CN102099492A - 抑郁症的生物标记 - Google Patents

抑郁症的生物标记 Download PDF

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Publication number
CN102099492A
CN102099492A CN2009801283679A CN200980128367A CN102099492A CN 102099492 A CN102099492 A CN 102099492A CN 2009801283679 A CN2009801283679 A CN 2009801283679A CN 200980128367 A CN200980128367 A CN 200980128367A CN 102099492 A CN102099492 A CN 102099492A
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CN
China
Prior art keywords
vivo imaging
polypeptide
polynucleotide
depression
compound
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Pending
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CN2009801283679A
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English (en)
Chinese (zh)
Inventor
P·汉森
D·希斯科克
C·莫里斯
A·托马斯
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GE Healthcare Ltd
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GE Healthcare Ltd
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Application filed by GE Healthcare Ltd filed Critical GE Healthcare Ltd
Publication of CN102099492A publication Critical patent/CN102099492A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—In situ hybridisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pathology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CN2009801283679A 2008-05-15 2009-05-15 抑郁症的生物标记 Pending CN102099492A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0808834.6A GB0808834D0 (en) 2008-05-15 2008-05-15 Biomarkers for depression
GB0808834.6 2008-05-15
PCT/EP2009/055943 WO2009138499A2 (en) 2008-05-15 2009-05-15 Biomarkers for depression

Publications (1)

Publication Number Publication Date
CN102099492A true CN102099492A (zh) 2011-06-15

Family

ID=39571408

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801283679A Pending CN102099492A (zh) 2008-05-15 2009-05-15 抑郁症的生物标记

Country Status (6)

Country Link
US (1) US20110064655A1 (https=)
EP (1) EP2281066A2 (https=)
JP (1) JP2011523636A (https=)
CN (1) CN102099492A (https=)
GB (1) GB0808834D0 (https=)
WO (1) WO2009138499A2 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103571849A (zh) * 2012-08-06 2014-02-12 北京市理化分析测试中心 用于检测抑郁症的基因及其检测方法和试剂盒
CN104040337A (zh) * 2011-09-22 2014-09-10 迈德维特科学有限公司 筛选方法
CN105177117A (zh) * 2015-07-03 2015-12-23 张理义 重症抑郁障碍生物标记物、筛选方法及试剂盒

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0808833D0 (en) * 2008-05-15 2008-06-18 Ge Healthcare Ltd Biomarkers for depression
GB0808832D0 (en) * 2008-05-15 2008-06-18 Ge Healthcare Ltd Biomarkers for depression
KR102047479B1 (ko) * 2018-01-24 2019-11-21 전남대학교산학협력단 노년기우울증 검출방법 및 진단키트
CN113444802B (zh) * 2021-07-01 2024-02-06 复旦大学附属肿瘤医院 Htr1a在乳腺癌诊断、治疗和预后中的应用
WO2024215722A1 (en) * 2023-04-10 2024-10-17 Board Of Regents, The University Of Texas System Methods and compositions for diagnosing and treating depression and suicide risk

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7247442B1 (en) * 1998-05-12 2007-07-24 Human Genome Sciences, Inc. Antibodies to HHPEN62 polypeptide
WO2004047727A2 (en) * 2002-11-01 2004-06-10 The Board Of Trustees Of The Leland Stanford Junior University Compositions and methods for diagnosing and treating mood disorders
US20050209181A1 (en) * 2003-11-05 2005-09-22 Huda Akil Compositions and methods for diagnosing and treating mental disorders
DK1766077T3 (da) * 2004-06-21 2012-07-16 Univ Leland Stanford Junior Differentielt udtrykte gener og veje i bipolar forstyrrelse og/eller alvorlig depressiv forstyrrelse
WO2008020435A2 (en) * 2006-08-15 2008-02-21 Quark Pharmaceuticals, Inc Compositions and methods for treatment of mood disorders
GB0808833D0 (en) * 2008-05-15 2008-06-18 Ge Healthcare Ltd Biomarkers for depression
GB0808832D0 (en) * 2008-05-15 2008-06-18 Ge Healthcare Ltd Biomarkers for depression

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104040337A (zh) * 2011-09-22 2014-09-10 迈德维特科学有限公司 筛选方法
CN104040337B (zh) * 2011-09-22 2017-07-14 迈德维特科学有限公司 筛选方法
US9920371B2 (en) 2011-09-22 2018-03-20 Medvet Sciences Pty. Ltd. Screening method
US10494674B2 (en) 2011-09-22 2019-12-03 Precision Medicine Holdings Pty Ltd Screening method
US11274346B2 (en) 2011-09-22 2022-03-15 Precision Medicine Holdings Pty Ltd Screening method
CN103571849A (zh) * 2012-08-06 2014-02-12 北京市理化分析测试中心 用于检测抑郁症的基因及其检测方法和试剂盒
CN103571849B (zh) * 2012-08-06 2015-05-13 北京市理化分析测试中心 用于检测抑郁症的基因及其检测方法和试剂盒
CN105177117A (zh) * 2015-07-03 2015-12-23 张理义 重症抑郁障碍生物标记物、筛选方法及试剂盒

Also Published As

Publication number Publication date
US20110064655A1 (en) 2011-03-17
WO2009138499A3 (en) 2010-02-25
WO2009138499A2 (en) 2009-11-19
EP2281066A2 (en) 2011-02-09
JP2011523636A (ja) 2011-08-18
GB0808834D0 (en) 2008-06-18

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Application publication date: 20110615