CN102089302A - 含氮二环性杂环化合物 - Google Patents

含氮二环性杂环化合物 Download PDF

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Publication number
CN102089302A
CN102089302A CN200980126960XA CN200980126960A CN102089302A CN 102089302 A CN102089302 A CN 102089302A CN 200980126960X A CN200980126960X A CN 200980126960XA CN 200980126960 A CN200980126960 A CN 200980126960A CN 102089302 A CN102089302 A CN 102089302A
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CN
China
Prior art keywords
compound
substituent
general formula
alkyl
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200980126960XA
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English (en)
Chinese (zh)
Inventor
跡部公和
长沼健二
森本晃史
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Asahi Kasei Pharma Corp
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Asahi Kasei Pharma Corp
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Application filed by Asahi Kasei Pharma Corp filed Critical Asahi Kasei Pharma Corp
Publication of CN102089302A publication Critical patent/CN102089302A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200980126960XA 2008-07-17 2009-07-10 含氮二环性杂环化合物 Pending CN102089302A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8149808P 2008-07-17 2008-07-17
US61/081,498 2008-07-17
PCT/JP2009/062587 WO2010007944A1 (ja) 2008-07-17 2009-07-10 含窒素二環性複素環化合物

Publications (1)

Publication Number Publication Date
CN102089302A true CN102089302A (zh) 2011-06-08

Family

ID=41550347

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200980126960XA Pending CN102089302A (zh) 2008-07-17 2009-07-10 含氮二环性杂环化合物

Country Status (9)

Country Link
US (1) US7994202B2 (ko)
EP (1) EP2298767A4 (ko)
JP (1) JPWO2010007944A1 (ko)
KR (1) KR20100122512A (ko)
CN (1) CN102089302A (ko)
AU (1) AU2009272034B2 (ko)
CA (1) CA2728098A1 (ko)
RU (1) RU2011105810A (ko)
WO (1) WO2010007944A1 (ko)

Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN107295799A (zh) * 2014-12-19 2017-10-24 癌症研究科技有限公司 Parg抑制化合物
CN107624112A (zh) * 2014-12-29 2018-01-23 美国政府健康及人类服务部 乳酸脱氢酶的小分子抑制剂及其使用方法

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CA2737349A1 (en) 2008-10-09 2010-04-09 Asahi Kasei Pharma Corporation Indazole derivatives
WO2011049987A2 (en) * 2009-10-20 2011-04-28 Eiger Biopharmaceuticals, Inc. Azaindazoles to treat flaviviridae virus infection
CA2825746A1 (en) * 2011-01-26 2012-08-02 Kyorin Pharmaceutical Co. Ltd. Pyrazolopyridine derivative or pharmacologically acceptable salt thereof
BR112014029674A2 (pt) 2012-06-27 2017-06-27 Hoffmann La Roche composto, composição farmacêutica, método para o tratamento de uma doença, utilização de um composto, conjunto para o tratamento de uma condição mediada pela quinase pim e invenção
US9234112B2 (en) * 2013-06-05 2016-01-12 Korea Institute Of Machinery & Materials Metal precursor powder, method of manufacturing conductive metal layer or pattern, and device including the same
MA41140A (fr) 2014-12-12 2017-10-17 Cancer Research Tech Ltd Dérivés de 2,4-dioxo-quinazoline-6-sulfonamide en tant qu'inhibiteurs de la parg
WO2018013430A2 (en) 2016-07-12 2018-01-18 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus infection

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WO2008049875A1 (en) * 2006-10-27 2008-05-02 Boehringer Ingelheim International Gmbh Novel substituted piperidyl-propane-thiols
WO2008054749A1 (en) * 2006-10-31 2008-05-08 Schering Corporation 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors

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WO2002015902A1 (en) 2000-08-23 2002-02-28 Merck & Co., Inc. Method of treating or preventing urinary incontinence using prostanoid ep1 receptor antagonists
US6820064B1 (en) * 2000-08-31 2004-11-16 Hewlett-Packard Development Company, L.P. E-commerce consumables
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Publication number Priority date Publication date Assignee Title
WO2005009993A1 (en) * 2003-07-15 2005-02-03 Smithkline Beecham Corporation Novel compounds
WO2008006793A1 (en) * 2006-07-14 2008-01-17 Glaxo Group Limited Indole compounds
WO2008049875A1 (en) * 2006-10-27 2008-05-02 Boehringer Ingelheim International Gmbh Novel substituted piperidyl-propane-thiols
WO2008054749A1 (en) * 2006-10-31 2008-05-08 Schering Corporation 2-aminothiazole-4-carboxylic amides as protein kinase inhibitors

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107295799A (zh) * 2014-12-19 2017-10-24 癌症研究科技有限公司 Parg抑制化合物
CN107295799B (zh) * 2014-12-19 2021-03-16 癌症研究科技有限公司 Parg抑制化合物
CN112979631A (zh) * 2014-12-19 2021-06-18 癌症研究科技有限公司 Parg抑制化合物
CN107624112A (zh) * 2014-12-29 2018-01-23 美国政府健康及人类服务部 乳酸脱氢酶的小分子抑制剂及其使用方法
US10961200B2 (en) 2014-12-29 2021-03-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
US11247971B2 (en) 2014-12-29 2022-02-15 The Trustees Of The University Of Pennsylvania Small molecule inhibitors of lactate dehydrogenase and methods of use thereof
CN107624112B (zh) * 2014-12-29 2022-03-04 美国政府健康及人类服务部 乳酸脱氢酶的小分子抑制剂及其使用方法

Also Published As

Publication number Publication date
AU2009272034B2 (en) 2011-10-13
RU2011105810A (ru) 2012-08-27
KR20100122512A (ko) 2010-11-22
AU2009272034A1 (en) 2010-01-21
US20100029733A1 (en) 2010-02-04
JPWO2010007944A1 (ja) 2012-01-05
WO2010007944A1 (ja) 2010-01-21
EP2298767A1 (en) 2011-03-23
CA2728098A1 (en) 2010-01-21
US7994202B2 (en) 2011-08-09
EP2298767A4 (en) 2011-10-19

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SE01 Entry into force of request for substantive examination
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WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20110608