CN102095844A - Biochemical analyzer and biochemical analysis method thereof - Google Patents
Biochemical analyzer and biochemical analysis method thereof Download PDFInfo
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- CN102095844A CN102095844A CN2011100080229A CN201110008022A CN102095844A CN 102095844 A CN102095844 A CN 102095844A CN 2011100080229 A CN2011100080229 A CN 2011100080229A CN 201110008022 A CN201110008022 A CN 201110008022A CN 102095844 A CN102095844 A CN 102095844A
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Abstract
The invention discloses a biochemical analyzer and a biochemical analysis method thereof. The biochemical analyzer comprises a biochemical analysis module, a rotating disc and a control unit, wherein the biochemical analysis module is used for carrying out biochemical analysis detection on samples to be detected; the rotating disc is provided with a plurality of reaction cups in which different agents for biochemical analysis are filled in advance; the outer side of the rotating disc is provided with a constant temperature device for carrying out incubation on the rotating disc; and the control unit is used for controlling the incubation time before the rotating disc conveys the reaction cups into the biochemical analysis module for analysis. In the biochemical analyzer and the biochemical analysis method thereof disclosed by the invention, as the rotating disc structure and the control unit are adopted, the rotating time of the rotating disc is controlled, and the reacted reaction cups are conveyed into the biochemical analysis module so as to be subjected to analysis and detection, so that the operation processes of operators are simplified, and fast obtaining of biochemical analysis and detection results can be realized with no need of operators with special professional standards.
Description
Technical field
The present invention relates to a kind of external biochemistry detection in analyzing analyser commonly used with and analytical approach, in particular a kind of reducing cost and Biochemical Analyzer and its analytical approach of the professional requirement of operating personnel.
Background technology
The clinical biochemical Interventions Requested not only have most important effect in clinical diagnosis, also with the prevention and the control of a lot of diseases inseparable relation is arranged, and have now become the indispensable detection means of clinician.Measure these projects at present and all must use some special-purpose analytical instrument, as automatic clinical chemistry analyzer, semi-automatic biochemical analyzer.
The process of biochemical analysis comprises following four steps: 1, sample is joined in the reaction cup; 2, reagent corresponding is added in the reaction cup; 3, the potpourri to sample in the reaction cup and reagent carries out incubation, to finish reaction; 4, the reaction product in the reaction cup is carried out photoelectro-colorimetric analysis.Automatic clinical chemistry analyzer is all finished four steps by machine, be characterized in automaticity height, fast, the measurement flux height of test speed, but also price is expensive, volume is big, in the big-and-middle-sized hospital of China, because its better economic benefit generally all adopts automatic clinical chemistry analyzer.
And semi-automatic biochemical analyzer is just finished the final step of four steps, and three steps of front all want the operator to finish by hand, the characteristics of semi-automatic biochemical analyzer are that volume is little, and low price is suitable for some small medical mechanisms such as She Kang center, city, villages and towns in rural areas commune hospital etc.But it is loaded down with trivial details relatively, high to operating personnel's operative skill and specialty requirement that automanual analyser is operated, and the instrument user of service of these small medical mechanisms does not generally pass through good professional training, degree of accuracy is very poor as a result to use automanual instrument to measure it, often can't obtain satisfied result.
With the liver function six (glutamic-pyruvic transaminase, glutamic-oxalacetic transaminease, total bilirubin, bilirubin direct, albumin, total proteins) of measuring a sample is example, and the loaded down with trivial details of its process is described.The checked operation personnel at first need to prepare 6 test tubes, add a certain amount of blood sample earlier in each test tube; In each test tube, add reagent corresponding separately then respectively; Adding finishes, and puts into incubator again and makes its reaction regular hour; And then, take in the semi-automatic biochemical analyzer respectively and detect the invisible spectro reaction product of difference.This process is very complicated, and consuming time, and needs operating personnel to have the professional knowledge of higher level, also needs operating personnel in time to control the time of incubation.
Because semi-automatic biochemical analyzer complex operation, require very high to operating personnel's operative skill, and automatic clinical chemistry analyzer costs an arm and a leg, volume is big, in the system of the She Kang center in city, all be every day sample to be put together to deliver to the large hospital that it belongs to generally at present, centralab by large hospital carries out Measurement and analysis with full automatic instrument, the result is delivered to the She Kang center then in second day again.But the drawback of this working method is the doctor at She Kang center can't in time obtain patient's testing result, and has prolonged the time that patient goes to a doctor.In order to obtain accurately and testing result timely, a lot of patients do not stint to seek something far and wide when it is within reach and go to large hospital to go to a doctor, and this has just caused overstaffed and She Kang center and the health clinics in towns and townships phenomenon that you can catch sparrows on the doorstep of each big general hospital of China.This prescription on individual diagnosis pattern had both been wasted the resource of large hospital, had also increased patient's unnecessary economy spending, caused the unbalanced of medical resource use, caused the level watching difficulty and saw a doctor slow phenomenon.
Therefore, develop a kind of simple to operate, volume is little, price is low, operation requires low automatic biochemistry analyzer, can carry out biochemical project in She Kang center, city and villages and towns in rural areas commune hospital and measure significant.
Summary of the invention
The object of the present invention is to provide a kind of Biochemical Analyzer and biochemical analysis method thereof,, provide a kind of low cost and operation to require low Biochemical Analyzer and biochemical analysis method at the defective of above-mentioned prior art.
Technical scheme of the present invention is as follows:
A kind of Biochemical Analyzer, it comprises a biochemical analysis module, is used for that detected sample is carried out biochemical analysis and detects; Wherein, also comprise a rotating disk, described rotating disk is provided with several reaction cup, sets in advance the different reagent that are useful on biochemical analysis in described reaction cup; The arranged outside of described rotating disk has thermostat, is used for that described rotating disk is carried out incubation and handles; Described biochemical analysis module is arranged on the part of described rotating disk, the position of corresponding described reaction cup; And a control module, be used to control the incubation time before described rotating disk is sent into described reaction cup described biochemical analysis module and analyzed.
Described Biochemical Analyzer, wherein, described reaction cup is set to around the edge of described rotating disk and arc shooting.
Described Biochemical Analyzer, wherein, described reaction cup is set to the stand-alone integrated parts that required reagent is housed in advance.
Described Biochemical Analyzer wherein, also is provided with the injection device that comprises that a pair of detected sample adds at the side of described rotating disk.
Described Biochemical Analyzer wherein, also is provided with an ISE electrolyte measurement module at described rotating disk side, injects detected sample to this ISE electrolyte measurement module by described injection device.
Described Biochemical Analyzer, wherein, described thermostat comprises the recessed dish that is arranged on the described rotating disk outside, the thermostatic heater spare in described recessed dish.
A kind of biochemical analysis method, it may further comprise the steps:
A, a plurality of reaction cup that will add different reagent in advance are set on the rotating disk, are injected into detected sample in the reaction cup respectively when detecting;
B, reaction cup remained on carry out incubation in the incubation chamber and reaction reaches the schedule time;
C, change reaction cup over to the biochemical analysis module and carry out photoelectro-colorimetric analysis.
Described biochemical analysis method, wherein, described a plurality of reaction cup independently set in a row, and described steps A also comprises: the injection device by described rotating disk side injects detected sample in described reaction cup.
A kind of Biochemical Analyzer provided by the present invention and biochemical analysis method thereof, owing to adopt turntable structure and control module, be used for controlling the rotation time of rotating disk and reacted reaction cup being sent into the biochemical analysis module carry out analyzing and testing, simplified operating personnel's operating process, need not the operator have professional level, can realize that quick biochemical analysis and testing result obtain, on the one hand, the project that patient can carry out some routines nearby, regularly need check; On the other hand, the doctor can in time obtain patient's testing result, formulates the proper treatment scheme, alleviates the phenomenon of China's difficulty and high cost of getting medical, the high cost of getting medical treatment to a certain extent.
Description of drawings
Fig. 1 a and Fig. 1 b are the structural representation of Biochemical Analyzer preferred embodiment of the present invention.
Fig. 2 is the schematic flow sheet of biochemical analysis method of the present invention.
Embodiment
Below preferred embodiment of the present invention is described in detail.
Biochemical Analyzer provided by the present invention and biochemical analysis method thereof, shown in Fig. 1 a and Fig. 1 b, in the preferred embodiment of described Biochemical Analyzer, it has comprised a biochemical analysis module 110, be used for detected sample such as blood are carried out the biochemical analysis detection, the technology of this biochemical analysis module is identical with the biochemical analysis technology of prior art, and what adopt basically is photoelectro-colorimetric analysis, and ins and outs do not repeat them here; Match with described biochemical analysis module 110 and to be provided with an incubation chamber 120, also be provided with a rotating disk 130 simultaneously, the thermostat that described incubation chamber 120 can be adopted in described rotating disk arranged outside, described thermostat comprises a recessed dish 121 in described rotating disk 130 arranged outside, and the thermostatic heater spare that in described recessed dish 121, is provided with, as resistance wire and sensor etc.
Described rotating disk 130 is provided with several or array reaction cup 140, reaction cup 140 can be by the stand-alone integrated setting of group, also can be wholely set with described rotating disk 130, in described reaction cup 140, set in advance the different reagent that are useful on biochemical analysis, for example, also multiple different reagent can be encapsulated in the integrated reaction cup respectively in advance at the different reagent of liver function or the detection of kidney merit.Simultaneously, a control module 150 is set also, is used for to controlling the schedule time of described rotating disk 130, and after reaching the corresponding time, described reaction cup 140 is sent into described biochemical analysis module and carry out biochemical analysis at described incubation chamber 120 internal reactions.Described control module 150 general motors by the described rotating disk 130 of controlling and driving are realized.
Described reaction cup 140 can be set to four groups, eight groups or other combination in any on described rotating disk 130, every group of several reaction cup 140 forms arc shooting, with convenient design to auxiliary pivoted arm etc., edge at described rotating disk 130 can be provided with fixed sturcture, is used for reaction cup 140 is fixed on the edge of described rotating disk 130.Certainly, the reaction cup 140 that also can be provided with on the described rotating disk 130 is other arrangement modes, and is for example in line.For convenient sample in the reaction cup 140 is added, side at described rotating disk 130 also is provided with the injection device 160 that comprises that a pair of detected sample adds, for example injection-tube can stop on the reaction cup 140 of correspondence and operate by an automatic swing arm setting, as shown in Figure 1a.Therefore, Biochemical Analyzer of the present invention can be set to inject automatically sample (as shown in Figure 1a), also can be set to only keep incubation chamber 120 and biochemical analysis module 110(shown in Fig. 1 b), inject sample by manually-operated, the reaction cup 140 that will inject sample then is put into carries out incubation reaction and enters biochemical analysis automatically realizing on the described rotating disk 130.
In the slewing area of described injection device 160, be provided with sample cup 170, can be one or several, so that described injection device 160 can join sample in the reaction cup 140 automatically, certainly, for guaranteeing the cleaning of injection device 160, between described sample cup 170 and reaction cup 140, also be provided with a cleaning unit 180, with be externally connected to cleaning fluid so that before described injection device 160 resets to new sample cup 170, on described cleaning unit 180, stop earlier and do and clean action.
In another preferred embodiment of the present invention, in the slewing area of described injection device 160, can also one ISE(Ion Selective Electrode be set at described rotating disk 130 sides, ion-selective electrode) the electrolyte measurement module 190, as shown in Figure 1a, inject detected sample to this ISE electrolyte measurement module 190 by described injection device 160, carry out electrolytical measurement, so, Biochemical Analyzer of the present invention can be applied in the emergency treatment, obtains fast and measures the needed result of emergency treatment.
The present invention also provides a kind of biochemical analysis method simultaneously, and as shown in Figure 2, it may further comprise the steps: in a plurality of reaction cup 140, add different reagent respectively, and detected sample, as blood; Described reagent can be encapsulated in the reaction cup 140 in advance, and with described reaction cup 140 independent settings; Control by described control module 150, described reaction cup 140 is remained on carry out in the incubation chamber 120 incubation and the reaction schedule time, when for example needing to react 10 minutes, described reaction cup 140 was kept 10 minutes in described incubation chamber 120; Then reaction cup 140 is changed over to and carry out the biochemical analysis detection in the biochemical analysis module 110, the biochemical analysis process of biochemical analysis module 110 is the known technology of prior art, does not repeat them here.When described a plurality of reaction cup 140 were independently set in a row, the process of described encapsulation reagent comprised: encapsulate different reagent respectively in described a plurality of reaction cup 140; Injection device 160 by described rotating disk 130 sides injects detected sample in described reaction cup 140, as blood, like this, Preservation of Reagent just can realize by the integrated kit with a plurality of reaction cup 140.
Biochemical Analyzer of the present invention and biochemical analysis method thereof are by being provided with the biochemical analysis process of semi-automatic or robotization, can adopt artificial injection detected sample, also can directly inject sample automatically by automatic biochemistry analyzer of the present invention, and by time of rotating disk 130 and control module 150 controls carrying out incubation, enter biochemical analysis module 110 then and carry out the biochemical analysis detection, Biochemical Analyzer of the present invention and biochemical analysis method cost are low, professional standards requirement to operating personnel is low, and the biochemical analysis that is particularly suitable under the town and country community medicine condition detects.
It is noted that, automatic biochemical analysis of the present invention is different from the automatic biochemistry analyzer of prior art, its reagent is to be encapsulated in advance in the reaction cup 140, therefore, concerning automatic biochemistry analyzer of the present invention, the process that adds reagent is save, only adding sample gets final product, so the volume of entire equipment can be very little, and its processing cost is also low, so price can be suitable for the relatively poor medical institutions of urban and rural economies condition.Simultaneously, incubation chamber 120 and rotating disk 130 are set to one, have further dwindled equipment volume.No matter whether adopt the injection device 160 of the rotating disk 130 sides sample of annotating automatically, to the automatic control of incubation process with enter the design that biochemical analysis module 110 is carried out biochemical analysis after the schedule time automatically, effectively reduce professional standards requirement to operating personnel, simplify personnel's operating process simultaneously, in the realization example of semi-automatic biochemical analyzer of the present invention, operating personnel only add sample according to quantity in the reaction cup 140 and get final product, other promptly control working time automatically by rotating disk 130 and control module 150, finish until analysis result data.
Should be understood that, for those of ordinary skills, can be improved according to the above description or conversion, and all these improvement and conversion all should belong to the protection domain of claims of the present invention.
Claims (8)
1. Biochemical Analyzer, it comprises a biochemical analysis module, is used for that detected sample is carried out biochemical analysis and detects; It is characterized in that also comprise a rotating disk, described rotating disk is provided with several reaction cup, in described reaction cup, set in advance the different reagent that are useful on biochemical analysis; The arranged outside of described rotating disk has thermostat, is used for that described rotating disk is carried out incubation and handles; Described biochemical analysis module is arranged on the part of described rotating disk, the position of corresponding described reaction cup; And a control module, be used to control the incubation time before described rotating disk is sent into described reaction cup described biochemical analysis module and analyzed.
2. Biochemical Analyzer according to claim 1 is characterized in that described reaction cup is set to around the edge of described rotating disk and arc shooting.
3. Biochemical Analyzer according to claim 2 is characterized in that, described reaction cup is set to the stand-alone integrated parts that required reagent is housed in advance.
4. according to the arbitrary described Biochemical Analyzer of claim 1 to 3, it is characterized in that, also be provided with at the side of described rotating disk and comprise the injection device that detected sample is added.
5. Biochemical Analyzer according to claim 4 is characterized in that, also is provided with an ISE electrolyte measurement module at described rotating disk side, injects detected sample to this ISE electrolyte measurement module by described injection device.
6. Biochemical Analyzer according to claim 1 is characterized in that, described thermostat comprises the recessed dish that is arranged on the described rotating disk outside, the thermostatic heater spare in described recessed dish.
7. biochemical analysis method of Biochemical Analyzer according to claim 1, it may further comprise the steps:
A, a plurality of reaction cup that will add different reagent in advance are set on the rotating disk, are injected into detected sample in the reaction cup respectively when detecting;
B, reaction cup remained on carry out incubation in the incubation chamber and reaction reaches the schedule time;
C, change reaction cup over to the biochemical analysis module and carry out photoelectro-colorimetric analysis.
8. biochemical analysis method according to claim 7 is characterized in that, described a plurality of reaction cup independently set in a row, and described steps A also comprises: the injection device by described rotating disk side injects detected sample in described reaction cup.
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| CN2011100080229A CN102095844A (en) | 2011-01-14 | 2011-01-14 | Biochemical analyzer and biochemical analysis method thereof |
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| CN2011100080229A CN102095844A (en) | 2011-01-14 | 2011-01-14 | Biochemical analyzer and biochemical analysis method thereof |
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Cited By (3)
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| CN102507566A (en) * | 2011-12-02 | 2012-06-20 | 江苏奥迪康医学科技有限公司 | Group detection method, reagent box and detection device for clinical biochemical samples |
| CN103969312A (en) * | 2013-01-28 | 2014-08-06 | 红电医学科技股份有限公司 | Detection device and detection method of detection test piece |
| CN105354445A (en) * | 2015-11-17 | 2016-02-24 | 南昌大学第二附属医院 | Blood marker-based intelligent recognition system for artificial neural network |
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Cited By (4)
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| CN102507566A (en) * | 2011-12-02 | 2012-06-20 | 江苏奥迪康医学科技有限公司 | Group detection method, reagent box and detection device for clinical biochemical samples |
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| CN103969312A (en) * | 2013-01-28 | 2014-08-06 | 红电医学科技股份有限公司 | Detection device and detection method of detection test piece |
| CN105354445A (en) * | 2015-11-17 | 2016-02-24 | 南昌大学第二附属医院 | Blood marker-based intelligent recognition system for artificial neural network |
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Application publication date: 20110615 |