CN102090414B - Bactericide composition with synergized action - Google Patents
Bactericide composition with synergized action Download PDFInfo
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- CN102090414B CN102090414B CN 201010605982 CN201010605982A CN102090414B CN 102090414 B CN102090414 B CN 102090414B CN 201010605982 CN201010605982 CN 201010605982 CN 201010605982 A CN201010605982 A CN 201010605982A CN 102090414 B CN102090414 B CN 102090414B
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Abstract
The invention discloses a bactericide composition with a synergized action, which relates to a bactericide composition with a synergized action for agriculture and horticulture. The composition comprises a compound A, namely 1,1'-imino di(1,8-octane) diguanidine (iminoctadine for short) or acid addition salt of the compound A and a compound B, namely 2-(2,4-dichlorophenyl)-1-[1,2,4] triazole-1-radical-hexylene-2-alcohol (hexaconazole for short), wherein the mass ratio of the compound A to the compound B is 1:20 to 20:1; the compound A and the compound B account for 5-80 percent by mass of the bactericide composition; and the compound A and the compound B are mixed with a liquid carrier or a solid carrier and/or a surfactant. The invention also discloses the application of the bactericide composition with the synergized action to the prevention and control of crop diseases.
Description
Technical field
What a kind of microbicide compositions with synergistic effect of the present invention related to is a kind of bacteriocide compositions for agricultural and horticultural use with synergistic effect.This composition contains 1,1 '-imino group two (1, the inferior octyl group of 8-) two guanidines (being called for short iminoctadine) or its acid-addition salts and 2-(2,4 dichloro benzene base)-1-[1,2,4] triazol-1-yl-oneself-2-alcohol (being called for short hexaconazole).
Background technology
Powdery mildew is to take place on many important crops generally, endanger seriously, difficult a kind of worldwide disease of preventing and treating.The multiple disease fungus of Ascomycotina all can cause powdery mildew, and the cause of disease crop species is a lot.Spore takes place in temperature to 10-30 ℃ and all can sprout in such germ, and not high to humidity requirement, normal condition can be finished and once infect circulation in following 10 days; Therefore caused season of growth of crop repeated multiple times to be infected, in case take place to cause irremediable massive losses to agricultural production under characteristics, especially the plastic greenhouse planting environment of very fast eruption and prevalence.
The gray mold germ belongs to Deuteromycotina, Botrytis, and wherein the Botrytis cinerea genus can infect vegetable crops such as tomato, eggplant, cucumber, custard squash.Gray mold is to protect regular incidence evil, particularly tomato, cucumber, the leek of ground vegetables to take place serious in recent years.The economic loss that this disease causes is generally 20-30%, can reach more than 50% when serious.
Iminoctadine or its acid-addition salts are effective (spy open clear 62-209003 communique) to the disease on a large scale of preventing and treating useful plant.Particularly tomato, cucumber, leek gray mold had remarkable control efficiency.But such disease of single control, the variation frequency of pathogen self is big in addition, causes pathogen that these medicaments have been produced pesticide resistance in various degree, and its anti-medicine heredity is very stable.
2-(2,4 dichloro benzene base)-1-[1,2; 4] triazol-1-yl-own-2-alcohol (being called for short hexaconazole); belong to azoles fungicide, the sterol demethylation inhibitor, the disease that fungi especially Basidiomycotina and Ascomycotina are caused has the protection and the therapeutic action of spectrum.Destroy and stop the biosynthesis of the cell membrane important composition composition ergosterol of germ, cause cell membrane not form, make germ death.Have interior suction, protection and therapeutic activity.Can prevent and treat disease that Basidiomycotina and Ascomycotina cause such as powdery mildew, rust, scab, brown spot, anthracnose effectively.Suitable crop and fruit tree such as apple, grape, banana, vegetables (melon and fruit, capsicum etc.), peanut, coffee, cereal crop and ornamental plants etc.
Iminoctadine or its acid-addition salts and own azoles alcohol can be respectively as the bactericide of gray mold and powdery mildew, but the effectiveness of these compounds differs and satisfies gray mold and powdery mildew surely and recur control requirement under the condition, in the long-term process of using, produced pesticide resistance in various degree, the defective that exists result of treatment to descend year by year.
Composite about iminoctadine or its acid-addition salts and own azoles alcohol do not see relevant report at present at home and abroad.
Summary of the invention
The present invention seeks to provides a kind of microbicide compositions with synergistic effect at above-mentioned weak point, the microbicide compositions that the present invention has synergistic effect is a kind of not only to the pathogenic disease, plant disease such as gray mold and powdery mildew particularly, have very good sterilization idiocratic, and also can show the novel composition of good control efficiency to these medicament drug resistance bacterium.Large-scale plant disease is effective to composition of the present invention under the condition to recurring.
The present invention has carried out various further investigations for solving above-mentioned problem, found that: contain iminoctadine or its acid-addition salts and 2-(2, the 4-dichlorophenyl)-and 1-[1,2,4] triazol-1-yl-oneself-composition of 2-alcohol (own azoles alcohol), not only for phytopathogen, to gray mold, plant diseases such as powdery mildew are effective especially, and also very effective to these medicament drug resistance bacterium, recur in disease and also to have good control efficiency under the condition, thereby finished the present invention.
Find out, contain the bacteriocide compositions for agricultural and horticultural use that following composition is made the novelty of active ingredient, have very good sterilizing power:
A) 1 of following formula, 1 '-imino group two (1, the inferior octyl group of 8-), two guanidines
Or its acid-addition salts, and
B) 2-of following formula (2,4 dichloro benzene base)-1-[1,2,4] triazol-1-yl-oneself-2-alcohol
Surprisingly, the bactericidal effect after the active compound combination of the present invention, more much bigger than single reactive compound effect sum.Thereby have expection less than, pure trade-off effect, this effect is not a simple addition.
A kind of microbicide compositions with synergistic effect of the present invention is to take following technical scheme to realize:
A kind of microbicide compositions with synergistic effect is characterized in that described composition contains:
A) following formula (Ia):
n＝10～13
1 of expression, 1 '-imino group two (1, the inferior octyl group of 8-), two guanidine trialkyl benzene sulfonates, and
B) following formula (II):
2-(2,4 dichloro benzene the base)-1-[1 of expression, 2,4] triazol-1-yl-oneself-2-alcohol;
Wherein the mass ratio of compd A and B is 1: 20-20: 1.
The mass ratio of described compd A and B is 1: 10-10: 1.
The mass percent that described compd A and B account in the microbicide compositions is 5%-80%.
The quality percentage composition that described compd A and B account in the microbicide compositions is 20%-60%.
Described compd A and B and liquid-carrier or solid carrier and/or surfactant mix.
The described a kind of application of microbicide compositions on control of crop disease with synergistic effect.
Described a kind of microbicide compositions with synergistic effect is used for the control of powdery mildew, gray mold.
Described 1,1 '-imino group two (1, the inferior octyl group of 8-), two guanidines are known to the specific expression of formula (I), iminoctadine generally by name.
The acid-addition salts of Iminoctadine can be enumerated for example carboxylate, sulfonate, hydrochloride, carbonate, lauryl sulfate, sulphate, phosphate etc.Said carboxylate can be enumerated acetate, oxalate, laruate, oleate, citrate etc.Said sulfonate can be enumerated alkylsulfonate and alkylbenzenesulfonate etc.Said alkylsulfonate can be enumerated bay acidic group sulfonate, dodecane sulfonate etc.
Said alkylbenzenesulfonate can be enumerated dodecyl benzene sulfonate, tosilate etc.Sulfonate such as optimization acid's salt and alkylbenzenesulfonate.Wherein have 1-18 carbon atom in the preferred alkyl, more preferably have the alkylbenzenesulfonate of 10-13 carbon atom.
Can enumerate 1,1 '-imino group two (1, the inferior octyl group of 8-), two guanidines. trialkyl benzene sulfonate (two eight guanidinesalts), as the acid-addition salts example of Iminoctadine.This compound is represented with following structural formula:
n＝10～13
(two eight guanidinesalts)
Formula (I) iminoctadine and acid-addition salts thereof are known material (opening clear 62-209003 communique referring to the spy).
The 2-of formula (II) (2,4 dichloro benzene base)-1-[1,2,4] triazol-1-yl-oneself-2-alcohol also is known compound (referring to US3,902,887)
Above-mentioned synergy, obvious especially when reactive compound is present in the composition of the present invention with the specified weight ratio.But the weight ratio of reactive compound can be selected in bigger scope.Generally speaking, the weight ratio of compd A and compd B is 1: 20-20: 1. preferred 1: 10-10: 1.
The content of present composition active component depends on the dosage when bactericide uses separately, also depends on the mixed ratio and the synergistic effect degree of a kind of bactericide and another kind of bactericide.In the described microbicide compositions with synergistic effect, the quality percentage composition that compd A and compd B account in the bactericidal composition is 5%-80%, and the quality percentage composition that compd A and compd B account in the bactericidal composition is preferably 20%-60%.
Bacteriocide compositions for agricultural and horticultural use of the present invention both can directly use, also can be with aqua, and common preparation form such as suspending agent, pulvis, missible oil, finish, lozenge, granula, aerosol is used.This preparation can be used usual method, for example with reactive compound and liquid-carrier or solid carrier, surfactant, other additive etc. with the suitable method preparation that mixes.
The liquid-carrier that is fit to preparation microbicide compositions of the present invention comprises aromatic hydrocarbons, aliphatic hydrocarbon.Particularly suitable be polar solvent, as alcohols and their ether and ester.Also have vegetable oil and the molten fiber of methyl in addition.Simultaneously, mixtures of different liquids also is suitable for.
The solid carrier that is fit to preparation microbicide compositions of the present invention is any carrier that is generally used for preparing bactericide.For example diatomite, Magnesiumaluminumsilicate, atlapulgite, kaolin, clay, gypsum, bentonite, white carbon, precipitated calcium carbonate, lime stone, wood chip, corn starch, soluble starch etc.
The emulsifier that is fit to preparation microbicide compositions of the present invention can be anion and/or non-example type emulsifier, for example alkylphenol polyoxyethylene, alkylphenol-polyethenoxy polyethenoxy ether, benzylphenol APEO, polyoxyethylene fatty acid ester, polyoxyethylene aliphatic alcohol ether, polyoxyethylene fatty amine, alkyl phenol polyglycol ether etc.
The dispersant that is fit to preparation microbicide compositions of the present invention can be alkylnaphthalene sulfonate, two (alkyl) naphthalenesulfonate formaldehyde condensation compound, naphthalene sulfonic acid-formaldehyde condensation product, the alkylphenol-polyethenoxy based phosphates, alkylphenol-polyethenoxy base ether formaldehyde condensation products sulphate, the alkylphenol polyoxyethylene phosphate, alkylphenol polyoxyethylene, the castor oil ethylene oxide adduct, ethylene oxide-propylene oxide block copolymer, the dirt of alkylphenol polyoxyethylene formaldehyde condensation, octylphenol polyethylene oxyethylene group ether sulfate and methylcellulose.For example sodium lignin sulfonate, calcium lignosulfonate, methyl naphthalene sulfonate formaldehyde condensate, the dirt of sodium naphthalene sulfonate formaldehyde condensation, methanonaphthalene sodium sulfonate etc.
Other additive can be enumerated the carboxymethyl cellulose that uses with the auxiliary agent form usually, ethylene glycol and propane diols etc. when preparation.
Composition of the present invention can also contain colouring agent, for example inorganic pigment iron oxide, titanium oxide or Prussia orchid; Organic dyestuff alizarin, azo dyes, metal phthalocyanine orchid or kiton colors etc.
Composition of the present invention can also have the medicament of weeding, desinsection or bactericidal property with other, particularly mixes use with protective fungicide, also can mix use with nematocide, protective agent, growth regulator, nutrient for plants or soil conditioner.
Composition of the present invention can be used by common method, and amount of application is with weather or crop state variation, use optimum period and be crop susceptible before or the susceptible initial stage.Its lasting period is relevant with the content in the composition, also relevant with extraneous factor usually.
The bactericidal composition that agriculture and garden of the present invention is used has very good sterilization idiocratic, can be used for the pathogen of agriculture and garden control plant.This composition can good control causes the pathogen and the medicament drug-fast bacteria of following disease: the phytophthora root rot of tomato, gray mold, leaf rust, spot disease, anthracnose and phytophthora root rot early; The downy mildew of cucumber, powdery mildew, gray mold, anthracnose, withered rattan disease, black spot and brown spot; Anthracnose of strawberry and gray mold; The powdery mildew of pumpkin, anthracnose and withered rattan disease; Hickie leaf blight, black spot, gray mold and the Mild Powder of onion; The powdery mildew of eggplant, gray mold and bacterial blight; The black spot of shallot; Leucoplakia of Chinese cabbage and black spot; The stalk break of green pepper and gray mold; The powdery mildew of cucumber, anthracnose and withered rattan disease; The powdery mildew of muskmelon, anthracnose and withered rattan disease; The gray mold of lettuce; Black spot of red bayberry and gray mold; The powdery mildew of persimmon, anthracnose, gray mold and defoliation; The gray mold of oranges and tangerines; The scab of pears, black spot and phytophthora root rot early; The gray mold of grape, anthracnose, brown spot, black rattan disease, withered rattan disease, sticking rot and the swollen disease of branch; The scab of peach, graywall, anthracnose; The scab of apple, zonate spot, early phytophthora root rot, brown spot, coal point disease, coal spot disease, diplostomiasis and brown rot; The stem wilt of mung bean, anthracnose, gray mold and stalk break; The anthracnose of Kidney bean, gray mold and stalk break; The ring spot of broad bean; Soybean purple speck; The powdery mildew of tobacco, the brown spot of beet and spot disease; Withered disease of the anthracnose of tea, zonate spot and sprouting and gray mold; The plant diseases such as scab, anthracnose, gray mold and powdery mildew of flower class.The powdery mildew of control tomato, cucumber, eggplant, strawberry, grape, peach and oranges and tangerines that particularly can be good and the phytopathogen of the gray mold cause of disease and medicament drug-fast bacteria.
This bacteriocide compositions for agricultural and horticultural use can be used for the breeding time of asparagus, strawberry, pumpkin, wild cabbage, cucumber, asparagus lettuce, watermelon, onion, tomato, eggplant, shallot, Chinese cabbage, green pepper, spinach, muskmelon, muskmelon, lettuce, red bayberry, persimmon, citrus, pears, grape, peach, apple, red bean, Kidney bean, broad bean, soybean, tobacco, beet, tea, flowers class crops such as (rose, chrysanthemum, carnation, ivyleaf cyclamen, felworts etc.).Special under the situation of grape, even in breeding time, also can well be applicable in the preceding-children's florescence of blooming.
Product described in the invention can the finished product preparation form provide, and promptly each material mixes in the composition, and the composition of composition also can provide with single agent form, directly directly mixes in bucket or in the jar before the use, is diluted to required concentration then.The frequency of administration of the present composition and amount of application change with weather condition and crop state, can reach the purpose of control by using suitable formulation.
The present invention also comprises on-the-spot method of administering fungi: handle this place with microbicide compositions of the present invention, wherein the place comprises and is subjected to fungal infection or the plant of not infecting, the seed of these plants or the medium of plant growing.
Composition of the present invention has the following advantages:
1. said composition can show fabulous synergistic effect in certain ratio range, and its bactericidal effect is remarkable;
2. said composition can reduce the mu using dosage of medicament in application, thereby both can reduce can significantly reduce agricultural cost again to influence degree;
3. in the said composition, iminoctadine or its acid-addition salts are mainly used in the gray mold of control crop, and own azoles alcohol has high activity to the white powder germ, so its composition has more the preventive and therapeutic effect targetedly of synergy to crop powdery mildew and gray mold.
Embodiment
In order to make purpose of the present invention, technical scheme and advantage clearer, the present invention describes with following specific embodiment, but the present invention is limited to these examples absolutely not.The following stated only is the present invention embodiment preferably, only in order to explain the present invention, can not therefore be interpreted as the restriction to claim of the present invention.Should be pointed out that all any modifications of being made within the spirit and principles in the present invention, be equal to replacement and improvement etc., all should be included within protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
The combination of active principles of different agricultural chemicals is made agricultural chemicals, is a kind of mode effectively and efficiently that exploitation at present and development novel pesticide and control agricultural go up the resistance germ.The agricultural chemicals of different cultivars shows three kinds of type of action: summation action, synergistic effect and antagonism after mixing usually.But be specially which kind of effect, unpredictable, have only by a large amount of experiments and just can know.Compound synergic is well filled a prescription, owing to obviously improved actual control efficiency, reduced the usage amount of agricultural chemicals, thereby delayed the drug-fast generation speed of germ widely, and be the important means of integrated control disease.
The inventor is by a large amount of screening tests, utilization iminoctadine and acid-addition salts thereof carry out the synergistic effect analysis of different proportionings with own azoles alcohol microbicide compositions, discovery is in certain ratio range, iminoctadine and acid-addition salts thereof and own azoles alcohol microbicide compositions antagonism phytopathogen have obvious role in synergism, and be not only the simple addition of two kinds of medicaments, specifically be illustrated with following biologicall test example.
Biologicall test embodiment 1:
Two eight guanidinesalts and own azoles alcohol adopt spray-on process to the Toxicity Determination and the proportioning screening of powdery mildew of cucumber, measure two eight guanidinesalts and the composite indoor virulence to powdery mildew of cucumber of own azoles alcohol of different proportion.
Calculate the toxicity index of each medicament and the co-toxicity coefficient of mixture (CTC value) according to the abundant method of Sun Yun, when CTC≤80, then compositions table reveals antagonism, when 80＜CTC＜120, then compositions table reveals summation action, and when CTC 〉=120, then compositions table reveals synergistic effect.
Actual measurement toxicity index (ATI)=(standard medicament EC
50/ reagent agent EC
50) X100
The percentage composition of B in percentage composition+B medicament toxicity index X mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index X mixture
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (the ATI)/theoretical toxicity index (TTI) of mixture] X100
Table 1 pair eight guanidinesalts and own azoles alcohol are to the Toxicity Determination and the proportioning screening of powdery mildew of cucumber
The result shows, two eight guanidinesalts and own azoles alcohol are at proportioning 1: 20-20: obvious synergistic effect is arranged between 1, and co-toxicity coefficient is more than 120.
Biologicall test example 2:
Two eight guanidinesalts and the composite Toxicity Determination of own azoles alcohol to apple mildew
Adopt spray-on process, measure two eight guanidinesalts and the composite indoor virulence of own azoles alcohol of different proportion apple mildew.
Table 2 pair eight guanidinesalts and own azoles alcohol are to the Toxicity Determination and the proportioning screening of apple mildew
The result shows, two eight guanidinesalts and own azoles alcohol are at proportioning 1: 20-20: obvious synergistic effect is arranged between 1, and co-toxicity coefficient is more than 120.
Biologicall test example 3:
Two eight guanidinesalts and the composite Toxicity Determination of own azoles alcohol to graw mold of tomato
Adopt spray-on process, measure two eight guanidinesalts and the composite indoor virulence of own azoles alcohol of different proportion graw mold of tomato.
Table 3 pair eight guanidinesalts and own azoles alcohol are to the Toxicity Determination and the proportioning screening of graw mold of tomato
The result shows, two eight guanidinesalts and own azoles alcohol are at proportioning 1: 20-20: obvious synergistic effect is arranged between 1, and co-toxicity coefficient is more than 120.
Biologicall test example 4:
Two eight guanidinesalts and the composite Toxicity Determination of own azoles alcohol to grape grey mould
Adopt spray-on process, measure two eight guanidinesalts and the composite indoor virulence of own azoles alcohol of different proportion grape grey mould.
The result shows, two eight guanidinesalts and own azoles alcohol are at proportioning 1: 20-20: obvious synergistic effect is arranged between 1, and co-toxicity coefficient is more than 120.
Fungicidal composition of the present invention can be prepared into known method and be fit to any one formulation that agricultural goes up use, and reasonable formulation is wetting powder, water dispersible granules, suspending agent and suspended emulsion.Below describe with specific embodiment.Percentage all is weight percentage in all prescriptions.The processing technology of the various preparations of the present composition is prior art, can change to some extent according to different situations.
Embodiment 1 water dispersible granules (gross weight of preparation is 100 parts)
Two eight guanidinesalts, 30.0 weight portions
Own azoles alcohol 30.0 weight portions
Polyvinyl alcohol 5.0 weight portions
Sodium Laurylsulfate 7.0 weight portions
Lignosulfonates 11.0 weight portions
The kaolin surplus
Above-mentioned substance is evenly mixed, grinds, mixes suitable quantity of water and granulation, promptly get said preparation after the drying.
This embodiment is used to prevent and treat powdery mildew of cucumber.By 4000 extraordinarily water dilution sprayings, 7 days control efficiency is 96.4% behind the medicine with said preparation.40,%00 can get wetting powder by 1000 times and 10% hexaconazole suspending agent by 1000 times, use with quadrat method and use, 7 days preventive effect is respectively 75.3% and 80.3% behind the medicine.The composite back synergistic effect of two eight guanidinesalts and own azoles alcohol is obvious, to the preventive effect of powdery mildew of cucumber significantly better than single agent; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
Embodiment 2 wetting powders (gross weight of preparation is 100 parts)
Two eight guanidinesalts, 20.0 weight portions
Own azoles alcohol 1.0 weight portions
Alkyl polyoxyethylene ether sulfonate 5.0 weight portions
Sodium lignin sulfonate 4.0 weight portions
NONIN HS 240 (8-9 moles of ethylene oxide) 3.0 weight portions
The kaolin surplus
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get said preparation.
This embodiment is used to prevent and treat grape powdery mildew.By 3000 extraordinarily water dilution sprayings, 7 days control efficiency is 95.6% behind the medicine with said preparation.40,%00 can get wetting powder by 1000 times and 10% hexaconazole suspending agent by 1000 times, with using with quadrat method, behind the medicine 7 days preventive effect be respectively 75.6% and two eight guanidinesalts of 86.3%. obvious with the composite synergistic effect afterwards of own azoles alcohol, to the preventive effect of grape powdery mildew significantly better than single agent; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
Embodiment 3 suspending agents (gross weight of preparation is 100 parts)
Two eight guanidinesalts, 40.0 weight portions
Own azoles alcohol 4.0 weight portions
Propane diols 3.0 weight portions
Lignosulfonates 10.0 weight portions
Sodium Polyacrylate 5.0 weight portions
Octyl phenol polyglycol ether (11-14 moles of ethylene oxide) 5.0 weight portions
Water surplus
The very thin active ingredient of mill is thoroughly mixed with auxiliary agent, and the suspending agent dilutable water that obtains becomes any suspension that needs concentration.
This embodiment is used to prevent and treat gray mold of cucumber.By 4000 extraordinarily water dilution sprayings, 7 days control efficiency is 94.8% behind the medicine with said preparation.40,%00 can get wetting powder by 1000 times and 10% own azoles alcohol missible oil by 2000 times, use with quadrat method and use, 7 days preventive effect is respectively 84.6% and 75.7% behind the medicine.The composite back synergistic effect of two eight guanidinesalts and own azoles alcohol is obvious, to the preventive effect of gray mold of cucumber significantly better than single agent; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
Embodiment 4 water dispersible granules (gross weight of preparation is 100 parts)
Two eight guanidinesalts, 2.0 weight portions
Own azoles alcohol 40.0 weight portions
Polyvinyl alcohol 5.0 weight portions
Sodium Laurylsulfate 7.0 weight portions
Lignosulfonates 11.0 weight portions
The kaolin surplus
Above-mentioned substance is evenly mixed, grinds, mixes suitable quantity of water and granulation, promptly get said preparation after the drying.
This embodiment is used to prevent and treat graw mold of tomato.By 4000 extraordinarily water dilution sprayings, 7 days control efficiency is 92.8% behind the medicine with said preparation.40,%00 can get wetting powder by 1000 times and 10% hexaconazole suspending agent by 2000 times, use with quadrat method and use, 7 days preventive effect is respectively 87.8% and 77.7% behind the medicine.The composite back synergistic effect of two eight guanidinesalts and own azoles alcohol is obvious, to the preventive effect of graw mold of tomato significantly better than single agent; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
Embodiment 5 wetting powders (gross weight of preparation is 100 parts)
Two eight guanidinesalts, 5.0 weight portions
Own azoles alcohol 25.0 weight portions
Alkyl polyoxyethylene ether sulfonate 5.0 weight portions
Sodium lignin sulfonate 4.0 weight portions
NONIN HS 240
(8-9 moles of ethylene oxide) 3.0 weight portions
The kaolin surplus
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get said preparation.
This embodiment is used to prevent and treat apple mildew.By 4000 extraordinarily water dilution sprayings, 7 days control efficiency is 96.8% behind the medicine with said preparation.40,%00 can get wetting powder by 1000 times and 10% hexaconazole microemulsion by 2000 times, use with quadrat method and use, 7 days preventive effect is respectively 72.8% and 86.7% behind the medicine.The composite back synergistic effect of two eight guanidinesalts and own azoles alcohol is obvious, to the preventive effect of apple mildew significantly better than single agent; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
Embodiment 6 suspended emulsions (gross weight of preparation is 100 parts)
Two eight guanidinesalts, 45.0 weight portions
Own azoles alcohol 9.0 weight portions
Dimethylbenzene 10.0 weight portions
Propane diols 3.0 weight portions
Lignosulfonates 10.0 weight portions
Sodium Polyacrylate 5.0 weight portions
Octyl phenol polyglycol ether (11-14 moles of ethylene oxide) 5.0 weight portions
Water surplus
The very thin active ingredient guazatine of mill is thoroughly mixed with auxiliary agent, obtain containing the water of guazatine; Own azoles alcohol is dissolved in mixes the oil phase that obtains containing own azoles alcohol in the dimethylbenzene again with auxiliary agent; Oil phase is added aqueous phase obtain suspended emulsion.
This embodiment is used to prevent and treat grey mould fruit rot of strawberry.By 4000 extraordinarily water dilution sprayings, 7 days control efficiency is 96.4% behind the medicine with said preparation.40,%00 can get wetting powder by 1000 times and 10% hexaconazole suspending agent by 2000 times, use with quadrat method and use, 7 days preventive effect is respectively 85.6% and 75.7% behind the medicine.The composite back synergistic effect of two eight guanidinesalts and own azoles alcohol is obvious, to the preventive effect of grey mould fruit rot of strawberry significantly better than single agent; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
Embodiment 7 water dispersible granules (gross weight of preparation is 100 parts)
Two eight guanidinesalts, 60.0 weight portions
Own azoles alcohol 20.0 weight portions
Polyvinyl alcohol 2.0 weight portions
Sodium Laurylsulfate 4.0 weight portions
Lignosulfonates 5.0 weight portions
The kaolin surplus
Above-mentioned substance is evenly mixed, grinds, mixes suitable quantity of water and granulation, promptly get said preparation after the drying.
This embodiment is used to prevent and treat the tomato powdery mildew.By 5000 extraordinarily water dilution sprayings, 7 days control efficiency is 98.8% behind the medicine with said preparation.40,%00 can get wetting powder by 1000 times and 10% hexaconazole suspending agent by 2000 times, use with quadrat method and use, 7 days preventive effect is respectively 73.5% and 86.3% behind the medicine.The composite back synergistic effect of two eight guanidinesalts and own azoles alcohol is obvious, to the preventive effect of tomato powdery mildew significantly better than single agent; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
Embodiment 8 wetting powders (gross weight of preparation is 100 parts)
Two eight guanidinesalts, 10.0 weight portions
Own azoles alcohol 10.0 weight portions
Alkyl polyoxyethylene ether sulfonate 5.0 weight portions
Sodium lignin sulfonate 4.0 weight portions
NONIN HS 240
(8-9 moles of ethylene oxide) 3.0 weight portions
The kaolin surplus
Active component, various auxiliary agent and filler etc. are fully mixed in the ratio of prescription, after ultrafine crusher is pulverized, promptly get said preparation.
This embodiment is used to prevent and treat the rose gray mold.By 4000 extraordinarily water dilution sprayings, 7 days control efficiency is 95.8% behind the medicine with said preparation.40,%00 can get wetting powder by 1000 times and 10% hexaconazole suspending agent by 2000 times, use with quadrat method and use, 7 days preventive effect is respectively 87.8% and 78.7% behind the medicine.The composite back synergistic effect of two eight guanidinesalts and own azoles alcohol is obvious, to the preventive effect of rose gray mold significantly better than single agent; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
Embodiment 9 suspending agents (gross weight of configuration is 100 parts)
Two eight guanidinesalts, 4.0 weight portions
Own azoles alcohol 1.0 weight portions
Propane diols 3.0 weight portions
Lignosulfonates 10.0 weight portions
Sodium Polyacrylate 5.0 weight portions
Octyl phenol polyglycol ether (11-14 moles of ethylene oxide) 5.0 weight portions
Water surplus
The very thin active ingredient of mill is thoroughly mixed with auxiliary agent, and the suspending agent dilutable water that obtains becomes any suspension that needs concentration.
This embodiment is used to prevent and treat the leek gray mold.By 2000 extraordinarily water dilution sprayings, 7 days control efficiency is 90.8% behind the medicine with said preparation.40,%00 can get wetting powder by 1000 times and 10% hexaconazole microemulsion by 2000 times, use with quadrat method and use, 7 days preventive effect is respectively 82.8% and 75.7% behind the medicine.The composite back synergistic effect of two eight guanidinesalts and own azoles alcohol is obvious, to the preventive effect of leek gray mold significantly better than single agent; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
Embodiment 10 suspending agents (gross weight of preparation is 100 parts)
Two eight guanidinesalts, 4.0 weight portions
Own azoles alcohol 40.0 weight portions
Propane diols 3.0 weight portions
Lignosulfonates 10.0 weight portions
Sodium Polyacrylate 5.0 weight portions
Octyl phenol polyglycol ether (11-14 moles of ethylene oxide) 5.0 weight portions
Water surplus
The very thin active ingredient of mill is thoroughly mixed with auxiliary agent, and the suspending agent dilutable water that obtains becomes any suspension that needs concentration.
This embodiment be used to prevent and treat grey mould of egg plant with said preparation by 4000 extraordinarily water dilution sprayings, 7 days control efficiency is 97.8% behind the medicine.40,%00 can get wetting powder by 1000 times and 10% own azoles alcohol missible oil by 2000 times, use with quadrat method and use, 7 days preventive effect is respectively 84.6% and 78.7% behind the medicine.The composite back synergistic effect of two eight guanidinesalts and own azoles alcohol is obvious, to the preventive effect of grey mould of egg plant significantly better than single agent; Because pharmacy control efficacy improves, the amount ratio of compound drug active ingredient uses obviously separately and reduces, thereby has alleviated the pollution to environment.
Claims (1)
1. the microbicide compositions with synergistic effect is used to prevent and treat the powdery mildew of fruit, vegetables, the application of gray mold;
Described microbicide compositions with synergistic effect is:
A) following formula (I):
n＝10～13
1 of expression, 1 '-imino group two (1, the inferior octyl group of 8-), two guanidine trialkyl benzene sulfonates, and
B) following formula (II):
2-(2,4 dichloro benzene the base)-1-[1 of expression, 2,4] triazol-1-yl-oneself-2-alcohol;
Wherein the mass ratio of compd A and B is 1: 20-20: 1.
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0255987A1 (en) * | 1986-07-21 | 1988-02-17 | Sandoz Ag | Improvements in or relating to fungicides |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101720755A (en) * | 2008-10-16 | 2010-06-09 | 广州植物龙生物技术有限公司 | Multiple synergy fungicide composite |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0255987A1 (en) * | 1986-07-21 | 1988-02-17 | Sandoz Ag | Improvements in or relating to fungicides |
Non-Patent Citations (1)
| Title |
|---|
| 俞勇权.5% 己唑醇SC 防治番茄灰霉病田间药效试验.《上海蔬菜》.2008,第5卷96-97. * |
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