CN102085264A - Method for preparing Rukuaixiao syrup - Google Patents
Method for preparing Rukuaixiao syrup Download PDFInfo
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- CN102085264A CN102085264A CN2009102730968A CN200910273096A CN102085264A CN 102085264 A CN102085264 A CN 102085264A CN 2009102730968 A CN2009102730968 A CN 2009102730968A CN 200910273096 A CN200910273096 A CN 200910273096A CN 102085264 A CN102085264 A CN 102085264A
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Abstract
The invention relates to the field of preparing medicaments, in particular to a method for preparing Rukuaixiao syrup. The preparation method comprises the following steps of: weighing 330 grams of orange leaf, 330 grams of root of red-rooted salvia, 220 grams of Chinese honeylocust spine, 220 grams of semen vaccariae, 220 grams of toosendan fruit and 220 grams of earthworm, washing, collecting, cutting and drying the raw materials, adding water in an amount which is 8 times that of the raw materials for decoction for one hour for the first time, filtering, adding water in an amount which is 6 times that of the raw materials for decoction for one hour for the second time, filtering, mixing the filter liquor, concentrating the filer liquor under reduced pressure at the temperature of between 60 and 70 DEG C to obtain clear paste(the relative density(85 DEG C) is 1.25 to 1.30), and naturally cooling the clear paste; weighing the semen vaccariae and the earthworm in the ratio, performing reflux extraction on the semen vaccariae and the earthworm twice by 70 percent ethanol, namely adding the ethanol in an amount which is 8 times that of the semen vaccariae for reflux extraction for 2 hours for the first time and adding the ethanol in an amount which is 6 times that of the semen vaccariae for reflux extraction for 1 hour for the second time, filtering the solution respectively, and mixing the filter liquor; adding the filter liquor into the clear paste, uniformly stirring to obtain the medicinal solution, adding the ethanol into the medicinal solution to increase the content of ethanol to 70 percent, uniformly stirring the medicinal solution, standing the medicinal solution for 24 hours, filtering the medicinal solution, recovering the ethanol from the filter liquor, condensing the filer liquor under reduced pressure at the temperature of between 60 and 70 DEG C to obtain thick paste(the relative density(85 DEG C) is 1.30 to 1.35), and naturally cooling the thick paste.
Description
Technical field
The present invention relates to the production field of medicine, is the syrupy preparation method of a kind of RUKUAIXIAO.Be a kind of treatment depression of liver-QI, qi depression to blood stasis, cyclomastopathy, the newtype drug of diseases such as distending pain of the breast.
Background technology
RUKUAIXIAO PIAN has depressed liver-energy dispersing and QI regulating, blood circulation promoting and blood stasis dispelling, dissolving breast mass.Be used for depression of liver-QI, qi depression to blood stasis, cyclomastopathy, distending pain of the breast.Cyclomastopathy is a kind of disease comparatively common in the gynecological, and sickness rate is higher in the adult women.This disease is characteristics with mammary gland tumor and pain clinically, is the hypertrophy of variform on the pathology, wherein levelling hypertrophy, ductal epithelium height hypertrophy, and atypical hyperplasias etc. have substantial connection with breast carcinoma.Doctor trained in Western medicine at present more adopts operation or gonadotherapy, but can not solve cause of disease problem, and side effect is many, and postoperative often recurs, and is not easy to be accepted by extensive patients, is not ideal method.The traditional Chinese medical science is with dispersing the stagnated live-QI to relieve the stagnation of QI, blood circulation promoting and blood stasis dispelling, and the fundamentum treatment primary disease of vanishing sputum and dispelling knot, multipotency reaches the purpose for the treatment of both the principal and secondary aspects of a disease.RUKUAIXIAO PIAN is used for the treatment of the qi stagnation and blood stasis type cyclomastopathy, proves that through clinical use of more than ten years the no toxicity determined curative effect of these product all obtains satisfactory result after the invalid patient of use antibiotic takes RUKUAIXIAO PIAN.
Summary of the invention
The objective of the invention is to provide a kind of new treatment depression of liver-QI, qi depression to blood stasis, cyclomastopathy, the newtype drug of diseases such as distending pain of the breast.On the basis of former RUKUAIXIAO PIAN, on its prescription, the constant basis of extraction process, change dosage form and make syrup, to satisfy different patients' clinical needs.
The present invention is achieved in that 1. pre-treatments: get Folium Citri tangerinae 330g, Radix Salviae Miltiorrhizae 330g, Spina Gleditsiae 220g, Semen Vaccariae 220g, Fructus Toosendan 220g, Pheretima 220g, through wash, pick up, cut, drying, standby; 2. preparation technology: measure Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Fructus Toosendan four Chinese medicine material by above-mentioned prescription, add 8 times of water gagings for the first time and decoct, add 6 times of water gagings for the second time and decoct, each 1 hour, decocting liquid filtered, and filtrate merges, and is standby; 3. concentrate: under 60-70 ℃, being evaporated to relative density is the clear paste of 1.25-1.30 (85 ℃), puts cold, standby with above-mentioned filtrate; 4. alcohol reflux: measure Pheretima, Semen Vaccariae with 70% alcohol reflux secondary by above-mentioned prescription, add for the first time 8 times of amount alcohol reflux 2 hours, add for the second time 6 times of amount alcohol reflux 1 hour, gradation filters, merging filtrate, join in the above-mentioned clear paste, stir medicinal liquid, standby; Precipitate with ethanol, reclaim ethanol: above-mentioned medicinal liquid is added ethanol makes and contain the alcohol amount and reach 70%, stir, left standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to relative density under 60-70 ℃ is the thick paste of 1.30-1.35 (85 ℃), puts cold, standby; 6. batching, fill: get sodium benzoate 1.5g, the stupid ethyl ester 0.3g of hydroxyl, be dissolved in the 330ml distilled water that boils, in the above-mentioned thick paste of impouring, stir evenly, cooling back adding distil water is adjusted to 1000ml, promptly gets syrup.
Owing to adopted technique scheme, in the dosage form moulding process, syrup has shortened technological process with respect to tablet, has improved production efficiency, is fit to industrialization production.
The specific embodiment
Below in conjunction with actual example the present invention is further described.
1. pre-treatment: get Folium Citri tangerinae 330g, Radix Salviae Miltiorrhizae 330g, Spina Gleditsiae 220g, Semen Vaccariae 220g, Fructus Toosendan 220g, Pheretima 220g by Pharmacopoeia of the People's Republic of China version requirement in 2005 wash, pick up, cut, drying, standby.2. preparation technology: measure Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Fructus Toosendan four Chinese medicine material by above-mentioned prescription, add 8 times of water gagings for the first time and decoct, add 6 times of water gagings for the second time and decoct, each 1 hour, decocting liquid filtered, and filtrate merges, and is standby.3. concentrate: under 60-70 ℃, being evaporated to relative density is the clear paste of 1.25-1.30 (85 ℃), puts cold, standby with above-mentioned filtrate.4. alcohol reflux: measure Pheretima, Semen Vaccariae with 70% alcohol reflux secondary by above-mentioned prescription, add for the first time 8 times of amount alcohol reflux 2 hours, add for the second time 6 times of amount alcohol reflux 1 hour, gradation filters, merging filtrate, join in the above-mentioned clear paste, stir medicinal liquid, standby.Precipitate with ethanol, reclaim ethanol: above-mentioned medicinal liquid is added ethanol makes and contain the alcohol amount and reach 70%, stir, left standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to relative density under 60-70 ℃ is the thick paste of 1.30-1.35 (85 ℃), puts cold, standby.6. batching, fill: get sodium benzoate 1.5g, the stupid ethyl ester 0.3g of hydroxyl, be dissolved in the 330ml distilled water that boils, in the above-mentioned thick paste of impouring, stir evenly, cooling back adding distil water is adjusted to 1000ml, promptly gets syrup.
Cyclomastopathy is the closely-related proliferative disease of endocrine dysfunction, claims mammary dysplasia again.Be characterized in because mammary gland composition hypertrophy, with regard to its essence neither inflammation, also non-tumor, but breast duct and lobule degeneration structurally and the variation of carrying out property, be a mammary gland tissue and a matter in various degree hypertrophy and subinvolution due to mammary gland tissue quantity increase, paramophia, mammary gland normal structure structure gets muddled.The traditional Chinese medical science is classified cyclomastopathy as following three types of liver qi stagnation types, suitable depressed liver-energy dispersing and QI regulating, dissipating phlegm and resolving masses; The genus liver-kidney yin deficiency, should transfer the liver the kidney invigorating, dissipating phlegm and resolving masses; The genus Chong and Ren channel disorder type, suitable Chong and Ren Meridians regulating, the kidney warming suppressing the hyperactive liver.Treatment cyclomastopathy medicine is a lot of at present, but mostly is tablet greatly.Change dosage form and make syrup, to satisfy different patients' clinical needs.
Claims (1)
1. syrupy preparation method of RUKUAIXIAO is characterized in that 1. pre-treatments: get Folium Citri tangerinae 330g, Radix Salviae Miltiorrhizae 330g, Spina Gleditsiae 220g, Semen Vaccariae 220g, Fructus Toosendan 220g, Pheretima 220g, through wash, pick up, cut, drying, standby; 2. preparation technology: measure Folium Citri tangerinae, Radix Salviae Miltiorrhizae, Spina Gleditsiae, Fructus Toosendan four Chinese medicine material by above-mentioned prescription, add 8 times of water gagings for the first time and decoct, add 6 times of water gagings for the second time and decoct, each 1 hour, decocting liquid filtered, and filtrate merges, and is standby; 3. concentrate: under 60-70 ℃, being evaporated to relative density is the clear paste of 1.25-1.30 (85 ℃), puts cold, standby with above-mentioned filtrate; 4. alcohol reflux: measure Pheretima, Semen Vaccariae with 70% alcohol reflux secondary by above-mentioned prescription, add for the first time 8 times of amount alcohol reflux 2 hours, add for the second time 6 times of amount alcohol reflux 1 hour, gradation filters, merging filtrate, join in the above-mentioned clear paste, stir medicinal liquid, standby; Precipitate with ethanol, reclaim ethanol: above-mentioned medicinal liquid is added ethanol makes and contain the alcohol amount and reach 70%, stir, left standstill 24 hours, filter, filtrate recycling ethanol, being evaporated to relative density under 60-70 ℃ is the thick paste of 1.30-1.35 (85 ℃), puts cold, standby; 6. batching, fill: get sodium benzoate 1.5g, the stupid ethyl ester 0.3g of hydroxyl, be dissolved in the 330ml distilled water that boils, in the above-mentioned thick paste of impouring, stir evenly, cooling back adding distil water is adjusted to 1000ml, promptly gets syrup.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009102730968A CN102085264A (en) | 2009-12-06 | 2009-12-06 | Method for preparing Rukuaixiao syrup |
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| CN2009102730968A CN102085264A (en) | 2009-12-06 | 2009-12-06 | Method for preparing Rukuaixiao syrup |
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| CN102085264A true CN102085264A (en) | 2011-06-08 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383467A (en) * | 2014-12-15 | 2015-03-04 | 许莹 | Traditional Chinese medicine for treating liver-qi depression type cervical cancer and preparation method of traditional Chinese medicine |
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2009
- 2009-12-06 CN CN2009102730968A patent/CN102085264A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104383467A (en) * | 2014-12-15 | 2015-03-04 | 许莹 | Traditional Chinese medicine for treating liver-qi depression type cervical cancer and preparation method of traditional Chinese medicine |
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Open date: 20110608 |