CN102099330B - 供给氧化氮的前列酰胺 - Google Patents

供给氧化氮的前列酰胺 Download PDF

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Publication number
CN102099330B
CN102099330B CN200980127115.4A CN200980127115A CN102099330B CN 102099330 B CN102099330 B CN 102099330B CN 200980127115 A CN200980127115 A CN 200980127115A CN 102099330 B CN102099330 B CN 102099330B
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mmol
ono
nmr
added
nitroxyl
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CN200980127115.4A
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Chinese (zh)
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CN102099330A (zh
Inventor
F·贝内迪尼
S·比翁迪
V·奇罗利
W·K·M·庄
L·董
A·H-P·克劳斯
F·尼科利
G·普拉萨纳
W·F·弗尼尔
Y·杨
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Nicox SA
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Nicox SA
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/02—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00 containing nitrogen-oxide bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200980127115.4A 2008-05-09 2009-05-11 供给氧化氮的前列酰胺 Active CN102099330B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5208408P 2008-05-09 2008-05-09
US61/052084 2008-05-09
US13933308P 2008-12-19 2008-12-19
US61/139333 2008-12-19
PCT/IB2009/005594 WO2009136281A1 (en) 2008-05-09 2009-05-11 Nitric oxide donating prostamides

Publications (2)

Publication Number Publication Date
CN102099330A CN102099330A (zh) 2011-06-15
CN102099330B true CN102099330B (zh) 2014-04-30

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ID=41020929

Family Applications (1)

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CN200980127115.4A Active CN102099330B (zh) 2008-05-09 2009-05-11 供给氧化氮的前列酰胺

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US (1) US8101658B2 (https=)
EP (1) EP2274279B1 (https=)
JP (1) JP5401540B2 (https=)
CN (1) CN102099330B (https=)
AR (1) AR076731A1 (https=)
CA (1) CA2723704C (https=)
ES (1) ES2428387T3 (https=)
WO (1) WO2009136281A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6087147B2 (ja) * 2009-06-22 2017-03-01 ジョンソン、マッセイ、パブリック、リミテッド、カンパニーＪｏｈｎｓｏｎ Ｍａｔｔｈｅｙ Ｐｕｂｌｉｃ Ｌｉｍｉｔｅｄ Ｃｏｍｐａｎｙ プロスタグランジンの精製方法
CN103459368B (zh) * 2011-02-14 2016-06-08 阿勒根公司 比马前列素组合物的酯衍生物和方法
US20150272988A1 (en) 2012-03-07 2015-10-01 Advanced Inhalation Therapies (Ait) Ltd. Inhalation of nitric oxide for treating respiratory diseases
CA2871292A1 (en) 2012-05-31 2013-12-05 Theravance Biopharma R&D Ip, Llc Nitric oxide donor neprilysin inhibitors
US10280138B2 (en) 2015-03-31 2019-05-07 Nicox S.A. Nitric oxide donating derivatives of fluprostenol
US10047047B2 (en) 2015-03-31 2018-08-14 Nicox S.A. Nitric oxide donating derivatives of latanoprost free acid
EP3088388A1 (en) 2015-04-30 2016-11-02 NicOx S.A. Nitric oxide donating derivatives of prostaglandins
CA2997896C (en) 2015-09-09 2026-03-17 Beyond Air Ltd Nitric oxide inhalation therapy for infants with bronchiolitis
US11058691B2 (en) 2016-11-08 2021-07-13 Nicox S.A. Nitric oxide releasing prostaglandin derivatives for treating normal tension glaucoma
ES2923623T3 (es) 2018-02-21 2022-09-29 Nicox Sa Procedimiento para la preparación de un análogo de prostaglandina donante de óxido nítrico
RU2718744C2 (ru) 2018-05-17 2020-04-14 Общество с ограниченной ответственностью "Гурус БиоФарм" Производные простагландина F2альфа для снижения внутриглазного давления
AU2019300203B2 (en) * 2018-07-12 2025-01-30 Nicox S.A. Ophthalmic compositions containing a nitric oxide releasing prostamide
EP3772511B1 (en) * 2019-08-05 2023-11-08 Nicox S.A. Process for the preparation of a nitric oxide donating prostaglandin analogue
HUE071098T2 (hu) * 2021-02-03 2025-08-28 Nicox Sa Eljárás nitrogén-monoxidot donáló prosztaglandin analóg elõállítására
EP4404936A1 (en) 2021-09-20 2024-07-31 Nicox SA Nitric oxide releasing prostamide as neuroprotective agent
CN113943266A (zh) * 2021-11-18 2022-01-18 广州楷石医药有限公司 一种氧化氮供体型贝前列素类衍生物及其药物组合物和用途
LT4303211T (lt) 2022-07-07 2024-11-25 Nicox S.A. Pramoninis procesas, skirtas heksano rūgšties, 6-(nitrooksi)-, (1s,2e)-3- [(1r,2r,3s,5r)-2-[(2z)-7-(etilamino)-7-okso-2-hepten-1-il]-3,5- dihidroksiciklopentil]-1-(2-feniletil)-2-propen-1-ilo esterio ir aukšto grynumo produkto gamybai
CN115677549A (zh) * 2022-10-27 2023-02-03 神隆医药（常熟）有限公司 一种贝美前列素手性异构体的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1420865A (zh) * 2000-02-08 2003-05-28 阿勒根公司 降眼压类脂类
CN1639117A (zh) * 2002-03-01 2005-07-13 阿勒根公司 前列腺酰胺的制备
WO2007000641A2 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives
CN1906159A (zh) * 2004-01-05 2007-01-31 尼考斯股份公司 前列腺素硝基氧衍生物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352708A (en) * 1992-09-21 1994-10-04 Allergan, Inc. Non-acidic cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents
TWI298257B (en) * 2001-05-31 2008-07-01 Allergan Inc Hypotensive lipid and timolol compositions and methods of using same
EP1336602A1 (en) * 2002-02-13 2003-08-20 Giovanni Scaramuzzino Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases
US20070015838A1 (en) * 2005-07-14 2007-01-18 Allergan, Inc. Cyclopentane n-lower alkyl heptenamide-5-cis-2-(3alpha-hydroxy-5-phenylpentyl)-3, 5-dihydroxy, [1alpha, 2beta, 3alpha, 5alpha] compounds as agents for lowering intraocular pressure

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1420865A (zh) * 2000-02-08 2003-05-28 阿勒根公司 降眼压类脂类
CN1639117A (zh) * 2002-03-01 2005-07-13 阿勒根公司 前列腺酰胺的制备
CN1906159A (zh) * 2004-01-05 2007-01-31 尼考斯股份公司 前列腺素硝基氧衍生物
WO2007000641A2 (en) * 2005-06-29 2007-01-04 Pfizer Inc. Prostaglandin derivatives

Also Published As

Publication number Publication date
JP5401540B2 (ja) 2014-01-29
CA2723704A1 (en) 2009-11-12
HK1160835A1 (en) 2012-08-17
CN102099330A (zh) 2011-06-15
WO2009136281A1 (en) 2009-11-12
EP2274279A1 (en) 2011-01-19
ES2428387T3 (es) 2013-11-07
AR076731A1 (es) 2011-07-06
JP2011519910A (ja) 2011-07-14
EP2274279B1 (en) 2013-07-31
CA2723704C (en) 2017-08-22
US8101658B2 (en) 2012-01-24
US20110092590A1 (en) 2011-04-21

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Denomination of invention: Prostacylamide for nitrogen oxide

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