid is to be formed by the fresh ginger squeezing.Other is identical with the specific embodiment one or two.
The specific embodiment four: what present embodiment was different with one of specific embodiment one to three is: capsaicin liquid is mixed after pulverize reuse 1300ml decocting by 50g tip chilli and 50g Pericarpium Zanthoxyli inspissates the liquid that shortens 500ml into.Other step is identical with one of specific embodiment one to three.
The specific embodiment five: the preparation method of ointment of treatment herpes zoster is undertaken by following step in the present embodiment: one, 20 gram Radix Notoginseng, 30 gram Herba speranskiae tuberculataes, 20 gram Flos Carthamis, 30 gram Rhizoma Chuanxiongs, the 20 gram Radixs Angelicae Dahuricae, 20 gram Radix Angelicae Sinensis, 20 gram Radix Saposhnikoviaes, 20 gram Borneolum Syntheticums, 20 gram Radix Isatidiss, 0.01 gram Moschus and 20 gram Olibanums are decocted after with 2000 gram water loggings bubbles and be condensed into 800 medicinal liquids that restrain, promptly obtain the Chinese medicine concentrated solution; Two, take by weighing 1.0%～2.0% glyceryl monostearate by weight percentage respectively, 1.5%～2.5% stearic acid, 0.05%～0.07% dibenzylatiooluene, 3.0%～5.0% hexadecanol, 2.0%～4.0% octadecanol, 2.0%～4.0% Flos Matricariae chamomillae, 0.1%～0.3% squalane, 2.0%～4.0% dimethicone, 5.0%～7.0% hydrogenated polydecene, 0.05%～0.07% Borneolum Syntheticum, 6.0%～10.0% glycerol, the Chinese medicine concentrated solution of 1.0%～3.0% step 1 preparation, 10.0%～14.0% ultra-fine lithium tourmaline powder, 0.4%～6.0% gingerol liquid, 0.4%～6.0% capsaicin liquid, 2.5%～6.5% Mentholum, 0.01%～0.05% Moschus, 0.05%～0.15% salicylic acid and balance of deionized water; Three, two glyceryl monostearates that take by weighing, stearic acid, dibenzylatiooluene, hexadecanol, octadecanol, Flos Matricariae chamomillae, squalane, dimethicone, hydrogenated polydecene and Borneolum Syntheticum mix set by step, under stirring, 70～80 ℃ of conditions, heat, obtain the A component; Four, two glycerol that take by weighing, Chinese medicine concentrated solution, ultra-fine lithium tourmaline powder, gingerol liquid, capsaicin liquid, Mentholum, Moschus, salicylic acid and deionized water mix set by step, stir, heating obtains the B component under 70～80 ℃ of conditions; Five, while hot A component and B component are mixed, agitating heating stops heating, continues to be stirred to room temperature; The ointment of herpes zoster promptly obtains medical treatment.
Through the treatment of the described medicine of present embodiment, herpes obviously disappears in the lighter's medication 2 days, and 2～4 days herpess of heavy person's medication disappear to some extent, and pain alleviates, and as seen this medicine is rapid-action; Generally can cure at 4～14 days, the effective percentage of this medicine is more than 97.2%, and cure rate is more than 88.88%.
The specific embodiment six: what present embodiment and the specific embodiment five were different is: the granularity of the described ultra-fine lithium tourmaline powder of step 2 is less than 0.5 μ m.Other step is identical with concrete mode five with parameter.
The specific embodiment seven: what present embodiment was different with the specific embodiment five or six is: the described gingerol liquid of step 2 is to be formed by the fresh ginger squeezing.Other step is identical with the specific embodiment five or six with parameter.
The specific embodiment eight: what present embodiment was different with one of specific embodiment five to six is: capsaicin liquid is mixed after pulverize reuse 1300ml decocting by 50g tip chilli and 50g Pericarpium Zanthoxyli inspissates the liquid that shortens 500ml into.Other step is identical with one of specific embodiment five to six with parameter.
The specific embodiment nine: the preparation method of ointment of treatment herpes zoster is undertaken by following step in the present embodiment: one, 20 gram Radix Notoginseng, 30 gram Herba speranskiae tuberculataes, 20 gram Flos Carthamis, 30 gram Rhizoma Chuanxiongs, the 20 gram Radixs Angelicae Dahuricae, 20 gram Radix Angelicae Sinensis, 20 gram Radix Saposhnikoviaes, 20 gram Borneolum Syntheticums, 20 gram Radix Isatidiss, 0.01 gram Moschus and 20 gram Olibanums are decocted into 800 after with 2000 gram water loggings bubbles and restrain, promptly obtain the Chinese medicine concentrated solution; Two, take by weighing 1.0% glyceryl monostearate by weight percentage respectively, 1.5% stearic acid, 0.05% dibenzylatiooluene, 3.0% hexadecanol, 2.0% octadecanol, 2.0% Flos Matricariae chamomillae, 1.0% Mentholum, 0.1% squalane, 2.0% dimethicone, 5.0% hydrogenated polydecene, 0.05% Borneolum Syntheticum, 6.0% glycerol, the Chinese medicine concentrated solution of 1.0% step 1 preparation, 10.0% ultra-fine lithium tourmaline powder (granularity is 0.5 μ m), 2.0% gingerol liquid, 0.4% capsaicin liquid, 3% Mentholum, 0.01% Moschus, 0.05% salicylic acid and balance of deionized water; Three, two glyceryl monostearates that take by weighing, stearic acid, dibenzylatiooluene, hexadecanol, octadecanol, Flos Matricariae chamomillae, squalane, dimethicone, hydrogenated polydecene and Borneolum Syntheticum mix set by step, under stirring (100r/min), 70～80 ℃ of conditions, heat, obtain the A component; Four, the glycerol that the step 2 amount of taking by weighing 70% and step 2 are taken by weighing, Chinese medicine concentrated solution, ultra-fine lithium tourmaline powder, gingerol liquid, capsaicin liquid, Mentholum, Moschus, salicylic acid and deionized water mix, and heating obtains the B component under (100r/min), 70～80 ℃ of conditions stirring; Five, while hot A component and B component are mixed, stir slow fire heating 30min under (100r/min) condition, stop heating, continue to be stirred to room temperature; The ointment of herpes zoster promptly obtains medical treatment.
The described gingerol liquid of step 2 is to form by removing the solid taking juice after the fresh ginger squeezing in the present embodiment.The described capsaicin liquid of step 2 with 1300ml decocting is inspissated the liquid that shortens 500ml through being ground into after Powdered by 50 gram tip chillis and 50 gram Pericarpium Zanthoxylies.
The specific embodiment ten: the preparation method of ointment of treatment herpes zoster is undertaken by following step in the present embodiment: one, 20 gram Radix Notoginseng, 30 gram Herba speranskiae tuberculataes, 20 gram Flos Carthamis, 30 gram Rhizoma Chuanxiongs, the 20 gram Radixs Angelicae Dahuricae, 20 gram Radix Angelicae Sinensis, 20 gram Radix Saposhnikoviaes, 20 gram Borneolum Syntheticums, 20 gram Radix Isatidiss, 0.01 gram Moschus and 20 gram Olibanums are decocted into 800 after with 2000 gram water loggings bubbles and restrain, promptly obtain the Chinese medicine concentrated solution; Two, take by weighing 1.5% glyceryl monostearate by weight percentage respectively, 2.0% stearic acid, 0.06% dibenzylatiooluene, 4.0% hexadecanol, 3.0% octadecanol, 3.0% Flos Matricariae chamomillae, 2.0% Mentholum, 0.2% squalane, 3.0% dimethicone, 6.0% hydrogenated polydecene, 0.06% Borneolum Syntheticum, 8.0% glycerol, the Chinese medicine concentrated solution of 2.0% step 1 preparation, 12.0% ultra-fine lithium tourmaline powder (granularity is 0.1 μ m), 5.0% gingerol liquid, 2.0% capsaicin liquid, 3% Mentholum, 0.01% Moschus, 0.1% salicylic acid and balance of deionized water; Three, two glyceryl monostearates that take by weighing, stearic acid, dibenzylatiooluene, hexadecanol, octadecanol, Flos Matricariae chamomillae, Mentholum, squalane, dimethicone, hydrogenated polydecene and Borneolum Syntheticum mix set by step, under stirring, 75 ℃ of conditions, heat, obtain the A component; Four, the glycerol that the step 2 amount of taking by weighing 60% and step 2 are taken by weighing, Chinese medicine concentrated solution, ultra-fine lithium tourmaline powder, gingerol liquid, capsaicin liquid, Mentholum, Moschus, salicylic acid and deionized water mix, stir, heating obtains the B component under 75 ℃ of conditions; Five, while hot A component and B component are mixed, stir slow fire heating 40min under (100r/min) condition, stop heating, continue to be stirred to room temperature; The ointment of herpes zoster promptly obtains medical treatment.
The described gingerol liquid of step 2 is to form by removing the solid taking juice after the fresh ginger squeezing in the present embodiment.The described capsaicin liquid of step 2 with 1300ml decocting is inspissated the liquid that shortens 500ml through being ground into after Powdered by 50 gram tip chillis and 50 gram Pericarpium Zanthoxylies.
Patient 70 people, wherein male 33 examples, women 37 examples; In age bracket 18-60 year, sick time is about 15 days.Be divided into two groups at random: A Luo former times Wei 34 examples for oral administration are matched group, and ointment 36 examples of smearing the present embodiment herpes zoster are the treatment group.The treatment group evenly applies the affected part, every day 3 times with the ointment of present embodiment herpes zoster; Matched group takes A Luo former times Wei, each 200mg that is grown up, the each 150mg of old man, early, middle and late 3 times of every day orally.
Table 1 treatment group and matched group effect comparison sheet
| Group | The example number | Recovery from illness | Effectively | Invalid | Effective percentage |
| The treatment group | 36 | 32 | 3 | 1 | 97.2％ |
| Matched group | 34 | 29 | 2 | 3 | 91.2％ |
The specific embodiment 11: the preparation method of ointment of treatment herpes zoster is undertaken by following step in the present embodiment: one, 20 gram Radix Notoginseng, 30 gram Herba speranskiae tuberculataes, 20 gram Flos Carthamis, 30 gram Rhizoma Chuanxiongs, the 20 gram Radixs Angelicae Dahuricae, 20 gram Radix Angelicae Sinensis, 20 gram Radix Saposhnikoviaes, 20 gram Borneolum Syntheticums, 20 gram Radix Isatidiss, 0.01 gram Moschus and 20 gram Olibanums are decocted into 800 after with 2000 gram water loggings bubbles and restrain, promptly obtain the Chinese medicine concentrated solution; Two, take by weighing 2.0% glyceryl monostearate by weight percentage respectively, 2.5% stearic acid, 0.07% dibenzylatiooluene, 5.0% hexadecanol, 4.0% octadecanol, 4.0% Flos Matricariae chamomillae, 3.0% Mentholum, 0.3% squalane, 4.0% dimethicone, 7.0% hydrogenated polydecene, 0.07% Borneolum Syntheticum, 10.0% glycerol, the Chinese medicine concentrated solution of 3.0% step 1 preparation, 14.0% ultra-fine lithium tourmaline powder, 6.0% gingerol liquid, 6.0% capsaicin liquid, 3% Mentholum, 0.01% Moschus, 0.15% salicylic acid and balance of deionized water; Three, the glyceryl monostearate that step 2 is taken by weighing, stearic acid, dibenzylatiooluene, hexadecanol, octadecanol, Flos Matricariae chamomillae, Mentholum, squalane, dimethicone, hydrogenated polydecene and Borneolum Syntheticum mix, under stirring, 70～80 ℃ of conditions, heat, obtain the A component; Four, the glycerol that step 2 is taken by weighing, Chinese medicine concentrated solution, ultra-fine lithium tourmaline powder, gingerol liquid, capsaicin liquid, Mentholum, salicylic acid and deionized water mix, stir, heating obtains the B component under 70～80 ℃ of conditions; Five, while hot A component and B component are mixed, stir slow fire heating 30min under (100r/min) condition, stop heating, continue to be stirred to room temperature; The ointment of herpes zoster promptly obtains medical treatment.
The described gingerol liquid of step 2 is to form by removing the solid taking juice after the fresh ginger squeezing in the present embodiment.The described capsaicin liquid of step 2 is inspissated the liquid that shortens 500ml into the 1300ml decocting after Powdered and is formed through being ground into by 50 gram tip chillis and 50 gram Pericarpium Zanthoxyli.
Evenly apply the affected part ointment every day of present embodiment treatment herpes zoster 3 times, and 7 days is a course of treatment.
Table 2 is clinical medicine reports of the ointment treatment herpes zoster of present embodiment treatment herpes zoster, wherein therapeutic outcome disappears to some extent for " effectively " expression herpes zoster patient herpes, pain alleviates, and after this radiated pain appears in disease sites sometimes, " recovery from illness " expression herpes zoster patient skin lesion inflammation Periostracum Cicadae, vesicle is dry, do not have new rash, subjective symptoms all disappears, and expression herpes zoster patient herpes alleviates, regression time reached more than 2 weeks, and local pain does not alleviate.
The herpes zoster patient at 36 18～60 years old age of example treats with the Chinese medicine that the present embodiment method obtains.Patient's premorbid all has tired, weak, inappetence companion low grade fever, and body temperature is at 37.8～38.2 ℃, and concrete clinical manifestation sees Table 2; All be diagnosed as " herpes zoster " through hospital.
Table 2
Herpes obviously disappears in the lighter's medication 2 days, and 2～4 days herpess of heavy person's medication disappear to some extent, and pain alleviates, and as seen this medicine is rapid-action.The effective percentage of the ointment of the described treatment herpes zoster of present embodiment is more than 97.2%, and cure rate is more than 88.88%.
Claims (8)
1. the ointment of treatment herpes zoster is characterized in that treating the ointment of herpes zoster by weight percentage by 1.0%～2.0% glyceryl monostearate, 1.5%～2.5% stearic acid, 0.05%～0.07% dibenzylatiooluene, 3.0%～5.0% hexadecanol, 2.0%～4.0% octadecanol, 2.0%～4.0% Flos Matricariae chamomillae, 0.1%～0.3% squalane, 2.0%～4.0% dimethicone, 5.0%～7.0% hydrogenated polydecene, 0.05%～0.07% Borneolum Syntheticum, 6.0%～10.0% glycerol, 1.0%～3.0% Chinese medicine concentrated solution, 10.0%～14.0% ultra-fine lithium tourmaline powder, 0.4%～6.0% gingerol liquid, 0.4%～6.0% capsaicin liquid, 2.5%～6.5% Mentholum Mentholum, 0.01%～0.05% Moschus, 0.05%～0.15% salicylic acid and balance of deionized water are made; Wherein said Chinese medicine concentrated solution is 20 gram Radix Notoginseng, 30 gram Herba speranskiae tuberculataes, 20 gram Flos Carthamis, 30 gram Rhizoma Chuanxiongs, the 20 gram Radixs Angelicae Dahuricae, 20 gram Radix Angelicae Sinensis, 20 gram Radix Saposhnikoviaes, 20 gram Borneolum Syntheticums, 20 gram Radix Isatidiss and 20 gram Olibanums to be decocted 800 after with 2000 gram water loggings bubbles restrain and make.
2. the ointment of treatment herpes zoster according to claim 1, the granularity that it is characterized in that described ultra-fine lithium tourmaline powder is less than 0.5 μ m.
3. the ointment of treatment herpes zoster according to claim 2 is characterized in that gingerol liquid is to be formed by the fresh ginger squeezing.
4. according to the ointment of claim 1,2 or 3 described treatment herpes zoster, it is characterized in that capsaicin liquid is mixed by 1: 1 mass ratio by tip chilli and Pericarpium Zanthoxyli after pulverize the reuse decocting and endure and form.
5. the ointment of treatment herpes zoster as claimed in claim 1, the preparation method that it is characterized in that treating the ointment of herpes zoster is undertaken by following step:
One, 20 gram Radix Notoginseng, 30 gram Herba speranskiae tuberculataes, 20 gram Flos Carthamis, 30 gram Rhizoma Chuanxiongs, the 20 gram Radixs Angelicae Dahuricae, 20 gram Radix Angelicae Sinensis, 20 gram Radix Saposhnikoviaes, 20 gram Borneolum Syntheticums, 20 gram Radix Isatidiss, 0.01 gram Moschus and 20 gram Olibanums are decocted into 800 after with 2000 gram water loggings bubbles and restrain, promptly obtain the Chinese medicine concentrated solution;
Two, take by weighing 1.0%～2.0% glyceryl monostearate by weight percentage respectively, 1.5%～2.5% stearic acid, 0.05%～0.07% dibenzylatiooluene, 3.0%～5.0% hexadecanol, 2.0%～4.0% octadecanol, 2.0%～4.0% Flos Matricariae chamomillae, 0.1%～0.3% squalane, 2.0%～4.0% dimethicone, 5.0%～7.0% hydrogenated polydecene, 0.05%～0.07% Borneolum Syntheticum, 6.0%～10.0% glycerol, the Chinese medicine concentrated solution of 1.0%～3.0% step 1 preparation, 10.0%～14.0% ultra-fine lithium tourmaline powder, 0.4%～6.0% gingerol liquid, 0.4%～6.0% capsaicin liquid, 2.5%～6.5% Mentholum, 0.01%～0.05% Moschus, 0.05%～0.15% salicylic acid and balance of deionized water;
Three, the glyceryl monostearate that the Mentholum and the step 2 of the step 2 amount of taking by weighing 10%～40% taken by weighing, stearic acid, dibenzylatiooluene, hexadecanol, octadecanol, Flos Matricariae chamomillae, squalane, dimethicone, hydrogenated polydecene and Borneolum Syntheticum mix, under stirring, 70～80 ℃ of conditions, heat, obtain the A component;
Four, remaining Mentholum and the glycerol that step 2 is taken by weighing, Chinese medicine concentrated solution, ultra-fine lithium tourmaline powder, gingerol liquid, capsaicin liquid, salicylic acid and deionized water are mixed, stir, heating obtains the B component under 70～80 ℃ of conditions;
Five, while hot A component and B component are mixed, agitating heating stops heating, continues to be stirred to room temperature; The ointment of herpes zoster promptly obtains medical treatment.
6. the preparation method of the ointment of treatment herpes zoster according to claim 5, the granularity that it is characterized in that the described ultra-fine lithium tourmaline powder of step 2 is less than 0.5 μ m.
7. the preparation method of the ointment of treatment herpes zoster according to claim 6 is characterized in that the described gingerol liquid of step 2 is to be formed by the fresh ginger squeezing.
8. according to the preparation method of the ointment of claim 5,6 or 7 described treatment herpes zoster, it is characterized in that enduring and forming through pulverizing the reuse decocting again after the described capsaicin liquid of step 2 is mixed by 1: 1 mass ratio by tip chilli and Pericarpium Zanthoxyli.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104784316A (en) * | 2015-04-10 | 2015-07-22 | 林粟 | Medicinal liquor for treating herpes zoster and preparation method thereof |
| CN114599336A (en) * | 2019-10-24 | 2022-06-07 | 宝洁公司 | Preservative level optimization for personal care compositions |
-
2011
- 2011-02-21 CN CN2011100415523A patent/CN102114238A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104784316A (en) * | 2015-04-10 | 2015-07-22 | 林粟 | Medicinal liquor for treating herpes zoster and preparation method thereof |
| CN104784316B (en) * | 2015-04-10 | 2018-06-22 | 林粟 | Treat medicinal liquor of herpes zoster and preparation method thereof |
| CN114599336A (en) * | 2019-10-24 | 2022-06-07 | 宝洁公司 | Preservative level optimization for personal care compositions |
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Application publication date: 20110706 |