CN102112870A - 挥发性烃、纤维材料降解/老化的标记物和病理标记物的图谱 - Google Patents
挥发性烃、纤维材料降解/老化的标记物和病理标记物的图谱 Download PDFInfo
- Publication number
- CN102112870A CN102112870A CN2009801241233A CN200980124123A CN102112870A CN 102112870 A CN102112870 A CN 102112870A CN 2009801241233 A CN2009801241233 A CN 2009801241233A CN 200980124123 A CN200980124123 A CN 200980124123A CN 102112870 A CN102112870 A CN 102112870A
- Authority
- CN
- China
- Prior art keywords
- collection
- illustrative plates
- volatile hydrocarbon
- degraded
- spme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000002430 hydrocarbons Chemical class 0.000 title claims abstract description 50
- 239000000463 material Substances 0.000 title claims abstract description 9
- 230000032683 aging Effects 0.000 title claims abstract description 8
- 201000010099 disease Diseases 0.000 title claims abstract 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract 5
- 238000006731 degradation reaction Methods 0.000 title abstract description 6
- 230000015556 catabolic process Effects 0.000 title abstract description 5
- 229930195733 hydrocarbon Natural products 0.000 claims abstract description 48
- 239000004215 Carbon black (E152) Substances 0.000 claims abstract description 47
- 238000000034 method Methods 0.000 claims abstract description 24
- 238000002470 solid-phase micro-extraction Methods 0.000 claims abstract description 21
- 239000013060 biological fluid Substances 0.000 claims abstract description 7
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 7
- 230000003859 lipid peroxidation Effects 0.000 claims abstract description 6
- 239000000126 substance Substances 0.000 claims abstract description 6
- 239000000835 fiber Substances 0.000 claims description 22
- 239000000523 sample Substances 0.000 claims description 14
- 238000004458 analytical method Methods 0.000 claims description 12
- 239000002657 fibrous material Substances 0.000 claims description 7
- 229910052799 carbon Inorganic materials 0.000 claims description 6
- 230000001575 pathological effect Effects 0.000 claims description 6
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 5
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 5
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims description 5
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 claims description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 5
- 238000003860 storage Methods 0.000 claims description 4
- 239000012472 biological sample Substances 0.000 claims description 3
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims description 3
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 claims description 3
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 3
- 239000004753 textile Substances 0.000 claims description 3
- 238000007654 immersion Methods 0.000 claims description 2
- 238000003556 assay Methods 0.000 claims 1
- 230000004060 metabolic process Effects 0.000 claims 1
- 238000006116 polymerization reaction Methods 0.000 claims 1
- 239000012855 volatile organic compound Substances 0.000 abstract description 12
- 238000002144 chemical decomposition reaction Methods 0.000 abstract description 3
- 229920000642 polymer Polymers 0.000 abstract description 3
- 238000003987 high-resolution gas chromatography Methods 0.000 abstract 1
- 238000004949 mass spectrometry Methods 0.000 abstract 1
- 238000011156 evaluation Methods 0.000 description 9
- 238000000926 separation method Methods 0.000 description 9
- 239000007789 gas Substances 0.000 description 6
- 238000004321 preservation Methods 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 230000004304 visual acuity Effects 0.000 description 5
- 230000001066 destructive effect Effects 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000012925 reference material Substances 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 239000003039 volatile agent Substances 0.000 description 3
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
- 241001597008 Nomeidae Species 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 230000000593 degrading effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- HYBBIBNJHNGZAN-UHFFFAOYSA-N furfural Chemical compound O=CC1=CC=CO1 HYBBIBNJHNGZAN-UHFFFAOYSA-N 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000005903 acid hydrolysis reaction Methods 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 238000006701 autoxidation reaction Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000004817 gas chromatography Methods 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 230000007170 pathology Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000011064 split stream procedure Methods 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N2030/009—Extraction
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/06—Preparation
- G01N2030/062—Preparation extracting sample from raw material
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
- G01N33/0047—Organic compounds
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/36—Textiles
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
本发明涉及挥发性的有机化合物,VOCs,亦即含2至24个碳原子(C2-C24)的烃的图谱(显著组),所用方法是固相微萃取(SPME)和高分辨率气相色谱-质谱联用法(GC-MS)。本发明提供纤维材料的图谱,文化遗产降解和/或老化的标记物的鉴定和表征,或生物学流体的图谱,病理标记物的鉴定和表征。本发明提供对烃、图谱的化学组成、纤维质聚合物化学降解的标记物或者由于病理状况引起的脂质过氧化的标记物的鉴定和表征。
Description
技术领域
本发明涉及含有2至24个碳原子(C2-C24)的烃,即所谓的挥发性有机化合物(VOCs)的图谱(显著组)的鉴定和表征;烃图谱的化学组成是纤维材料老化的标记物,其使得可以鉴定和表征基于文化遗产物质的纤维素的保藏或降解状态;生物学样品的挥发性烃图谱的化学组成是存在脂质过氧化的标记物。本发明提供图谱及其化学组成,挥发性烃,纤维质聚合物的化学降解或者由于病理状态引起的脂质过氧化的标记物的鉴定和表征。
由于取样/收集过程受限,对属于文化遗产的古迹的分析常常难于进行。古迹的历史价值及其完整性通常超过为了化学分析对物品进行破坏性取样所获得的科学知识。在分析纸和其它纤维质物质时,有重要意义的参数实际上是pH。降解过程取决于下述情况:在酸性环境中,纤维素通过酸催化水解降解;而在适度碱性的环境中,它通过自氧化降解。后者过程要缓慢很多,对于1850之前生产的适度碱性纸所估计的平均降解时间是数千年。1850至1990期间生产的酸性纸预期不会存在超过又一世纪,这意味着属于该段时期的文献会完全遗失。灾难性的问题是据估计西方图书馆中所藏文献有超过70%是酸性的[1]。
现有技术
开发可用于文化遗产的非破坏性分析方法最近集中于挥发性有机化合物(VOC)的分析技术。挥发物的意义和有机挥发性化合物是优异的信息来源的事实自HPLC和IEC技术在1982[2]的使用就成为已知。固相微萃取(SPME)[3-5]取样技术的出现使得能够分析自文化遗产基体释放出的挥发性化合物。通过将SPME与气相色谱-质谱联用法(GC-MS)组合,已对文化遗产基体包括纤维质物质[6,7]进行了有关分析。然而,其靶标化合物是糠醛和乙酸[6,7],羧酸,醛,酮,苯及其衍生物,萘及其衍生物,和某些烃[8,9,10]。
本发明提供出人意料的创新:鉴定纤维质物品中的挥发性烃的图谱,确定烃图谱、年代测定和/或物品的降解/保藏状态之间的关系,这是迄今首创。又一出人意料的创新是用固相微萃取与气相色谱和质谱(SPME-GC-MS)的偶联经过保持文物古籍亦即书籍、纺织品和衣料绝对完整的非破坏性分析确立一组烃类作为降解和/或老化的标记物,而并非迄今所确定的一种或两种有机化合物。还应注意图谱作为分析工具特别有用,其能够促进生物学流体和呼出气体的鉴定和表征,使得可以鉴定作为由于病理状态引起的脂质过氧化的标记物的挥发性烃的图谱。
本发明在于新的、简单且快速的确定纤维质聚合物的化学降解的新标记物和图谱的方法,这使得可以确立保藏文化遗产的适当条件。
该方法具有自动化/机器化的可能,这使得可以进行文物古籍样品和生物学样品的自动化分析从而鉴定纤维材料降解/老化的标记物或病理状态的标记物。
发明详述
本发明涉及挥发性有机化合物,VOCs,亦即含2至24个碳原子(C2-C24)的烃的图谱,所用方法是固相微萃取(SPME)和高分辨率气相色谱-质谱联用法(GC-MS)。
在本发明的优选实施方式中,所述方法首先包括制备样品,通过将装入注射器/容器(Supelco)的固相微萃取(SPME)纤维与待分析物质接触收集挥发性化合物,将后者保持在惰性、封闭的容器中以便收集和浓缩靶标化合物,也即挥发性烃(C2-C24)。纤维由聚二甲基硅氧烷(PDMS,Supelco)或其衍生物构成,接触时间为0.5-36小时。通过通过高分辨率气相色谱-质谱联用法(GC-MS)进行分析。在使用之前,将纤维于260/270℃调理5-60分钟。首先调理纤维并进行袋空白测定;在各分析之前还进行纤维空白测定。
实验部分
设备和一般试剂
所用烃的等级是可商购的最高纯度水平。用高分辨率气相色谱-质谱联用法(HRGC-MS)使用配有分流-不分流注射器(split-splitless injector)的四极TRACE GC-MS装置(Finnigan)进行分离。注射器温度为230℃。不分流时间为2.5分钟而分流比率为1∶30。毛细管柱是BPX5(30m×0.25mm×1μm film厚度)。用氦作载气,流速为1mL/分。以完整扫描模式进行MS分析,扫描范围是30-460原子质量单位。采用扫描率为3.46次扫描/秒。离子化:EI,70eV,离子源和接口温度分别为200℃和250℃。收集数据并通过软件Xcalibur处理。柱温程序为在35℃保持10分钟,以3℃/分增加至150℃,以10℃/分增加至220℃,以5℃/分增加至最终温度240℃,然后保持恒定10分钟。
实施例
实施例1:确定新近书籍中的挥发性烃的图谱:新近书籍(2003)的色谱分析-挥发性烃的分离和鉴定。
在样品收集过程期间,将书籍在拉链袋中保持分离。在书籍的书页之间引入纤维并暴露在室温下0.5-36小时。在进行分析之前收集纤维,然后用已经描述的条件进行GC-MS分析。
挥发性烃的图谱,所实现的分离的结果示于图1。
实施例2:确定经降解的旧书中的烃的图谱:经降解的旧书(1900)的色谱分析-挥发性烃的分离和鉴定。
如实施例1所述,将书籍在拉链袋中保持分离。在书籍的书页之间引入纤维并暴露在室温下0.5-36小时。在进行分析之前收集纤维,然后用前文描述的条件进行GC-MS分析。
作为所实现分离的结果,挥发性烃的图谱示于图2。
实施例3:确定经降解的旧书中的烃的图谱:经降解的旧书(~1930)的色谱分析-挥发性烃的分离和鉴定。
类似地,将书籍在拉链袋中保持分离。在书籍的书页之间引入纤维并暴露在室温下0.5-36小时。在进行分析之前收集纤维,然后用已经描述的条件进行GC-MS分析。
作为所实现的分离的结果,图3显示经降解的旧书的挥发性烃的图谱。
实施例4:确定古籍中的烃的图谱:保藏古籍(1629)的色谱分析-挥发性烃的分离和鉴定。
在拉链袋分离的书籍的书页之间引入纤维并暴露在室温下0.5-36小时。在进行分析之前收集纤维,然后用已经描述的条件进行GC-MS分析。作为所实现的分离的结果,图4代表保藏古籍的挥发性烃的图谱。
实施例5:确定标准物即具有C8至C24碳原子的烃的色谱图谱。
将SPME纤维插入含有烃标准物的密封瓶中30秒,该密封瓶已在室温下平衡30分钟。在进行分析之前收集纤维,然后用已经描述的条件进行GC-MS分析。图5代表具有C8至C24碳原子的标准挥发性烃的图谱。
附图说明
图1-新近书籍(2003)的挥发性烃的图谱;rt=21.01分钟:C10;rt=25.19分钟:C11。
图2-经降解的旧书(1900)的挥发性烃的图谱;rt=21.05分钟:C10;rt=25.19:C11。
图3-经降解的旧书(~1930)的挥发性烃的图谱;C10:rt=20.98;C11:rt=25.15;C12:rt=29.08;C13:rt=32.78;C14:rt=36.26;C15:rt=39.54;C16:rt=42.65;C17:rt=45.57;C18:rt=48.34分钟。
图4-保藏古籍(1629)的挥发性烃的图谱;C14:rt=36.28;C15:rt=39.56;C16:rt=42.66;C17:rt=45.59;C18:rt=48.36;C19:rt=50.66;C20:rt=53.17分钟。
图5-挥发性烃标准物的保留时间:C8:rt=12.89;C9:rt=16.53;C10:rt=20.93;C11:rt=25.11;C12:rt=29.05;C13:rt=32.75;C14:rt=36.23;C15:rt=39.51;C16:rt=42.61;C17:rt=45.54;C18:rt=48.34;C19:rt=50.96;C20:rt=53.51;C21:rt=55.92;C22:rt=58.23;C23:rt=60.44,和C24:rt=62.55分钟。
图1至4显示所获得的结果:新近书籍、保持在较差保藏条件下的旧书和由于老化发生″普通″降解的旧书的图谱,考虑其年代和时间间隔;它们显示所实现的分离和构成不同图谱的挥发性烃的特征身份。
图5显示用HS-SPME-GC-MS分析时,在分离某些烃标准物期间获得的保留时间。
在各情况下,化合物的图谱特征性很强,其在化学上与分析目标的性质相吻合:新近书籍(图1)几乎不含挥发性烃,该结果与缺乏纤维材料的降解相吻合。古籍(1629)的图谱(图4)显示,尽管由棉质纤维素而不是木质纤维素构成,该图谱含有一系列长链烃,C12-C20,其中图谱最大值牵涉C16-C17烃。由此确认存在老化″降解″,即由于时间进程引起的纤维素降解。比较旧但是完全降解的书籍实际上由于水分和酸性环境的存在而成为碎片(图2),其图谱显示该图谱包括C8至C11烃的存在,这意味着随降解增加图谱组成的碳链缩短,这些化合物的强度揭示它们存在的相对量。图3显示的图谱指出由于老化存在长链烃,并且由于纤维素的降解化合物含有C8-C11。
用来自历史文化遗产的书籍作为实例,结果显示可容易辨别的挥发性烃的图谱(简单视觉观察分析就足以辨别,甚至不需要应用定义图谱和标记物的统计学方法),年代测定和/或老化(由于正常时间进行)和/或由于不适当保藏条件的纤维材料过早降解的标记物和特征物(尽管较为粗略)。采用呼出空气获得的相似结果,也即挥发性烃的特征图谱,显示所述图谱可以充当存在由于病理状态引起的脂质过氧化的标记物。
参考文献
Shafizadeh,F.,J.Anal.Appl.Pyrolysis 3,283[1982).
Pawliszyn,J.,Trends Anal.Chem.14,113(1995).
Vas,G.,Vékey,K.,J.Mass Spectrom.39,233(2004)
Godoi,A.F.L.,Van Vaeck,L.,Van Grieten,R.,J.Chromatogr.A1067,331(2005).
Lattuati-Derieux,A.,Bonnassies-Termes,S.,Lavédrine,B.,J.Chromatogr.A 1026,9(2004).
Lattuati-Derieux,A.,Bonnassies-Termes,S.,Lavédrine,B.,J.Cult.Herit.7,123(2006).
Wenzl,T.,Lankmayr,E.P.,J.Chromatogr.A 897,269(2000).
权利要求书(按照条约第19条的修改)
1.通过使用固相微萃取(SPME)和高分辨率气相色谱-质谱联用法(HRCG-MS)鉴定并定量给定样品中存在的包含2至24个碳原子(C2-C24)的挥发性有机化合物(VOC)之间的关系的方法。
2.根据前述权利要求的方法,其包括下述步骤:
a)通过固相微萃取(SPME)收集所述样品的VOC;
b)通过高分辨率气相色谱-质谱联用法(HRCG-MS)分析VOC;
c)将先前步骤的结果与已知标记物进行比较。
3.根据前述权利要求中任一项的方法,其中步骤a)用顶空式(HS-SPME)和/或直接浸入式(DI-SPME)SPME方法来进行。
4.根据权利要求2的方法,其中采用聚二甲基硅氧烷(PDMS)纤维和/或含PDMS的衍生纤维。
5.根据权利要求2的方法,其中步骤b)用一个或多个普通色谱柱和/或手性色谱柱来进行。
6.根据前述权利要求中任一项的方法,其中经分析的样品是包含纤维素的有机材料。
7.根据权利要求1至5中任一项的方法,其中经分析的样品是生物学流体或呼出气体。
8.根据前述权利要求中任一项的方法,其中该方法以自动化、机器化和/或在线方式进行。
9.标记物的库,其包含用已知来源的样品进行前述权利要求中任一项的方法所获得的一种或多种标记物。
10.通过权利要求1至8中任一项的方法获得的标记物。
11.权利要求1至8的方法的用途,其用于对含纤维质的样品进行年代测定和/或对其降解状态进行测量和/或对生物学流体和呼出气体进行鉴定和表征。
12.根据前述权利要求的用途,其中所述对含纤维质的样品所进行年代测定和/或对其降解状态所进行的测量以对所述样品的非破坏性分析来进行。
13.权利要求9的库的用途,其用于确定纤维质样品的年代和/或对其降解状态进行测量和/或对生物学流体和呼出气体进行鉴定和表征。
14.权利要求10的标记物的用途,其用于确定纤维质样品的年代和/或对其降解状态进行测量和/或对生物学流体和呼出气体进行鉴定和表征。
Claims (6)
1.含有2至24个碳原子(C2-C24)的挥发性烃的图谱,其特征在于使用顶空式(HS-SPME)或直接浸入式(DI-SPME)SPME方法,即DI/HS-SPME-GC-MS,所述方法采用聚二甲基硅氧烷(PDMS)纤维和/或含PDMS的衍生纤维,和各种色谱柱,包括手性色谱分离柱。
2.根据权利要求1的挥发性烃(C2-C24)的图谱,其特征在于确定纤维材料的聚合化学降解和生物过程中的脂质过氧化。
3.根据权利要求1和2的挥发性烃(C2-C24)的图谱,其特征在于分析文化遗产样品以确定物品存在降解和物品的保藏条件,或分析生物学样品以确定存在病理状态/疾病,所述分析以自动化/机器化/在线的方式进行。
4.根据权利要求1和2的挥发性烃(C2-C24)的图谱的用途,其特征在于检测文化遗产的降解和来自书籍、纺织品和衣料的纤维材料的保藏条件。
5.根据权利要求1和3的挥发性烃(C2-C24)的图谱的用途,其特征在于通过在生物学流体和呼出气体中对病理状态和/或肿瘤学疾病进行基本检测来确定人体代谢的变化。
6.根据权利要求1至3的分析方法,其特征在于通过分析书籍、纺织品和衣料中的烃的图谱检测老化/聚合(纤维质)降解的标记物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT104077A PT104077A (pt) | 2008-05-28 | 2008-05-28 | Perfis de compostos hibrocarbonados voláteis, marcadores de degradação/envelhecimento de material celulósico e marcadores de patalogia |
PT104077 | 2008-05-28 | ||
PCT/IB2009/052256 WO2009144677A2 (pt) | 2008-05-28 | 2009-05-28 | Perfis de compostos hidrocarbonados voláteis, marcadores de degradação/envelhecimento de material celulósico e marcadores de patologia |
Publications (1)
Publication Number | Publication Date |
---|---|
CN102112870A true CN102112870A (zh) | 2011-06-29 |
Family
ID=41168593
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009801241233A Pending CN102112870A (zh) | 2008-05-28 | 2009-05-28 | 挥发性烃、纤维材料降解/老化的标记物和病理标记物的图谱 |
Country Status (8)
Country | Link |
---|---|
US (1) | US20110124513A1 (zh) |
EP (1) | EP2293059A2 (zh) |
JP (1) | JP2011522244A (zh) |
CN (1) | CN102112870A (zh) |
BR (1) | BRPI0912127A2 (zh) |
CA (1) | CA2726152A1 (zh) |
PT (1) | PT104077A (zh) |
WO (1) | WO2009144677A2 (zh) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102879511B (zh) * | 2012-09-27 | 2014-10-15 | 甘肃烟草工业有限责任公司 | 一种聚醋酸乙烯类水基胶所含挥发性有机化合物的测定方法 |
DE102015208785B4 (de) * | 2015-05-12 | 2020-03-19 | Zf Friedrichshafen Ag | Verstellbarer Federträger |
KR102549115B1 (ko) * | 2018-10-05 | 2023-06-28 | 주식회사 엘지화학 | 고상 마이크로추출법을 이용한 수용액 중 극성 화합물의 분석방법 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4003257A (en) * | 1974-03-12 | 1977-01-18 | Nasa | Analysis of volatile organic compounds |
AU2003207552A1 (en) * | 2002-01-29 | 2003-09-02 | James D. Talton | Methods of collecting and analyzing human breath |
GB0216650D0 (en) * | 2002-07-18 | 2002-08-28 | Univ Bristol | Detection of disease by analysis of emissions |
-
2008
- 2008-05-28 PT PT104077A patent/PT104077A/pt not_active Application Discontinuation
-
2009
- 2009-05-28 JP JP2011511153A patent/JP2011522244A/ja active Pending
- 2009-05-28 BR BRPI0912127A patent/BRPI0912127A2/pt not_active Application Discontinuation
- 2009-05-28 EP EP09754302A patent/EP2293059A2/en not_active Withdrawn
- 2009-05-28 CA CA2726152A patent/CA2726152A1/en not_active Abandoned
- 2009-05-28 WO PCT/IB2009/052256 patent/WO2009144677A2/pt active Application Filing
- 2009-05-28 CN CN2009801241233A patent/CN102112870A/zh active Pending
- 2009-05-28 US US12/995,142 patent/US20110124513A1/en not_active Abandoned
Non-Patent Citations (4)
Title |
---|
AGNÈS LATTUATE - DERIEUX等: "Characterisation of compounds emitted during natural and artificial ageing of a book. Use of headspace-solid-phase microextraction/gas chromatography/mass spectrometry", 《JOURNAL OF CULTURAL HERITAGE》 * |
AGNÈS LATTUATE - DERIEUX等: "identification of volatile organic compounds emitted by a naturally aged book using solid-phase microextraction/gas chromatography/mass spectrometry", 《JOURNAL OF CHROMATOGRAPHY A》 * |
THOMAS WENZI等: "Reduction of adsorption phenomena of volatile aldehydes and aromatic compounds for static headspace analysis of cellulose based packaging materials", 《JOURNAL OF CHROMATOGRAPHY A》 * |
郭方遒等: "顶空固相微萃取-气相色谱-质谱法用于白术中挥发性成分的分析", 《色谱》 * |
Also Published As
Publication number | Publication date |
---|---|
US20110124513A1 (en) | 2011-05-26 |
PT104077A (pt) | 2009-11-30 |
CA2726152A1 (en) | 2009-12-09 |
JP2011522244A (ja) | 2011-07-28 |
EP2293059A2 (en) | 2011-03-09 |
WO2009144677A3 (pt) | 2010-01-14 |
WO2009144677A4 (pt) | 2010-03-11 |
WO2009144677A2 (pt) | 2009-12-03 |
BRPI0912127A2 (pt) | 2015-11-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Whelton et al. | A call for caution in the analysis of lipids and other small biomolecules from archaeological contexts | |
Bindschedler et al. | Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study | |
Sleighter et al. | Multivariate statistical approaches for the characterization of dissolved organic matter analyzed by ultrahigh resolution mass spectrometry | |
KR101931420B1 (ko) | 세포의 분화 상태의 평가 방법 | |
WO2008022205A3 (en) | Thyroxine-containing compound analysis methods | |
ATE525482T1 (de) | Nanoreporter und verfahren zu deren herstellung und verwendung | |
Woudneh et al. | A novel derivatization-based liquid chromatography tandem mass spectrometry method for quantitative characterization of naphthenic acid isomer profiles in environmental waters | |
WO2004063700A3 (en) | Multiplex analytical platform using molecular tags | |
CN111638303A (zh) | 一种区分金属离子Al3+及Zn2+的方法 | |
JPWO2017068801A1 (ja) | 細胞の分化状態の評価方法 | |
CN102636375A (zh) | 从白酒中提取目标气味物质的方法及白酒气味分析方法 | |
WO2009086186A3 (en) | Automated method and apparatus for detecting erroneous sample collection in clinical assays | |
CN102288697B (zh) | 一种空气和废气中己内酰胺含量的测定方法 | |
CN102112870A (zh) | 挥发性烃、纤维材料降解/老化的标记物和病理标记物的图谱 | |
WO2006074441A3 (en) | Quantifying graphic features of handwriting for analysis | |
CN112578046A (zh) | 一种基于气相色谱-离子迁移谱技术对芒果品种快速鉴定的方法 | |
US20120129706A1 (en) | Method of Assessing Soil Quality and Health | |
Míka et al. | Phenolic compounds as chemical markers of low taxonomic levels in the family Poaceae | |
Nierop et al. | Simultaneous analysis of tannin and lignin signatures in soils by thermally assisted hydrolysis and methylation using 13C-labeled TMAH | |
Cooke et al. | Interlaboratory comparison of methodologies for the measurement of urinary 8-oxo-7, 8-dihydro-2′-deoxyguanosine | |
CN105334282B (zh) | 一种地表水体中环境雌激素的共检测方法 | |
CN102608050B (zh) | 精制地沟油的鉴别及定量分析方法 | |
Baeyens et al. | Investigation of headspace and solvent extraction methods for the determination of dimethyl-and monomethylmercury in environmental matrices | |
CN113533587A (zh) | 基于气相离子迁移谱鉴别辣椒粉品种的方法 | |
WO2011059066A1 (ja) | 植物代謝産物を利用した植物の種、雑種及び雑種両親種同定方法、並びにその方法により同定された植物の植栽方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20110629 |